Abstract:
:This study evaluates the association between indoor microbial diversity early in life and hyperactivity/inattention symptoms in children at ages 10 and 15 years.A random sample enriched with subjects with hyperactivity/inattention at age 15 years was selected from the German LISA birth cohort. Bedroom floor dust was collected at age 3 months and 4 bacterial and fungal diversity measures [number of observed operational taxonomic units (OTUs), Chao1, Shannon and Simpson indices] were calculated from Illumina MiSeq sequencing data. Hyperactivity/inattention was based on the Strengths and Difficulties Questionnaire at ages 10 and 15 (cut-off ≥7). Adjusted associations between 4 diversity measures in tertiles and hyperactivity/inattention were investigated with weighted and survey logistic regression models. We included 226 individuals with information on microbial diversity and hyperactivity/inattention. Early life bacterial diversity was inversely associated with hyperactivity/inattention at age 10 [bacterial OTUs (medium vs low: aOR = 0.4, 95%CI = (0.2-0.8)) and Chao1 (medium vs low: 0.3 (0.1-0.5); high vs low: 0.3 (0.2-0.6)], whereas fungal diversity was directly associated [Chao1 (high vs low: 2.1 (1.1-4.0)), Shannon (medium vs low: 2.8 (1.3-5.8)), and Simpson (medium vs low: 4.7 (2.4-9.3))]. At age 15, only Shannon index was significantly associated with hyperactivity/inattention [bacteria (medium vs low: 2.3 (1.2-4.2); fungi (high vs low: 0.5 (0.3-0.9))]. In conclusion, early life exposure to microbial diversity may play a role in the psychobehavioural development. We observe heterogeneity in the direction of the associations encouraging further longitudinal studies to deepen our understanding of the characteristics of the microbial community underlying the observed associations.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Casas L,Karvonen AM,Kirjavainen PV,Täubel M,Hyytiäinen H,Jayaprakash B,Lehmann I,Standl M,Pekkanen J,Heinrich Jdoi
10.1038/s41598-019-53527-1subject
Has Abstractpub_date
2019-11-22 00:00:00pages
17355issue
1issn
2045-2322pii
10.1038/s41598-019-53527-1journal_volume
9pub_type
杂志文章abstract::Antiphospholipid syndrome is associated with an increased risk of thrombosis and pregnancy loss. Annexin A5 (Anxa5) is a candidate autoantigen. It is not known, however, whether endogenous Anxa5 prevents foetal loss during normal pregnancy. We found significant reductions in litter size and foetal weight in Anxa5-null...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00827
更新日期:2012-01-01 00:00:00
abstract::Phytic acid (PA) is the primary phosphorus (P) storage compound in the seeds of cereals and legumes. Low PA crops, which are considered an effective way to improve grain nutrient availability and combat environmental issues relating to seed P have been developed using mutational and reverse genetics approaches. Here, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51485-2
更新日期:2019-10-16 00:00:00
abstract::Platelet aggregation and adhesion are critically involved in both normal hemostasis and thrombosis during vascular injury. Before any surgery, it is important to identify the number of platelets and their functionality to reduce the risk of bleeding; therefore, platelet function testing is a requirement. We introduce ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52953-5
更新日期:2019-11-11 00:00:00
abstract::The continuous search for natural products that attenuate age-related losses has increasingly gained notice; among them, those applicable for skin care have drawn significant attention. The bioester generated from the Chenopodium quinoa's oil is a natural-origin ingredient described to produce replenishing skin effect...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76325-6
更新日期:2020-11-10 00:00:00
abstract::The primary method for measuring brain metabolism in humans is positron emission tomography (PET) imaging using the tracer 18F-fluorodeoxyglucose (FDG). Standardized uptake value ratios (SUVR) are commonly calculated from FDG-PET images to examine intra- and inter-subject effects. Various reference regions are used in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65957-3
更新日期:2020-06-09 00:00:00
abstract::Tumor-associated immune response plays a critical role in cancer pathogenesis. This study evaluated clinical implications of T cell cytokines and regulatory T cells (Tregs) in HCC patients treated with TACE. Whole blood was obtained for analysis of T cell cytokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40078-8
更新日期:2019-03-01 00:00:00
abstract::Risks threatening modern societies form an intricately interconnected network that often underlies crisis situations. Yet, little is known about how risk materializations in distinct domains influence each other. Here we present an approach in which expert assessments of likelihoods and influence of risks underlie a q...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10998
