当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > FTY720-induced endocytosis of yeast and human amino acid transporters is preceded by reduction of their inherent activity and TORC1 inhibition.

FTY720-induced endocytosis of yeast and human amino acid transporters is preceded by reduction of their inherent activity and TORC1 inhibition.

Abstract：

:FTY720 is a sphingoid base analog that acts as an anticancer agent in animal models. Its effect on tumor cells stems largely from its ability to trigger endocytosis of several nutrient transporters. The observation that FTY720 similarly stimulates downregulation of amino acid permeases in yeast suggests that the cellular mechanisms it targets, which are still poorly characterized, are evolutionarily conserved. We here report that adding FTY720 to yeast cells results in rapid inhibition of the intrinsic activity of multiple permeases. This effect is associated with inhibition of the TORC1 kinase complex, which in turn promotes ubiquitin-dependent permease endocytosis. Further analysis of the Gap1 permease showed that FTY720 elicits its ubiquitylation via the same factors that promote this modification when TORC1 is inhibited by rapamycin. We also show that FTY720 promotes endocytosis of the LAT1/SLC7A5 amino acid transporter in HeLa cells, this being preceded by loss of its transport activity and by mTORC1 inhibition. Our data suggest that in yeast, TORC1 deactivation resulting from FTY720-mediated inhibition of membrane transport elicits permease endocytosis. The same process seems to occur in human cells even though our data and previous reports suggest that FTY720 promotes transporter endocytosis via an additional mechanism insensitive to rapamycin.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Barthelemy C,Barry AO,Twyffels L,André B

doi

10.1038/s41598-017-14124-2

subject

Has Abstract

pub_date

2017-10-23 00:00:00

pages

13816

issue

1

issn

2045-2322

pii

10.1038/s41598-017-14124-2

journal_volume

7

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Persistence of a stage-structured food-web.

    abstract：:Contrary to a theoretical prediction, natural communities comprise many interacting species, thereby developing complex ecosystems. Earlier theoretical studies assumed that each component species within an ecological network has a simple life history, despite the fact that the interaction partners of many species, suc...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-11686-z

    authors： Mougi A

    更新日期：2017-09-08 00:00:00

  • Maskless inverted pyramid texturization of silicon.

    abstract：:We discovered a technical solution of such outstanding importance that it can trigger new approaches in silicon wet etching processing and, in particular, photovoltaic cell manufacturing. The so called inverted pyramid arrays, outperforming conventional pyramid textures and black silicon because of their superior ligh...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep10843

    authors： Wang Y,Yang L,Liu Y,Mei Z,Chen W,Li J,Liang H,Kuznetsov A,Xiaolong D

    更新日期：2015-06-02 00:00:00

  • Evaluation of real-world early response of DMO to aflibercept therapy to inform future clinical trial design of novel investigational agents.

    abstract：:New clinical trials for diabetic macular oedema (DMO) are being designed to prove superiority over aflibercept when this agent is already very effective in improving visual acuity (VA) and DMO. The aim of this study was to determine the optimal inclusion-exclusion criteria for trials to aim for superiority in visual o...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-73571-6

    authors： Halim S,Gurudas S,Chandra S,Greenwood J,Sivaprasad S

    更新日期：2020-10-05 00:00:00

  • Assembly of flexible CoMoO4@NiMoO4·xH2O and Fe2O3 electrodes for solid-state asymmetric supercapacitors.

    abstract：:In this work, CoMoO4@NiMoO4·xH2O core-shell heterostructure electrode is directly grown on carbon fabric (CF) via a feasible hydrothermal procedure with CoMoO4 nanowires (NWs) as the core and NiMoO4 nanosheets (NSs) as the shell. This core-shell heterostructure could provide fast ion and electron transfer, a large num...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep41088

    authors： Wang J,Zhang L,Liu X,Zhang X,Tian Y,Liu X,Zhao J,Li Y

    更新日期：2017-01-20 00:00:00

  • Direct observation of symmetrization of hydrogen bond in δ-AlOOH under mantle conditions using neutron diffraction.

