Abstract:
:Coexisting bacteria form various microbial communities in human body parts. In these ecosystems they interact in various ways and the properties of the interaction network can be related to the stability and functional diversity of the local bacterial community. In this study, we analyze the interaction network among bacterial OTUs in 11 locations of the human body. These belong to two major groups. One is the digestive system and the other is the female genital tract. In each local ecosystem we determine the key species, both the ones being in key positions in the interaction network and the ones that dominate by frequency. Beyond identifying the key players and discussing their biological relevance, we also quantify and compare the properties of the 11 networks. The interaction networks of the female genital system and the digestive system show totally different architecture. Both the topological properties and the identity of the key groups differ. Key groups represent four phyla of prokaryotes. Some groups appear in key positions in several locations, while others are assigned only to a single body part. The key groups of the digestive and the genital tracts are totally different.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Jordán F,Lauria M,Scotti M,Nguyen TP,Praveen P,Morine M,Priami Cdoi
10.1038/srep15920subject
Has Abstractpub_date
2015-10-30 00:00:00pages
15920issn
2045-2322pii
srep15920journal_volume
5pub_type
杂志文章abstract::Phytic acid (PA) is the primary phosphorus (P) storage compound in the seeds of cereals and legumes. Low PA crops, which are considered an effective way to improve grain nutrient availability and combat environmental issues relating to seed P have been developed using mutational and reverse genetics approaches. Here, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51485-2
更新日期:2019-10-16 00:00:00
abstract::Proteins that act as global transcriptional regulators play key roles in bacterial adaptation to new niches. These proteins recognize multiple DNA sites across the bacterial genome by different mechanisms. Enterococcus faecalis is able to survive in various niches of the human host, either as a commensal or as a leadi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42484-4
更新日期:2019-04-16 00:00:00
abstract::Pulse wave transit time (PWTT) has been widely used as an index in assessing arterial stiffness. Percutaneous coronary intervention (PCI) is usually applied to the treatment of coronary artery disease (CAD). Research on the changes in PWTT caused by PCI is helpful for understanding the impact of the PCI procedure. In ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18520-6
更新日期:2018-01-08 00:00:00
abstract::Glycans are biologically important structures synthesised by glycosyltransferase (GT) enzymes. Disruptive genetic null variants in GT genes can lead to serious illness but benign phenotypes are also seen, including antigenic differences on the red blood cell (RBC) surface, giving rise to blood groups. To characterise ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24445-5
更新日期:2018-04-16 00:00:00
abstract::Although aversive memory has been mainly addressed by analysing the changes occurring in average populations, the study of neuronal mechanisms of outliers allows understanding the involvement of individual differences in fear conditioning and extinction. We recently developed an innovative experimental model of indivi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21205
更新日期:2016-02-15 00:00:00
abstract::Type-II Diabetes Mellitus (T2DM) is one of the fastest growing public health issues of modern times, consuming 12% of worldwide health budgets and affecting an estimated 400 million people. A key pathological trait associated with this disease is the failure of normal glucose-stimulated insulin secretion (GSIS) from p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39681-6
更新日期:2019-02-27 00:00:00
abstract::The essential cochaperone Sgt1 recruits Hsp90 chaperone activity to a range of cellular factors including SCF E3 ubiquitin ligases and the kinetochore in eukaryotes. In these pathways Sgt1 interacts with Skp1, a small protein that heterodimerizes with proteins containing the F-box motif. We have determined the crystal...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41626
更新日期:2017-01-31 00:00:00
abstract::Streptococcus mutans is known to be a major causative agent of dental caries, and strains expressing the cell surface collagen-binding Cnm protein contribute to the development of several systemic diseases. A relationship between tonsillar immunity and glomerulonephritis has been recognized in IgA nephropathy (IgAN), ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56679-2
更新日期:2019-12-27 00:00:00
abstract::Phytophthora blight is one of the most serious diseases affecting melon (Cucumis melo) production. Due to the lack of highly resistant germplasms, the progress on disease-resistant research is slow. To understand the genetics of melon resistance to Phytophthora capsici, an F2 population containing 498 individuals was ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77600-2
更新日期:2020-11-24 00:00:00
abstract::Reliable quantification of miRNA expression by qRT-PCR crucially depends on validated housekeepers for data normalization. Here we present thoroughly tested miRNAs eligible as references in immunological studies utilizing endothelial cells and macrophages, respectively. Endothelial cells (cell line: TIME) and macropha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49241-7
更新日期:2019-09-04 00:00:00
abstract::Saturn rings are most beautiful and dynamic places in the solar system, consisting of ice particles in a constant battle between the gravitational forces of Saturn and its many moons. Fan, spiral, propellers, moonlets and streamer-channels observed by CASSINI in the F-ring have been attributed to encounters by Prometh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01276
更新日期:2013-01-01 00:00:00
abstract::We aimed to investigate the association of smoking and physical exercise on ventricular function and structure, determined by cardiac magnetic resonance imaging (CMR), in subjects without known cardiovascular diseases. A total of 381 participants (median age 57 years) of the Cooperative Health Research in the Region o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54956-8
更新日期:2019-12-09 00:00:00
abstract::The extracellular matrix (ECM) impacts stem cell differentiation, but identifying formulations supportive of differentiation is challenging in 3D models. Prior efforts involving combinatorial ECM arrays seemed intuitively advantageous. We propose an alternative that suggests reducing sample size and technological burd...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18705
更新日期:2015-12-21 00:00:00
