Abstract：
:Hand preference is a conspicuous variation in human behaviour, with a worldwide proportion of around 90% of people preferring to use the right hand for many tasks, and 10% the left hand. We used the large cohort of the UK biobank (~500,000 participants) to study possible relations between early life factors and adult hand preference. The probability of being left-handed was affected by the year and location of birth, likely due to cultural effects. In addition, hand preference was affected by birthweight, being part of a multiple birth, season of birth, breastfeeding, and sex, with each effect remaining significant after accounting for all others. Analysis of genome-wide genotype data showed that left-handedness was very weakly heritable, but shared no genetic basis with birthweight. Although on average left-handers and right-handers differed for a number of early life factors, all together these factors had only a minimal predictive value for individual hand preference.
journal_name
Sci Repjournal_title
Scientific reportsauthors
de Kovel CGF,Carrión-Castillo A,Francks Cdoi
10.1038/s41598-018-37423-8subject
Has Abstractpub_date
2019-01-24 00:00:00pages
584issue
1issn
2045-2322pii
10.1038/s41598-018-37423-8journal_volume
9pub_type
杂志文章abstract：:Food and flavour pairing are commonly used as an empirically based phenomenology by chefs and food innovators for creating delicious dishes. However, there is little if any science behind the pairing systems used, and it appears that pairing is determined by food culture and tradition rather than by chemical food comp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77107-w
更新日期：2020-11-18 00:00:00
abstract：:Enrofloxacin-loaded docosanoic acid solid lipid nanoparticles (SLNs) with different physicochemical properties were developed to enhance activity against intracellular Salmonella. Their cellular uptake, intracellular elimination and antibacterial activity were studied in RAW 264.7 cells. During the experimental period...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41104
更新日期：2017-01-23 00:00:00
abstract：:We consider synchronization properties of arrays of spin-torque nano-oscillators coupled via an RC load. We show that while the fully synchronized state of identical oscillators may be locally stable in some parameter range, this synchrony is not globally attracting. Instead, regimes of different levels of composition...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04918-9
更新日期：2017-07-05 00:00:00
abstract：:Microbial survival in dynamic environments requires the ability to successfully respond to abrupt changes in osmolarity. The mechanosensitive channel of large conductance (MscL) is a ubiquitous channel that facilitates the survival of bacteria and archaea under severe osmotic downshock conditions by relieving excess t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32536-6
更新日期：2018-10-01 00:00:00
abstract：:Neurotransmission and secretion of hormones involve a sequence of protein/lipid interactions with lipid turnover impacting on vesicle trafficking and ultimately fusion of secretory vesicles with the plasma membrane. We previously demonstrated that sphingosine, a sphingolipid metabolite, promotes formation of the SNARE...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05948-z
更新日期：2017-07-20 00:00:00
abstract：:The prediction of drug-target interactions is a key step in the drug discovery process, which serves to identify new drugs or novel targets for existing drugs. However, experimental methods for predicting drug-target interactions are expensive and time-consuming. Therefore, the in silico prediction of drug-target inte...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13867
更新日期：2015-09-09 00:00:00
abstract：:The exponential growth in knowledge has resulted in a better understanding of the lactation process in a wide variety of animals. However, the underlying genetic mechanisms are not yet clearly known. In order to identify the mechanisms involved in the lactation process, various mehods, including meta-analysis, weighte...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81888-z
更新日期：2021-01-27 00:00:00
abstract：:Whole genome sequencing (WGS) can elucidate Mycobacterium tuberculosis (Mtb) transmission patterns but more data is needed to guide its use in high-burden settings. In a household-based TB transmissibility study in Peru, we identified a large MIRU-VNTR Mtb cluster (148 isolates) with a range of resistance phenotypes, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41967-8
更新日期：2019-04-03 00:00:00
abstract：:Ferromagnetism can occur in wide-band gap semiconductors as well as in carbon-based materials when specific defects are introduced. It is thus desirable to establish a direct relation between the defects and the resulting ferromagnetism. Here, we contribute to revealing the origin of defect-induced ferromagnetism usin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08999
更新日期：2015-03-11 00:00:00
abstract：:Clinical data have been equivocal and controversial as to the benefits to the brain and cognition of hormone therapy (HT) in postmenopausal women. Recent reevaluation of the role of estrogens proposed that HT may effectively prevent the deleterious effects of aging on cognition, and reduces the risks of dementia, incl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44917
更新日期：2017-03-21 00:00:00
abstract：:Crohn's disease (CD) has been associated with an increased consumption of n-6 polyunsaturated fatty acid (PUFA), while greater intake of n-3 PUFA has been associated with a reduced risk. We sought to investigate serum fatty acid composition in CD, and associations of fatty acids with disease activity, cytokines, and a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39232-z
更新日期：2019-02-27 00:00:00
abstract：:Exploration of genetic variant-to-gene relationships by quantitative trait loci such as expression QTLs is a frequently used tool in genome-wide association studies. However, the wide range of public QTL databases and the lack of batch annotation features complicate a comprehensive annotation of GWAS results. In this ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75770-7
更新日期：2020-11-24 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-73065-5
更新日期：2020-10-09 00:00:00
abstract：:Multicolor microscopy tools necessary to localize and visualize the complexity of subcellular systems are limited by current fluorophore technology. While commercial fluorophores cover spectral space from the ultraviolet to the near infrared region and are optimized for conventional bandpass based fluorescence microsc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22892-8