    abstract：:At ambient pressure, the hydrogen bond in materials such as ice, hydrates, and hydrous minerals that compose the Earth and icy planets generally takes an asymmetric O-H···O configuration. Pressure significantly affects this configuration, and it is predicted to become symmetric, such that the hydrogen is centered betw...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-33598-2

    authors： Sano-Furukawa A,Hattori T,Komatsu K,Kagi H,Nagai T,Molaison JJ,Dos Santos AM,Tulk CA

    更新日期：2018-10-19 00:00:00

  • Deterioration of willow seeds during storage.

    abstract：:Willow (Salix spp.) seeds are able to tolerate desiccation, but differ from typical orthodox seeds in that they lose viability in a few days at room temperature, and in that the chloroplasts in embryo tissues do not dedifferentiate during maturation drying, thus retaining chlorophyll and maintaining intact their thyla...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-35476-3

    authors： López-Fernández MP,Moyano L,Correa MD,Vasile F,Burrieza HP,Maldonado S

    更新日期：2018-11-21 00:00:00

  • Sensitive detection of copper ions via ion-responsive fluorescence quenching of engineered porous silicon nanoparticles.

    abstract：:Heavy metal pollution has been a problem since the advent of modern transportation, which despite efforts to curb emissions, continues to play a critical role in environmental pollution. Copper ions (Cu2+), in particular, are one of the more prevalent metals that have widespread detrimental ramifications. From this pe...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep35565

    authors： Hwang J,Hwang MP,Choi M,Seo Y,Jo Y,Son J,Hong J,Choi J

    更新日期：2016-10-18 00:00:00

  • Genetic diversity and ecology of coronaviruses hosted by cave-dwelling bats in Gabon.

    abstract：:Little research on coronaviruses has been conducted on wild animals in Africa. Here, we screened a wide range of wild animals collected in six provinces and five caves of Gabon between 2009 and 2015. We collected a total of 1867 animal samples (cave-dwelling bats, rodents, non-human primates and other wild animals). W...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-64159-1

    authors： Maganga GD,Pinto A,Mombo IM,Madjitobaye M,Mbeang Beyeme AM,Boundenga L,Ar Gouilh M,N'Dilimabaka N,Drexler JF,Drosten C,Leroy EM

    更新日期：2020-04-30 00:00:00

  • Genuine antiplasticizing effect of water on a glass-former drug.

    abstract：:Water is the most important plasticizer of biological and organic hydrophilic materials, which generally exhibit enhanced mechanical softness and molecular mobility upon hydration. The enhancement of the molecular dynamics upon mixing with water, which in glass-forming systems implies a lower glass transition temperat...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-07643-5

    authors： Ruiz GN,Romanini M,Hauptmann A,Loerting T,Shalaev E,Tamarit JL,Pardo LC,Macovez R

    更新日期：2017-08-07 00:00:00

  • Computationally-driven engineering of sublattice ordering in a hexagonal AlHfScTiZr high entropy alloy.

    abstract：:Multi-principle element alloys have enormous potential, but their exploration suffers from the tremendously large range of configurations. In the last decade such alloys have been designed with a focus on random solid solutions. Here we apply an experimentally verified, combined thermodynamic and first-principles desi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-02385-w

    authors： Rogal L,Bobrowski P,Körmann F,Divinski S,Stein F,Grabowski B

    更新日期：2017-05-19 00:00:00

  • Full annual monitoring of Subantarctic Emiliania huxleyi populations reveals highly calcified morphotypes in high-CO2 winter conditions.

    abstract：:Ocean acidification is expected to have detrimental consequences for the most abundant calcifying phytoplankton species Emiliania huxleyi. However, this assumption is mainly based on laboratory manipulations that are unable to reproduce the complexity of natural ecosystems. Here, E. huxleyi coccolith assemblages colle...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-59375-8

    authors： Rigual-Hernández AS,Trull TW,Flores JA,Nodder SD,Eriksen R,Davies DM,Hallegraeff GM,Sierro FJ,Patil SM,Cortina A,Ballegeer AM,Northcote LC,Abrantes F,Rufino MM

