A transgenic mouse model expressing an ERα folding biosensor reveals the effects of Bisphenol A on estrogen receptor signaling.

abstract：:To date, only two pigments have been identified in avian eggshells: rusty-brown protoporphyrin IX and blue-green biliverdin IXα. Most avian eggshell colours can be produced by a mixture of these two tetrapyrrolic pigments. However, tinamou (Tinamidae) eggshells display colours not easily rationalised by combination of...

journal_title：Scientific reports

authors： Hamchand R,Hanley D,Prum RO,Brückner C

更新日期：2020-07-09 00:00:00

abstract：:The molecular bases of the Frank-Starling law of the heart and of its cellular counterpart, the length dependent activation (LDA), are largely unknown. However, the recent discovery of the thick filament activation, a second pathway beside the well-known calcium mediated thin filament activation, is promising for eluc...

journal_title：Scientific reports

authors： Marcucci L,Washio T,Yanagida T

更新日期：2019-02-04 00:00:00

abstract：:Breast cancer susceptibility gene 1 (BRCA1) located at chromosome 17q12-21 is a classic tumor suppressor gene, and has been considered as a significant role in hereditary breast cancers. Moreover, numerous studies demonstrated the methylation status of CpG islands in the promoter regions of BRCA1 gene was aberrant in ...

journal_title：Scientific reports

authors： Zhang L,Long X

更新日期：2015-12-08 00:00:00

abstract：:Articular cartilage (AC) lacks the ability to self-repair and cell-based approaches, primarily based on using chondrocytes and mesenchymal stem cells (MSCs), are emerging as effective technology to restore cartilage functionality, because cells synergic functionality may support the maintenance of chondrogenic phenoty...

journal_title：Scientific reports

authors： Scalzone A,Ferreira AM,Tonda-Turo C,Ciardelli G,Dalgarno K,Gentile P

更新日期：2019-10-10 00:00:00

abstract：:Rabies is still a public health threat in China. Evaluating the exposure history, clinical characteristics, and post-exposure prophylaxis (PEP) of the cases could help in identifying approaches to reducing the number of these preventable deaths. We analysed data collected from 10,971 case-investigations conducted in C...

journal_title：Scientific reports

authors： Guo C,Li Y,Huai Y,Rao CY,Lai S,Mu D,Yin W,Yu H,Nie S

更新日期：2018-11-21 00:00:00

abstract：:Caenorhabditis elegans presents functioning, biologically relevant phenotypes and is frequently used as a bioindicator of toxicity. However, most C. elegans in vivo effect-assessment methods are laborious and time consuming. Therefore, we developed a novel method to measure the oxygen consumption rate of C. elegans as...

journal_title：Scientific reports

authors： Preez GD,Fourie H,Daneel M,Miller H,Höss S,Ricci C,Engelbrecht G,Zouhar M,Wepener V

更新日期：2020-03-06 00:00:00

abstract：:The ability of coral reefs to engineer complex three-dimensional habitats is central to their success and the rich biodiversity they support. In tropical reefs, encrusting coralline algae bind together substrates and dead coral framework to make continuous reef structures, but beyond the photic zone, the cold-water co...

journal_title：Scientific reports

authors： Hennige SJ,Morrison CL,Form AU,Büscher J,Kamenos NA,Roberts JM

更新日期：2014-10-27 00:00:00

abstract：:While cerebrospinal fluid (CSF) biomarkers for Creutzfeldt-Jakob disease (CJD) are established and partly included in the diagnostic criteria, no blood biomarkers are available. Here, we assessed the utility of serum neurofilament light chain (NF-L) and tau protein in comparison to CSF markers (NF-L and phosphorylated...

journal_title：Scientific reports

authors： Steinacker P,Blennow K,Halbgebauer S,Shi S,Ruf V,Oeckl P,Giese A,Kuhle J,Slivarichova D,Zetterberg H,Otto M

更新日期：2016-12-08 00:00:00

abstract：:Hydrophilic polymers have garnered much attention due to their critical roles in various applications such as molecular separation membranes, bio-interfaces, and surface engineering. However, a long-standing problem is that their mechanical properties usually deteriorate at high relative humidity (RH). Through the sim...

journal_title：Scientific reports

authors： Liu T,An QF,Zhao Q,Wu JK,Song YH,Zhu BK,Gao CJ

更新日期：2015-01-14 00:00:00

abstract：:Classical Lotka-Volterra (LV) competition equation has shown that coexistence of competitive species is only possible when intraspecific competition is stronger than interspecific competition, i.e., the species inhibit their own growth more than the growth of the other species. Note that density effect is assumed to b...

journal_title：Scientific reports

authors： Gavina MKA,Tahara T,Tainaka KI,Ito H,Morita S,Ichinose G,Okabe T,Togashi T,Nagatani T,Yoshimura J

