Iron-specific Signal Separation from within Heavy Metal Stained Biological Samples Using X-Ray Microtomography with Polychromatic Source and Energy-Integrating Detectors.

abstract：:Prestin in the lateral membrane of outer hair cells, is responsible for electromotility (EM) and a corresponding nonlinear capacitance (NLC). Prestin's voltage sensitivity is influenced by intracellular chloride. A regulator of intracellular chloride is a stretch-sensitive, non-selective conductance within the lateral...

journal_title：Scientific reports

authors： Bai JP,Moeini-Naghani I,Zhong S,Li FY,Bian S,Sigworth FJ,Santos-Sacchi J,Navaratnam D

更新日期：2017-04-19 00:00:00

abstract：:The objective of this study was to examine the relationship between sleep duration and ischemic and hemorrhagic stroke in a community-based cohort. The current analysis included 95,023 Chinese participants who were free of stroke at the baseline survey (2006-2007). Cox proportional hazards models were used to calculat...

journal_title：Scientific reports

authors： Song Q,Liu X,Zhou W,Wang L,Zheng X,Wang X,Wu S

更新日期：2016-09-16 00:00:00

abstract：:We investigated the ability of children with ASD to discriminate a small cylinder from a large cube by observing a point-light movie of an actor grasping the object, either from an allocentric or egocentric viewpoint (observing action of others or self). Compared with typically developing controls, high functioning au...

journal_title：Scientific reports

authors： Turi M,Muratori F,Tinelli F,Morrone MC,Burr DC

更新日期：2017-10-04 00:00:00

abstract：:Ichthyoarchaeological evidence is uncommon at ancient hunter-gatherer sites from various regions and timeframes. This research contributes to the development of microarchaeological techniques useful for identifying fishing economies in situations where classifiable bones are unavailable. Specifically, traces of heat a...

journal_title：Scientific reports

authors： Butler DH,Shahack-Gross R

更新日期：2017-06-15 00:00:00

abstract：:Early detection of dementia in Parkinson disease is a prerequisite for preventive therapeutic approaches. Modified serpinA1 in cerebrospinal fluid (CSF) was suggested as an early biomarker for differentiation between Parkinson patients with (PDD) or without dementia (PD). Within this study we aimed to further explore ...

journal_title：Scientific reports

authors： Halbgebauer S,Nagl M,Klafki H,Haußmann U,Steinacker P,Oeckl P,Kassubek J,Pinkhardt E,Ludolph AC,Soininen H,Herukka SK,Wiltfang J,Otto M

更新日期：2016-05-17 00:00:00

abstract：:BMPs are multifunctional growth factors implicated in regulating the ovarian function as key intra-ovarian factors. Biological effects of BMPs are mediated through binding with membrane bound receptors like BMPR-IB and initiating downstream Smad signaling pathway. FecB mutation, regarded as a loss of function mutation...

journal_title：Scientific reports

authors： Kumar S,Punetha M,Jose B,Bharati J,Khanna S,Sonwane A,Green JA,Whitworth K,Sarkar M

更新日期：2020-11-24 00:00:00

abstract：:Little research on coronaviruses has been conducted on wild animals in Africa. Here, we screened a wide range of wild animals collected in six provinces and five caves of Gabon between 2009 and 2015. We collected a total of 1867 animal samples (cave-dwelling bats, rodents, non-human primates and other wild animals). W...

journal_title：Scientific reports

authors： Maganga GD,Pinto A,Mombo IM,Madjitobaye M,Mbeang Beyeme AM,Boundenga L,Ar Gouilh M,N'Dilimabaka N,Drexler JF,Drosten C,Leroy EM

更新日期：2020-04-30 00:00:00

abstract：:Traditional Protein-Protein Interaction (PPI) networks, which use a node and edge representation, lack some valuable information about the mechanistic details of biological processes. Mapping protein structures to these PPI networks not only provides structural details of each interaction but also helps us to find the...

journal_title：Scientific reports

authors： Halakou F,Kilic ES,Cukuroglu E,Keskin O,Gursoy A

更新日期：2017-08-03 00:00:00

abstract：:Unprecedented coastal upwelling off the southern coast of the Korean Peninsula was reported during the summer of 2013. The upwelling continued for more than a month after a plunge in upwelling-favourable winds and had serious impacts on fisheries. This is a rare phenomenon, as most coastal upwelling events relax a few...

journal_title：Scientific reports

authors： Jung J,Cho YK

更新日期：2020-07-20 00:00:00

abstract：:A disposable cyclic voltammetry (CV) tag is printed on a plastic film by integrating wireless power transmitter, polarized triangle wave generator, electrochemical cell and signage through a scalable gravure printing method. By proximity of 13.56 MHz RF reader, the printed CV tag generates 320 mHz of triangular sweep ...

