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The gut microbiome in dogs with congestive heart failure: a pilot study.

Abstract：

:Compromised gut health and dysbiosis in people with heart failure has received a great deal of attention over the last decade. Whether dogs with heart failure have a similar dysbiosis pattern to what is described in people is currently unknown. We hypothesised that dogs with congestive heart failure have quantifiable dysbiosis compared to healthy dogs that are similar in sex and age. A total of 50 dogs (15 healthy dogs and 35 dogs with congestive heart failure) were prospectively recruited, and their faecal gut microbiome was assessed using 16S rRNA sequencing (Illumina MiSeq platform). There was no significant change in the microbial diversity and richness in dogs with congestive heart failure. However, there was an increase in abundance of Proteobacteria in the congestive heart failure group (p = 0.014), particularly due to an increase in the family Enterobacteriaceae (p = 0.002) and Escherichia coli (p = 0.033). We conclude that dogs with congestive heart failure have dysbiosis, and we show additional trends in our data suggesting that dogs may have a similar pattern to that described in people. The results of this study provide useful preliminary information and raise the possibility that dogs represent a clinically relevant animal model of dysbiosis in people with heart failure.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Seo J,Matthewman L,Xia D,Wilshaw J,Chang YM,Connolly DJ

doi

10.1038/s41598-020-70826-0

subject

Has Abstract

pub_date

2020-08-13 00:00:00

pages

13777

issue

1

issn

2045-2322

pii

10.1038/s41598-020-70826-0

journal_volume

10

pub_type

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