当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Mito-oncology agent: fermented extract suppresses the Warburg effect, restores oxidative mitochondrial activity, and inhibits in vivo tumor growth.

Mito-oncology agent: fermented extract suppresses the Warburg effect, restores oxidative mitochondrial activity, and inhibits in vivo tumor growth.

Abstract：

:Mitochondrial dysfunction and significant changes in metabolic pathways accompany cancer development and are responsible for maintaining the tumor microenvironment. Normal mitochondria can trigger intrinsic apoptosis by releasing cytochrome c into the cytosol. The survival of malignant cells highly depends on the suppression of this function. We validated that A250, a highly purified fraction of fermented wheat germ extract (FWGE), increases the carbon flux into the mitochondria, the expression of key elements of the Krebs cycle and oxidative phosphorylation (OXPHOS). The increased respiratory chain activity is related to the mitochondria's ability to release cytochrome c into the cytosol, which triggers the apoptotic cascade. The 68% tumor growth inhibitory effect observed in the murine melanoma study is related to this effect, as proteomic analysis validated similar changes in mitochondrial protein levels in the isolated tumor tissue samples. Blood count data indicated that this effect was not accompanied by general toxicity. This study is significant, as it shows that a highly concentrated form of FWGE is an effective agent that increases normal mitochondrial functionality. The lack of hepatotoxic and general toxic effects makes A250 an excellent candidate targeting mitochondria function in cancer therapy.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Bencze G,Bencze S,Rivera KD,Watson JD,Hidvegi M,Orfi L,Tonks NK,Pappin DJ

doi

10.1038/s41598-020-71118-3

subject

Has Abstract

pub_date

2020-08-25 00:00:00

pages

14174

issue

1

issn

2045-2322

pii

10.1038/s41598-020-71118-3

journal_volume

10

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Cognition based bTBI mechanistic criteria; a tool for preventive and therapeutic innovations.

    abstract：:Blast-induced traumatic brain injury has been associated with neurodegenerative and neuropsychiatric disorders. To date, although damage due to oxidative stress appears to be important, the specific mechanistic causes of such disorders remain elusive. Here, to determine the mechanical variables governing the tissue da...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-28271-7

    authors： Garcia-Gonzalez D,Race NS,Voets NL,Jenkins DR,Sotiropoulos SN,Acosta G,Cruz-Haces M,Tang J,Shi R,Jérusalem A

    更新日期：2018-07-06 00:00:00

  • Early vaccination protects against childhood leukemia: A systematic review and meta-analysis.

    abstract：:Leukemia is the most commonly diagnosed childhood cancer, although its etiology is still largely unknown. Growing evidence supports a role for infection in the etiology of acute lymphocytic leukemia (ALL), and the involvement of the immune system suggests that vaccination may also play a role. However, the findings pr...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析

    doi：10.1038/s41598-017-16067-0

    authors： Morra ME,Kien ND,Elmaraezy A,Abdelaziz OAM,Elsayed AL,Halhouli O,Montasr AM,Vu TL,Ho C,Foly AS,Phi AP,Abdullah WM,Mikhail M,Milne E,Hirayama K,Huy NT

    更新日期：2017-11-22 00:00:00

  • Fast response of complementary electrochromic device based on WO3/NiO electrodes.

    abstract：:Nanoporous structures have proven as an effective way for enhanced electrochromic performance by providing a large surface area can get fast ion/electron transfer path, leading to larger optical modulation and fast response time. Herein, for the first time, application of vacuum cathodic arc plasma (CAP) deposition te...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-65191-x

    authors： Chen PW,Chang CT,Ko TF,Hsu SC,Li KD,Wu JY

    更新日期：2020-05-21 00:00:00

  • Fecal Bacterial Communities in treated HIV infected individuals on two antiretroviral regimens.

