Abstract：
:Lactobacillus species are the predominant vaginal microbiota found in healthy women of reproductive age and help to prevent pathogen infection by producing lactic acid, H2O2 and anti-microbial compounds. Identification of novel vaginal Lactobacillus isolates that exhibit efficient colonisation and secrete anti-Candida factors is a promising strategy to prevent vulvovaginal candidiasis. The azole antifungal agents used to treat vulvovaginal candidiasis elicit adverse effects such as allergic responses and exhibit drug interactions. Candida strains with resistance to antifungal treatments are often reported. In this study, we isolated Lactobacillus species from healthy Korean women and investigated their antifungal effects against C. albicans in vitro and in vivo. Lactobacillus conditioned supernatant (LCS) of L. crispatus and L. fermentum inhibited C. albicans growth in vitro. A Lactobacillus-derived compound, which was not affected by proteolytic enzyme digestion and heat inactivation, inhibited growth and hyphal induction of C. albicans after adjustment to neutral pH. Combination treatment with neutral LCSs of L. crispatus and L. fermentum effectively inhibited propagation of C. albicans in a murine in vivo model of vulvovaginal candidiasis.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Jang SJ,Lee K,Kwon B,You HJ,Ko Gdoi
10.1038/s41598-019-44579-4subject
Has Abstractpub_date
2019-05-31 00:00:00pages
8121issue
1issn
2045-2322pii
10.1038/s41598-019-44579-4journal_volume
9pub_type
杂志文章abstract：:SRY, a sex-determining gene, induces testis development in chromosomally female (XX) individuals. However, mouse XX Sertoli cells carrying Sry (XX/Sry Sertoli cells) are incapable of fully supporting germ cell development, even when the karyotype of the germ cells is XY. While it has therefore been assumed that XX/Sry...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41912
更新日期：2017-02-02 00:00:00
abstract：:Knee osteoarthritis (OA) is the most common musculoskeletal disorder. OA diagnosis is currently conducted by assessing symptoms and evaluating plain radiographs, but this process suffers from subjectivity. In this study, we present a new transparent computer-aided diagnosis method based on the Deep Siamese Convolution...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20132-7
更新日期：2018-01-29 00:00:00
abstract：:Plasmacytoid dendritic cells (pDCs) are specialized in the production of interferons (IFNs) in response to viral infections. The Flaviviridae family comprises enveloped RNA viruses such as Hepatitis C virus (HCV) and Dengue virus (DENV). Cell-free flaviviridae virions poorly stimulate pDCs to produce IFN. By contrast,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29235-7
更新日期：2018-07-18 00:00:00
abstract：:Advancing the design of thin-film composite membrane surfaces is one of the most promising pathways to deal with treating varying water qualities and increase their long-term stability and permeability. Although plasma technologies have been explored for surface modification of bulk micro and ultrafiltration membrane ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29206
更新日期：2016-07-01 00:00:00
abstract：:In adipose tissue, agonists of the β3-adrenergic receptor (ADRB3) regulate lipolysis, lipid oxidation, and thermogenesis. The deficiency in the thermogenesis induced by neuroblast differentiation-associated protein AHNAK in white adipose tissue (WAT) of mice fed a high-fat diet suggests that AHNAK may stimulate energy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23426
更新日期：2016-03-18 00:00:00
abstract：:Our goals was to evaluate how sentinel lymph node biopsy (SLNB) benefit neck management in patients with parotid cancer. Patients diagnosed with cN0 parotid cancer by preoperative fine needle puncture were prospectively enrolled. The neck status was evaluated by SLNB. If node metastasis was proved by SLNB, a neck diss...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44790-3
更新日期：2019-06-06 00:00:00
abstract：:Rho GTPases are master regulators of the eukaryotic cytoskeleton. The activation of Rho GTPases is governed by Rho guanine nucleotide exchange factors (GEFs). Three RhoGEF isoforms are produced by the gene ARHGEF25; p63RhoGEF580, GEFT and a recently discovered longer isoform of 619 amino acids (p63RhoGEF619). The subc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36825
更新日期：2016-11-11 00:00:00
abstract：:Spontaneous pattern formation in a variety of spatially extended nonlinear systems always occurs through a modulation instability, sometimes called Turing instability: the homogeneous state of the system becomes unstable with respect to growing modulation modes. Therefore, the manipulation of the modulation instabilit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13268
