Abstract:
:The airways of individuals with cystic fibrosis (CF) are abundantly colonised by Staphylococcus aureus and Pseudomonas aeruginosa. Co-infecting hypoxic regions of static mucus within CF airways, together with decreases in pulmonary function, mucus plugging and oxygen consumption by host neutrophils gives rise to regions of anoxia. This study determined the impact of anaerobiosis upon S. aureus-P. aeruginosa interactions in planktonic co-culture and mixed species biofilms in vitro. Whilst anoxia reduced the ability for P. aeruginosa CF isolates to dominate over S. aureus, this occurred in an isolate dependent manner. Investigations into the underlying mechanisms suggest that the anti-staphylococcal compound facilitating P. aeruginosa dominance under normoxia and anoxia is greater than 3 kDa in size and is heat-stable. Not all interspecies interactions studied were antagonistic, as S. aureus exoproducts were shown to restore and enhance P. aeruginosa motility under normoxia and anoxia in an isolate dependent manner. Collectively, this study suggests changes in oxygen availability within regions of the CF lung is likely to influence interspecies interactions and in turn, potentially influence disease progression.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Pallett R,Leslie LJ,Lambert PA,Milic I,Devitt A,Marshall LJdoi
10.1038/s41598-019-42952-xsubject
Has Abstractpub_date
2019-05-01 00:00:00pages
6748issue
1issn
2045-2322pii
10.1038/s41598-019-42952-xjournal_volume
9pub_type
杂志文章abstract::The activation of the majority of AGC kinases is regulated by two phosphorylation events on two conserved serine/threonine residues located on the activation loop and on the hydrophobic motif, respectively. In AGC kinase family, phosphomimetic substitutions with aspartate or glutamate, leading to constitutive activati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56937-3
更新日期:2020-01-17 00:00:00
abstract::Pompe disease (PD) is a metabolic myopathy due to acid alpha-glucosidase deficiency and characterized by extensive glycogen storage and impaired autophagy. We previously showed that modulation of autophagy and lysosomal exocytosis by overexpression of the transcription factor EB (TFEB) gene was effective in improving ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15352-2
更新日期:2017-11-08 00:00:00
abstract::Dirac-like surface states on surfaces of topological insulators have a chiral spin structure with spin locked to momentum, which is interesting in physics and may also have important applications in spintronics. In this work, by measuring the tunable helicity-dependent photocurrent (HDP), we present an identification ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04889
更新日期:2014-05-08 00:00:00
abstract::Translesion synthesis (TLS) is the mechanism by which DNA polymerases replicate through unrepaired DNA lesions. TLS is activated by monoubiquitination of the homotrimeric proliferating cell nuclear antigen (PCNA) at lysine-164, followed by the switch from replicative to specialized polymerases at DNA damage sites. Pol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15759
更新日期:2015-10-27 00:00:00
abstract::Natural variability in pH in the diffusive boundary layer (DBL), the discrete layer of seawater between bulk seawater and the outer surface of organisms, could be an important factor determining the response of corals and coralline algae to ocean acidification (OA). Here, two corals with different morphologies and one...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49044-w
更新日期:2019-09-06 00:00:00
abstract::Here we report two types of defect-induced photoluminescence (PL) blinking behaviors observed in single epitaxial InGaAs quantum dots (QDs). In the first type of PL blinking, the "off" period is caused by the trapping of hot electrons from the higher-lying excited state (absorption state) to the defect site so that it...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08898
更新日期:2015-03-10 00:00:00
abstract::The study aims to evaluate the effectiveness of local injection of autologous platelet rich plasma (A-PRP) as a treatment for women suffering from stress urinary incontinence (SUI). In a prospective intervention study, twenty consecutive women suffering from SUI were treated with A-PRP injection at anterior vaginal wa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80598-2
更新日期:2021-01-15 00:00:00
abstract::We propose a novel scheme to realize an optical waveguide induced by an active Raman gain (ARG) process in a four-level N-type atomic system. Because of the nature of the ARG, there are two distinct features related to the waveguide: i) It is not absorptive, on the contrary, weak gain is presented; ii) It can be impro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14456-z
更新日期:2017-10-27 00:00:00
abstract::Aminoacyl-tRNA synthetases are the key enzymes for protein synthesis. Glycine, alanine, serine and tyrosine are the major amino acids composing fibroin of silkworm. Among them, the genes of alanyl-tRNA synthetase (AlaRS) and glycyl-tRNA synthetase (GlyRS) have been cloned. In this study, the seryl-tRNA synthetase (Ser...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41563
更新日期:2017-01-30 00:00:00
abstract::1β-hydroxy alantolactone, a sesquiterpene lactone, exhibits potent anti-inflammatory and anticancer activities. Recently, it has been found to target UbcH5s by covalently bonding with Cys85 specifically, but the exact molecular basis remains unclear. Here, we analyzed the structural specificity of the catalytic site o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-57104-4
更新日期:2020-01-10 00:00:00
abstract::A highly sensitive microwave near-field sensor based on electrically-small planar resonators is proposed for highly accurate characterization of dielectric materials. The proposed sensor was developed in a robust complete-cycle topology optimization procedure wherein first the sensing area was pixelated. By maximizing...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49767-w
更新日期:2019-09-16 00:00:00
abstract::Tolerance to Dutch elm disease (DED) has been linked to the rapid and/or high induction of disease-responsive genes after infection with the fungus Ophiostoma novo-ulmi. Although the fungal infection by O. novo-ulmi primarily takes places in xylem vessels, it is still unclear how xylem contributes to the defense again...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07779-4
更新日期:2017-08-02 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies. The genomic landscape of the PDAC genome features four frequently mutated genes (KRAS, CDKN2A, TP53, and SMAD4) and dozens of candidate driver genes altered at low frequency, including potential clinical targets. Circulating cell-free...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/srep18425
更新日期:2015-12-16 00:00:00
abstract::When faced with adverse environmental conditions, the marsupial Dromiciops gliroides uses either daily or seasonal torpor to support survival and is the only known hibernating mammal in South America. As the sole living representative of the ancient Order Microbiotheria, this species can provide crucial information ab...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24627
更新日期:2016-04-19 00:00:00
abstract::Local and systemic oxidative stress in intraocular pressure (IOP) elevation and optic nerve damage may be involved in the pathogenesis of glaucoma. We reported previously that a lower level of systemic antioxidative capacity is associated with IOP elevation in open-angle glaucoma (OAG). We assessed the correlation bet...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25792
更新日期:2016-05-11 00:00:00
abstract::Animal models are indispensible to investigate the pathogenesis and treatments of non-alcoholic fatty liver diseases (NAFLD). Altered cholesterol metabolism has been implicated into the pathogenesis of NAFLD. Here, using high fat, cholesterol and cholate diet (HFHC), we generated a novel tree shrew (Tupaia belangeri c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15970
更新日期:2015-11-02 00:00:00
abstract::Benign prostatic hyperplasia (BPH) results in a significant public health burden due to the morbidity caused by the disease and many of the available remedies. As much as 70% of men over 70 will develop BPH. Few studies have been conducted to discover the genetic determinants of BPH risk. Understanding the biological ...