更新日期：2018-01-19 00:00:00

abstract：:Interleukin-27 (IL-27) is an important cytokine in inflammatory diseases, including coronary artery disease (CAD). To explore the precise role of IL-27 in CAD, we investigated the genetic association between IL27 and CAD in the GeneID Chinese Han population. A two-stage case control association analysis was performed ...

journal_title：Scientific reports

authors： Fan Q,Nie S,Li S,Liao Y,Zhang H,Zha L,Wang F,Tang T,Xia N,Xu C,Wang P,Xie T,Xie J,Lu Q,Li Q,Qian J,Li B,Wu G,Wu Y,Yang Y,Wang QK,Tu X,Cheng X

更新日期：2016-05-12 00:00:00

abstract：:Historical records indicate that extensive cultural, commercial and technological interaction occurred between European and Asian populations. What have been the biological consequences of these contacts in terms of gene flow? We systematically estimated gene flow between Eurasian groups using genome-wide polymorphism...

journal_title：Scientific reports

authors： Qin P,Zhou Y,Lou H,Lu D,Yang X,Wang Y,Jin L,Chung YJ,Xu S

更新日期：2015-04-02 00:00:00

abstract：:Diatoms are known for their intricate, silicified cell walls (frustules). Silica polymerization occurs in a compartment called the silica deposition vesicle (SDV) and it was proposed that the cytoskeleton influences silica patterning through the SDV membrane (silicalemma) via interactions with transmembrane proteins. ...

journal_title：Scientific reports

authors： Tesson B,Lerch SJL,Hildebrand M

更新日期：2017-10-18 00:00:00

abstract：:A detailed characterisation of the molecular determinants of membrane binding by α-synuclein (αS), a 140-residue protein whose aggregation is associated with Parkinson's disease, is of fundamental significance to clarify the manner in which the balance between functional and dysfunctional processes are regulated for t...

journal_title：Scientific reports

authors： Fusco G,De Simone A,Arosio P,Vendruscolo M,Veglia G,Dobson CM

更新日期：2016-06-08 00:00:00

abstract：:Propofol sedation has been applied during esophagogastroduodenoscopy procedures, but whether topical pharyngeal anesthesia should be administered at the same time has rarely been reported. Our study examined the role of topical pharyngeal anesthesia in sedated endoscopies in a randomized controlled double-blinded clin...

journal_title：Scientific reports

authors： Sun X,Xu Y,Zhang X,Li A,Zhang H,Yang T,Liu Y

更新日期：2018-04-27 00:00:00

abstract：:Obesity involves alterations in transcriptional programs that can change in response to genetic and environmental signals through chromatin modifications. Since chromatin modifications involve different biochemical, neurological and molecular signaling pathways related to energy homeostasis, we hypothesize that geneti...

journal_title：Scientific reports

authors： Giri AK,Parekatt V,Dwivedi OP,Banerjee P,Bandesh K,Prasad G,Tandon N,Bharadwaj D

更新日期：2018-03-02 00:00:00

abstract：:We report on an all-dielectric, polarization-independent angular filter with one-dimension (1D) photonic crystal (PC) composed of semiconductor compatible Si/SiO2 pairs. The near-symmetric directional band gap of p- and s-polarized components and Fabry-Pérot (F-P) resonances are utilized to realize efficient polarizat...

journal_title：Scientific reports

authors： Qian Q,Xu C,Wang C

更新日期：2017-11-29 00:00:00

abstract：:Epidermal electronic systems (EESs) are skin-like electronic systems, which can be used to measure several physiological parameters from the skin. This paper presents materials and a simple, straightforward fabrication process for skin-conformable inkjet-printed temperature sensors. Epidermal temperature sensors are a...

journal_title：Scientific reports

authors： Vuorinen T,Niittynen J,Kankkunen T,Kraft TM,Mäntysalo M

更新日期：2016-10-18 00:00:00

abstract：:Terminally misfolded proteins are selectively recognized and cleared by the endoplasmic reticulum-associated degradation (ERAD) pathway. SEL1L, a component of the ERAD machinery, plays an important role in selecting and transporting ERAD substrates for degradation. We have determined the crystal structure of the mouse...

journal_title：Scientific reports

authors： Jeong H,Sim HJ,Song EK,Lee H,Ha SC,Jun Y,Park TJ,Lee C

更新日期：2016-02-09 00:00:00

abstract：:Despite dedicated research has been carried out to adequately map the distribution of the sperm whale in the Mediterranean Sea, unlike other regions of the world, the species population status is still presently uncertain. The analysis of two years of continuous acoustic data provided by the ANTARES neutrino telescope...

journal_title：Scientific reports

authors： André M,Caballé A,van der Schaar M,Solsona A,Houégnigan L,Zaugg S,Sánchez AM,Castell JV,Solé M,Vila F,Djokic D,Adrián-Martínez S,Albert A,Anghinolfi M,Anton G,Ardid M,Aubert JJ,Avgitas T,Baret B,Barrios-Martí J,Ba

