Optic Disc Hemorrhage and Lamina Cribrosa Defects in Glaucoma Progression.

abstract：:We study complex scaling properties of RR and QT intervals of electrocardiograms (ECGs) with their equivalences at the cellular level, that is, inter-beat intervals (IBI) and field potential durations (FPD) of spontaneously beating human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) aggregates. Our de...

journal_title：Scientific reports

authors： Kim J,Shah D,Potapov I,Latukka J,Aalto-Setälä K,Räsänen E

更新日期：2019-03-06 00:00:00

abstract：:Oxidative stress and the formation of plaques which contain amyloid-β (Aβ) peptides are two key hallmarks of Alzheimer's disease (AD). Dityrosine is found in the plaques of AD patients and Aβ dimers have been linked to neurotoxicity. Here we investigate the formation of Aβ dityrosine dimers promoted by Cu2+/+ Fenton r...

journal_title：Scientific reports

authors： Gu M,Bode DC,Viles JH

更新日期：2018-11-01 00:00:00

abstract：:The ability to accurately forecast seizures could significantly improve the quality of life of patients with drug-refractory epilepsy. Prediction capabilities rely on the adequate identification of seizure activity precursors from electroencephalography recordings. Although a long list of features has been proposed, n...

journal_title：Scientific reports

authors： Bou Assi E,Gagliano L,Rihana S,Nguyen DK,Sawan M

更新日期：2018-10-19 00:00:00

abstract：:Methamphetamine (METH) is a highly addictive psychostimulant that causes long-lasting effects in the brain and increases the risk of developing neurodegenerative diseases. The cellular and molecular effects of METH in the brain are functionally linked to alterations in glutamate levels. Despite the well-documented eff...

journal_title：Scientific reports

authors： Jones B,Balasubramaniam M,Lebowitz JJ,Taylor A,Villalta F,Khoshbouei H,Grueter C,Grueter B,Dash C,Pandhare J

更新日期：2021-01-14 00:00:00

abstract：:Discovered in 1813, the conoscopic interference pattern observed due to light propagating through a crystal, kept between crossed polarizers, shows isochromates and isogyres, respectively containing information about the dynamic and geometric phase acquired by the beam. We propose and demonstrate a closed-fringe Fouri...

journal_title：Scientific reports

authors： Samlan CT,Naik DN,Viswanathan NK

更新日期：2016-09-14 00:00:00

abstract：:Footprint evidence of human-megafauna interactions remains extremely rare in the archaeological and palaeontological records. Recent work suggests ancient playa environments may hold such evidence, though the prints may not be visible. These so-called "ghost tracks" comprise a rich archive of biomechanical and behavio...

journal_title：Scientific reports

authors： Urban TM,Bennett MR,Bustos D,Manning SW,Reynolds SC,Belvedere M,Odess D,Santucci VL

更新日期：2019-11-11 00:00:00

abstract：:First identified in The Netherlands in 2004, human coronavirus NL63 (HCoV-NL63) was found to cause worldwide infections. Patients infected by HCoV-NL63 are typically young children with upper and lower respiratory tract infection, presenting with symptoms including croup, bronchiolitis, and pneumonia. Unfortunately, t...

journal_title：Scientific reports

authors： Wang F,Chen C,Tan W,Yang K,Yang H

更新日期：2016-03-07 00:00:00

abstract：:Materials with a layered structure have attracted tremendous attention because of their unique properties. The ultrathin nanosheet structure can result in extremely rapid intercalation/de-intercalation of Na ions in the charge-discharge progress. Herein, we report a manganese oxide with pre-intercalated K and Na ions ...

journal_title：Scientific reports

authors： Feng M,Du Q,Su L,Zhang G,Wang G,Ma Z,Gao W,Qin X,Shao G

更新日期：2017-05-22 00:00:00

abstract：:Angulin proteins are a group of evolutionally conserved type I transmembrane proteins that contain an extracellular Ig-like domain. In mammals, three angulin proteins have been identified, namely immunoglobulin-like domain containing receptor 1 (ILDR1), immunoglobulin-like domain containing receptor 2 (ILDR2), and lip...

journal_title：Scientific reports

authors： Liu Y,Nie H,Liu C,Zhai X,Sang Q,Wang Y,Shi D,Wang L,Xu Z

更新日期：2017-08-07 00:00:00

abstract：:Primary Sjogren's syndrome (pSS) confers increased risk for non-Hodgkin lymphoma (NHL) development. Two common polymorphisms, the c. 677C > T and c. 1298A > C, of the methylene-tetrahydrofolate reductase (MTHFR) gene, an enzyme essential in DNA synthesis and methylation, have been associated with susceptibility to NHL...

