Abstract：
:Malaria is a fatal disease that displays a spectrum of symptoms and severity, which are determined by complex host-parasite interactions. It has been difficult to study the effects of parasite strains on disease severity in human infections, but the mechanisms leading to specific disease phenotypes can be investigated using strains of rodent malaria parasites that cause different disease symptoms in inbred mice. Using a unique mouse malaria model, here we investigated the mechanisms of splenic cell death and their relationship to control of parasitemia and host mortality. C57BL/6 mice infected with Plasmodium yoelii nigeriensis N67C display high levels of pro-inflammatory cytokines and chemokines (IL-6, IFN-γ, TNF-α, CXCL1, and CCL2) and extensive splenic damage with dramatic reduction of splenic cell populations. These disease phenotypes were rescued in RAG2-/-, IFN-γ-/-, or T cell depleted mice, suggesting IFN-γ and T cell mediated disease mechanisms. Additionally, apoptosis was one of the major pathways involved in splenic cell death, which coincides with the peaks of pro-inflammatory cytokines. Our results demonstrate the critical roles of T cells and IFN-γ in mediating splenic cell apoptosis, parasitemia control, and host lethality and thus may provide important insights for preventing/reducing morbidity associated with severe malaria in humans.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lacerda-Queiroz N,Riteau N,Eastman RT,Bock KW,Orandle MS,Moore IN,Sher A,Long CA,Jankovic D,Su XZdoi
10.1038/s41598-017-10776-2subject
Has Abstractpub_date
2017-09-05 00:00:00pages
10438issue
1issn
2045-2322pii
10.1038/s41598-017-10776-2journal_volume
7pub_type
杂志文章abstract：:Geranylated 4-phenylcoumarins DMDP-1 and DMDP-2 isolated from Mesua elegans were elucidated for their role in inducing caspase-independent programmed cell death (CI-PCD) in prostate cancer cell lines, PC-3 and DU 145, respectively. Cell homeostasis disruption was demonstrated upon treatment, as shown by the increase i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57781-6
更新日期：2020-01-22 00:00:00
abstract：:The early diverged Magnoliaceae shows a historical temperate-tropical distribution among lineages indicating divergent evolution, yet which ecophysiological traits are phylogenetically conserved, and whether these traits are involved in correlated evolution remain unclear. Integrating phylogeny and 20 ecophysiological...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12246
更新日期：2015-07-16 00:00:00
abstract：:The role of topical corticosteroids in management of Acanthamoeba keratitis (AK) remains controversial. Using a rabbit AK model, we investigated whether corticosteroid use is a risk factor of AK. Acanthamoeba (1 × 105/ml) was incubated with two densities of P. aeruginosa (PA; high-PA: 1 × 108/ml, low-PA: 3 × 105/ml) b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49128-7
更新日期：2019-09-06 00:00:00
abstract：:There is a variety of cases in nature when the action-reaction symmetry is broken. In particular, suitable conditions for this are realized in colloidal suspensions and complex plasmas. Since the first theories and simulations of the nonreciprocal effective interactions between microparticles in complex plasmas were p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70441-z
更新日期：2020-08-12 00:00:00
abstract：:The catalytic and optical properties of metal nanoparticles can be combined to create platforms for light-driven chemical energy storage and enhanced in-situ reaction monitoring. However, the heavily damped plasmon resonances of many catalytically active metals (e.g. Pt, Pd) prevent this dual functionality in pure nan...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17431
更新日期：2015-11-30 00:00:00
abstract：:Hepatitis E Virus-like particles self-assemble in to noninfectious nanocapsids that are resistant to proteolytic/acidic mucosal delivery conditions. Previously, the nanocapsid was engineered to specifically bind and enter breast cancer cells, where successful tumor targeting was demonstrated in animal models. In the p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17171-x
更新日期：2017-12-06 00:00:00
abstract：:A tetrameric N-acetyl galactosaminyl (GalNAc) peptidomimetic was constructed by N-acetylation of repeating proline-based hydroxamic acid units, followed by a convergent 'click chemistry' coupling. This novel glycopeptidomimetic was determined to effectively antagonize the interaction between a transmembrane hepatic le...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05513
更新日期：2014-07-01 00:00:00