    更新日期：2020-02-13 00:00:00

  • Parasite infection accelerates age polyethism in young honey bees.

    abstract：:Honey bees (Apis mellifera) are important pollinators and their health is threatened worldwide by persistent exposure to a wide range of factors including pesticides, poor nutrition, and pathogens. Nosema ceranae is a ubiquitous microsporidian associated with high colony mortality. We used lab micro-colonies of honey ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep22042

    authors： Lecocq A,Jensen AB,Kryger P,Nieh JC

    更新日期：2016-02-25 00:00:00

  • Two yellow luminescence bands in undoped GaN.

    abstract：:Two yellow luminescence bands related to different defects have been revealed in undoped GaN grown by hydride vapor phase epitaxy (HVPE). One of them, labeled YL1, has the zero-phonon line (ZPL) at 2.57 eV and the band maximum at 2.20 eV at low temperature. This luminescence band is the ubiquitous yellow band observed...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-26354-z

    authors： Reshchikov MA,McNamara JD,Helava H,Usikov A,Makarov Y

    更新日期：2018-05-25 00:00:00

  • Tracking actomyosin at fluorescence check points.

    abstract：:Emerging concepts for on-chip biotechnologies aim to replace microfluidic flow by active, molecular-motor driven transport of cytoskeletal filaments, including applications in bio-simulation, biocomputation, diagnostics, and drug screening. Many of these applications require reliable detection, with minimal data acqui...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep01092

    authors： Lard M,ten Siethoff L,Månsson A,Linke H

    更新日期：2013-01-01 00:00:00

  • Cyclophilin A is associated with peripheral artery disease and chronic kidney disease in geriatrics: The Tianliao Old People (TOP) study.

    abstract：:Cyclophilin A (CyPA), secreted by vascular smooth muscle cells in response to oxidative stress, is important in the pathogenesis of progressive peripheral arterial occlusion disease (PAOD), which is common among chronic kidney disease. We explored the prevalence of PAOD in Taiwan's elderly (≥ 65 years old) population ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09937

    authors： Liu MC,Lee YW,Lee PT,Chang CS,Tai YL,Yu JR,Su XT,Hsu LW,Lin SH,Wu CH,Liu PY

    更新日期：2015-04-24 00:00:00

  • A 64-pin Nanowire Surface Fastener Like a Ball Grid Array Applied for Room-temperature Electrical Bonding.

    abstract：:Surface-mount techniques primarily depend on soldering. However, soldering techniques have encountered some challenges in recent years. These challenges include rare metal recycling, thermal problems, and Pb toxicity. We recently developed a metallic nanowire surface fastener (NSF) to resolve the abovementioned proble...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-37693-2

    authors： Toku Y,Ichioka K,Morita Y,Ju Y

    更新日期：2019-01-31 00:00:00

  • Preparation of Zr(Mo,W)2O8 with a larger negative thermal expansion by controlling the thermal decomposition of Zr(Mo,W)2(OH,Cl)2∙2H2O.

    abstract：:Solid solutions of Zr(Mo,W)2O7(OH,Cl)2∙2H2O with a preset ratio of components were prepared by a hydrothermal method. The chemical composition of the solutions was determined by energy dispersive X-ray spectroscopy (EDX). For all the samples of ZrMoxW2-xO7(OH,Cl)2∙2H2O (x = 0.0, 0.2, 0.4, 0.6, 0.8, 1.0, 1.2, 1.4, 1.6,...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-23529-6

    authors： Petrushina MY,Dedova ES,Filatov EY,Plyusnin PE,Korenev SV,Kulkov SN,Derevyannikova EA,Sharafutdinov MR,Gubanov AI

