The effects of simulated +Gz and microgravity on intervertebral disc degeneration in rabbits.

Abstract:

:The overall objective of this study was to test the hypothesis that +Gz (hypergravity/positive acceleration) and microgravity can both aggravate intervertebral disc degeneration (IVDD). Due to +Gz and microgravity, many pilots develop IVDD. However, the lack of animal models of IVDD under conditions of simulated +Gz and microgravity has hampered research on the onset and prevention of IVDD. Rabbits were randomly allotted to a control group, microgravity group, +Gz group, or mixed (+Gz + microgravity) group. A tail-suspension model was utilized to simulate a microgravity environment and an animal centrifuge to mimic +Gz conditions. After exposure to the above conditions for 4, 8, and 24 weeks, the body weights (BW) of animals in the control group gradually increased over time, while those of animals in the microgravity and mixed groups both decreased (p < 0.001). As compared with the control group, the proteoglycan content of animals in the other three groups was significantly reduced (F = 192.83, p < 0.001). The imageological, histopathological, and immunohistochemical changes to the L6-S1 intervertebral disc samples suggests that the effects of +Gz and microgravity can aggravate IVDD over time. The mixed effects of +Gz and microgravity had the greatest effect on degeneration and +Gz had a particularly greater effect than microgravity.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Wu D,Zhou X,Zheng C,He Y,Yu L,Qiu G,Wu Z,Wu J,Liu Y

doi

10.1038/s41598-019-53246-7

subject

Has Abstract

pub_date

2019-11-12 00:00:00

pages

16608

issue

1

issn

2045-2322

pii

10.1038/s41598-019-53246-7

journal_volume

9

pub_type

杂志文章
  • Spatial-temporal variation of marginal land suitable for energy plants from 1990 to 2010 in China.

    abstract::Energy plants are the main source of bioenergy which will play an increasingly important role in future energy supplies. With limited cultivated land resources in China, the development of energy plants may primarily rely on the marginal land. In this study, based on the land use data from 1990 to 2010(every 5 years i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep05816

    authors: Jiang D,Hao M,Fu J,Zhuang D,Huang Y

    更新日期:2014-07-24 00:00:00

  • The impact of injury on apparent survival of whale sharks (Rhincodon typus) in South Ari Atoll Marine Protected Area, Maldives.

    abstract::The whale shark (Rhincodon typus) is an endangered species with a declining global population. The South Ari Atoll Marine Protected Area (SAMPA), Maldives, is one of few locations globally where year-long residency of individuals occurs. This SAMPA aggregation appears to consist almost exclusively of immature males. D...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-79101-8

    authors: Harvey-Carroll J,Stewart JD,Carroll D,Mohamed B,Shameel I,Zareer IH,Araujo G,Rees R

    更新日期:2021-01-13 00:00:00

  • Disturbance type determines how connectivity shapes ecosystem resilience.

    abstract::Connectivity is fundamentally important for shaping the resilience of complex human and natural networks when systems are disturbed. Ecosystem resilience is, in part, shaped by the spatial arrangement of habitats, the permeability and fluxes between them, the stabilising functions performed by organisms, their dispers...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-021-80987-1

    authors: Pearson RM,Schlacher TA,Jinks KI,Olds AD,Brown CJ,Connolly RM

    更新日期:2021-01-13 00:00:00

  • Design methodology for a confocal imaging system using an objective microlens array with an increased working distance.

    abstract::In this study, a design methodology for a multi-optical probe confocal imaging system was developed. To develop an imaging system that has the required resolving power and imaging area, this study focused on a design methodology to create a scalable and easy-to-implement confocal imaging system. This system overcomes ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep33278

    authors: Choi W,Shin R,Lim J,Kang S

    更新日期:2016-09-12 00:00:00

  • Genetic markers and continuity of healthy metabolic status: Tehran cardio-metabolic genetic study (TCGS).

    abstract::Obese individuals can be categorized as "healthy obese" (MHO) and "unhealthy obese" (MUO) based on the presence or absence of metabolic abnormality. This study sets out to assess potential genetic causes behind persistence of healthy metabolic status in individuals categorized as "healthy obese". This study was conduc...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-70627-5

    authors: Gharooi Ahangar O,Javanrouh N,Daneshpour MS,Barzin M,Valizadeh M,Azizi F,Hosseinpanah F

    更新日期:2020-08-12 00:00:00

  • Internal fixation treatments for intertrochanteric fracture: a systematic review and meta-analysis of randomized evidence.

