Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells.

abstract：:Transgenic expression of I-E molecules prevents diabetes in NOD mice. So far, the precise role of these non-classical MHC II molecules remains elusive. Here, we showed that transgenic expression of I-E(k) alpha 16 molecule in NOD mice selectively reduced Th17 cells in the thymus and pancreatic draining lymph nodes. Th...

journal_title：Scientific reports

authors： Yang C,Guo N,Liu J,Yang J,Zhu K,Xiao H,Leng Q

更新日期：2015-08-07 00:00:00

abstract：:The pathophysiological mechanism involved in side effects of radiation therapy, and especially the role of the endothelium remains unclear. Previous results showed that plasminogen activator inhibitor-type 1 (PAI-1) contributes to radiation-induced intestinal injury and suggested that this role could be driven by an e...

journal_title：Scientific reports

authors： Rannou E,François A,Toullec A,Guipaud O,Buard V,Tarlet G,Mintet E,Jaillet C,Iruela-Arispe ML,Benderitter M,Sabourin JC,Milliat F

更新日期：2015-10-29 00:00:00

abstract：:The micro-mechanisms of brittle failure affect the bulk mechanical behaviour and permeability of crustal rocks. In low-porosity crystalline rocks, these mechanisms are related to mineralogy and fabric anisotropy, while confining pressure, temperature and strain rates regulate the transition from brittle to ductile beh...

journal_title：Scientific reports

authors： Agliardi F,Dobbs MR,Zanchetta S,Vinciguerra S

更新日期：2017-11-10 00:00:00

abstract：:The development of efficient green light-emitting diodes (LEDs) is of paramount importance for the realization of colour-mixing white LEDs with a high luminous efficiency. While the insertion of an InGaN/GaN superlattice (SL) with a lower In content before the growth of InGaN/GaN multiple quantum wells (MQWs) is known...

journal_title：Scientific reports

authors： Zhou S,Liu X,Yan H,Gao Y,Xu H,Zhao J,Quan Z,Gui C,Liu S

更新日期：2018-07-23 00:00:00

abstract：:Atmospheric new particle formation (NPF) and growth significantly influences climate by supplying new seeds for cloud condensation and brightness. Currently, there is a lack of understanding of whether and how marine biota emissions affect aerosol-cloud-climate interactions in the Arctic. Here, the aerosol population ...

journal_title：Scientific reports

authors： Dall Osto M,Beddows DCS,Tunved P,Krejci R,Ström J,Hansson HC,Yoon YJ,Park KT,Becagli S,Udisti R,Onasch T,O Dowd CD,Simó R,Harrison RM

更新日期：2017-06-12 00:00:00

abstract：:The toxicity associated with concentrated synthetic surfactants and the poor stability at gastrointestinal condition are two major constraints for practical applications of solid lipid nanoparticles (SLN) as oral delivery vehicles. In this study, a synthetic surfactant-free and cross-linker-free method was developed t...

journal_title：Scientific reports

authors： Wang T,Xue J,Hu Q,Zhou M,Chang C,Luo Y

更新日期：2017-06-05 00:00:00

abstract：:The pathogenesis of glioblastoma (GBM) is characterized by highly invasive behavior allowing dissemination and progression. A conclusive image of the invasive process is not available. The aim of this work was to study invasion dynamics in GBM using an innovative in vivo imaging approach. Primary brain tumor initiatin...

journal_title：Scientific reports

authors： Alieva M,Leidgens V,Riemenschneider MJ,Klein CA,Hau P,van Rheenen J

更新日期：2019-02-14 00:00:00

abstract：:Nowadays Field Emission Gun-Scanning Electron Microscopes provide detailed crystallographic information with high spatial and angular resolutions, and allow direct observation of crystalline defects, such as dislocations, through an attractive technique called Electron Channeling Contrast Imaging (ECCI). Dislocations ...

journal_title：Scientific reports

authors： Kriaa H,Guitton A,Maloufi N

更新日期：2017-08-29 00:00:00

abstract：:To better understand the recognition mechanism of RISC and the repertoire of guide-target interactions we introduced G:U wobbles and mismatches at various positions of the microRNA (miRNA) 'seed' region and performed all-atom molecular dynamics simulations of the resulting Ago-miRNA:mRNA ternary complexes. Our simulat...

journal_title：Scientific reports

authors： Xia Z,Clark P,Huynh T,Loher P,Zhao Y,Chen HW,Ren P,Rigoutsos I,Zhou R

更新日期：2012-01-01 00:00:00

abstract：:The aim of the study was to compare background characteristics, microbiology and outcome of patients with right-sided and left-sided intravenous drug use (IDU) associated infective endocarditis (IE). A nationwide retrospective study using the Swedish Registry on Infective Endocarditis between 2008 and 2019 was conduct...