journal_title：Scientific reports

authors： Jung Y,Park H,Park JA,Noh J,Choi Y,Jung M,Jung K,Pyo M,Chen K,Javey A,Cho G

更新日期：2015-01-29 00:00:00

abstract：:Identification of hot spots, a small portion of protein-protein interface residues that contribute the majority of the binding free energy, can provide crucial information for understanding the function of proteins and studying their interactions. Based on our previous method (PredHS), we propose a new computational a...

journal_title：Scientific reports

authors： Wang H,Liu C,Deng L

更新日期：2018-09-24 00:00:00

abstract：:The study of the preparation phase of large earthquakes is essential to understand the physical processes involved, and potentially useful also to develop a future reliable short-term warning system. Here we analyse electron density and magnetic field data measured by Swarm three-satellite constellation for 4.7 years,...

journal_title：Scientific reports

authors： De Santis A,Marchetti D,Pavón-Carrasco FJ,Cianchini G,Perrone L,Abbattista C,Alfonsi L,Amoruso L,Campuzano SA,Carbone M,Cesaroni C,De Franceschi G,De Santis A,Di Giovambattista R,Ippolito A,Piscini A,Sabbagh D,Soldani M

更新日期：2019-12-30 00:00:00

abstract：:A larger amount of sequence data in private and public databases produced by next-generation sequencing put new challenges due to limitation associated with the alignment-based method for sequence comparison. So, there is a high need for faster sequence analysis algorithms. In this study, we developed an alignment-fre...

journal_title：Scientific reports

authors： Saw AK,Raj G,Das M,Talukdar NC,Tripathy BC,Nandi S

更新日期：2019-03-06 00:00:00

abstract：:Although there is evidence that non-steroidal anti-inflammatory drugs (NSAIDs) might be able to prevent pancreatic cancer, the findings from epidemiological studies have been inconsistent. In this paper, we conducted a meta-analysis of observational studies to examine this possibility. We searched PubMed and Embase fo...

journal_title：Scientific reports

authors： Zhang YP,Wan YD,Sun YL,Li J,Zhu RT

更新日期：2015-10-21 00:00:00

abstract：:The expression of aminoglycoside-modifying enzymes represents a survival strategy of antibiotic-resistant bacteria. Aminoglycoside 2'-N-acetyltransferase [AAC(2')] neutralizes aminoglycoside drugs by acetylation of their 2' amino groups in an acetyl coenzyme A (CoA)-dependent manner. To understand the structural featu...

journal_title：Scientific reports

authors： Jeong CS,Hwang J,Do H,Cha SS,Oh TJ,Kim HJ,Park HH,Lee JH

更新日期：2020-12-09 00:00:00

abstract：:Aging is a highly controlled biological process characterized by a progressive deterioration of various cellular activities. One of several hallmarks of aging describes a link to transcriptional alteration, suggesting that it may impact the steady-state mRNA levels. We analyzed the mRNA steady-state levels of polyCAG-...

journal_title：Scientific reports

authors： Adamla F,Ignatova Z

更新日期：2015-06-02 00:00:00

abstract：:In this study, the anatomical and ultrastructural responses of Capsicum annuum to iron nanoparticles (Fe NPs) were determined. The results showed that the bio-effects of Fe NPs on plants could be positive or negative, depending on the additive concentrations. Low concentrations of Fe NPs were found to promote plant gr...

journal_title：Scientific reports

authors： Yuan J,Chen Y,Li H,Lu J,Zhao H,Liu M,Nechitaylo GS,Glushchenko NN

更新日期：2018-02-19 00:00:00

abstract：:Posttraumatic growth (PTG) is defined as positive psychological change in the wake of highly challenging circumstances. Healthcare workers in particular are more vulnerable to stressors and trauma than the general population. The current study examined the use and effectiveness of a novel positive psychological interv...

journal_title：Scientific reports

authors： Xu X,Hu ML,Song Y,Lu ZX,Chen YQ,Wu DX,Xiao T

更新日期：2016-12-20 00:00:00

abstract：:The ability of wild animals to respond flexibly to anthropogenic environmental changes, including agriculture, is critical to survival in human-impacted habitats. Understanding use of human foods by wildlife can shed light on the acquisition of novel feeding habits and how animals respond to human-driven land-use chan...

journal_title：Scientific reports

authors： McLennan MR,Hockings KJ

更新日期：2014-08-05 00:00:00

abstract：:Boulders are ubiquitously found on the surfaces of small rocky bodies in the inner solar system and their spatial and size distributions give insight into the geological evolution and collisional history of the parent bodies. Using images acquired by the Chang'e-2 spacecraft, more than 200 boulders have been identifie...