    abstract：:Intestinal microbiome changes that occur in HIV positive individuals on different antiretroviral therapy (ART) regimens are important to understand, as they are potentially linked with chronic inflammation and microbiome-linked comorbidities that occur at increased incidence in this population. We conducted a cross-se...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep43741

    authors： Pinto-Cardoso S,Lozupone C,Briceño O,Alva-Hernández S,Téllez N,Adriana A,Murakami-Ogasawara A,Reyes-Terán G

    更新日期：2017-03-06 00:00:00

  • Interconnecting Carbon Fibers with the In-situ Electrochemically Exfoliated Graphene as Advanced Binder-free Electrode Materials for Flexible Supercapacitor.

    abstract：:Flexible energy storage devices are highly demanded for various applications. Carbon cloth (CC) woven by carbon fibers (CFs) is typically used as electrode or current collector for flexible devices. The low surface area of CC and the presence of big gaps (ca. micro-size) between individual CFs lead to poor performance...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep11792

    authors： Zou Y,Wang S

    更新日期：2015-07-07 00:00:00

  • Searching for signatures across microbial communities: Metagenomic analysis of soil samples from mangrove and other ecosystems.

    abstract：:In this study, we categorize the microbial community in mangrove sediment samples from four different locations within a vast mangrove system in Kerala, India. We compared this data to other samples taken from the other known mangrove data, a tropical rainforest, and ocean sediment. An examination of the microbial com...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-09254-6

    authors： Imchen M,Kumavath R,Barh D,Azevedo V,Ghosh P,Viana M,Wattam AR

    更新日期：2017-08-18 00:00:00

  • Combination of Platelet expression of PKCepsilon and cardiac troponin-I for early diagnosis of chest pain patients in the emergency department.

    abstract：:A rapid differential diagnosis of the clinical conditions underlying chest pain is a relevant clinical issue. Specifically, a fast rule-in or -out of acute myocardial infarction (AMI) is mandatory to improve diagnostic outcome and cost-effectiveness of patient management. We demonstrated that Protein Kinase C (PKC) ep...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-38624-5

    authors： Carubbi C,Masselli E,Pozzi G,Mattioli M,Martini S,Goldoni M,Aloe R,Cervellin G,Vitale M,Gobbi G

    更新日期：2019-02-14 00:00:00

  • CD4(+)CD25(+) T Cells in primary malignant hypertension related kidney injury.

    abstract：:CD4(+)CD25(+) T cells are critical for maintenance of immunologic self-tolerance. We measured the number of CD4(+)CD25(+) cells in the patients with primary malignant hypertension related kidney injury, to explore the molecular pathogenesis of this disease. We selected 30 patients with primary malignant hypertension r...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27659

    authors： Huang H,Luo Y,Liang Y,Long X,Peng Y,Liu Z,Wen X,Jia M,Tian R,Bai C,Li C,He F,Lin Q,Wang X,Dong X

    更新日期：2016-06-09 00:00:00

  • Identification of brain antigens recognized by autoantibodies in experimental autoimmune encephalomyelitis-induced animals treated with etomoxir or interferon-β.

    abstract：:Multiple sclerosis (MS) is a neurodegenerative autoimmune disease, where chronic inflammation plays an essential role in its pathology. A feature of MS is the production of autoantibodies stimulated by an altered-peptide-ligand response and epitope spreading, resulting in loss of tolerance for self-proteins. The invol...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-25391-y

    authors： Mørkholt AS,Kastaniegaard K,Trabjerg MS,Gopalasingam G,Niganze W,Larsen A,Stensballe A,Nielsen S,Nieland JD

    更新日期：2018-05-04 00:00:00

  • Systematic comparison between methods for the detection of influential spreaders in complex networks.

    abstract：:Influence maximization is the problem of finding the set of nodes of a network that maximizes the size of the outbreak of a spreading process occurring on the network. Solutions to this problem are important for strategic decisions in marketing and political campaigns. The typical setting consists in the identificatio...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-51209-6

    authors： Erkol Ş,Castellano C,Radicchi F

    更新日期：2019-10-22 00:00:00

  • A functional investigation of the suppression of CpG and UpA dinucleotide frequencies in plant RNA virus genomes.