更新日期：2018-03-15 00:00:00
abstract：:Tumor genetic heterogeneity may underlie poor clinical outcomes because diverse subclones could be comprised of metastatic and drug resistant cells. Targeted deep sequencing has been used widely as a diagnostic tool to identify actionable mutations in cancer patients. In this study, we evaluated the clinical utility o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41098-0
更新日期：2019-03-14 00:00:00
abstract：:FTY720 is a sphingoid base analog that acts as an anticancer agent in animal models. Its effect on tumor cells stems largely from its ability to trigger endocytosis of several nutrient transporters. The observation that FTY720 similarly stimulates downregulation of amino acid permeases in yeast suggests that the cellu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14124-2
更新日期：2017-10-23 00:00:00
abstract：:Hydrogen sulfide is the third and most recently discovered gaseous signaling molecule following nitric oxide and carbon monoxide, playing important roles both in normal physiological conditions and disease progression. The trimethylsulfonium ion (TMS) can result from successive methylation reactions of hydrogen sulfid...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27038
更新日期：2016-06-01 00:00:00
abstract：:Both disc hemorrhages (DH) and focal lamina cribrosa (LC) defects are recently considered as a progression factor in glaucoma. However, the clinical relevance of the presence of LC findings at the site of the DH has not yet been determined. We conducted a prospective study enrolling a total of 98 glaucoma eyes with DH...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03828-0
更新日期：2017-06-14 00:00:00
abstract：:Substance P (SP) has been implicated in major depressive disorder (MDD), with SP antagonists being studied as potential antidepressants. Although impaired neural plasticity is considered a key mechanism in MDD pathophysiology, the association between SP and brain structural changes in depression has not been investiga...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10100-y
更新日期：2017-08-29 00:00:00
abstract：:With the surge of GPS-technology, many studies uncovered space use of mobile animals and shed light on the underlying behavioral mechanisms of habitat selection. Habitat selection and variation in either occurrence or strength of functional responses (i.e. how selection changes with availability) have given new insigh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23111-0
更新日期：2018-03-23 00:00:00
abstract：:Increasing evidence suggests that pathological hallmarks of chronic degenerative syndromes progressively spread among interconnected brain areas in a disease-specific stereotyped pattern. Functional brain imaging from patients affected by various neurological syndromes such as traumatic brain injury and stroke indicat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29918-1
更新日期：2018-08-02 00:00:00
abstract：:Adequate responses to environmental stresses are essential for cell survival. The regulation of cellular energetics that involves mitochondrial energy production and oxidative stress is central in the process of stress adaptation and response. The p38α signalling pathway plays a key role in the response to stress stim...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11309-7
更新日期：2017-09-12 00:00:00
abstract：:The anterior chamber of the eye (ACE) has emerged as a promising clinical islet transplantation site because of its multiple advantages over the conventional intra-hepatic portal site. This includes reduced surgical invasiveness and increased islet graft survival rate. It also allows for enhanced accessibility and mon...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40404-0
更新日期：2019-03-08 00:00:00
abstract：:There are three sex ratio strategies (SRS) in nature-male-biased sex ratio, female-biased sex ratio and, equal sex ratio. It was R. A. Fisher who first explained why most species in nature display a sex ratio of ½. Consequent SRS theories such as Hamilton's local mate competition (LMC) and Clark's local resource compe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39807
更新日期：2016-12-23 00:00:00
abstract：:We report the transient memory device by means of a water soluble SSG (solid sodium with glycerine) paper. This material has a hydroscopic property hence it can be soluble in water. In terms of physical security of memory devices, prompt abrogation of a memory device which stored a large number of data is crucial when...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38324
更新日期：2016-12-05 00:00:00
abstract：:We study the tight-binding model for a graphene tube with perimeter N threaded by a magnetic field. We show exactly that this model has different nontrivial topological phases as the flux changes. The winding number, as an indicator of topological quantum phase transition (QPT) fixes at N/3 if N/3 equals to its intege...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31953
更新日期：2016-08-24 00:00:00
abstract：:Safe management of high level nuclear waste is a worldwide significant issue for which vitrification has been selected by many countries. There exists a crucial need for improving our understanding of the ageing of the glass under irradiation. While external irradiation by ions provides a rapid simulation of damage in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25499
更新日期：2016-05-05 00:00:00
abstract：:A typical assumption made in the existing opinion formation models is that two individuals can communicate with each other only if the distance between their opinions is less than a threshold called bound of confidence. However, in the real world it is quite possible that people may also have a few friends with quite ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02968
更新日期：2013-10-17 00:00:00
abstract：:One of the most challenging issues in HIV-associated neurocognitive disorders (HAND) caused by HIV-1 virotoxins and drug abuse is the lack of understanding the underlying mechanisms that are commonly associated with disorders of the blood-brain barrier (BBB), which mainly consists of brain microvascular endothelial ce...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40467
更新日期：2017-01-11 00:00:00
abstract：:The innate and adaptive immune systems fail to control HCV infection in the majority of infected individuals. HCV is an ssRNA virus, which suggests a role for Toll-like receptors (TLRs) 7 and 8 in initiating the anti-viral response. Here we demonstrate that HCV genomic RNA harbours specific sequences that initiate an ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29447
更新日期：2016-07-07 00:00:00
