Abstract：
:Most women with ovarian cancer are diagnosed at an advanced stage and there are few therapeutic options. Recently, monoclonal antibody therapies have had limited success, thus more effective antibodies are needed to improve long-term survival. In this report, we prepared polyclonal rabbit anti-ovarian cancer antibody (Poly Ab) by immunizing rabbits with the human ovarian cancer cell line SKOV3. The Poly Ab bound to SKOV3 and inhibited the cancer cells proliferation. Western blot analysis was conducted, which indicated that Poly Ab inhibited cancer cells through apoptosis involving the caspase signaling pathway including caspase-3 and caspase-9. Finally, compared with the control antibody, administration of Poly Ab reached 64% and 72% tumor inhibition in the subcutaneous and intraperitoneal xenograft mouse model, respectively. Our findings suggest that Poly Ab is an effective agent for apoptosis induction and may be useful as a safe anticancer agent for ovarian cancer therapy.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhang S,Yu M,Deng H,Shen G,Wei Ydoi
10.1038/srep04984subject
Has Abstractpub_date
2014-05-15 00:00:00pages
4984issn
2045-2322pii
srep04984journal_volume
4pub_type
杂志文章abstract：:Tendon is composed of fascicles bound together by the interfascicular matrix (IFM). Energy storing tendons are more elastic and extensible than positional tendons; behaviour provided by specialisation of the IFM to enable repeated interfascicular sliding and recoil. With ageing, the IFM becomes stiffer and less fatigu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09995-4
更新日期：2017-08-30 00:00:00
abstract：:The Field Effect sensors are broadly used for detecting various target analytes in chemical and biological solutions. We report the conditions under which the pH sensitivity of an Ion Sensitive Field Effect transistor (ISFET) sensor can be significantly enhanced. Our theory and simulations show that by using pH buffer...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41305
更新日期：2017-02-02 00:00:00
abstract：:To assess the correlation between penile hypersensitivity and premature ejaculation (PE), a total of 420 consecutive subjects attending our andrologic clinic for suspected PE were enrolled. The entire cohort was asked to complete the self-report intravaginal ejaculation latency time (IELT) by stopwatch. According to t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09155-8
更新日期：2017-09-05 00:00:00
abstract：:Magnetic vortex is one of the simplest topologically non-trivial textures in condensed matter physics. It is the ground state of submicron magnetic elements (dots) of different shapes: cylindrical, square etc. So far, the vast majority of the vortex dynamics studies were focused on thin dots with thickness 5-50 nm and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13881
更新日期：2015-09-10 00:00:00
abstract：:With the advent of nanotechnology, a variety of nanoarchitectures with varied physicochemical properties have been designed. Owing to the unique characteristics, DNAs have been used as a functional building block for novel nanoarchitecture. In particular, a self-assembly of long DNA molecules via a piece DNA staple ha...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17722
更新日期：2015-12-04 00:00:00
abstract：:Alterations in the gut microbiota play a crucial role in host physiology and metabolism; however, the molecular pathways underlying these changes in diet-induced obesity are unclear. Mechanistic target of rapamycin (mTOR) signaling pathway is associated with metabolic disorders such as obesity and type 2 diabetes (T2D...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30887
更新日期：2016-07-29 00:00:00
abstract：:Compromised gut health and dysbiosis in people with heart failure has received a great deal of attention over the last decade. Whether dogs with heart failure have a similar dysbiosis pattern to what is described in people is currently unknown. We hypothesised that dogs with congestive heart failure have quantifiable ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70826-0
更新日期：2020-08-13 00:00:00
abstract：:Endothelial plasticity enables the cells to switch their phenotype according to the surrounding vascular microenvironment. MicroRNAs (miRNAs) are small noncoding RNAs that control endothelial plasticity. The objective of this study was to investigate the differences in miRNA profiles of tissue-derived cells and cultur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11487-4
更新日期：2017-09-08 00:00:00
abstract：:Although guidelines recommend BRCA testing for all women with non-mucinous epithelial ovarian cancer, there is significant variability in access to testing across the UK. A germline BRCA mutation (BRCAm) in ovarian cancer patients provides prognostic and predictive information and influences clinical management, such ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60149-5
更新日期：2020-02-25 00:00:00
abstract：:Biological samples are frequently stained with heavy metals in preparation for examining the macro, micro and ultra-structure using X-ray microtomography and electron microscopy. A single X-ray microtomography scan reveals detailed 3D structure based on staining density, yet it lacks both material composition and func...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-25099-z
更新日期：2018-05-15 00:00:00
abstract：:Enzyme replacement therapies have revolutionized patient treatment for multiple rare lysosomal storage diseases but show limited effectiveness for addressing pathologies in "hard-to-treat" organs and tissues including brain and bone. Here we investigate the plant lectin RTB as a novel carrier for human lysosomal enzym...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14144
更新日期：2015-09-18 00:00:00
abstract：:Mixed species biofilms are shaped and influenced by interactions between species. In the oral cavity, dysbiosis of the microbiome leads to diseases such as periodontitis. Porphyromonas gingivalis is a keystone pathogen of periodontitis. In this study, we showed that polymicrobial biofilm formation promoted the toleran...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41467-9
更新日期：2019-03-20 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease for which the pathophysiological mechanisms of motor neuron loss are not precisely clarified. Environmental and epigenetic mechanisms such as microRNAs (miRNAs) could have a role in disease progression. We studied the expression pattern of miRNAs in AL...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61246-1
更新日期：2020-03-09 00:00:00
abstract：:Betaine alleviates high-fat diet-induced fatty liver and prenatal betaine programs offspring hepatic lipid metabolism. Excessive corticosterone (CORT) exposure causes fatty liver in chickens, yet it remains unknown whether and how prenatal betaine modulates the susceptibility of CORT-induced fatty liver later in life....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40251
更新日期：2017-01-06 00:00:00
abstract：:Results on the relationships between vitamin D receptor (VDR) gene polymorphisms and postmenopausal osteoporosis (PMOP) susceptibility and bone mineral density (BMD) are conflicting. The aim of the study is to identify more eligible studies that calculated pooled OR and WMD with 95% CI to assess their associations. Ov...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析,评审
doi：10.1038/s41598-017-18670-7
更新日期：2018-01-17 00:00:00
abstract：:Various methods for the direct reprogramming of human somatic cells have been developed. However, a therapeutic method to reprogram and eliminate human solid tumor cells has not been developed. Here we show a novel therapeutic method to reprogram and eliminate human solid tumor cells with chemicals. This therapeutic m...