journal_title：Scientific reports

authors： Jiang Y,Ji J,Huang J,Marchi S,Li Y,Ip WH

更新日期：2015-11-02 00:00:00

abstract：:In "classic" biomedical research, diseases have usually been studied individually. The pioneering human disease network (HDN) studies jointly consider a large number of diseases, analyse their interconnections, and provide a more comprehensive description of diseases. However, most of the existing HDN studies are base...

journal_title：Scientific reports

authors： Jiang Y,Ma S,Shia BC,Lee TS

更新日期：2018-03-14 00:00:00

abstract：:Age-related changes to the balance between the pressure inside the eye (intraocular pressure, IOP) and the pressure inside the brain (intracranial pressure, ICP) can modify the risk of glaucoma. In this study, we consider whether the optic nerve in older rat eyes is more susceptible to acute IOP and ICP modification. ...

journal_title：Scientific reports

authors： Zhao D,Nguyen CTO,He Z,Wong VHY,van Koeverden AK,Vingrys AJ,Bui BV

更新日期：2018-02-13 00:00:00

abstract：:Enhanced and immediate expression of cyclooxygenase-2 (COX-2) mRNA is observed in IL-1β-stimulated OA chondrocytes but the synthesis of protein found significantly delayed. Here we investigated the role of stress granules (SGs), ribonucleoprotein complexes that regulate mRNA translation, in the delayed translation of ...

journal_title：Scientific reports

authors： Ansari MY,Haqqi TM

更新日期：2016-06-08 00:00:00

abstract：:The field of genome editing was founded on the establishment of methods, such as the clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR-associated protein (CRISPR/Cas) system, used to target DNA double-strand breaks (DSBs). However, the efficiency of genome editing also largely depends on the...

journal_title：Scientific reports

authors： Hirotsune S,Kiyonari H,Jin M,Kumamoto K,Yoshida K,Shinohara M,Watanabe H,Wynshaw-Boris A,Matsuzaki F

更新日期：2020-02-13 00:00:00

abstract：:Loss-of-function mutations in TREM2 cause Nasu-Hakola disease (NHD), a rare genetic disease characterized by early-onset dementia with leukoencephalopathy and bone cysts. An NHD-associated mutation, c.482 + 2 T > C, disrupts the splice donor site of intron 3 and causes aberrant skipping of exon 3, resulting in the los...

journal_title：Scientific reports

authors： Yanaizu M,Sakai K,Tosaki Y,Kino Y,Satoh JI

更新日期：2018-05-02 00:00:00

abstract：:For more than 30 years, the remarkable superconducting properties of REBa2Cu3O7-x (RE = rare earth) compounds have triggered research studies across the world. Accordingly, significant progresses have been made both from a basic understanding and a fabrication processes perspective. Yet, today, the major technological...

journal_title：Scientific reports

authors： Fête A,Senatore C

更新日期：2018-12-07 00:00:00

abstract：:Intrahepatic cholestasis represents a frequent manifestation of drug-induced liver injury; however, the mechanisms underlying such injuries are poorly understood. In this study of human HepaRG and primary hepatocytes, we found that bile canaliculi (BC) underwent spontaneous contractions, which are essential for bile a...

journal_title：Scientific reports

authors： Sharanek A,Burban A,Burbank M,Le Guevel R,Li R,Guillouzo A,Guguen-Guillouzo C

更新日期：2016-05-12 00:00:00

abstract：:Germline mutations in Mir96, one of three co-expressed polycistronic miRNA genes (Mir96, Mir182, Mir183), cause hereditary hearing loss in humans and mice. Transgenic FVB/NCrl- Tg(GFAP-Mir183,Mir96,Mir182)MDW1 mice (Tg1MDW), which overexpress this neurosensory-specific miRNA cluster in the inner ear, were developed as...

journal_title：Scientific reports

authors： Weston MD,Tarang S,Pierce ML,Pyakurel U,Rocha-Sanchez SM,McGee J,Walsh EJ,Soukup GA

更新日期：2018-02-23 00:00:00

abstract：:Sauropodomorpha were herbivorous saurischian dinosaurs that incorporate Sauropoda and early-diverging sauropodomorphs. The oldest sauropodomorph remains are known from Late Triassic deposits, most of them Gondwanan. The Laurasian record comprises some Triassic forms, but the bulk is Jurassic in age. Among the 14 Juras...

journal_title：Scientific reports

authors： Peyre de Fabrègues C,Bi S,Li H,Li G,Yang L,Xu X

更新日期：2020-07-03 00:00:00

abstract：:Hand preference is a conspicuous variation in human behaviour, with a worldwide proportion of around 90% of people preferring to use the right hand for many tasks, and 10% the left hand. We used the large cohort of the UK biobank (~500,000 participants) to study possible relations between early life factors and adult ...

journal_title：Scientific reports

authors： de Kovel CGF,Carrión-Castillo A,Francks C

更新日期：2019-01-24 00:00:00