    abstract::The relative effects of internal fixation strategies for intertrochanteric fracture after operation remain uncertain. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to address this important issue. We searched PubMed, EMBASE and CENTRAL for RCTs that compared different intern...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析,评审

    doi:10.1038/srep18195

    authors: Yu J,Zhang C,Li L,Kwong JS,Xue L,Zeng X,Tang L,Li Y,Sun X

    更新日期:2015-12-11 00:00:00

  • Segmentation of biological multivariate time-series data.

    abstract::Time-series data from multicomponent systems capture the dynamics of the ongoing processes and reflect the interactions between the components. The progression of processes in such systems usually involves check-points and events at which the relationships between the components are altered in response to stimuli. Det...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep08937

    authors: Omranian N,Mueller-Roeber B,Nikoloski Z

    更新日期:2015-03-11 00:00:00

  • Activity concentrations of environmental samples collected in Fukushima Prefecture immediately after the Fukushima nuclear accident.

    abstract::Radionuclide concentrations in environmental samples such as surface soils, plants and water were evaluated by high purity germanium detector measurements. The contribution rate of short half-life radionuclides such as (132)I to the exposure dose to residents was discussed from the measured values. The highest values ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep02283

    authors: Hosoda M,Tokonami S,Tazoe H,Sorimachi A,Monzen S,Osanai M,Akata N,Kakiuchi H,Omori Y,Ishikawa T,Sahoo SK,Kovács T,Yamada M,Nakata A,Yoshida M,Yoshino H,Mariya Y,Kashiwakura I

    更新日期:2013-01-01 00:00:00

  • RNA seq analyses of chicken reveals biological pathways involved in acclimation into different geographical locations.

    abstract::Transcriptome expression reflects genetic response in diverse conditions. In this study, RNA sequencing was utilized to profile multiple tissues such as liver, breast, caecum, and gizzard of Korean commercial chicken raised in Korea and Kyrgyzstan. We analyzed ten samples per tissue from each location to identify cand...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-76234-8

    authors: Kumar H,Choo H,Iskender AU,Srikanth K,Kim H,Zhunushov AT,Jang GW,Lim Y,Song KD,Park JE

    更新日期:2020-11-06 00:00:00

  • DNA barcoding of Mobulid Ray Gill Rakers for Implementing CITES on Elasmobranch in China.

    abstract::The Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) has been counted on for conserving threatened marine fish since it regulates the commercial international trade of these species. Implementation of the international treaty for Mantas included on CITES Appendix II is challengin...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep37567

    authors: Zeng Y,Wu Z,Zhang C,Meng Z,Jiang Z,Zhang J

    更新日期:2016-11-23 00:00:00

  • The Distribution Characteristics and Applications for Maternal Cells on Chicken Egg Vitelline Membrane.

    abstract::The major components of vitelline membrane (VM) are ovomucin, VM outer (VMO) I and VMO II. At present, the distribution pattern of maternal cells on the VM has not been described in detail. In this study, the existence and distribution characteristics of maternal cells on VM were observed. There were more than 3.2 × 1...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-06996-1

    authors: Li Q,Li W,Li X,Liu L,Zhang Y,Guo Y,Chen X,Xu G,Zheng J

    更新日期:2017-07-26 00:00:00

  • Risk of active tuberculosis development in contacts exposed to infectious tuberculosis in congregate settings in Korea.

    abstract::Contact investigation is an important and effective active case-finding strategy, but there is a lack of research on congregate settings in countries with an intermediate incidence. This study determined the incidence of and risk factors for tuberculosis (TB) development after exposure in congregate settings. This ret...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-57697-1

    authors: Park SY,Han S,Kim YM,Kim J,Lee S,Yang J,Kim UN,Park MS

    更新日期:2020-01-28 00:00:00

  • Comprehensive Multi-Dimensional MRI for the Simultaneous Assessment of Cardiopulmonary Anatomy and Physiology.

    abstract::Diagnostic testing often assesses the cardiovascular or respiratory systems in isolation, ignoring the major pathophysiologic interactions between the systems in many diseases. When both systems are assessed currently, multiple modalities are utilized in costly fashion with burdensome logistics and decreased accessibi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-04676-8

    authors: Cheng JY,Zhang T,Alley MT,Uecker M,Lustig M,Pauly JM,Vasanawala SS

    更新日期:2017-07-13 00:00:00

  • Application of Bld-1-Embedded Elastin-Like Polypeptides in Tumor Targeting.

    abstract::Expression of various molecules on the surface of cancer cells compared to normal cells creates a platform for the generation of various drug vehicles for targeted therapy. Multiple interactions between ligands and their receptors mediated by targeting peptide-modified polymer could enable simultaneous delivery of a d...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-21910-z

    authors: Sarangthem V,Cho EA,Yi A,Kim SK,Lee BH,Park RW

    更新日期:2018-03-01 00:00:00

  • Structural basis for substrate and product recognition in human phosphoglucomutase-1 (PGM1) isoform 2, a member of the α-D-phosphohexomutase superfamily.