abstract：:Insulin secretion from pancreatic beta-cells is dependent on zinc ions as essential components of insulin crystals, zinc transporters are thus involved in the insulin secretory process. Zip14 (SLC39a14) is a zinc importing protein that has an important role in glucose homeostasis. Zip14 knockout mice display hyperinsu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44954-1
更新日期：2019-06-13 00:00:00
abstract：:Liquid-ordered lipid domains represent a lateral inhomogeneity in cellular membranes. These domains have elastic and physicochemical properties different from those of the surrounding membrane. In particular, their thickness exceeds that of the disordered membrane. Thus, elastic deformations arise at the domain bounda...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61110-2
更新日期：2020-03-05 00:00:00
abstract：:The aim of this study was to find an accurate method for the detection of extracapsular extension (ECE) in papillary thyroid carcinoma (PTC). A total of 102 patients with 109 PTC nodules were retrospectively enrolled. Contrast-enhanced ultrasound (CEUS) characteristics were evaluated. The diagnostic efficacy of quanti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01650-2
更新日期：2017-05-03 00:00:00
abstract：:The F1F0-ATP synthase, an enzyme complex, is mainly located on the mitochondrial inner membrane or sometimes cytomembrane to generate or hydrolyze ATP, play a role in cell proliferation. This study focused on the role of F1F0-ATP synthase in keratinocyte differentiation, and its relationship with intracellular and ext...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42672
更新日期：2017-02-17 00:00:00
abstract：:This paper reports the presence of tear strips on the surface of a Ti-22Al-25Nb alloy sheet stretched at 960 °C. The test piece reveals a "bamboo"-shaped pattern on its surface, which severely affects the quality of the alloy. Microstructure analysis indicates that the formation mechanism of the tear strip is related ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01889-9
更新日期：2017-05-10 00:00:00
abstract：:Geophysical data from the South Kara Sea reveal U-shaped erosional structures buried beneath the 50-250 m deep seafloor of the continental shelf across an area of ~32 000 km2. These structures are interpreted as thermokarst, formed in ancient yedoma terrains during Quaternary interglacial periods. Based on comparison ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32826-z
更新日期：2018-09-25 00:00:00
abstract：:We compared coincidence-anticipation performance in normal vision and stroboscopic vision as a function of time-on-task. Participants estimated the arrival time of a real object that moved with constant acceleration (-0.7, 0, +0.7 m/s2) in a pseudo-randomised order across 4 blocks of 30 trials in both vision condition...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18092-5
更新日期：2017-12-20 00:00:00
abstract：:Newly synthesized mitochondrial precursor proteins have to become unfolded to cross the mitochondrial membranes. This unfolding is achieved primarily by mitochondrial Hsp70 (mtHsp70) for presequence-containing precursor proteins. However, the membrane potential across the inner membrane (ΔΨ) could also contribute to u...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44152-z
更新日期：2019-05-21 00:00:00
abstract：:The crystal structure of the Sb6O13 oxide, exhibiting a defect pyrochlore crystal structure with atomic vacancies, has been studied using a complete set of state-of-the-art techniques. The degree of antimony disproportionation in Sb3+ and Sb5+ valence states has been directly determined around 36% and 64%, respectivel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73860-0
更新日期：2020-10-12 00:00:00
abstract：:In face-to-face communication, audio-visual (AV) stimuli can be fused, combined or perceived as mismatching. While the left superior temporal sulcus (STS) is presumably the locus of AV integration, the process leading to combination is unknown. Based on previous modelling work, we hypothesize that combination results ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75201-7
更新日期：2020-10-22 00:00:00
abstract：:We propose a homomorphic search protocol based on quantum homomorphic encryption, in which a client Alice with limited quantum ability can give her encrypted data to a powerful but untrusted quantum server and let the server search for her without decryption. By outsourcing the interactive key-update process to a trus...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61791-9
更新日期：2020-03-20 00:00:00
abstract：:We present a method by which the spectral intensity of an ultrafast laser pulse can be accumulated at selected frequencies by a controllable amount. Using a 4-f pulse shaper we modulate the phase of the frequency components of a femtosecond laser. By inducing femtosecond filamentation with the modulated pulse, we can ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43367