journal_title:Scientific reports
pub_type: 杂志文章,多中心研究
doi:10.1038/s41598-019-42427-z
更新日期:2019-04-15 00:00:00
abstract::To explore the feasibility of 3D-printed navigation template in proximal femoral varus rotation and shortening osteotomy for older children with developmental dysplasia of the hip (DDH). Between June 2014 and May 2015, navigation templates were designed and used for 12 DDH patients. Surgical information and outcomes w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44993
更新日期:2017-03-21 00:00:00
abstract::We have applied a combined computational procedure based on inverse and direct docking in order to identify putative protein targets of a panel of mycotoxins and xenobiotic compounds that can contaminate food and that are known to have several detrimental effects on human health. This procedure allowed us to identify ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15148-4
更新日期:2017-11-09 00:00:00
abstract::Various sea foods including fish, shellfish and shrimp were collected from different coastal areas of Fujian in China, and their Pb species characteristics were investigated in detail. The results indicated that there are two different species characteristics of Pb existing in sea food samples. About half of samples w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33294
更新日期:2016-09-14 00:00:00
abstract::Regional differences in ion channel activity in the heart control the sequence of repolarization and may contribute to differences in contraction. Corticosteroids such as aldosterone or corticosterone increase the L-type Ca2+ current (ICaL) in the heart via the mineralocorticoid receptor (MR). Here, we investigate the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68308-4
更新日期:2020-07-14 00:00:00
abstract::Current literature suggests that epigenetically regulated super-enhancers (SEs) are drivers of aberrant gene expression in cancers. Many tumor types are still missing chromatin data to define cancer-specific SEs and their role in carcinogenesis. In this work, we develop a simple pipeline, which can utilize chromatin d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51018-x
更新日期:2019-10-21 00:00:00
abstract::The use of microwave (MW) irradiation to increase the rate of chemical reactions has attracted much attention recently in nearly all fields of chemistry due to substantial enhancements in reaction rates. However, the intrinsic nature of the effects of MW irradiation on chemical reactions remains unclear. Herein, the h...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25149
更新日期:2016-04-27 00:00:00
abstract::Increased prostaglandin E2 (PGE2) levels were detected in mitochondrial disease patient cells harboring nuclear gene mutations in structural subunits of complex I, using a metabolomics screening approach. The increased levels of this principal inflammation mediator normalized following exposure of KH176m, an active re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79466-w
更新日期:2021-01-13 00:00:00
abstract::The ultrathin SmCo5 nanoflakes with average thickness smaller than 50 nm are prepared by a novel method of solid particle (NaCl) and surfactant co-assisted ball milling. The as-prepared nanoflakes exhibit a narrower thickness distribution of 10-50 nm and high coercivity of 23 kOe. The possible formation mechanism of n...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25805
更新日期:2016-05-13 00:00:00
abstract::Cathelicidins are short cationic host defense peptides and play a central role in host innate immune system. Here we identified two novel cathelicidins, Cl-CATH2 and 3, from Columba livia. Evolutionary analysis of avian cathelicidins via phylogenetic tree and Ka/Ks calculations supported the positive selection that pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11082
更新日期:2015-07-21 00:00:00
abstract::We consider an optimal quantum key distribution setup based on minimal number of measurement bases with binary yields used by parties against an eavesdropper limited only by the no-signaling principle. We note that in general, the maximal key rate can be achieved by determining the optimal tradeoff between measurement...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30959
更新日期:2016-08-03 00:00:00
abstract::Aberrant restoration of AR activity is linked with prostate tumor growth, therapeutic failures and development of castrate-resistant prostate cancer. Understanding the processes leading to AR-reactivation should provide the foundation for novel avenues of drug discovery. A differential gene expression study was conduc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10068-9
更新日期:2017-08-29 00:00:00
abstract::The protective effects of statins against stenosis for permanent hemodialysis access have been repeatedly demonstrated in animal studies, but remain controversial in human studies. This study aims to evaluate the association between statin use and permanent hemodialysis access patency using a nationwide hemodialysis c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22197
更新日期:2016-02-23 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-55967-1
更新日期:2019-12-24 00:00:00