    abstract：:Frequencies of CpG and UpA dinucleotides in most plant RNA virus genomes show degrees of suppression comparable to those of vertebrate RNA viruses. While pathways that target CpG and UpAs in HIV-1 and echovirus 7 genomes and restrict their replication have been partly characterised, whether an analogous process drives...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-54853-0

    authors： Ibrahim A,Fros J,Bertran A,Sechan F,Odon V,Torrance L,Kormelink R,Simmonds P

    更新日期：2019-12-04 00:00:00

  • A graph-theoretical representation of multiphoton resonance processes in superconducting quantum circuits.

    abstract：:We propose a graph-theoretical formalism to study generic circuit quantum electrodynamics systems consisting of a two level qubit coupled with a single-mode resonator in arbitrary coupling strength regimes beyond rotating-wave approximation. We define colored-weighted graphs, and introduce different products between t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep37544

    authors： Jooya HZ,Reihani K,Chu SI

    更新日期：2016-11-21 00:00:00

  • Drought and heat waves associated with climate change affect performance of the potato aphid Macrosiphum euphorbiae.

    abstract：:The combined effect of drought and heat waves on insect-plant interactions is complex and not fully understood. Insects may indirectly benefit from water-deficit stress through increased plant nitrogen levels. Heat stress may have a direct negative effect, yet insect performance may be improved when day-time heat is f...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-37493-8

    authors： Beetge L,Krüger K

    更新日期：2019-03-06 00:00:00

  • Integrated transcriptomic and metabolomic data reveal the flavonoid biosynthesis metabolic pathway in Perilla frutescens (L.) leaves.

    abstract：:Perilla frutescens (L.) is an important medicinal and edible plant in China with nutritional and medical uses. The extract from leaves of Perilla frutescens contains flavonoids and volatile oils, which are mainly used in traditional Chinese medicine. In this study, we analyzed the transcriptomic and metabolomic data o...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-73274-y

    authors： Jiang T,Guo K,Liu L,Tian W,Xie X,Wen S,Wen C

    更新日期：2020-10-01 00:00:00

  • The First Two Clostridium difficile Ribotype 027/ST1 Isolates Identified in Beijing, China-an Emerging Problem or a Neglected Threat?

    abstract：:Clostridium difficile hyper-virulent ribotype 027 strain has become a significant concern globally, but has rarely been reported in Asian countries including China. Recently, a retrospective single-center study in Beijing, China, detected two ribotype 027 C. difficile isolates from two patients coming for outpatient v...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep18834

    authors： Cheng JW,Xiao M,Kudinha T,Xu ZP,Hou X,Sun LY,Zhang L,Fan X,Kong F,Xu YC

    更新日期：2016-01-07 00:00:00

  • MicroRNA-96-5p represses breast cancer proliferation and invasion through Wnt/β-catenin signaling via targeting CTNND1.

    abstract：:Low miR-96-5p expression is characteristic of many cancers but its role in breast cancer (BCa) remains poorly defined. Here, the role of miR-96-5p in BC development was assessed. We demonstrate that exogenously expressing miR-96-5p inhibits the proliferative, migratory and invasive capacity of BCa cells. Mechanistical...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-56571-z

    authors： Gao XH,Zhang YL,Zhang ZY,Guo SS,Chen XB,Guo YZ

    更新日期：2020-01-08 00:00:00

  • Inherently stealthy and highly tumor-selective gold nanoraspberries for photothermal cancer therapy.