journal_title：Scientific reports
pub_type： 杂志文章,收录出版
doi：10.1038/srep00280
更新日期：2012-01-01 00:00:00
abstract：:Sex hormones may have a role in the pathophysiology of substance use disorders, as demonstrated by the association between testosterone and addictive behaviour in opioid dependence. Although opioid use has been found to suppress testosterone levels in men and women, the extent of this effect and how it relates to meth...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06189
更新日期：2014-08-26 00:00:00
abstract：:Micron-scale droplets isolated by an immiscible liquid can provide miniaturised reaction vessels which can be manipulated in microfluidic networks, and has seen a rapid growth in development. In many experiments, the precise volume of these microdroplets is a critical parameter which can be influenced by many external...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11254-5
更新日期：2017-09-05 00:00:00
abstract：:Heart failure after myocardial infarction (MI) depends on infarct size and adverse left ventricular (LV) remodelling, both influenced by the inflammatory response. Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) is an inhibitory receptor of ITAM-dependent cell activation, present on almost all immune cell...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13678-5
更新日期：2017-12-21 00:00:00
abstract：:Climatic changes can induce geographic expansion and altitudinal shifts in the distribution of invasive species by offering more thermally suitable habitats. At the remote sub-Antarctic Kerguelen Islands, the predatory insect Merizodus soledadinus (Coleoptera: Carabidae), introduced in 1913, rapidly invaded coastal ha...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57868-0
更新日期：2020-01-27 00:00:00
abstract：:The prognostic factors for survival among patients with secondary osteosarcoma remain unclear. The aim of this study was to develop a practical nomogram for predicting cancer-specific survival (CSS) in patients with osteosarcoma as a secondary malignancy. The surveillance, epidemiology, and end results database was us...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-69740-2
更新日期：2020-07-30 00:00:00
abstract：:Cover crops (plants grown in an agricultural rotation between cash crops) can significantly improve soil quality via sequestering carbon, retaining nutrients, decreasing soil erosion, and maintaining belowground biodiversity. However, little is known about the effects of such plants upon soil structure. The aim of the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43937-6
更新日期：2019-05-16 00:00:00
abstract：:Bioactive gibberellins (GAs) are essential phytohormones involved in the regulation of many aspects of plant development. GA receptors are crucial in GA signal transduction in plants. The GA receptor GoGID1 promotes plant elongation and improves biomass production when ectopically expressed in tobacco. Here, we discov...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41296
更新日期：2017-01-27 00:00:00
abstract：:At 50 kg in estimated weight, the extinct Siamogale melilutra is larger than all living otters, and ranks among the largest fossil otters. The biomechanical capability of S. melilutra jaws as related to their large size is unknown but crucial to reconstructing the species' potentially unique ecological niche. Here we ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15391-9
更新日期：2017-11-09 00:00:00
abstract：:Axillary lymph node status is an important prognostic factor for breast cancer patients and sentinel lymph node biopsy (SLNB) is a less invasive surgical proxy. We examined if consecutively derived molecular subtypes from primary breast cancers provide additional predictive value for SLNB status. 1556 patients with a ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81538-4
更新日期：2021-01-26 00:00:00
abstract：:Dibutyl phthalate (DBP) is well known as a high-priority pollutant. This study explored the impacts of DBP on the metabolic pathways of microbes in black soils in the short term (20 days). The results showed that the microbial communities were changed in black soils with DBP. In nitrogen cycling, the abundances of the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21030-8
更新日期：2018-02-08 00:00:00
abstract：:To provide a comprehensive analysis of small molecule genotoxic potential we have developed and validated an automated, high-content, high throughput, image-based in vitro Micronucleus (IVM) assay. This assay simultaneously assesses micronuclei and multiple additional cellular markers associated with genotoxicity. Aco...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-82115-5
更新日期：2021-01-28 00:00:00
abstract：:Mechanistic studies of deregulated ERG in prostate cancer and other cancers continue to enhance its role in cancer biology and its utility as a biomarker and therapeutic target. Here, we show that ERG, through its physical interaction with androgen receptor, induces AR aggregation and endoplasmic reticulum stress in t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01187-4
更新日期：2017-04-24 00:00:00
abstract：:The high density nucleation of α-Al2O3 nanocrystallites was observed by rapid heating of the aluminum formate hydroxide-based precursor powder at 1200 °C for 50 s. The nucleation of α-Al2O3 nanocrystallites with less 10 nm in size from high purity aluminum oxide matrix has not been observed to our knowledge. Based on ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51156-2
更新日期：2019-10-17 00:00:00
abstract：:Blowflies and houseflies are mechanical vectors inhabiting synanthropic environments around the world. They feed and breed in fecal and decaying organic matter, but the microbiome they harbour and transport is largely uncharacterized. We sampled 116 individual houseflies and blowflies from varying habitats on three co...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16353-x
更新日期：2017-11-24 00:00:00
