Co-delivery of doxorubicin and curcumin by pH-sensitive prodrug nanoparticle for combination therapy of cancer.

abstract：:We investigated the effects of different intraoperative eyeball fixation techniques (superior rectus muscle suture [MS] and traction suture at the corneal limbus [CS]), on intraocular pressure (IOP) and the incidence of ptosis after phacotrabeculectomy. Forty-one eyes with different glaucoma types which qualified for ...

journal_title：Scientific reports

authors： Konopińska J,Lisowski Ł,Mariak Z,Wojnar M,Obuchowska I,Rękas M

更新日期：2021-01-12 00:00:00

abstract：:Critical limb ischemia (CLI) is associated with a high risk of limb amputation. It has been shown that cell therapy is safe and has beneficial effects on ischemic clinical symptoms in patients with CLI. The aim of this study was to further investigate the outcomes of intramuscular injection of autologous bone-marrow m...

journal_title：Scientific reports

authors： Yusoff FM,Kajikawa M,Matsui S,Hashimoto H,Kishimoto S,Maruhashi T,Chowdhury M,Noma K,Nakashima A,Kihara Y,Sueda T,Higashi Y

更新日期：2019-05-22 00:00:00

abstract：:A novel and simple method to fabricate microchannels is reported based on an inkjet printing of a volatile solid mold. A liquid ink -1,6 hexanediol- ejected from a piezoelectric nozzle is instantaneously frozen when touching a cooled substrate. The created mold is then poured with PDMS. Once the PDMS is crosslinked, t...

journal_title：Scientific reports

authors： Brossard R,Brouchet T,Malloggi F

更新日期：2019-11-25 00:00:00

abstract：:NiFe nanoparticles-decorated & N-doped graphene is introduced as an effective and stable non-precious electrocatalyst for ORR in the acid medium. Compared to conventional Pt/C electrodes under the same conditions, the proposed nanocatalyst shows closer onset potential and current density. Typically, the observed onset...

journal_title：Scientific reports

authors： Barakat NAM,El-Deen AG,Ghouri ZK,Al-Meer S

更新日期：2018-02-28 00:00:00

abstract：:The distinguishing of the multiphoton quantum interference effect from the classical one forms one of the most important issues in modern quantum mechanics and experimental quantum optics. For a long time, the two-photon interference (TPI) of correlated photons has been recognized as a pure quantum effect that cannot ...

journal_title：Scientific reports

authors： Kim H,Kwon O,Moon HS

更新日期：2019-12-05 00:00:00

abstract：:Urinary albumin excretion is an early sign of diabetic kidney disease, affecting every third individual with diabetes. Despite substantial estimated heritability, only variants in the GLRA3 gene have been genome-wide significantly associated (p-value < 5 × 10-8) with diabetic albuminuria, in Finnish individuals with t...

journal_title：Scientific reports

authors： Sandholm N,Haukka JK,Toppila I,Valo E,Harjutsalo V,Forsblom C,Groop PH

更新日期：2018-08-17 00:00:00

abstract：:Saliva, as a non-invasive and easily accessible biofluid, has been shown to contain RNA biomarkers for prediction and diagnosis of several diseases. However, systematic analysis done by our group identified two problematic issues not coherently described before: (1) most of the isolated RNA originates from the oral mi...

journal_title：Scientific reports

authors： Ostheim P,Tichý A,Sirak I,Davidkova M,Stastna MM,Kultova G,Paunesku T,Woloschak G,Majewski M,Port M,Abend M

更新日期：2020-07-07 00:00:00

abstract：:Dravet syndrome is the prototype of SCN1A-mutation associated epilepsies. It is characterised by prolonged seizures, typically provoked by fever. We describe the evaluation of an SCN1A mutation in a child with early-onset temperature-sensitive seizures. The patient carries a heterozygous missense variant (c3818C > T; ...

journal_title：Scientific reports

authors： Peters C,Rosch RE,Hughes E,Ruben PC

更新日期：2016-09-01 00:00:00

abstract：:In everyday life, people must often determine how much time and effort to allocate to cooperative activities. In the current study, we tested the hypothesis that the perception of others' effort investment in a cooperative activity may elicit a sense of commitment, leading people to allocate more time and effort to th...

journal_title：Scientific reports

authors： Chennells M,Michael J

更新日期：2018-10-24 00:00:00

abstract：:Here, we report direct band gap transition for Gallium Phosphide (GaP) when alloyed with just 1-2 at% antimony (Sb) utilizing both density functional theory based computations and experiments. First principles density functional theory calculations of GaSbxP(1-x) alloys in a 216 atom supercell configuration indicate t...

journal_title：Scientific reports

authors： Russell HB,Andriotis AN,Menon M,Jasinski JB,Martinez-Garcia A,Sunkara MK

