Modified serpinA1 as risk marker for Parkinson's disease dementia: Analysis of baseline data.

Abstract:

:Early detection of dementia in Parkinson disease is a prerequisite for preventive therapeutic approaches. Modified serpinA1 in cerebrospinal fluid (CSF) was suggested as an early biomarker for differentiation between Parkinson patients with (PDD) or without dementia (PD). Within this study we aimed to further explore the diagnostic value of serpinA1. We applied a newly developed nanoscale method for the detection of serpinA1 based on automated capillary isoelectric focusing (CIEF). A clinical sample of 102 subjects including neurologically healthy controls (CON), PD and PDD patients was investigated. Seven serpinA1 isoforms of different charge were detected in CSF from all three diagnostic groups. The mean CSF signals of the most acidic serpinA1 isoform differed significantly (p < 0.01) between PDD (n = 29) and PD (n = 37) or CON (n = 36). Patients above the cut-off of 6.4 have a more than six times higher risk for an association with dementia compared to patients below the cut off. We propose this serpinA1 CIEF-immunoassay as a novel tool in predicting cognitive impairment in PD patients and therefore for patient stratification in therapeutic trials.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Halbgebauer S,Nagl M,Klafki H,Haußmann U,Steinacker P,Oeckl P,Kassubek J,Pinkhardt E,Ludolph AC,Soininen H,Herukka SK,Wiltfang J,Otto M

doi

10.1038/srep26145

subject

Has Abstract

pub_date

2016-05-17 00:00:00

pages

26145

issn

2045-2322

pii

srep26145

journal_volume

6

pub_type

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