    abstract：:Owing to their unique optical properties such as large absorption and scattering cross section and large enhancement of electromagnetic field at the surface, plasmonic nanostructures have received extensive attention as a highly promising class of materials for nano-oncology. Most of the existing plasmonic nanostructu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep10311

    authors： Gandra N,Portz C,Nergiz SZ,Fales A,Vo-Dinh T,Singamaneni S

    更新日期：2015-05-14 00:00:00

  • Multiple specialised goose-type lysozymes potentially compensate for an exceptional lack of chicken-type lysozymes in Atlantic cod.

    abstract：:Previous analyses of the Atlantic cod genome showed unique combinations of lacking and expanded number of genes for the immune system. The present study examined lysozyme activity, lysozyme gene distribution and expression in cod. Enzymatic assays employing specific bacterial lysozyme inhibitors provided evidence for ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep28318

    authors： Seppola M,Bakkemo KR,Mikkelsen H,Myrnes B,Helland R,Irwin DM,Nilsen IW

    更新日期：2016-06-21 00:00:00

  • Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84.

    abstract：:Medium chain fatty acids can activate the pro-inflammatory receptor GPR84 but so also can molecules related to 3,3'-diindolylmethane. 3,3'-Diindolylmethane and decanoic acid acted as strong positive allosteric modulators of the function of each other and analysis showed the affinity of 3,3'-diindolylmethane to be at l...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-18159-3

    authors： Mahmud ZA,Jenkins L,Ulven T,Labéguère F,Gosmini R,De Vos S,Hudson BD,Tikhonova IG,Milligan G

    更新日期：2017-12-20 00:00:00

  • A microcosm approach highlights the response of soil mineral weathering bacterial communities to an increase of K and Mg availability.

    abstract：:The access and recycling of the base cations are essential processes for the long-lasting functioning of forest ecosystems. While the role of soil bacterial communities has been demonstrated in mineral weathering and tree nutrition, our understanding of the link between the availability of base cations and the functio...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-50730-y

    authors： Nicolitch O,Feucherolles M,Churin JL,Fauchery L,Turpault MP,Uroz S

    更新日期：2019-10-07 00:00:00

  • Corrigendum: HIV-1 Env associates with HLA-C free-chains at the cell membrane modulating viral infectivity.

    abstract：:This corrects the article DOI: 10.1038/srep40037. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/srep46991

    authors： Serena M,Parolini F,Biswas P,Sironi F,Blanco Miranda A,Zoratti E,Scupoli MT,Ziglio S,Valenzuela-Fernandez A,Gibellini D,Romanelli MG,Siccardi A,Malnati M,Beretta A,Zipeto D

    更新日期：2018-05-22 00:00:00

  • DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma.

    abstract：:Decrease in blood concentration of branched-chain amino acids, especially leucine, is known to promote liver carcinogenesis in patients with chronic liver disease, but the mechanism is unclear. We herein established hepatocellular carcinoma (HCC) cells knocked out for DEPDC5 by using the CRISPR/Cas9 system, and elucid...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-18323-9

    authors： Mizuno Y,Shimada S,Akiyama Y,Watanabe S,Aida T,Ogawa K,Ono H,Mitsunori Y,Ban D,Kudo A,Arii S,Yamaoka S,Tanabe M,Tanaka S

    更新日期：2018-01-08 00:00:00

  • Cadherin 23-C Regulates Microtubule Networks by Modifying CAMSAP3's Function.

    abstract：:Cadherin-related 23 (CDH23) is an adhesive protein important for hearing and vision, while CAMSAP3/Marshalin is a microtubule (MT) minus-end binding protein that regulates MT networks. Although both CDH23 and CAMSAP3/Marshalin are expressed in the organ of Corti, and carry several protein-protein interaction domains, ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep28706

    authors： Takahashi S,Mui VJ,Rosenberg SK,Homma K,Cheatham MA,Zheng J

    更新日期：2016-06-28 00:00:00

  • Polymorphisms in the P2X7 receptor, and differential expression of Toll-like receptor-mediated cytokines and defensins, in a Canadian Indigenous group.

