Abstract:
:Early detection of dementia in Parkinson disease is a prerequisite for preventive therapeutic approaches. Modified serpinA1 in cerebrospinal fluid (CSF) was suggested as an early biomarker for differentiation between Parkinson patients with (PDD) or without dementia (PD). Within this study we aimed to further explore the diagnostic value of serpinA1. We applied a newly developed nanoscale method for the detection of serpinA1 based on automated capillary isoelectric focusing (CIEF). A clinical sample of 102 subjects including neurologically healthy controls (CON), PD and PDD patients was investigated. Seven serpinA1 isoforms of different charge were detected in CSF from all three diagnostic groups. The mean CSF signals of the most acidic serpinA1 isoform differed significantly (p < 0.01) between PDD (n = 29) and PD (n = 37) or CON (n = 36). Patients above the cut-off of 6.4 have a more than six times higher risk for an association with dementia compared to patients below the cut off. We propose this serpinA1 CIEF-immunoassay as a novel tool in predicting cognitive impairment in PD patients and therefore for patient stratification in therapeutic trials.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Halbgebauer S,Nagl M,Klafki H,Haußmann U,Steinacker P,Oeckl P,Kassubek J,Pinkhardt E,Ludolph AC,Soininen H,Herukka SK,Wiltfang J,Otto Mdoi
10.1038/srep26145subject
Has Abstractpub_date
2016-05-17 00:00:00pages
26145issn
2045-2322pii
srep26145journal_volume
6pub_type
杂志文章abstract::When individuals breed more than once, parents are faced with the choice of whether to re-mate with their old partner or divorce and select a new mate. Evolutionary theory predicts that, following successful reproduction with a given partner, that partner should be retained for future reproduction. However, recent wor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72521-6
更新日期:2020-09-23 00:00:00
abstract::Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare disease, characterised by the aplasia of vagina and uterus in women with a 46,XX karyotype. Most cases are sporadic, but familial recurrence has also been described. Herein, we investigated an Italian cohort of 36 unrelated MRKH patients to explore the presence ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79827-5
更新日期:2021-01-11 00:00:00
abstract::The development of new anode materials having high electrochemical performances and interesting reaction mechanisms is highly required to satisfy the need for long-lasting mobile electronic devices and electric vehicles. Here, we report a layer crystalline structured SnP3 and its unique electrochemical behaviors with ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35980
更新日期:2016-10-24 00:00:00
abstract::Clinical success of effective gene therapy is mainly hampered by the insufficiency of safe and efficient internalization of a transgene to the targeted cellular site. Therefore, the development of a safe and efficient nanocarrier system is one of the fundamental challenges to transfer the therapeutic genes to the dise...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78123-6
更新日期:2020-12-08 00:00:00
abstract::Statistical learning is a key mechanism for detecting regularities from a variety of sensory inputs. Precocial newborn domestic chicks provide an excellent model for (1) exploring unsupervised forms of statistical learning in a comparative perspective, and (2) elucidating the ecological function of statistical learnin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72090-8
更新日期:2020-09-15 00:00:00
abstract::This study investigated interactive effects of CYP2B6 genotypes and liver metastasis on the prognosis of metastatic breast cancer patients who received combined chemotherapy of docetaxel and thiotepa. Totally 153 patients were retrospectively genotyped rs8192719 (c.1294 + 53C > T) and rs2279343 (c.785A > G). Kaplan-Me...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/srep16775
更新日期:2015-11-25 00:00:00
abstract::The palette of laser technology has significantly been enriched by the innovations in ultrafast optical pulse generation. Our knowledge of the complex pulse dynamics, which is often highly nonlinear and stochastic in nature, is however limited by the scarcity of technologies that can measure fast variation/fluctuation...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27937
更新日期:2016-06-13 00:00:00
abstract::The existing acoustic emission (AE) source location methods assume that acoustic waves propagate along straight lines, and the source location is determined by average wave velocity. Because of the heterogeneity of materials, location results often fail to meet the accuracy requirement. For this reason, an AE source l...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07371-w
更新日期:2017-08-07 00:00:00
abstract::This study aims to assess the utility of internet search query analysis in pertussis surveillance. This study uses an empirical time series model based on internet search metrics to detect the pertussis incidence in Australia. Our research demonstrates a clear seasonal pattern of both pertussis infections and Google T...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11195-z
更新日期:2017-09-05 00:00:00
abstract::Ammonia can be utilised as an alternative nitrogen source to glutamine to support cell proliferation. However, the underlying molecular mechanisms and whether all cells have this ability is not fully understood. We find that eleven cancer and non-cancerous cell lines have opposite abilities to tolerate and utilise amm...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37509-3
更新日期:2019-02-06 00:00:00
abstract::Few studies have investigated the relationship between chronic rhinosinusitis (CRS) and erectile dysfunction (ED). This case-control study aimed to investigate the association between CRS and the risk of ED in a large national sample. Tapping Taiwan's National Health Insurance Research Database, we identified people 3...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/srep32195
更新日期:2016-08-31 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-75952-3
更新日期:2020-10-29 00:00:00
abstract::Scaling up atmospheric pressure glow discharge to large volume is desirable for low-temperature plasma applications. In this paper, an approach to generate a glow discharge in a planar shape with a fairly large volume is proposed in atmospheric pressure air through utilizing a direct-current excited rod array electrod...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03007-1
更新日期:2017-06-01 00:00:00
abstract::In this paper, 4-(dicyanomethylene)-2-t-butyl-6(1,1,7,7-tetramethyljulolidyl-9-enyl)-4H-pyran (DCJTB) has been used in interface modification of dye-sensitized solar cells (DSCs) with combined effects of retarding charge recombination and Förster resonant energy transfer (FRET). DCJTB interface modification significan...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05570
