Abstract：
:Multiple sclerosis (MS) is a neurodegenerative autoimmune disease, where chronic inflammation plays an essential role in its pathology. A feature of MS is the production of autoantibodies stimulated by an altered-peptide-ligand response and epitope spreading, resulting in loss of tolerance for self-proteins. The involvement of autoantibodies in MS pathogenesis has been suggested to initiate and drive progression of inflammation; however, the etiology of MS remains unknown. The effect of etomoxir and interferon-β (IFN-β) was examined in an experimental-autoimmune-encephalomyelitis (EAE) model of MS. Moreover, the impact of etomoxir and IFN-β on recognition of brain proteins in serum from EAE rats was examined with the purpose of identifying the autoantibody reactivities involved in MS. Animals treated with etomoxir on day 1 exhibited a statistically significantly lower disease score than animals treated with IFN-β (on day 1 or 5) or placebo. Etomoxir treatment on day 5 resulted in a significantly lower disease score than IFN-β treatment on day 1. After disease induction antibodies was induced to a broad pallet of antigens in the brain. Surprisingly, by blocking CPT1 and therewith lipid metabolism several alterations in the antibody response was observed suggesting that autoantibodies play a role in the EAE animal model.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Mørkholt AS,Kastaniegaard K,Trabjerg MS,Gopalasingam G,Niganze W,Larsen A,Stensballe A,Nielsen S,Nieland JDdoi
10.1038/s41598-018-25391-ysubject
Has Abstractpub_date
2018-05-04 00:00:00pages
7092issue
1issn
2045-2322pii
10.1038/s41598-018-25391-yjournal_volume
8pub_type
杂志文章abstract：:Plasmonics has established itself as a branch of physics which promises to revolutionize data processing, improve photovoltaics, and increase sensitivity of bio-detection. A widespread use of plasmonic devices is notably hindered by high losses and the absence of stable and inexpensive metal films suitable for plasmon...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05517
更新日期：2014-07-01 00:00:00
abstract：:As the natural boundary between the Yunnan-Guizhou Plateau and the Hengduan Mountains in China, the large-scale prominent terrain of Ailaoshan Mountain leads to obvious regional differences in climate and vegetation. In this article, a comparative analysis is made on both species composition and floristic components o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48324-9
更新日期：2019-08-19 00:00:00
abstract：:A histoanatomical context is imperative in an analysis of gene expression in a cell in a tissue to elucidate physiological function of the cell. In this study, we made technical advances in fluorescence laser microdissection (LMD) in combination with the absolute quantification of small amounts of mRNAs from a region ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00783
更新日期：2012-01-01 00:00:00
abstract：:The psychrophilic (cold-loving) fungus Pseudogymnoascus destructans was discovered more than a decade ago to be the pathogen responsible for white-nose syndrome, an emerging disease of North American bats causing unprecedented population declines. The same species of fungus is found in Europe but without associated mo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70375-6
更新日期：2020-08-17 00:00:00
abstract：:A total of 185 cases (150 retrospectively and 35 prospectively) of malignant liver masses were collected. In the retrospectively collected cases hyperenhancement during wash-in was the most common feature in HCCs but there was a high percentage of cases showing no enhancement or hypo/isoenhancement. ICCs displayed a l...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63220-3
更新日期：2020-04-08 00:00:00
abstract：:Solid state memory and switching devices aimed at replacing the flash memory technology operate by switching from the high to low resistance when conductive filaments are created in response to the electric pulse. The filaments are identified with either structurally different protrusions or purely electronic conducti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30700-6
更新日期：2018-08-15 00:00:00
abstract：:This paper addresses the issue of the sorption process on coal concerning propylene released from the source of coal heating in the deposit. In this study, the interaction between Polish coals and propylene molecules, as well as three other hydrocarbons (ethylene, ethane, and propane) with the application of a fixed-b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67472-x
更新日期：2020-07-09 00:00:00