    abstract::Human phosphoglucomutase 1 (PGM1) is an evolutionary conserved enzyme that belongs to the ubiquitous and ancient α-D-phosphohexomutases, a large enzyme superfamily with members in all three domains of life. PGM1 catalyzes the bi-directional interconversion between α-D-glucose 1-phosphate (G1P) and α-D-glucose 6-phosph...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-62548-0

    authors: Backe PH,Laerdahl JK,Kittelsen LS,Dalhus B,Mørkrid L,Bjørås M

    更新日期:2020-03-27 00:00:00

  • Ecosystem responses to warming and watering in typical and desert steppes.

    abstract::Global warming is projected to continue, leading to intense fluctuations in precipitation and heat waves and thereby affecting the productivity and the relevant biological processes of grassland ecosystems. Here, we determined the functional responses to warming and altered precipitation in both typical and desert ste...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep34801

    authors: Xu Z,Hou Y,Zhang L,Liu T,Zhou G

    更新日期:2016-10-10 00:00:00

  • Effect of NIR laser therapy by MLS-MiS source against neuropathic pain in rats: in vivo and ex vivo analysis.

    abstract::Neuropathic pain is characterized by an uncertain etiology and by a poor response to common therapies. The ineffectiveness and the frequent side effects of the drugs used to counteract neuropathic pain call for the discovery of new therapeutic strategies. Laser therapy proved to be effective for reducing pain sensitiv...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-45469-5

    authors: Micheli L,Cialdai F,Pacini A,Branca JJV,Morbidelli L,Ciccone V,Lucarini E,Ghelardini C,Monici M,Di Cesare Mannelli L

    更新日期:2019-06-26 00:00:00

  • The activation of Mucolipin TRP channel 1 (TRPML1) protects motor neurons from L-BMAA neurotoxicity by promoting autophagic clearance.

    abstract::Cellular clearance mechanisms including the autophagy-lysosome pathway are impaired in amyotrophic lateral sclerosis (ALS). One of the most important proteins involved in the regulation of autophagy is the lysosomal Ca2+ channel Mucolipin TRP channel 1 (TRPML1). Therefore, we investigated the role of TRPML1 in a neuro...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-46708-5

    authors: Tedeschi V,Petrozziello T,Sisalli MJ,Boscia F,Canzoniero LMT,Secondo A

    更新日期:2019-07-24 00:00:00

  • Leakage of astrocyte-derived extracellular vesicles in stress-induced exhaustion disorder: a cross-sectional study.

    abstract::Patients with stress-induced exhaustion disorder (SED) demonstrate cognitive dysfunction similar to patients with minor traumatic brain injury (TBI). We have previously detected elevated concentrations of astrocyte-derived extracellular vesicles (EVs) in patients with TBI. As such, we hypothesized that astrocyte-deriv...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-021-81453-8

    authors: Wallensten J,Nager A,Åsberg M,Borg K,Beser A,Wilczek A,Mobarrez F

    更新日期:2021-01-21 00:00:00

  • BRD4 regulates adiponectin gene induction by recruiting the P-TEFb complex to the transcribed region of the gene.

    abstract::We previously reported that induction of the adipocyte-specific gene adiponectin (Adipoq) during 3T3-L1 adipocyte differentiation is closely associated with epigenetic memory histone H3 acetylation on the transcribed region of the gene. We used 3T3-L1 adipocytes and Brd4 heterozygous mice to investigate whether the in...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-12342-2

    authors: Sakurai N,Inamochi Y,Inoue T,Hariya N,Kawamura M,Yamada M,Dey A,Nishiyama A,Kubota T,Ozato K,Goda T,Mochizuki K

    更新日期:2017-09-20 00:00:00

  • Causal relevance of circulating high-density lipoprotein cholesterol with cancer: a Mendelian randomization meta-analysis.

    abstract::We summarized published data on the associations of apolipoprotein E (APOE) gene ε2/ε3/ε4 polymorphism with both cancer risk and circulating lipid profiles, aiming to examine the causal relevance between lipids and cancer risk. Article identification and data abstraction were conducted in duplicate and independently b...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析

    doi:10.1038/srep09495

    authors: Yang C,Tian G,Mi J,Wei X,Li X,Li X,Wang W,Wang B

    更新日期:2015-03-30 00:00:00

  • A Novel Y-Specific Long Non-Coding RNA Associated with Cellular Lipid Accumulation in HepG2 cells and Atherosclerosis-related Genes.