journal_title：Scientific reports

authors： Fragkioudaki S,Nezos A,Souliotis VL,Chatziandreou I,Saetta AA,Drakoulis N,Tzioufas AG,Voulgarelis M,Sfikakis PP,Koutsilieris M,Crow MK,Moutsopoulos HM,Mavragani CP

更新日期：2017-08-04 00:00:00

abstract：:Drug resistance in Clostridioides difficile becomes a public health concern worldwide, especially as the hypervirulent strains show decreased susceptibility to the first-line antibiotics for C. difficile treatment. Therefore, the simultaneous discovery and development of new compounds to fight this pathogen are urgent...

journal_title：Scientific reports

authors： Phanchana M,Phetruen T,Harnvoravongchai P,Raksat P,Ounjai P,Chankhamhaengdecha S,Janvilisri T

更新日期：2020-04-16 00:00:00

abstract：:Transforming growth factor-β/Smad3 signaling plays a critical role in the process of chronic kidney disease (CKD), but targeting Smad3 systematically may cause autoimmune disease by impairing immunity. In this study, we used whole-transcriptome RNA-sequencing to identify the differential gene expression profile, gene ...

journal_title：Scientific reports

authors： Zhou Q,Xiong Y,Huang XR,Tang P,Yu X,Lan HY

更新日期：2015-12-09 00:00:00

abstract：:The patterns of life exhibited by large populations have been described and modeled both as a basic science exercise and for a range of applied goals such as reducing automotive congestion, improving disaster response, and even predicting the location of individuals. However, these studies have had limited access to c...

journal_title：Scientific reports

authors： Frank MR,Mitchell L,Dodds PS,Danforth CM

更新日期：2013-01-01 00:00:00

abstract：:Charge densities of iso-structural metal hexaborides, a transparent metal LaB6 and a semiconductor BaB6, have been determined using the d > 0.22 Å ultra-high resolution synchrotron radiation X-ray diffraction data by a multipole refinement and a maximum entropy method (MEM). The quality of the experimental charge dens...

journal_title：Scientific reports

authors： Kasai H,Nishibori E

更新日期：2017-01-25 00:00:00

abstract：:Estrogen receptor-α (ERα) plays an important role in normal and abnormal physiology of the human reproductive system by interacting with the endogenous ligand estradiol (E2). However, other ligands, either analogous or dissimilar to E2, also bind to ERα. This may create unintentional activation of ER signaling in repr...

journal_title：Scientific reports

authors： Sekar TV,Foygel K,Massoud TF,Gambhir SS,Paulmurugan R

更新日期：2016-10-10 00:00:00

abstract：:Telomerase activation and telomere maintenance are critical for cellular immortalization and transformation. PIN2/TERF1-interacting telomerase inhibitor 1 (PinX1) is a telomerase regulator and the aberrant expression of PinX1 causes telomere shortening. Identifying PinX1-interacting proteins is important for understan...

journal_title：Scientific reports

authors： Cheung DH,Ho ST,Lau KF,Jin R,Wang YN,Kung HF,Huang JJ,Shaw PC

更新日期：2017-03-03 00:00:00

abstract：:All models of evolution of human behaviour depend on the correct identification and interpretation of bone surface modifications (BSM) on archaeofaunal assemblages. Crucial evolutionary features, such as the origin of stone tool use, meat-eating, food-sharing, cooperation and sociality can only be addressed through co...

journal_title：Scientific reports

authors： Domínguez-Rodrigo M,Baquedano E

更新日期：2018-04-10 00:00:00

abstract：:Scanning micro-mirror actuators are silicon-based oscillatory micro-electro-mechanical systems (MEMS). They enable laser distance measurements for automotive LIDAR applications as well as projection modules for the consumer market. For MEMS applications, the geometric structure is typically designed to serve a number ...

journal_title：Scientific reports

authors： Nabholz U,Schatz F,Mehner JE,Degenfeld-Schonburg P

更新日期：2019-03-08 00:00:00

abstract：:ADC is a potential post treatment imaging biomarker in colorectal liver metastasis however measurements are affected by respiratory motion. This is compounded by increased statistical uncertainty in ADC measurement with decreasing tumour volume. In this prospective study we applied a retrospective motion correction me...

journal_title：Scientific reports

authors： Pathak R,Tian J,Thacker NA,Morris DM,Ragheb H,Saunders C,Saunders M,Jackson A

更新日期：2019-03-07 00:00:00

abstract：:This study aimed to determine the characteristics of CT changes in patients with severe coronavirus disease 2019 (COVID-19) based on prognosis. Serial CT scans in 47 patients with severe COVID-19 were reviewed. The patterns, distribution and CT score of lung abnormalities were assessed. Scans were classified according...