更新日期:2014-07-04 00:00:00
abstract::We investigate the refractive error after phacovitrectomy for rhegmatogenous retinal detachment (RRD; 100 eyes) and epiretinal membrane (ERM; 102 eyes). Axial lengths were measured by optical biometry in most patients. The main outcome measures were the refractive and absolute prediction errors. The overall mean refra...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29553-w
更新日期:2018-07-27 00:00:00
abstract::The increased risk of cardiovascular events in older men is multifactorial, but the significant reduction of testosterone levels has been involved. As this hormone regulates the expression of TFPI by unknown mechanisms, we aimed to evaluate the role of miRNAs in the regulation of TFPIα expression under normal conditio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43500
更新日期:2017-02-27 00:00:00
abstract::Enzymatic gold nanoparticles (B-GNPs) have been synthesized using a natural anticancer agent bromelain (a cysteine protease) and these nanoparticles were used to bioconjugate Cisplatin (highly effective against osteosarcoma and lung cancer). Cisplatin bioconjugated bromelain encapsulated gold nanoparticles (B-C-GNPs) ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50215-y
更新日期:2019-09-25 00:00:00
abstract::Coherent, optically dressed media composed of two-level molecular systems without inversion symmetry are considered as all-optically tunable sources of coherent radiation in the microwave domain. A theoretical model and a numerical toolbox are developed to confirm the main finding: the generation of low-frequency radi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74569-w
更新日期:2020-10-19 00:00:00
abstract::The accelerated discovery of disease-related genes emerging from genomic studies has strained the capacity of traditional genetically engineered mouse models (GEMMs) to provide in-vivo validation. Direct, somatic, genetic engineering approaches allow for accelerated and flexible genetic manipulation and represent an a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11061
更新日期:2015-06-05 00:00:00
abstract::Despite the initiative by WHO and other international organizations to eliminate HCV in the medium term, hepatitis C infection is still a major public health problem. Even non-injecting drugs users who engage in harmful or addictive drug use are at greater risk of acquiring the infection, when compared to the general ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35657-0
更新日期:2019-01-24 00:00:00
abstract::Virus production in the deep-sea environment has been found to be high, and viruses have been suggested to play significant roles in the overall functioning of this ecosystem. Nevertheless, little is known about these viruses, including the mechanisms that control their production, which makes them one of the least un...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21908
更新日期:2016-02-22 00:00:00
abstract::The innate and adaptive immune systems fail to control HCV infection in the majority of infected individuals. HCV is an ssRNA virus, which suggests a role for Toll-like receptors (TLRs) 7 and 8 in initiating the anti-viral response. Here we demonstrate that HCV genomic RNA harbours specific sequences that initiate an ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29447
更新日期:2016-07-07 00:00:00
abstract::Associations between cognitive decline and cerebral microbleeds (CMBs) have received increasing attention. An association between CMB distribution (deep or lobar) and cognitive decline has been reported, but these findings are controversial. We investigated the association between magnetic resonance imaging (MRI) find...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73404-6
更新日期:2020-10-02 00:00:00
abstract::The first-ever study of nickel selenide materials as efficient anode materials for Na-ion rechargeable batteries is conducted using the electrospinning process. NiSe2-reduced graphene oxide (rGO)-C composite nanofibers are successfully prepared via electrospinning and a subsequent selenization process. The electrospun...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23338
更新日期:2016-03-21 00:00:00
abstract::Southern rice black-streaked dwarf virus (SRBSDV), a newly emerged fijivirus causing great loss to rice production in eastern and southeastern Asian countries in recent years, is efficiently transmitted by a rice pest, white-backed planthopper (WBPH, Sogatella furcifera) in a persistent, circulative propagative manner...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31521
更新日期:2016-08-17 00:00:00
abstract::Mobile phone microscopes are a natural platform for point-of-care imaging, but current solutions require an externally powered illumination source, thereby adding bulk and cost. We present a mobile phone microscope that uses the internal flash or sunlight as the illumination source, thereby reducing complexity whilst ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21543-2
更新日期:2018-02-19 00:00:00
abstract::It is widely acknowledged that transcriptional diversity largely contributes to biological regulation in eukaryotes. Since the advent of second-generation sequencing technologies, a large number of RNA sequencing studies have considerably improved our understanding of transcriptome complexity. However, it still remain...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08138-z
更新日期:2017-08-09 00:00:00
abstract::Serratia marcescens is one of the important nosocomial pathogens which rely on quorum sensing (QS) to regulate the production of biofilm and several virulence factors. Hence, blocking of QS has become a promising approach to quench the virulence of S. marcescens. For the first time, QS inhibitory (QSI) and antibiofilm...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16507-x
更新日期:2017-11-27 00:00:00
abstract::To demonstrate the identification of corneal diseases using a novel deep learning algorithm. A novel hierarchical deep learning network, which is composed of a family of multi-task multi-label learning classifiers representing different levels of eye diseases derived from a predefined hierarchical eye disease taxonomy...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75027-3
更新日期:2020-10-20 00:00:00
abstract::Intrinsically disordered proteins are abundant in the eukaryotic proteome, and they are implicated in a range of different diseases. However, there is a paucity of experimental data on molecular details of the coupled binding and folding of such proteins. Two interacting and relatively well studied disordered protein ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02076
更新日期:2013-01-01 00:00:00