Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design.

abstract：:Super-Planckian near-field radiative heat transfer allows effective heat transfer between a hot and a cold body to increase beyond the limits long known for black bodies. Until present, experimental techniques to measure the radiative heat flow relied on steady-state systems. Here, we present a dynamic measurement app...

journal_title：Scientific reports

authors： Lang S,Sharma G,Molesky S,Kränzien PU,Jalas T,Jacob Z,Petrov AY,Eich M

更新日期：2017-10-24 00:00:00

abstract：:Understanding the transcriptional regulatory elements that influence the progression of liver disease in the presence of hepatitis C virus (HCV) infection is critical for the development of diagnostic and therapeutic approaches. Systems biology provides a roadmap by which these elements may be integrated. In this stud...

journal_title：Scientific reports

authors： Zahra M,Azzazy H,Moustafa A

更新日期：2018-09-24 00:00:00

abstract：:Meishan boars are known for their early sexual maturity. However, they exhibit a significantly smaller testicular size and a reduced proportion of Sertoli cells and daily sperm production compared with Duroc boars. The testes of Duroc and Meishan boars at 20, 75 and 270 days of age were used for histological and trans...

journal_title：Scientific reports

authors： Ding H,Luo Y,Liu M,Huang J,Xu D

更新日期：2016-02-11 00:00:00

abstract：:The observation and analysis of dendritic spines morphological changes poses a major challenge in neuroscience studies. The alterations of their density and/or morphology are indicators of the cellular processes involved in neural plasticity underlying learning and memory, and are symptomatic in neuropsychiatric disor...

journal_title：Scientific reports

authors： Basu S,Saha PK,Roszkowska M,Magnowska M,Baczynska E,Das N,Plewczynski D,Wlodarczyk J

更新日期：2018-02-23 00:00:00

abstract：:Environmental pollutants as non-heritable factors are now recognized as triggers for multiple human inflammatory diseases involving T cells. We postulated that lipid antigen presentation mediated by cluster of differentiation 1 (CD1) proteins for T cell activation is susceptible to lipophilic environmental pollutants....

journal_title：Scientific reports

authors： Sharma M,Zhang X,Zhang S,Niu L,Ho SM,Chen A,Huang S

更新日期：2017-05-18 00:00:00

abstract：:Microorganisms are key components for plant biomass breakdown within rumen environments. Fibrobacter succinogenes have been identified as being active and dominant cellulolytic members of the rumen. In this study, F. succinogenes type strain S85 was adapted for steady state growth in continuous culture at pH 5.75 and ...

journal_title：Scientific reports

authors： Wu CW,Spike T,Klingeman DM,Rodriguez M,Bremer VR,Brown SD

更新日期：2017-05-23 00:00:00

abstract：:Studies have reported that neck and/or shoulder pain (NSP) was prevalent and a non-ignorable occupational health problem in healthcare providers. Considering data deficiency on NSP, we aimed to investigate the prevalence and sick leave absence of NSP among public hospital workers in Shandong, China and to explore the ...

journal_title：Scientific reports

authors： Dong H,Zhang Q,Liu G,Shao T

更新日期：2020-07-23 00:00:00

abstract：:Rapid integration of high-quality functional devices in microchannels is in highly demand for miniature lab-on-a-chip applications. This paper demonstrates the embellishment of existing microfluidic devices with integrated micropatterns via femtosecond laser MRAF-based holographic patterning (MHP) microfabrication, wh...

journal_title：Scientific reports

authors： Zhang C,Hu Y,Du W,Wu P,Rao S,Cai Z,Lao Z,Xu B,Ni J,Li J,Zhao G,Wu D,Chu J,Sugioka K

更新日期：2016-09-13 00:00:00

abstract：:Soft tissue prostheses such as artificial ear, eye and nose are widely used in the maxillofacial rehabilitation. In this report we demonstrate how to fabricate soft prostheses mold with a low cost desktop 3D printer. The fabrication method used is referred to as Scanning Printing Polishing Casting (SPPC). Firstly the ...

journal_title：Scientific reports

authors： He Y,Xue GH,Fu JZ

更新日期：2014-11-27 00:00:00

abstract：:Inherited the advantages of inorganic salts and organic solvents, ionic liquids (ILs) exhibit many superior properties allowing them promising green solvents for the future. Although it has been widely acknowledged that the unique features of ILs originate from their dual ionic and organic nature, its microscopic phys...

journal_title：Scientific reports

authors： Shi R,Wang Y

更新日期：2016-01-19 00:00:00

abstract：:Micronutrient deficiency is common in patients with HIV/AIDS, usually caused by mal-absorption and/or drug interactions. 25-hydroxyvitamin D is of fundamental importance for the homeostasis of musculoskeletal health. The current study aimed to evaluate the nutritional status of HIV-infected subjects in order to make t...