更新日期:2015-06-18 00:00:00
abstract::The recently described site of Kalinga in the Philippines adds to our understanding of Early-Middle Pleistocene hominin behaviour. Yet, disentangling the natural from the anthropogenic modifications that have taken place in such an old archaeological site is challenging. In this paper we use a set of taphonomic tools ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68066-3
更新日期:2020-07-06 00:00:00
abstract::No consensus currently exist on the optimal treatment of patients with high-risk nonmuscle invasive (HGT1) micropapillary variant of bladder cancer (MPBC). Transcripsome analysis may allow stratification of MPBC-HGT1 enabling prediction of recurrence and guide therapeutic management for individual patients. Whole tran...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76904-7
更新日期:2020-11-18 00:00:00
abstract::Trimethylamine-N-Oxide (TMAO) is a microbiome-related metabolite that is cleared by the kidney and linked to renal function. We explored the relationship between TMAO and all-cause mortality, and determined whether this association was modified by renal function. A prospective study was performed among PREVEND partici...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13739-9
更新日期:2017-10-23 00:00:00
abstract::The recombination is one of the most frequently identified drivers of double-stranded DNA viruses evolution. However, the recombination events in African swine fever virus (ASFV) genomes have been poorly annotated. We hypothesize that the genetic determinants of ASFV variability are potential hot-spots for recombinati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75377-y
更新日期:2020-10-28 00:00:00
abstract::The placenta forms a maternal-fetal junction that supports many physiological functions such as the supply of nutrition and exchange of gases and wastes. Establishing an in vitro culture model of human and non-human primate trophoblast stem/progenitor cells is important for investigating the process of early placental...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63602-7
更新日期:2020-04-22 00:00:00
abstract::High quality factor (High-Q) and transmission optical devices are required for various applications in the fields of physics and engineering. Critical for these applications is the realization of a structure with high-Q, complete transmission and small volume. A robust high-Q filter with complete transmission by conju...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64076-3
更新日期:2020-04-27 00:00:00
abstract::Whole exome sequencing is a technique that aims to selectively sequence all exons of protein-coding genes. A canine whole exome sequencing enrichment kit was designed based on the latest canine reference genome (build 3.1.72). Its performance was tested by sequencing 2 exome captures, each consisting of 4 pre-capture ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05597
更新日期:2014-07-07 00:00:00
abstract::DNA is organized and compacted into higher-order structures in order to fit within nuclei and to facilitate gene regulation. Mechanisms by which higher order chromatin structures are established and maintained are poorly understood. In C. elegans, nuclear-localized small RNAs engage the nuclear RNAi machinery to regul...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45052-y
更新日期:2019-06-21 00:00:00
abstract::This study aims to develop a prognostic risk prediction model for the development of silicosis among workers exposed to silica dust in China. The prediction model was performed by using retrospective cohort of 3,492 workers exposed to silica in an iron ore, with 33 years of follow-up. We developed a risk score system ...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/srep11059
更新日期:2015-06-19 00:00:00
abstract::Novel-morphological Fe3O4 nanosheets with magnetochromatic property have been prepared by a modified solvothermal method. Such nanosheets could form one-dimension photonic crystal under an external magnetic field. The Fe3O4 nanosheets suspension could strongly diffract visible light and display varied colors with chan...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09320
更新日期:2015-03-23 00:00:00
abstract::In response to endotoxemia, the organism triggers an inflammatory response, and the visceral adipose tissue represents a major source of proinflammatory cytokines. The regulation of inflammation response in the adipose tissue is thus of crucial importance. We demonstrated that Regulated in development and DNA damage r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07182-z
更新日期:2017-08-01 00:00:00