    更新日期：2018-03-28 00:00:00

  • Random mutagenesis of the hyperthermophilic archaeon Pyrococcus furiosus using in vitro mariner transposition and natural transformation.

    abstract：:Transposition mutagenesis is a powerful tool to identify the function of genes, reveal essential genes and generally to unravel the genetic basis of living organisms. However, transposon-mediated mutagenesis has only been successfully applied to a limited number of archaeal species and has never been reported in Therm...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep36711

    authors： Guschinskaya N,Brunel R,Tourte M,Lipscomb GL,Adams MWW,Oger P,Charpentier X

    更新日期：2016-11-08 00:00:00

  • Leukocyte telomere length, lipid parameters and gestational diabetes risk: a case-control study in a Chinese population.

    abstract：:Telomere length (TL) is linked to various age-related diseases, but little is known about telomeres in gestational diabetes mellitus (GDM). We surveyed 509 subjects (113 GDM patients and 396 frequency matched controls) in Nanjing Drum Tower Hospital, Jiangsu province of eastern China. Relative telomere length (RTL) of...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44968-9

    authors： Weng Q,Deng K,Wu F,Gan M,Li J,Dai Y,Jiang Y,Chen J,Dai J,Ma H,Hu Z,Shen H,Du J,Hu Y,Jin G

    更新日期：2019-06-11 00:00:00

  • Bacterial and archaeal communities in the deep-sea sediments of inactive hydrothermal vents in the Southwest India Ridge.

    abstract：:Active deep-sea hydrothermal vents harbor abundant thermophilic and hyperthermophilic microorganisms. However, microbial communities in inactive hydrothermal vents have not been well documented. Here, we investigated bacterial and archaeal communities in the two deep-sea sediments (named as TVG4 and TVG11) collected f...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep25982

    authors： Zhang L,Kang M,Xu J,Xu J,Shuai Y,Zhou X,Yang Z,Ma K

    更新日期：2016-05-12 00:00:00

  • The Arabidopsis-Trichoderma interaction reveals that the fungal growth medium is an important factor in plant growth induction.

    abstract：:Trichoderma spp colonizes the plant rhizosphere and provides pathogen resistance, abiotic stress tolerance, and enhance growth and development. We evaluated the Arabidopsis-Trichoderma interaction using a split system in which Trichoderma atroviride and Trichoderma virens were grown on PDA or MS medium. Arabidopsis gr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-34500-w

    authors： González-Pérez E,Ortega-Amaro MA,Salazar-Badillo FB,Bautista E,Douterlungne D,Jiménez-Bremont JF

    更新日期：2018-11-06 00:00:00

  • Prevalence and diversity of Bartonella species in small rodents from coastal and continental areas.

    abstract：:Worldwide, Bartonella infections are known to inflict a wide range of mammals and, within rodents alone, more than 20 Bartonella species have been detected. There is, however, a lack of studies on the presence of Bartonella spp. in rodents in the Baltic region. We analysed 580 individuals belonging to eight small rode...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-48715-y

    authors： Mardosaitė-Busaitienė D,Radzijevskaja J,Balčiauskas L,Bratchikov M,Jurgelevičius V,Paulauskas A

    更新日期：2019-08-26 00:00:00

  • Role of subsurface ocean in decadal climate predictability over the South Atlantic.

    abstract：:Decadal climate predictability in the South Atlantic is explored by performing reforecast experiments using a coupled general circulation model with two initialization schemes; one is assimilated with observed sea surface temperature (SST) only, and the other is additionally assimilated with observed subsurface ocean ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-26899-z

    authors： Morioka Y,Doi T,Storto A,Masina S,Behera SK

    更新日期：2018-06-04 00:00:00

  • Matching relations for optimal entanglement concentration and purification.