abstract：:The rivers originating in the southern Andes (18°-55°S) support numerous ecosystems and a large number of human populations and socio-economic activities in the adjacent lowlands of Chile, Argentina and Bolivia. Here we show that ca. 75% of the total variance in the streamflow records from this extensive region can be...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53981-x
更新日期：2019-11-29 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is not sensitive to radiotherapy and chemotherapy and experiences postoperative relapse extremely easy, which is the major cause of the high mortality rate. The Notch signaling pathway is expected to become a new target for the biological treatment of HCC. We searched databases for studi...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-017-14897-6
更新日期：2017-11-01 00:00:00
abstract：:To evaluate the relative importance of photosynthetic versus morphological adaptations of submersed macrophytes to low light intensity in lakes, rapid light curves (RLCs), morphological parameters, relative growth rate (RGR), clonal reproduction and abundance of two submersed macrophytes (Potamogeton maackianus and Va...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34028
更新日期：2016-10-03 00:00:00
abstract：:The plasmonic waveguide made of uniform corrugated metallic strip can support and guide spoof surface plasmon polaritons (SSPPs) with high confinements. Here, we propose periodically-modulated plasmonic waveguide composed of non-uniform corrugated metallic strip to convert SSPPs to radiating waves, in which the main b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29600
更新日期：2016-07-12 00:00:00
abstract：:Three-dimensionally (3D) porous morphology of nanostructures can effectively improve their electrocatalytic activity and durability for various electrochemical reactions owing to big surface area and interconnected structure. Cyanogel, a jelly-like inorganic polymer, can be used to synthesize various three-dimensional...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07619
更新日期：2015-01-05 00:00:00
abstract：:Robust biomarker quantification is essential for the accurate diagnosis of diseases and is of great value in cancer management. In this paper, an innovative diagnostic platform is presented which provides automated molecularly imprinted solid-phase extraction (MISPE) followed by liquid chromatography-mass spectrometry...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44298
更新日期：2017-03-17 00:00:00
abstract：:p-Alkoxyphenols (AOPs) are a class of ethers that are widely used in industrial and agricultural productions and daily necessities. p-Phenoxyphenol (PhOP) and p-pentyloxyphenol (PeOP) belong to this class and have been reported to be estrogenic in vitro. However, their in vivo estrogenic activities have rarely been of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73271-1
更新日期：2020-10-14 00:00:00
abstract：:Next generation sequencing (NGS) of DNAs amplified by rolling circle amplification from 6 tomato (Solanum lycopersicum) plants with leaf curl symptoms identified a number of monopartite begomoviruses, including Tomato yellow leaf curl virus (TYLCV), and a betasatellite (Tomato leaf curl betasatellite [ToLCB]). Both TY...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53106-4
更新日期：2019-11-12 00:00:00
abstract：:Psoriatic skin differs distinctly from normal skin by its thickened epidermis. Most gene expression comparisons utilize full-thickness biopsies, with substantial amount of dermis. We assayed the transcriptomes of normal, lesional, and non-lesional psoriatic epidermis, sampled as split-thickness skin grafts, with 5'-en...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22745
更新日期：2016-03-15 00:00:00
abstract：:Bispecific killer cells engagers (BiKEs) which can bind to natural killer (NK) cells through the activating receptor CD16A and guide them to cells expressing the HIV-1 envelope glycoprotein (Env) are a promising new weapon for elimination of infected cells and eradication of the virus. Here we report the design, gener...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07966-3
更新日期：2017-08-22 00:00:00
abstract：:Neuroinflammation in utero may result in life-long neurological disabilities. Microglia play a pivotal role, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance neuroprotective potential of microglia. We hypothesized that agonism on α7 nicotinic acetylcholine receptor (α7...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09439-z
更新日期：2017-09-06 00:00:00
abstract：:YidC, a bacterial member of the YidC/Alb3/Oxa1 insertase family, mediates membrane protein assembly and insertion. Cytoplasmic loops are known to have functional significance in membrane proteins such as YidC. Employing microsecond-level molecular dynamics (MD) simulations, we show that the crystallographically unreso...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51052-9