更新日期：2017-03-07 00:00:00
abstract：:There has been increasing interest in diatom-based bio-assessment but we still lack a comprehensive understanding of how to capture diatoms' temporal dynamics with an appropriate sampling frequency (ASF). To cover this research gap, we collected and analyzed daily riverine diatom samples over a 1-year period (25 April...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36950
更新日期：2016-11-14 00:00:00
abstract：:Baeyer-Villiger monooxygenases (BVMOs) are able to catalyze regiospecific Baeyer-Villiger oxygenation of a variety of cyclic and linear ketones to generate the corresponding lactones and esters, respectively. However, the enzymes are usually difficult to express in a functional form in microbial cells and are rather u...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28223
更新日期：2016-06-17 00:00:00
abstract：:A complete understanding of signaling processes at the plasma membrane depends on a quantitative characterization of the interactions of the involved proteins. Fluorescence recovery after photobleaching (FRAP) is a widely used and convenient technique to obtain kinetic parameters on protein interactions in living cell...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39865-0
更新日期：2019-03-01 00:00:00
abstract：:Optical thermometry based on the up-conversion intensity ratio of thermally coupled levels of rare earth ions has been widely studied to achieve an inaccessible temperature measurement in submicron scale. In this work, a novel optical temperature sensing strategy based on the energy transfer from charge transfer bands...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06421-7
更新日期：2017-07-20 00:00:00
abstract：:Circularly polarized laser sources with small footprints and high efficiencies can possess advanced functionalities in optical communication and biophotonic integrated systems. However, the conventional lasers with additional circular-polarization converters are bulky and hardly compatible with nanophotonic circuits, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26578
更新日期：2016-05-25 00:00:00
abstract：:Combining strong magnetic anisotropy with strong exchange interaction is a long standing goal in the design of quantum magnets. The lanthanide complexes, while exhibiting a very strong ionic anisotropy, usually display a weak exchange coupling, amounting to only a few wavenumbers. Recently, an isostructural series of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24046
更新日期：2016-04-18 00:00:00
abstract：:Tsetse flies are the transmitting vector of trypanosomes causing human sleeping sickness and animal trypanosomiasis in sub-saharan Africa. 3-alkylphenols are used as attractants in tsetse fly traps to reduce the spread of the disease. Here we present an inexpensive production method for 3-ethylphenol (3-EP) and 3-prop...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66997-5
更新日期：2020-06-19 00:00:00
abstract：:Recreational boating is an increasing activity in coastal areas and its spatiotemporal overlap with key habitats of marine species pose a risk for negative noise impacts. Yet, recreational vessels are currently unaccounted for in vessel noise models using Automatic Identification System (AIS) data. Here we conduct a c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51222-9
更新日期：2019-10-29 00:00:00
abstract：:Genome-scale metabolic network models can be used for various analyses including the prediction of metabolic responses to changes in the environment. Legumes are well known for their rhizobial symbiosis that introduces nitrogen into the global nutrient cycle. Here, we describe a fully compartmentalised, mass and charg...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30884-x
更新日期：2018-08-21 00:00:00
abstract：:Spotted seal (Phoca largha) is a critically endangered pinniped in China and South Korea. The conventional method to protect and maintain the P. largha population is to keep them captive in artificially controlled environments. However, little is known about the physiological differences between wild and captive P. la...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75759-2
更新日期：2020-10-30 00:00:00
abstract：:Functional reactivation of p53 pathway, although arduous, can potentially provide a broad-based strategy for cancer therapy owing to frequent p53 inactivation in human cancer. Using a phosphoprotein-screening array, we found that Benzyl Isothiocynate, (BITC) increases p53 phosphorylation in breast cancer cells and rev...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40070
更新日期：2017-01-10 00:00:00