    abstract：:Canadian Indigenous peoples (First Nations and Inuit) exhibit a high burden of infectious diseases including tuberculosis influenced by societal factors, and biological determinants. Toll-like receptor (TLR)-mediated innate immune responses are the first line of defence against infections. We examined the production o...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-50596-0

    authors： Semple C,Choi KG,Kroeker A,Denechezhe L,Orr P,Mookherjee N,Larcombe L

    更新日期：2019-10-02 00:00:00

  • Ubiquitin-specific Protease 15 Negatively Regulates Virus-induced Type I Interferon Signaling via Catalytically-dependent and -independent Mechanisms.

    abstract：:Viral infection triggers a series of signaling cascades, which converge to activate the transcription factors nuclear factor-κB (NF-κB) and interferon regulatory factor 3 (IRF3), thereby inducing the transcription of type I interferons (IFNs). Although not fully characterized, these innate antiviral responses are fine...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep11220

    authors： Zhang H,Wang D,Zhong H,Luo R,Shang M,Liu D,Chen H,Fang L,Xiao S

    更新日期：2015-06-10 00:00:00

  • Reprogrammable Graphene-based Metasurface Mirror with Adaptive Focal Point for THz Imaging.

    abstract：:Recent emergence of metasurfaces has enabled the development of ultra-thin flat optical components through different wavefront shaping techniques at various wavelengths. However, due to the non-adaptive nature of conventional metasurfaces, the focal point of the resulting optics needs to be fixed at the design stage, ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-39266-3

    authors： Hosseininejad SE,Rouhi K,Neshat M,Faraji-Dana R,Cabellos-Aparicio A,Abadal S,Alarcón E

    更新日期：2019-02-27 00:00:00

  • Substrate promiscuity of polyketide synthase enables production of tsetse fly attractants 3-ethylphenol and 3-propylphenol by engineering precursor supply in yeast.

    abstract：:Tsetse flies are the transmitting vector of trypanosomes causing human sleeping sickness and animal trypanosomiasis in sub-saharan Africa. 3-alkylphenols are used as attractants in tsetse fly traps to reduce the spread of the disease. Here we present an inexpensive production method for 3-ethylphenol (3-EP) and 3-prop...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-66997-5

    authors： Hitschler J,Grininger M,Boles E

    更新日期：2020-06-19 00:00:00

  • Host mechanisms involved in cattle Escherichia coli O157 shedding: a fundamental understanding for reducing foodborne pathogen in food animal production.

    abstract：:The host mechanisms involved in Escherichia coli O157 super-shedding in cattle is largely unknown. In this study, the comparison of transcriptomes of intestinal tissues between super-shedders (SS) and cattle negative for E. coli O157 (NS) was performed, aiming to identify genes that are potentially associated with sup...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-06737-4

    authors： Wang O,McAllister TA,Plastow G,Stanford K,Selinger B,Guan LL

    更新日期：2017-08-09 00:00:00

  • Antibody-antigen kinetics constrain intracellular humoral immunity.

    abstract：:During infection with non-enveloped viruses, antibodies stimulate immunity from inside cells by activating the cytosolic Fc receptor TRIM21. This intracellular humoral response relies on opsonized viral particles reaching the cytosol intact but the antigenic and kinetic constraints involved are unknown. We have solved...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep37457

    authors： Bottermann M,Lode HE,Watkinson RE,Foss S,Sandlie I,Andersen JT,James LC

    更新日期：2016-11-24 00:00:00

  • Learning a Health Knowledge Graph from Electronic Medical Records.

    abstract：:Demand for clinical decision support systems in medicine and self-diagnostic symptom checkers has substantially increased in recent years. Existing platforms rely on knowledge bases manually compiled through a labor-intensive process or automatically derived using simple pairwise statistics. This study explored an aut...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-05778-z

    authors： Rotmensch M,Halpern Y,Tlimat A,Horng S,Sontag D

    更新日期：2017-07-20 00:00:00