journal_title：Scientific reports

authors： Liang B,Xie L,Yang F,Makamure J,Zhang L,Pang R,Du P,Fan W,Zheng C

更新日期：2020-12-14 00:00:00

abstract：:Recently, mesoporous carbon nitride (MCN) has aroused extensive interest for its potential applications in organocatalysis, photo- and electrochemistry and CO2 capture. However, further surface functionalization of MCN for advanced nanomaterials and catalysis still remains very challenging. Here we show that acidic ca...

journal_title：Scientific reports

authors： Zhong L,Anand C,Lakhi KS,Lawrence G,Vinu A

更新日期：2015-08-05 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Montaner A,da Silva Santana TT,Schroeder T,Einicker-Lamas M,Girardini J,Costa MR,Banchio C

更新日期：2019-12-24 00:00:00

abstract：:Recurrence risk stratification of patients undergoing primary surgical resection for hepatocellular carcinoma (HCC) is an area of active investigation, and several staging systems have been proposed to optimize treatment strategies. However, as many as 70% of patients still experience tumor recurrence at 5 years post-...

journal_title：Scientific reports

authors： Yamashita R,Long J,Saleem A,Rubin DL,Shen J

更新日期：2021-01-21 00:00:00

abstract：:In most organisms, ribosomal RNA (rRNA) contributes to >85% of total RNA. Thus, to obtain useful information from RNA-sequencing (RNA-seq) analyses at reasonable sequencing depth, typically, mature polyadenylated transcripts are enriched or rRNA molecules are depleted. Targeted depletion of rRNA is particularly useful...

journal_title：Scientific reports

authors： Kraus AJ,Brink BG,Siegel TN

更新日期：2019-08-22 00:00:00

abstract：:Distillers grains are co-products of the corn ethanol industry widely used in animal feed. We examined the effects of erythromycin, penicillin, and virginiamycin at low concentrations reflective of those detected in distillers grains on bacterial resistance selection. At 0.1 µg/ml erythromycin, macrolide-resistant mut...

journal_title：Scientific reports

authors： Ge B,Domesle KJ,Yang Q,Young SR,Rice-Trujillo CL,Bodeis Jones SM,Gaines SA,Keller MW,Li X,Piñeiro SA,Whitney BM,Harbottle HC,Gilbert JM

更新日期：2017-09-08 00:00:00

abstract：:An on-going debate concerning the dietary adaptations of archaic hominins and early Homo has been fuelled by contradictory inferences obtained using different methodologies. This work presents an extensive comparative sample of 30 extant primate species that was assembled to perform a morpho-functional comparison of t...

journal_title：Scientific reports

authors： Marcé-Nogué J,Püschel TA,Daasch A,Kaiser TM

更新日期：2020-04-22 00:00:00

abstract：:Lung cancer is the leading cause of death among all malignancies due to rapid tumor progression and relapse; however, the underlying molecular mechanisms of tumor progression are unclear. In the present study, we identified ANKRD22 as a novel tumor-associated gene in non-small cell lung cancer (NSCLC). According to th...

journal_title：Scientific reports

authors： Yin J,Fu W,Dai L,Jiang Z,Liao H,Chen W,Pan L,Zhao J

更新日期：2017-06-30 00:00:00

abstract：:Accidental transmission of prions during neurosurgery has been reported as a consequence of re-using contaminated surgical instruments. Several decontamination methods have been studied using the 263K-hamster prion; however, no studies have directly evaluated human prions. A newly developed in vitro amplification syst...

journal_title：Scientific reports

authors： Mori T,Atarashi R,Furukawa K,Takatsuki H,Satoh K,Sano K,Nakagaki T,Ishibashi D,Ichimiya K,Hamada M,Nakayama T,Nishida N

更新日期：2016-04-26 00:00:00

abstract：:Tumor-associated macrophages (TAMs) play critical roles in promoting tumor progression and invasion. However, the molecular mechanisms underlying TAM regulation remain to be further investigated and may make significant contributions to cancer treatment. Mammalian microRNAs (miRNAs) have recently been identified as im...

journal_title：Scientific reports

authors： Li Y,Zhao L,Shi B,Ma S,Xu Z,Ge Y,Liu Y,Zheng D,Shi J

更新日期：2015-12-22 00:00:00

abstract：:Water, methane, and ammonia are commonly considered to be the key components of the interiors of Uranus and Neptune. Modelling the planets' internal structure, evolution, and dynamo heavily relies on the properties of the complex mixtures with uncertain exact composition in their deep interiors. Therefore, characteris...

journal_title：Scientific reports

authors： Guarguaglini M,Hernandez JA,Okuchi T,Barroso P,Benuzzi-Mounaix A,Bethkenhagen M,Bolis R,Brambrink E,French M,Fujimoto Y,Kodama R,Koenig M,Lefevre F,Miyanishi K,Ozaki N,Redmer R,Sano T,Umeda Y,Vinci T,Ravasio A

更新日期：2019-07-12 00:00:00