    abstract：:The bilateral controlled NOT (CNOT) operation plays a key role in standard entanglement purification process, but the CNOT operation may not be the optimal joint operation in the sense that the output entanglement is maximized. In this paper, the CNOT operations in both the Schmidt-projection based entanglement concen...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep25958

    authors： Kong FZ,Xia HZ,Yang M,Yang Q,Cao ZL

    更新日期：2016-05-18 00:00:00

  • Sedimentary geology of the middle Carboniferous of the Donbas region (Dniepr-Donets Basin, Ukraine).

    abstract：:The Paleozoic Dniepr-Donets Basin in Belarus, Ukraine, and Russia forms a major hydrocarbon province. Although well- and seismic data have established a 20 km thick stratigraphy, field-studies of its sediments are scarce. The inverted Donbas segment (Ukraine) exposes the middle Carboniferous part of the basin's strati...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09099

    authors： van Hinsbergen DJ,Abels HA,Bosch W,Boekhout F,Kitchka A,Hamers M,van der Meer DG,Geluk M,Stephenson RA

    更新日期：2015-03-20 00:00:00

  • Solvodynamic Printing As A High Resolution Printing Method.

    abstract：:Printing techniques are becoming increasingly prevalent in modern manufacturing. However, its biggest drawback is the limit in printing resolution. In this paper, we present solvodynamic printing as a novel printing system which aims to improve print resolution by incorporating an additional immiscible carrier solvent...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-47105-8

    authors： Liu WC,Watt AAR

    更新日期：2019-07-24 00:00:00

  • Copy Number Variations in a Cohort of 420 Individuals with Neurodevelopmental Disorders From the South of Brazil.

    abstract：:Chromosomal microarray (CMA) is now recommended as first tier for the evaluation in individuals with unexplained neurodevelopmental disorders (ND). However, in developing countries such as Brazil, classical cytogenetic tests are still the most used in clinical practice, as reflected by the scarcity of publications of ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-54347-z

    authors： Chaves TF,Baretto N,Oliveira LF,Ocampos M,Barbato IT,Anselmi M,De Luca GR,Barbato Filho JH,Pinto LLC,Bernardi P,Maris AF

    更新日期：2019-11-28 00:00:00

  • Prevalence and associated factors of cataract and cataract-related blindness in the Russian Ural Eye and Medical Study.

    abstract：:To assess the prevalence of cataract and cataract surgery in a population from Russia, we conducted the population-based Ural Eye and Medical Study with 5899 participants (80.5% out of 7328 eligible individuals), with an age of 40 + years as the eligibility criterion. In the phakic population, the prevalence of nuclea...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-75313-0

    authors： Bikbov MM,Kazakbaeva GM,Gilmanshin TR,Zainullin RM,Nuriev IF,Zaynetdinov AF,Israfilova GZ,Panda-Jonas S,Arslangareeva II,Rakhimova EM,Rusakova IA,Jonas JB

    更新日期：2020-10-23 00:00:00

  • Early life home microbiome and hyperactivity/inattention in school-age children.

    abstract：:This study evaluates the association between indoor microbial diversity early in life and hyperactivity/inattention symptoms in children at ages 10 and 15 years.A random sample enriched with subjects with hyperactivity/inattention at age 15 years was selected from the German LISA birth cohort. Bedroom floor dust was c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-53527-1

    authors： Casas L,Karvonen AM,Kirjavainen PV,Täubel M,Hyytiäinen H,Jayaprakash B,Lehmann I,Standl M,Pekkanen J,Heinrich J

    更新日期：2019-11-22 00:00:00

  • Complete inclusion of bioactive molecules and particles in polydimethylsiloxane: a straightforward process under mild conditions.

    abstract：:By applying a slow curing process, we show that biomolecules can be incorporated via a simple process as liquid stable phases inside a polydimethylsiloxane (PDMS) matrix. The process is carried out under mild conditions with regards to temperature, pH and relative humidity, and is thus suitable for application to biol...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-54155-5

    authors： Faccio G,Cont A,Mailand E,Zare-Eelanjegh E,Innocenti Malini R,Maniura-Weber K,Rossi RM,Spano F

    更新日期：2019-11-26 00:00:00