更新日期：2015-08-19 00:00:00
abstract：:We compare two approaches for deriving corrections to the "linear model" of cavity optomechanics, in order to describe effects that are beyond first order in the radiation pressure coupling. In the regime where the mechanical frequency is much lower than the cavity one, we compare: (I) a widely used phenomenological H...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26739-0
更新日期：2018-06-14 00:00:00
abstract：:Direct growth of MoS2 nanowalls on vapor grown carbon nanofibers (VGCNFs) has been achieved using a microwave-assisted hydrothermal (MAH) method under an acidic condition. The acidic condition was obtained through the addition of an HCl aqueous solution. We demonstrate that the HCl not only modifies the pH value for l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05805-z
更新日期：2017-07-20 00:00:00
abstract：:Although Heme Oxygenase-1 (HO-1) induction in various forms of kidney injury is protective, its role in age-related renal pathology is unknown. In the ageing kidney there is nephron loss and lesions of focal glomerulosclerosis, interstitial fibrosis, tubular atrophy and arteriolosclerosis. Underlying mechanisms includ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62016-9
更新日期：2020-03-31 00:00:00
abstract：:Oxygen-induced retinopathy (OIR) upregulates Müller cell vascular endothelial growth factor A (VEGFA) that causes intravitreal neovascularization similar to severe retinopathy of prematurity (ROP). Safety concerns exist with anti-VEGF treatment for ROP. We evaluated long-term knockdown of Müller cell-VEGFA with short-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20278-4
更新日期：2018-01-31 00:00:00
abstract：:The nervous system controls most rhythmic behaviors, with a remarkable exception. In Caenorhabditis elegans periodic defecation rhythm does not appear to involve the nervous system. Such oscillations are studied in detail with genetic and molecular biology tools. The small size of C. elegans cells impairs the use of s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18118-y
更新日期：2017-12-19 00:00:00
abstract：:Understanding how a species utilises its habitat, and the processes that give rise to its movements and patterns of space use, is critical for its conservation. Southern Ground-hornbills Bucorvus leadbeateri are listed as Endangered in South Africa, as a result of habitat loss and persecution. The National Species Rec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73236-4
更新日期：2020-10-01 00:00:00
abstract：:Long Terminal Repeats (LTRs) are nearly identical DNA sequences found at either end of Human Endogenous Retroviruses (HERVs). The high sequence similarity that exists among different LTRs suggests they could be substrate of ectopic gene conversion events. To understand the extent to which gene conversion occurs and to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28710
更新日期：2016-06-27 00:00:00
abstract：:Link prediction in complex networks aims at predicting the missing links from available datasets which are always incomplete and subject to interfering noises. To obtain high prediction accuracy one should try to complete the missing information and at the same time eliminate the interfering noise from the datasets. G...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14847-2
更新日期：2017-11-07 00:00:00
abstract：:Most women with ovarian cancer are diagnosed at an advanced stage and there are few therapeutic options. Recently, monoclonal antibody therapies have had limited success, thus more effective antibodies are needed to improve long-term survival. In this report, we prepared polyclonal rabbit anti-ovarian cancer antibody ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04984
更新日期：2014-05-15 00:00:00
abstract：:An effective analysis method was developed based on a chemometric tool for the simultaneous quantification of five different post-harvest pesticides (2,4-dichlorophenoxyacetic acid (2,4-D), carbendazim, thiabendazole, iprodione, and prochloraz) in fruits and vegetables. In the modified QuEChERS (quick, easy, cheap, ef...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42489
更新日期：2017-02-22 00:00:00
abstract：:Solar-cells based on Schottky junctions between metals and semiconductors (without or with an intermediate insulator) are among the main possibilities towards economical photovoltaic conversion of the solar energy. This is mainly due to their structural simplicity and hence the ease of their realization. We propose he...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14528-0