journal_title：Scientific reports

authors： Clarelin A,Rasmussen M,Olaison L,Ragnarsson S

更新日期：2021-01-13 00:00:00

abstract：:Fundamental life history processes of mycorrhizal fungi with inconspicuous fruiting bodies can be difficult to elucidate. In this study we investigated the species identities and life history of the orchid mycorrhizal Tulasnella fungi, which associate with the south eastern Australia orchid genus Chiloglottis. Tulasne...

journal_title：Scientific reports

authors： Ruibal MP,Triponez Y,Smith LM,Peakall R,Linde CC

更新日期：2017-07-17 00:00:00

abstract：:Application of controlled-release urea (CRU) improves crop yield and nitrogen use efficiency (NUE) compared with conventional urea. However, the effectiveness of CRU differs with fertilization placement. A two site-year field experiment was carried out in fluvo-aquic soil in central China to study the effects of two N...

journal_title：Scientific reports

authors： Liu W,Xiong Y,Xu X,Xu F,Hussain S,Xiong H,Yuan J

更新日期：2019-12-30 00:00:00

abstract：:Orb2 is a functional amyloid that plays a key role in Drosophila long-term memory formation. Orb2 has two isoforms that differ in their N-termini. The N-terminus of the A isoform (Orb2A) that precedes its Q-rich prion-like domain has been shown to be important for Orb2 aggregation and long-term memory. However, beside...

journal_title：Scientific reports

authors： Cervantes SA,Bajakian TH,Soria MA,Falk AS,Service RJ,Langen R,Siemer AB

更新日期：2016-12-06 00:00:00

abstract：:The regular rise and fall of the sun resulted in the development of 24-h rhythms in virtually all organisms. In an evolutionary heartbeat, humans have taken control of their light environment with electric light. Humans are highly sensitive to light, yet most people now use light until bedtime. We evaluated the impact...

journal_title：Scientific reports

authors： Cain SW,McGlashan EM,Vidafar P,Mustafovska J,Curran SPN,Wang X,Mohamed A,Kalavally V,Phillips AJK

更新日期：2020-11-05 00:00:00

abstract：:The physiological function of the pancreas is controlled by the circadian clock. The aim of this study was to determine whether aging-induced changes in glucose homeostasis affect properties of the circadian clock in the pancreas and/or its sensitivity to disturbances in environmental lighting conditions. mPer2Luc mic...

journal_title：Scientific reports

authors： Novosadová Z,Polidarová L,Sládek M,Sumová A

更新日期：2018-08-03 00:00:00

abstract：:Accumulating of evidence suggests that activation of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs) exacerbates early brain injury (EBI) following subarachnoid hemorrhage (SAH) by provoking pro-inflammatory and pro-apoptotic signaling. Myeloid differentiation primary response protein 88 (...

journal_title：Scientific reports

authors： Yan H,Zhang D,Wei Y,Ni H,Liang W,Zhang H,Hao S,Jin W,Li K,Hang CH

更新日期：2017-11-17 00:00:00

abstract：:Active immunotherapy targeting β-amyloid (Aβ) is the most promising strategy to prevent or treat Alzheimer's disease (AD). Based on pre-clinical studies and clinical trials, a safe and effective AD vaccine requires a delicate balance between providing therapeutically adequate anti-Aβ antibodies and eliminating or supp...

journal_title：Scientific reports

authors： Liu S,Shi D,Wang HC,Yu YZ,Xu Q,Sun ZW

更新日期：2015-01-14 00:00:00

abstract：:By using silver nanoplatelets with a widely tunable localized surface plasmon resonance (LSPR), and their corresponding local field enhancement, here we show large manipulation of plasmonic enhanced upconversion in NaYF4:Yb(3+)/Er(3+) nanocrystals at the single particle level. In particular, we show that when the plas...

journal_title：Scientific reports

authors： Wang YL,Mohammadi Estakhri N,Johnson A,Li HY,Xu LX,Zhang Z,Alù A,Wang QQ,Shih CK

更新日期：2015-05-15 00:00:00

abstract：:In 2013, U.S. swine producers were confronted with the disruptive emergence of porcine epidemic diarrhoea (PED). Movement of animals among farms is hypothesised to have played a role in the spread of PED among farms. Via this or other mechanisms, the rate of spread may also depend on the geographic density of farms an...

journal_title：Scientific reports

authors： O'Dea EB,Snelson H,Bansal S

更新日期：2016-03-07 00:00:00

abstract：:The key to arthritis management is early diagnosis and treatment to prevent further joint destruction and maximize functional ability. Osteoarthritis (OA) and rheumatoid arthritis (RA) are two common types of arthritis that the primary care provider must differentiate, in terms of diagnosis and treatment. Effective an...