更新日期：2016-02-10 00:00:00

abstract：:Histone lysine acetyltransferase (KAT)-catalyzed acetylation of lysine residues in histone tails plays a key role in regulating gene expression in eukaryotes. Here, we examined the role of lysine side chain length in the catalytic activity of human KATs by incorporating shorter and longer lysine analogs into synthetic...

journal_title：Scientific reports

authors： Proietti G,Wang Y,Rainone G,Mecinović J

更新日期：2020-08-03 00:00:00

abstract：:Poor oral health is not only associated with diabetes and cardiovascular disease but adverse pregnancy outcomes. However the influence of dental caries on pregnancy is unknown. The aim of this study was to evaluate the association between dental caries and adverse pregnancy outcomes and the effect of treatment for den...

journal_title：Scientific reports

authors： Cho GJ,Kim SY,Lee HC,Kim HY,Lee KM,Han SW,Oh MJ

更新日期：2020-03-24 00:00:00

abstract：:Conserving crop wild relatives (CWR) is critical for maintaining food security. However, CWR-focused conservation plans are lacking, and are often based on the entire genus, even though only a few taxa are useful for crop improvement. We used taxonomic and geographic prioritisation to identify the best locations for i...

journal_title：Scientific reports

authors： Moray C,Game ET,Maxted N

更新日期：2014-06-17 00:00:00

abstract：:Animal gut harbors diverse microbes that play crucial roles in the nutrition uptake, metabolism, and the regulation of host immune responses. The intestinal microbiota homeostasis is critical for health but poorly understood. Probiotics Paracoccus marcusii DB11 and Bacillus cereus G19, and antibiotics florfenicol did ...

journal_title：Scientific reports

authors： Yang G,Peng M,Tian X,Dong S

更新日期：2017-07-06 00:00:00

abstract：:Central to intrinsic apoptosis signaling is the release of cytochrome c from mitochondria, which depends on the pro-apoptotic effector proteins Bax, Bak or Bok. These pore-forming effector proteins share four Bcl-2 homology (BH) domains, a functionally essential and conserved sequence of hydrophobic amino acids in the...

journal_title：Scientific reports

authors： Stehle D,Grimm M,Einsele-Scholz S,Ladwig F,Johänning J,Fischer G,Gillissen B,Schulze-Osthoff K,Essmann F

更新日期：2018-08-20 00:00:00

abstract：:The discovery of novel ligand chemotypes allows to explore uncharted regions in chemical space, thereby potentially improving synthetic accessibility, potency, and the drug-likeness of molecules. Here, we demonstrate the scaffold-hopping ability of the new Weighted Holistic Atom Localization and Entity Shape (WHALES) ...

journal_title：Scientific reports

authors： Grisoni F,Merk D,Byrne R,Schneider G

更新日期：2018-11-07 00:00:00

abstract：:The development of high energy-density lithium-ion secondary batteries as storage batteries in vehicles is attracting increasing attention. In this study, high-voltage bipolar stacked batteries with a quasi-solid-state electrolyte containing a Li-Glyme complex were prepared, and the performance of the device was evalu...

journal_title：Scientific reports

authors： Gambe Y,Sun Y,Honma I

更新日期：2015-03-09 00:00:00

abstract：:Subduction zones facilitate chemical exchanges between Earth's deep interior and volcanism that affects habitability of the surface environment. Lavas erupted at subduction zones are oxidized and release volatile species. These features may reflect a modification of the oxidation state of the sub-arc mantle by hydrous...

journal_title：Scientific reports

authors： Debret B,Sverjensky DA

更新日期：2017-09-04 00:00:00

abstract：:Root damage due to aluminum (Al) toxicity restricts crop production on acidic soils, which are extensive in the tropics. The sorghum root Al-activated citrate transporter, SbMATE, underlies the Al tolerance locus, AltSB, and increases grain yield under Al toxicity. Here, AltSB loci associated with Al tolerance were co...

journal_title：Scientific reports

authors： Hufnagel B,Guimaraes CT,Craft EJ,Shaff JE,Schaffert RE,Kochian LV,Magalhaes JV

更新日期：2018-07-04 00:00:00

abstract：:Insulin resistance is common among children with overweight and obesity. However, knowledge about glucose fluctuations in these children is scarce. This study aims to evaluate glycaemic profiles in children with overweight and obesity in free-living conditions, and to examine the association between glycaemic profiles...

journal_title：Scientific reports

authors： Rijks J,Karnebeek K,van Dijk JW,Dorenbos E,Gerver WJ,Stouthart P,Plat J,Vreugdenhil A

