Abstract：
:In cloud water, microorganisms are exposed to very strong stresses especially related to the presence of reactive oxygen species including H2O2 and radicals, which are the driving force of cloud chemistry. In order to understand how the bacterium Pseudomonas graminis isolated from cloud water respond to this oxidative stress, it was incubated in microcosms containing a synthetic solution of cloud water in the presence or in the absence of H2O2. P. graminis metabolome was examined by LC-MS and NMR after 50 min and after 24 hours of incubation. After 50 min, the cells were metabolizing H2O2 while this compound was still present in the medium, and it was completely biodegraded after 24 hours. Cells exposed to H2O2 had a distinct metabolome as compared to unexposed cells, revealing modulations of certain metabolic pathways in response to oxidative stress. These data indicated that the regulations observed mainly involved carbohydrate, glutathione, energy, lipid, peptides and amino-acids metabolisms. When cells had detoxified H2O2 from the medium, their metabolome was not distinguishable anymore from unexposed cells, highlighting the capacity of resilience of this bacterium. This work illustrates the interactions existing between the cloud microbial metabolome and cloud chemistry.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wirgot N,Lagrée M,Traïkia M,Besaury L,Amato P,Canet I,Sancelme M,Jousse C,Diémé B,Lyan B,Delort AMdoi
10.1038/s41598-019-49319-2subject
Has Abstractpub_date
2019-09-05 00:00:00pages
12799issue
1issn
2045-2322pii
10.1038/s41598-019-49319-2journal_volume
9pub_type
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