journal_title：Scientific reports

authors： Chen B,Zhao Y,Li S,Yang L,Wang H,Wang T,Bin Shi,Gai Z,Heng X,Zhang C,Yang J,Zhang L

更新日期：2018-11-20 00:00:00

abstract：:Spin thermoelectrics represents a new paradigm of thermoelectricity that has a potential to overcome the fundamental limitation posed by the Wiedmann-Franz law on the efficiency of conventional thermoelectric devices. A typical spin thermoelectric device consists of a bilayer of a magnetic insulator and a high spin-or...

journal_title：Scientific reports

authors： Tian K,Tiwari A

更新日期：2019-02-28 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Wang Y,Chen D,He X,Shen J,Xiong M,Wang X,Zhou D,Wei Z

更新日期：2020-02-20 00:00:00

abstract：:The presence of hepatic steatosis (HS) is an important histological feature in a variety of liver disease. It is critical to assess HS accurately, particularly where it plays an integral part in defining the disease. Conventional methods of quantifying HS remain semi-quantitative, with potential limitations in precisi...

journal_title：Scientific reports

authors： Goh GB,Leow WQ,Liang S,Wan WK,Lim TKH,Tan CK,Chang PE

更新日期：2019-02-27 00:00:00

abstract：:A central goal of electronics based on correlated materials or 'Mottronics' is the ability to switch between distinct collective states with a control voltage. Small changes in structure and charge density near a transition can tip the balance between competing phases, leading to dramatic changes in electronic and mag...

journal_title：Scientific reports

authors： Liu M,Hoffman J,Wang J,Zhang J,Nelson-Cheeseman B,Bhattacharya A

更新日期：2013-01-01 00:00:00

abstract：:This study aimed to investigate whether interleukin-34 (IL-34) mRNA expression is aberrant and modulated by tumor necrosis factor-alpha (TNF-α) in knee osteoarthritis (OA) fibroblast-like synoviocytes (FLS) and determine associations of IL-34 mRNA and protein in the systemic and local joint environments with severity ...

journal_title：Scientific reports

authors： Udomsinprasert W,Jinawath A,Teerawattanapong N,Honsawek S

更新日期：2020-05-14 00:00:00

abstract：:Adipose tissue dysfunction is considered an important contributor to systemic insulin resistance and Type 2 diabetes (T2D). Recently, a novel family of endogenous lipids, palmitic acid hydroxy stearic acids (PAHSAs), was discovered. These have anti-diabetic and anti-inflammatory effects in mice and are reduced in seru...

journal_title：Scientific reports

authors： Hammarstedt A,Syed I,Vijayakumar A,Eliasson B,Gogg S,Kahn BB,Smith U

更新日期：2018-10-25 00:00:00

abstract：:Culture expanded mesenchymal stromal cells (MSCs) are being extensively studied for therapeutic applications, including treatment of graft-versus-host disease, osteogenesis imperfecta and for enhancing engraftment of hematopoietic stem cells after transplantation. Thus far, clinical trials have shown that the therapeu...

journal_title：Scientific reports

authors： Dorland YL,Cornelissen AS,Kuijk C,Tol S,Hoogenboezem M,van Buul JD,Nolte MA,Voermans C,Huveneers S

更新日期：2019-10-07 00:00:00

abstract：:Cell penetrating peptides (CPPs) are peptides that can be translocated into cells and used as a carrier platform for the intracellular uptake of cargo molecules. Subject to the source of CPP sequences and their positively charged nature, the cytotoxicity and immunogenicity of conventional CPPs needs to be optimized to...

journal_title：Scientific reports

authors： Young Kim H,Young Yum S,Jang G,Ahn DR

更新日期：2015-06-26 00:00:00

abstract：:Transparent heaters have attracted increasing attention for their usefulness in vehicle windows, outdoor displays, and periscopes. We present high performance transparent heaters based on Ag nanowires with electron beam irradiation. We obtained an Ag-nanowire thin film with 48 ohm/sq of sheet resistance and 88.8% (sub...

journal_title：Scientific reports

authors： Hong CH,Oh SK,Kim TK,Cha YJ,Kwak JS,Shin JH,Ju BK,Cheong WS

更新日期：2015-12-07 00:00:00

abstract：:Neurotransmitter release from the presynaptic terminal is under very precise spatial and temporal control. Following neurotransmitter release, synaptic vesicles are recycled by endocytosis and refilled with neurotransmitter. During the exocytosis event leading to release, SNARE proteins provide most of the mechanical ...

journal_title：Scientific reports

authors： Craig TJ,Anderson D,Evans AJ,Girach F,Henley JM

更新日期：2015-12-04 00:00:00