abstract::Primates are now known to possess well-developed olfactory sensitivity and discrimination capacities that can play a substantial role in many aspects of their interaction with conspecifics and the environment. Several studies have demonstrated that olfactory cues may be useful in fruit selection. Here, using a conditi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14895
更新日期:2015-10-06 00:00:00
abstract::One of the major drawbacks of cheminformatics is a large amount of information present in the datasets. In the majority of cases, this information contains redundant instances that affect the analysis of similarity measurements with respect to drug design and discovery. Therefore, using classical methods such as the p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71502-z
更新日期:2020-09-02 00:00:00
abstract::It has been well established that some Armillaria species are symbionts of Polyporus umbellatus, However, little is known about the evolutionary history of P. umbellatus-Armillaria associations. In this research, we used an analysis based on the strength of the phylogenetic signal to investigate P. umbellatus-Armillar...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04578-9
更新日期:2017-06-26 00:00:00
abstract::Melamine detection has attracted much attention since the discovery of the damage of melamine to human health. Herein, we have developed a sensitive homogeneous electroanalytical platform for melamine detection, which is relied on the formation of triplex molecular beacon integrated with exonuclease III (Exo III)-medi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04812-4
更新日期:2017-07-03 00:00:00
abstract::Stem and progenitor cells are the critical units for tissue maintenance, regeneration, and repair. The activation of regenerative events in response to tissue injury has been correlated with mobilization of tissue-resident progenitor cells, which is functional to the wound healing process. However, until now there has...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16574
更新日期:2015-11-12 00:00:00
abstract::A better understanding of the structure and extent of genetic variability in a breeding population of a crop is essential for translating genetic diversity to genetic gain. We assessed the nature and pattern of genetic variability and differentiation in a panel of 100 winged-yam (Dioscorea alata) accessions using 24 p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54761-3
更新日期:2019-12-03 00:00:00
abstract::We investigated whether dogs remember their spontaneous past actions relying on episodic-like memory. Dogs were trained to repeat a small set of actions upon request. Then we tested them on their ability to repeat other actions produced by themselves, including actions performed spontaneously in everyday situations. D...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67302-0
更新日期:2020-06-26 00:00:00
abstract::To investigate the role of the circadian clock in the development of alcohol-induced fatty liver disease we examined livers of mice chronically alcohol-fed over 4-weeks that resulted in steatosis. Here we show time-of-day specific changes in expression of clock genes and clock-controlled genes, including those associa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03725
更新日期:2014-01-16 00:00:00
abstract::At present, there is a growing interest in the study of the neurotropic activity of polyunsaturated fatty acids ethanolamides (N-acylethanolamines). N-docosahexaenoylethanolamine (DHEA, synaptamide) is an endogenous metabolite and structural analogue of anandamide, a widely studied endocannabinoid derived from arachid...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80818-9
更新日期:2021-01-12 00:00:00
abstract::Recently, there has been a debate whether implicit Theory of Mind can be reliably measured using anticipatory looking tasks. Previous anticipatory looking paradigms used video stimuli to measure implicit Theory of Mind; however, numerous replications of these paradigms were unsuccessful. This lack of replications may ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80614-5
更新日期:2021-01-13 00:00:00
abstract::Scleroderma is a refractory autoimmune skin fibrotic disorder. Alterations of microRNAs in lesional skin could be a new approach to treating the disease. Here, we found that expression of miR-155 was up regulated in lesional skin tissue from patients with either systemic or localized scleroderma, and correlated with f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20314
更新日期:2016-02-01 00:00:00
abstract::Temporal binding of urea to lysozyme was examined using X-ray diffraction of single crystals of urea/lysozyme complexes prepared by soaking native lysozyme crystals in solutions containing 9 M urea. Four different soak times of 2, 4, 7 and 10 hours were used. The five crystal structures (including the native lysozyme)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32277
更新日期:2016-08-30 00:00:00
abstract::Ecosystem functions are regulated by compositional and functional traits of bacterial communities, shaped by stochastic and deterministic processes. Biogeographical studies have revealed microbial community taxonomy in a given ecosystem to change alongside varying environmental characteristics. Considering that stable...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40315-0
更新日期:2019-03-06 00:00:00
abstract::Natural Bacillus isolates generate limited amounts of surfactin (<10% of their biomass), which functions as an antibiotic or signalling molecule in inter-/intra-specific interactions. However, overproduction of surfactin in Bacillus amyloliquefaciens MT45 was observed at a titre of 2.93 g/l, which is equivalent to hal...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40976
更新日期:2017-01-23 00:00:00
abstract::We compared commercial kits for extraction of genomic DNA from the Gram-negative bacterium Klebsiella pneumoniae for subsequent Miseq sequencing. Purification of DNA was based on matrix binding (silica or anion exchange resin) or differential precipitation (salting out), respectively. The choice of extraction kit had ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28063
更新日期:2016-06-17 00:00:00
abstract::In this study, we demonstrate that the lysine methyltransferase G9a inhibits sarcomere organization through regulation of the MEF2C-HDAC5 regulatory axis. Sarcomeres are essential for muscle contractile function. Presently, skeletal muscle disease and dysfunction at the sarcomere level has been associated with mutatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34163
更新日期:2016-09-26 00:00:00
abstract::We assessed 1-year outcomes in patients with atrial fibrillation enrolled in the EurObservational Research Programme AF General Pilot Registry (EORP-AF), in relation to kidney function, as assessed by glomerular filtration rate (eGFR). In a cohort of 2398 patients (median age 69 years; 61% male), eGFR (ml/min/1.73 m(2...
journal_title:Scientific reports
pub_type: 杂志文章,多中心研究
doi:10.1038/srep30271
更新日期:2016-07-28 00:00:00