abstract::Aberrant fetal growth is associated with morbidities and mortality during childhood and adult life. Although genetic and environmental factors are known to influence in utero growth, their relative contributions over pregnancy is unknown. We estimated, across gestation, the genetic heritability, contribution of shared...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25706-z
更新日期:2018-05-08 00:00:00
abstract::Nicotinamide riboside (NR) is a newly discovered nicotinamide adenine dinucleotide (NAD+) precursor vitamin. A crystal form of NR chloride termed NIAGEN is generally recognized as safe (GRAS) for use in foods and the subject of two New Dietary Ingredient Notifications for use in dietary supplements. To evaluate the ki...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-019-46120-z
更新日期:2019-07-05 00:00:00
abstract::Agricultural soil is often subjected to waterlogging after heavy rainfalls, resulting in sharp and explosive increases in the emission of nitrous oxide (N2O), an important greenhouse gas primarily released from agricultural soil ecosystems. Previous studies on waterlogged soil examined the abundance of denitrifiers bu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00953-8
更新日期:2017-04-11 00:00:00
abstract::The accelerated discovery of disease-related genes emerging from genomic studies has strained the capacity of traditional genetically engineered mouse models (GEMMs) to provide in-vivo validation. Direct, somatic, genetic engineering approaches allow for accelerated and flexible genetic manipulation and represent an a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11061
更新日期:2015-06-05 00:00:00
abstract::In clinical populations, olfactory abilities parallel executive function, implicating shared neuroanatomical substrates within the ventral prefrontal cortex. In healthy individuals, the relationship between olfaction and personality traits or certain cognitive and behavioural characteristics remains unexplored. We the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34056-9
更新日期:2018-10-22 00:00:00
abstract::Copper-based compounds are promising entities for target-specific next-generation anticancer and NSAIDS therapeutics. In lieu of this, benzimidazole scaffold plays an important role, because of their wide variety of potential functionalizations and coordination modes. Herein, we report three copper complexes 1-3 with ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41063-x
更新日期:2019-03-27 00:00:00
abstract::Tsunamis can propagate thousands of kilometres across the ocean. Precise calculations of arrival times are essential for reliable early warning systems, determination of source and earth properties using the inverse problem, and time series modulation due to frequency dependency of phase speed. Far field observatories...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52475-0
更新日期:2019-11-14 00:00:00
abstract::There is no preclinical mouse model to investigate pulmonary Mycobacteroides abscessus (formerly Mycobacterium abscessus) infection in an immunocompetent mouse strain, especially in the context of antibiotic testing and regimen development. We developed a mouse model of pulmonary M. abscessus infection using the aeros...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60452-1
更新日期:2020-02-28 00:00:00
abstract::The structural and mechanical properties of tissue and the interplay between them play a critical role in tissue function. We introduce the optomechanogram, a combined quantitative and qualitative visualization of spatially co-registered measurements of the microstructural and micromechanical properties of any tissue....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79602-6
更新日期:2021-01-11 00:00:00
abstract::Processing the meaning of action language correlates with somatotopic activity in premotor cortex (PMC). A previous neurostimulation study supported a causal contribution of PMC activity to action verb understanding, but the direction of the effect was unexpected: inhibiting PMC made participants respond faster to act...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29600-6
更新日期:2018-07-30 00:00:00
abstract::This study tested the hypothesis that acquired epileptogenesis is accompanied by DNA methylation changes independent of etiology. We investigated DNA methylation and gene expression in the hippocampal CA3/dentate gyrus fields at 3 months following epileptogenic injury in three experimental models of epilepsy: focal am...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25668
更新日期:2016-05-09 00:00:00
abstract::This study aimed to identify single nucleotide polymorphisms (SNPs) associated with milk cholesterol (CHL) content via a genome wide association study (GWAS). Milk CHL content was determined by gas chromatography and expressed as mg of CHL in 100 g of fat (CHL_fat) or in 100 mg of milk (CHL_milk). GWAS was performed w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31427-0
更新日期:2018-09-05 00:00:00