更新日期：2017-04-12 00:00:00

abstract：:Monanchoxymycalin C (MomC) is a new marine pentacyclic guanidine alkaloid, recently isolated from marine sponge Monanchora pulchra by us. Here, anticancer activity and mechanism of action was investigated for the first time using a human prostate cancer (PCa) model. MomC was active in all PCa cell lines at low micromo...

journal_title：Scientific reports

authors： Dyshlovoy SA,Kaune M,Kriegs M,Hauschild J,Busenbender T,Shubina LK,Makarieva TN,Hoffer K,Bokemeyer C,Graefen M,Stonik VA,von Amsberg G

更新日期：2020-08-06 00:00:00

abstract：:Crosslinking is an effective way to fabricate high-selective CO2 separation membranes because of its unique crosslinking framework. Thus, it is essentially significant to study the influence of crosslinking degree on the permeation selectivities of CO2. Herein, we report a successful and facile synthesis of a series o...

journal_title：Scientific reports

authors： Li J,Chen Z,Umar A,Liu Y,Shang Y,Zhang X,Wang Y

更新日期：2017-01-04 00:00:00

abstract：:Ample attention has focused on cancer drug delivery via prodrug nanoparticles due to their high drug loading property and comparatively lower side effects. In this study, we designed a PEG-DOX-Cur prodrug nanoparticle for simultaneous delivery of doxorubicin (DOX) and curcumin (Cur) as a combination therapy to treat c...

journal_title：Scientific reports

authors： Zhang Y,Yang C,Wang W,Liu J,Liu Q,Huang F,Chu L,Gao H,Li C,Kong D,Liu Q,Liu J

更新日期：2016-02-15 00:00:00

abstract：:In photodynamic therapy (PDT), cells are impregnated with a photosensitizing agent that is activated by light irradiation, thereby photochemically generating reactive oxygen species (ROS). The amounts of ROS produced depends on the PDT dose and the nature of the photosensitizer. Although high levels of ROS are cytotox...

journal_title：Scientific reports

authors： Kushibiki T,Tu Y,Abu-Yousif AO,Hasan T

更新日期：2015-08-17 00:00:00

abstract：:Infection diagnosis and antibiotic susceptibility testing (AST) are time-consuming and often laborious clinical practices. This paper presents a microwave-microfluidic biosensor for rapid, contactless and non-invasive device for testing the concentration and growth of Escherichia Coli (E. Coli) in medium solutions of ...

journal_title：Scientific reports

authors： Narang R,Mohammadi S,Ashani MM,Sadabadi H,Hejazi H,Zarifi MH,Sanati-Nezhad A

更新日期：2018-10-25 00:00:00

abstract：:Mutations in genes that encode components of tuberous sclerosis complex 2 (TSC2) are associated with tuberous sclerosis complex disease. TSC2 interacts with tuberous sclerosis complex 1 to form a complex that negatively regulates cell growth and proliferation via the inactivation of mechanistic target of rapamycin com...

journal_title：Scientific reports

authors： Gen S,Matsumoto Y,Kobayashi KI,Suzuki T,Inoue J,Yamamoto Y

更新日期：2020-12-03 00:00:00

abstract：:Growing evidences showed that a large number of miRNAs were abnormally expressed in cervical cancer tissues and played irreplaceable roles in tumorigenesis, progression and metastasis. The aim of the present study was to identify the differential miRNAs expression between cervical cancer and normal cervical tissues by...

journal_title：Scientific reports

authors： Liang B,Li Y,Wang T

更新日期：2017-07-17 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Ezewudo M,Borens A,Chiner-Oms Á,Miotto P,Chindelevitch L,Starks AM,Hanna D,Liwski R,Zignol M,Gilpin C,Niemann S,Kohl TA,Warren RM,Crook D,Gagneux S,Hoffner S,Rodrigues C,Comas I,Engelthaler DM,Alland D,Rigouts L,

更新日期：2020-02-21 00:00:00

abstract：:The study explored differences in the steroidogenic pathway between obese and nonobese women with polycystic ovary syndrome (PCOS) using liquid chromatography-tandem mass spectrometry (LC-MS/MS). 1044 women with PCOS (including 350 lean, 312 overweight and 382 obese) and 366 control women without PCOS (including 203 l...

journal_title：Scientific reports

authors： Deng Y,Zhang Y,Li S,Zhou W,Ye L,Wang L,Tao T,Gu J,Yang Z,Zhao D,Gu W,Hong J,Ning G,Liu W,Wang W

更新日期：2017-10-26 00:00:00

abstract：:A novel type of transparent monitor with high-resolution images based on Si-SiO2 core-shell nanoparticles is presented in this contribution. In this monitor, a quasi-array of nanoparticles was used to obtain a very sharp scattering profile. For this purpose, the Si-SiO2 nanoparticles were synthesized and with controll...

journal_title：Scientific reports

authors： Dolatyari M,Jafari A,Rostami A,Klein A

更新日期：2019-02-19 00:00:00