更新日期：2019-10-08 00:00:00
abstract：:Wave propagation is an important characteristic for pattern formation and pattern dynamics. To date, various waves in homogeneous media have been investigated extensively and have been understood to a great extent. However, the wave behaviors in heterogeneous media have been studied and understood much less. In this w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25177
更新日期：2016-05-04 00:00:00
abstract：:We report on the first realization of an ultrafast Airy beam optical parametric oscillator (OPO). By introducing intracavity cubic phase modulation to the resonant Gaussian signal in a synchronously-pumped singly-resonant OPO cavity and its subsequent Fourier transformation, we have generated 2-dimensional Airy beam i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30701
更新日期：2016-08-01 00:00:00
abstract：:Gene loss is a major contributor to the evolution of bacterial gene content. Gene loss may occur as a result of shifts in environment leading to changes in the intensity and/or directionality of selection applied for the maintenance of specific genes. Gene loss may also occur in a more neutral manner, when gene functi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35168
更新日期：2016-10-13 00:00:00
abstract：:The feedback between dyke and sill intrusions and the evolution of stresses within volcanic systems is poorly understood, despite its importance for magma transport and volcano instability. Long-lived ocean island volcanoes are crosscut by thousands of dykes, which must be accommodated through a combination of flank s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74361-w
更新日期：2020-10-15 00:00:00
abstract：:Assistive wearable soft robotic systems have recently made a surge in the field of biomedical robotics, as soft materials allow safe and transparent interactions between the users and devices. A recent interest in the field of soft pneumatic actuators (SPAs) has been the introduction of a new class of actuators called...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65003-2
更新日期：2020-06-15 00:00:00
abstract：:Nucleoporins have been reported to regulate pluripotent biology, but how they do so remains partially characterized. This study examined the effects of nup155 gene disruption on mouse embryonic stem cells to gain insights into possible mechanisms by which nucleoporins regulate pluripotency in a pro-arrhythmogenic stem...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49147-4
更新日期：2019-09-03 00:00:00
abstract：:The Killari Earthquake (Moment magnitude 6.1) of September 30, 1993, occurred in the state of Maharashtra, India, has an epicenter (18°03' N, 76°33' E) located at ~ 40 km SSW of Killari Town. The ~ 125 km long basin of Tirna River, close to the Killari Town, currently occupies the area that has witnessed episodic intr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77542-9
更新日期：2020-11-25 00:00:00
abstract：:Silicon is the second most common element on the Earth's crust and its oxide (SiO(2)) the most abundant mineral. Silica and silicates are widely used in medicine and industry as well as in micro- and nano-optics and electronics. However, the fabrication of glass fibres and components requires high temperature and non-...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00607
更新日期：2012-01-01 00:00:00
abstract：:HPIVs are serologically and genetically grouped into four species that account for up to 10% of all hospitalizations due to acute respiratory infection in children under the age of five. Genetic and epidemiological data for the four HPIVs derived from two pediatric cohorts in Viet Nam are presented. Respiratory sample...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24767-4
更新日期：2018-05-01 00:00:00
abstract：:Tumors are characterized by a rigid, highly cross-linked extracellular matrix (ECM), which impedes homogeneous drug distribution and potentially protects malignant cells from exposure to therapeutics. Lysyl oxidases are major contributors to tissue stiffness and the elevated expression of these enzymes observed in mos...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17576
更新日期：2015-12-01 00:00:00
abstract：:Global ocean acidification is expected to chronically lower the pH to 7.3 (>2200 µatm seawater pCO2) by the year 2300. Acute hypercapnia already occurs along the South African west and south coasts due to upwelling- and low-oxygen events, with increasing frequency. In the present project we investigated the impact of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54795-7
更新日期：2019-12-19 00:00:00