    abstract::There is an increasing appreciation for the role of the human Y chromosome in phenotypic differences between the sexes in health and disease. Previous studies have shown that genetic variation within the Y chromosome is associated with cholesterol levels, which is an established risk factor for atherosclerosis, the un...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17165-9

    authors: Molina E,Chew GS,Myers SA,Clarence EM,Eales JM,Tomaszewski M,Charchar FJ

    更新日期:2017-12-01 00:00:00

  • Pyridoxamine improves survival and limits cardiac dysfunction after MI.

    abstract::Advanced glycation end products (AGEs) play a key role in the progression of heart failure. Whether treatments limiting AGEs formation would prevent adverse left ventricular remodeling after myocardial infarction (MI) remain unknown. We investigated whether pyridoxamine (PM) could limit adverse cardiac outcome in MI. ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-16255-y

    authors: Deluyker D,Ferferieva V,Driesen RB,Verboven M,Lambrichts I,Bito V

    更新日期:2017-11-22 00:00:00

  • Magnetically-induced ferroelectricity in the (ND4)2[FeCl5(D2O)] molecular compound.

    abstract::The number of magnetoelectric multiferroic materials reported to date is scarce, as magnetic structures that break inversion symmetry and induce an improper ferroelectric polarization typically arise through subtle competition between different magnetic interactions. The (NH4)2[FeCl5(H2O)] compound is a rare case wher...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep14475

    authors: Alberto Rodríguez-Velamazán J,Fabelo Ó,Millán Á,Campo J,Johnson RD,Chapon L

    更新日期:2015-09-29 00:00:00

  • Task-dependent functional organizations of the visual ventral stream.

    abstract::The visual hierarchy of the ventral stream has been widely studied. However, it remains unclear how the hierarchical system organizes its functional coupling during top-down cognitive process. The present fMRI study investigated task-dependent functional connectivity along the ventral stream, while twenty-eight partic...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-45707-w

    authors: Jo HG,Ito J,Schulte Holthausen B,Baumann C,Grün S,Habel U,Kellermann T

    更新日期:2019-06-27 00:00:00

  • Selective capturing of phenolic derivative by a binary metal oxide microcubes for its detection.

    abstract::Development of highly efficient and potential material for toxic p-nitrophenol is an important design for sensitive detection of hazardous species from ecology and environment. Here it is developed, an efficient as well as selective of p-nitrophenol using binary material by electrochemical performances, including good...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-55891-4

    authors: Rahman MM

    更新日期:2019-12-17 00:00:00

  • A novel and effective method to generate human porcine-specific regulatory T cells with high expression of IL-10, TGF-β1 and IL-35.

    abstract::Organ transplantation remains the most effective treatment for patients with late stage organ failure. Transgenic pigs provide an alternative organ donor source to the limited availability of human organs. However, cellular rejection still remains to be the obstacle for xenotransplantation. Superior to other methods, ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-04322-3

    authors: Li M,Eckl J,Geiger C,Schendel DJ,Pohla H

    更新日期:2017-06-21 00:00:00

  • Comparison of the microbial composition of African fermented foods using amplicon sequencing.

    abstract::Fermented foods play a major role in the diet of people in Africa, where a wide variety of raw materials are fermented. Understanding the microbial populations of these products would help in the design of specific starter cultures to produce standardized and safer foods. In this study, the bacterial diversity of Afri...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-50190-4

    authors: Diaz M,Kellingray L,Akinyemi N,Adefiranye OO,Olaonipekun AB,Bayili GR,Ibezim J,du Plessis AS,Houngbédji M,Kamya D,Mukisa IM,Mulaw G,Manthi Josiah S,Onyango Chienjo W,Atter A,Agbemafle E,Annan T,Bernice Ackah N,Buys EM

    更新日期:2019-09-25 00:00:00

  • Altered regional homogeneity and functional brain networks in Type 2 diabetes with and without mild cognitive impairment.

    abstract::Patients with Type-2 Diabetes Mellitus (T2DM) have a considerably higher risk of developing mild cognitive impairment (MCI) and dementia. The initial symptoms are very insidious at onset. We investigated the alterations in spontaneous brain activity and network connectivity through regional homogeneity (ReHo) and grap...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-76495-3

    authors: Xiong Y,Chen X,Zhao X,Fan Y,Zhang Q,Zhu W

    更新日期:2020-12-04 00:00:00

  • An evidence-based knowledgebase of metastasis suppressors to identify key pathways relevant to cancer metastasis.

    abstract::Metastasis suppressor genes (MS genes) are genes that play important roles in inhibiting the process of cancer metastasis without preventing growth of the primary tumor. Identification of these genes and understanding their functions are critical for investigation of cancer metastasis. Recent studies on cancer metasta...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15478

    authors: Zhao M,Li Z,Qu H

    更新日期:2015-10-21 00:00:00