更新日期：2017-10-27 00:00:00
abstract：:The crystal structure of the Sb6O13 oxide, exhibiting a defect pyrochlore crystal structure with atomic vacancies, has been studied using a complete set of state-of-the-art techniques. The degree of antimony disproportionation in Sb3+ and Sb5+ valence states has been directly determined around 36% and 64%, respectivel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73860-0
更新日期：2020-10-12 00:00:00
abstract：:Generating various laser sources is important in the communication systems. We propose an approach that uses a mechanical resonator coupled with the optical fibre system to produce periodic and chaotic optical signals. The resonator is structured in such a way that the nonlinear oscillation occurs conveniently. The me...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05020-w
更新日期：2017-07-06 00:00:00
abstract：:Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal forms of cancer. One major reason for this is that PDAC quickly metastasizes to other organs, thereby making its treatment difficult. The molecular machinery driving PDAC metastasis is still poorly understood. In this study, we applied an unbiased appro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58448-y
更新日期：2020-01-30 00:00:00
abstract：:Detection dogs, specially trained domestic dogs (Canis familiaris), have become a valuable, noninvasive, conservation tool because they remove the dependence of attracting species to a particular location. Further, detection dogs locate samples independent of appearance, composition, or visibility allowing researchers...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32244-1
更新日期：2018-09-14 00:00:00
abstract：:Diagnosis of sleep apnea (SA) using simple tools has the potential to improve the efficacy of cardiac implants in the prevention of cardiac arrhythmias. The aim of the present study was to validate a transthoracic impedance sensor for SA diagnosis in patients with cardiac implants. We compared the apnea-hypopnea index...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45255-3
更新日期：2019-07-03 00:00:00
abstract：:Meat quality has an important genetic component and can be modified by the fatty acid (FA) composition and the amount of fat contained in adipose tissue and muscle. The present study aimed to find genomic regions associated with the FA composition in backfat and muscle (longissimus dorsi) in 439 pigs with three differ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70894-2
更新日期：2020-08-18 00:00:00
abstract：:Adaptation to systematic visual distortions is well-documented but there is little evidence of similar adaptation to radical changes in audition. We use a pseudophone to transpose the sound streams arriving at the left and right ears, evaluating the perceptual effects it provokes and the possibility of learning to loc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61332-4
更新日期：2020-03-12 00:00:00
abstract：:While the feasibility of transpapillary drug delivery has previously been established, localized transport via the mammary ducts may be improved with tailored drug delivery formulations. The objective of this study was to investigate the impact of nanoemulsion encapsulation on transpapillary delivery in vitro. Nanoemu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48144-x
更新日期：2019-08-14 00:00:00
abstract：:This study investigates the relationship between objective cognitive impairment (OCI), subjective cognitive complaints and depressive symptoms in men and women with classical and non-classical Fabry disease (FD). Cognitive functioning was assessed using a neuropsychological test battery, subjective cognitive complaint...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37320-0
更新日期：2019-01-17 00:00:00
abstract：:The aim of this study is to compare patients with and without mastalgia and to analyze the factors affecting mastalgia and its severity. The patient's age, height, weight, educational status, marital status, and occupation were recorded in all subjects. In addition, the women were asked about the presence of any risk ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-82099-2
更新日期：2021-01-29 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is not sensitive to radiotherapy and chemotherapy and experiences postoperative relapse extremely easy, which is the major cause of the high mortality rate. The Notch signaling pathway is expected to become a new target for the biological treatment of HCC. We searched databases for studi...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-017-14897-6
更新日期：2017-11-01 00:00:00