更新日期：2016-08-18 00:00:00

abstract：:Novel-morphological Fe3O4 nanosheets with magnetochromatic property have been prepared by a modified solvothermal method. Such nanosheets could form one-dimension photonic crystal under an external magnetic field. The Fe3O4 nanosheets suspension could strongly diffract visible light and display varied colors with chan...

journal_title：Scientific reports

authors： Zhuang L,Zhang W,Zhao Y,Shen H,Lin H,Liang J

更新日期：2015-03-23 00:00:00

abstract：:Plants deploy several ammonium transporter (AMT) and nitrate transporter (NRT) genes to acquire NH4+ and NO3- from the soil into the roots and then transport them to other plant organs. Coding sequences of wheat genes obtained from ENSEMBL were aligned to known AMT and NRT sequences of Arabidopsis, barley, maize, rice...

journal_title：Scientific reports

authors： Bajgain P,Russell B,Mohammadi M

更新日期：2018-05-04 00:00:00

abstract：:Inflammatory and metabolic diseases can originate during early-life and have been correlated with shifts in intestinal microbial ecology. Here we demonstrate that minor environmental fluctuations during the early neonatal period had sustained effects on the developing porcine microbiota and host-microbe interface. The...

journal_title：Scientific reports

authors： Lewis MC,Merrifield CA,Berger B,Cloarec O,Duncker S,Mercenier A,Nicholson JK,Holmes E,Bailey M

更新日期：2017-07-13 00:00:00

abstract：:The photo-reduction of metal ions in solution induced by femtosecond laser is an important and novel method for fabricating three-dimensional metal microstructures. However, the nonlinear absorption cross section of metal ions remains unknown because its measurement is difficult. In the present study, a method based o...

journal_title：Scientific reports

authors： Ma ZC,Chen QD,Han B,Liu XQ,Song JF,Sun HB

更新日期：2015-12-11 00:00:00

abstract：:Tumor cell-derived exosomes (TEX) suppress functions of immune cells. Here, changes in the gene profiles of primary human T lymphocytes exposed in vitro to exosomes were evaluated. CD4(+) Tconv, CD8(+) T or CD4(+) CD39(+) Treg were isolated from normal donors' peripheral blood and co-incubated with TEX or exosomes iso...

journal_title：Scientific reports

authors： Muller L,Mitsuhashi M,Simms P,Gooding WE,Whiteside TL

更新日期：2016-02-04 00:00:00

abstract：:MicroRNAs can promote translation of specific mRNAs in quiescent (G0) mammalian cells and immature Xenopus laevis oocytes. We report that microRNA-mediated upregulation of target mRNAs in oocytes is dependent on nuclear entry of the microRNA; cytoplasmically-injected microRNA repress target mRNAs. Components of the ac...

journal_title：Scientific reports

authors： Truesdell SS,Mortensen RD,Seo M,Schroeder JC,Lee JH,LeTonqueze O,Vasudevan S

更新日期：2012-01-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs) are vital for diverse biological functions, including vision, smell, and aging. They are involved in a wide range of diseases, and are among the most important targets of medicinal drugs. Tools that facilitate GPCR studies or GPCR-based technologies or therapies are thus critical to...

journal_title：Scientific reports

authors： Tegler L,Corin K,Pick H,Brookes J,Skuhersky M,Vogel H,Zhang S

更新日期：2020-12-07 00:00:00

abstract：:We describe a new species of an ornithischian dinosaur, Isaberrysaura mollensis gen. et sp. nov. The specimen, consisting in an almost complete skull and incomplete postcranium was collected from the marine-deltaic deposits of the Los Molles Formation (Toarcian-Bajocian), being the first reported dinosaur for this uni...

journal_title：Scientific reports

authors： Salgado L,Canudo JI,Garrido AC,Moreno-Azanza M,Martínez LC,Coria RA,Gasca JM

更新日期：2017-02-16 00:00:00

abstract：:The spatio-temporal distribution soil pH is critical for understanding the productivity and long-term sustainability of our agri-ecosystem. This study quantified the spatio-temporal distribution of paddy soil pH in Jiangxi province, China, and the potential driver of the change between 1980 and 2010. Data from the Soi...

journal_title：Scientific reports

authors： Guo X,Li H,Yu H,Li W,Ye Y,Biswas A

更新日期：2018-02-09 00:00:00

abstract：:Honey bees (Apis mellifera) are important pollinators and their health is threatened worldwide by persistent exposure to a wide range of factors including pesticides, poor nutrition, and pathogens. Nosema ceranae is a ubiquitous microsporidian associated with high colony mortality. We used lab micro-colonies of honey ...

journal_title：Scientific reports

authors： Lecocq A,Jensen AB,Kryger P,Nieh JC

更新日期：2016-02-25 00:00:00