journal_title：Scientific reports

authors： Sales SH,Matta SM,da Silva DC,Assone TA,Fonseca LA,Duarte AJ,Casseb J

更新日期：2015-08-10 00:00:00

abstract：:We report the fabrication of flower-like CuO nanostructured surfaces via submerged photo-synthesis of crystallites (SPSC), which requires only UV illumination in neutral water. In this paper, we discuss the reaction mechanism of the photochemical formation of the SPSC-fabricated CuO nanostructures in detail based on s...

journal_title：Scientific reports

authors： Nishino F,Jeem M,Zhang L,Okamoto K,Okabe S,Watanabe S

更新日期：2017-04-21 00:00:00

abstract：:Constrained by the diffraction limit, a lens can only resolve features larger than half of the incident wavelength owing to the decaying nature of evanescent waves. Several novel devices have been proposed, for example, superlenses and hyperlenses to break this limit. In this work, we present a flat hyperlens composed...

journal_title：Scientific reports

authors： Tao CW,Yen TJ,Huang TY

更新日期：2020-03-24 00:00:00

abstract：:Endocytosis and postendocytic sorting of G-protein-coupled receptors (GPCRs) is important for the regulation of both their cell surface density and signaling profile. Unlike the mechanisms of clathrin-dependent endocytosis (CDE), the mechanisms underlying the control of GPCR signaling by clathrin-independent endocytos...

journal_title：Scientific reports

authors： Wan M,Zhang W,Tian Y,Xu C,Xu T,Liu J,Zhang R

更新日期：2015-06-22 00:00:00

abstract：:Radial migration of pyramidal neurons is an important event during the development of cerebral cortex. Neurons experience series of morphological and directional transitions to get to their final laminar positions. Here we report that the histone methyltransferase enhancer of zest homolog 2 (Ezh2) is involved in the r...

journal_title：Scientific reports

authors： Zhao L,Li J,Ma Y,Wang J,Pan W,Gao K,Zhang Z,Lu T,Ruan Y,Yue W,Zhao S,Wang L,Zhang D

更新日期：2015-10-26 00:00:00

abstract：:Hydrogen sulfide (H2S) signaling has been considered a key regulator of plant developmental processes and defenses. In this study, we demonstrate that high levels of H2S inhibit auxin transport and lead to alterations in root system development. H2S inhibits auxin transport by altering the polar subcellular distributi...

journal_title：Scientific reports

authors： Jia H,Hu Y,Fan T,Li J

更新日期：2015-02-05 00:00:00

abstract：:Hemodialysis patients are a special group of patients with higher mortality rates. Hemodialysis patients with vitamin D deficiency {plasma levels of 25-hydroxyvitamin D [25(OH)D] below 20 ng/mL} are associated with even higher mortality rates. The prognostic importance of vitamin D deficiency in hemodialysis patients ...

journal_title：Scientific reports

authors： Hsu HJ,Wu IW,Hsu KH,Sun CY,Chen CY,Lee CC

更新日期：2020-05-05 00:00:00

abstract：:Humans have an innate set of emotions recognised universally. However, emotion recognition also depends on socio-cultural rules. Although adults recognise vocal emotions universally, they identify emotions more accurately in their native language. We examined developmental trajectories of universal vocal emotion recog...

journal_title：Scientific reports

authors： Chronaki G,Wigelsworth M,Pell MD,Kotz SA

更新日期：2018-06-14 00:00:00

abstract：:Essential oils are volatile compounds commonly used by several industries, easily degradable, which restrains their applications. Therefore, we developed and validated a methodology for producing microcapsules loaded with orange essential oil, using a spray-drying process. The experimental design results showed that t...

journal_title：Scientific reports

authors： Aguiar MCS,das Graças Fernandes da Silva MF,Fernandes JB,Forim MR

更新日期：2020-07-16 00:00:00

abstract：:HOXA transcript antisense RNA myeloid-specific 1 (HOTAIRM1) is a long non-coding RNA (lncRNA) that plays a pivotal role in regulating myeloid cell development via targeting HOXA1 gene expression. We and others have previously shown that myeloid-derived suppressor cells (MDSCs), a heterogeneous population of immature m...

journal_title：Scientific reports

authors： Thakuri BKC,Zhang J,Zhao J,Nguyen LN,Nguyen LNT,Khanal S,Cao D,Dang X,Schank M,Wu XY,Morrison ZD,Gazzar ME,Li Z,Jiang Y,Ning S,Wang L,Moorman JP,Yao ZQ

更新日期：2020-12-16 00:00:00

abstract：:Ribonucleotide reductases (RNR) catalyze the last step of deoxyribonucleotide synthesis, and are therefore essential to DNA-based life. Three forms of RNR exist: classes I, II, and III. While eukaryotic cells use only class Ia RNR, bacteria can harbor any combination of classes, granting them adaptability. The opportu...

journal_title：Scientific reports

authors： Crespo A,Pedraz L,Van Der Hofstadt M,Gomila G,Torrents E

更新日期：2017-12-20 00:00:00

abstract：:Recently, a genome-wide analysis identified DNA methylation of the HIF3A (hypoxia-inducible factor 3A) as strongest correlate of BMI. Here we tested the hypothesis that HIF3A mRNA expression and CpG-sites methylation in adipose tissue (AT) and genetic variants in HIF3A are related to parameters of AT distribution and ...

journal_title：Scientific reports

authors： Pfeiffer S,Krüger J,Maierhofer A,Böttcher Y,Klöting N,El Hajj N,Schleinitz D,Schön MR,Dietrich A,Fasshauer M,Lohmann T,Dreßler M,Stumvoll M,Haaf T,Blüher M,Kovacs P

更新日期：2016-06-27 00:00:00

abstract：:Malaria is a fatal disease that displays a spectrum of symptoms and severity, which are determined by complex host-parasite interactions. It has been difficult to study the effects of parasite strains on disease severity in human infections, but the mechanisms leading to specific disease phenotypes can be investigated...

journal_title：Scientific reports

authors： Lacerda-Queiroz N,Riteau N,Eastman RT,Bock KW,Orandle MS,Moore IN,Sher A,Long CA,Jankovic D,Su XZ

更新日期：2017-09-05 00:00:00

abstract：:Sleep has been hypothesised to maintain a close relationship with metabolism. Here we focus on the brain structure that triggers slow-wave sleep, the ventrolateral preoptic nucleus (VLPO), to explore the cellular and molecular signalling pathways recruited by an increase in glucose concentration. We used infrared vide...

journal_title：Scientific reports

authors： Scharbarg E,Daenens M,Lemaître F,Geoffroy H,Guille-Collignon M,Gallopin T,Rancillac A

更新日期：2016-01-12 00:00:00

abstract：:We present a method by which the spectral intensity of an ultrafast laser pulse can be accumulated at selected frequencies by a controllable amount. Using a 4-f pulse shaper we modulate the phase of the frequency components of a femtosecond laser. By inducing femtosecond filamentation with the modulated pulse, we can ...

journal_title：Scientific reports

authors： Thompson JV,Zhokhov PA,Springer MM,Traverso AJ,Yakovlev VV,Zheltikov AM,Sokolov AV,Scully MO

更新日期：2017-03-07 00:00:00

abstract：:Using single-trial cortical signals calculated by weighted minimum norm solution estimation (WMNE), the present study explored a feature extraction method based on rhythm entropy to classify the scalp electroencephalography (EEG) signals of error response from that of correct response during performing auditory-track ...

journal_title：Scientific reports

authors： Tian Y,Xu W,Yang L

更新日期：2018-04-17 00:00:00

abstract：:Graphite's capacity of intercalating lithium in rechargeable batteries is limited (theoretically, 372 mAh g-1) due to low diffusion within commensurately-stacked graphene layers. Graphene foam with highly enriched incommensurately-stacked layers was grown and applied as an active electrode in rechargeable batteries. A...

journal_title：Scientific reports

authors： Paronyan TM,Thapa AK,Sherehiy A,Jasinski JB,Jangam JS

更新日期：2017-01-06 00:00:00

abstract：:Major overturn within a magma chamber can bring together felsic and mafic magmas, prompting de-volatilisation and acting as the driver for Plinian eruptions. Until now identification of mixing has been limited to analysis of lavas or individual crystals ejected during eruptions. We have recovered partially developed c...

journal_title：Scientific reports

authors： Stock MJ,Taylor RN,Gernon TM

更新日期：2012-01-01 00:00:00

abstract：:The subjective experience of thermal pain follows the detection and encoding of noxious stimuli by primary afferent neurons called nociceptors. However, nociceptor morphology has been hard to access and the mechanisms of signal transduction remain unresolved. In order to understand how heat transducers in nociceptors ...

journal_title：Scientific reports

authors： Dezhdar T,Moshourab RA,Fründ I,Lewin GR,Schmuker M

更新日期：2015-12-07 00:00:00

abstract：:Optical phased arrays have been demonstrated to enable a variety of applications ranging from high-speed on-chip communications to vertical surface emitting lasers. Despite the prosperities of the researches on optical phased arrays, presently, the reported designs of optical phased arrays are based on silicon photoni...

journal_title：Scientific reports

authors： Zeng YS,Qu SW,Chen BJ,Chan CH

更新日期：2017-08-30 00:00:00