miR-203 inhibits proliferation and self-renewal of leukemia stem cells by targeting survivin and Bmi-1.

abstract：:Developmental neurotoxic compounds impair the developing human nervous system at lower doses than those affecting adults. Standardized test methods for assessing developmental neurotoxicity (DNT) require the use of high numbers of laboratory animals. Here, we use a novel assay that is based on the development of an in...

journal_title：Scientific reports

authors： Bode K,Nolte L,Kamin H,Desens M,Ulmann A,Bergmann GA,Betker P,Reitmeier J,Ripken T,Stern M,Meyer H,Bicker G

更新日期：2020-02-14 00:00:00

abstract：:Mechanical function of the heart during open-chest cardiac surgery is exclusively monitored by echocardiographic techniques. However, little is known about local kinematics, particularly for the reperfused regions after ischemic events. We report a novel imaging modality, which extracts local and global kinematic para...

journal_title：Scientific reports

authors： Fassina L,Rozzi G,Rossi S,Scacchi S,Galetti M,Lo Muzio FP,Del Bianco F,Colli Franzone P,Petrilli G,Faggian G,Miragoli M

更新日期：2017-04-11 00:00:00

abstract：:Polymer-derived silicon oxycarbide (SiCO) presents excellent performance for high temperature and lithium-ion battery applications. Current experiments have provided some information on nano-structure of SiCO, while it is very challenging for experiments to take further insight into the molecular structure and its rel...

journal_title：Scientific reports

authors： Liao N,Zhang M,Zhou H,Xue W

更新日期：2017-02-14 00:00:00

abstract：:In low-resource hospitals of central Africa, neurological disorders are frequent and etiologies very diverse. The difficulty to identify invasive bacterial infections in this setting results in major antibiotic overuse. Biomarkers such as C-reactive protein (CRP) and procalcitonin (PCT) may help discriminate these con...

journal_title：Scientific reports

authors： Bottieau E,Mukendi D,Kalo JL,Lutumba P,Barbé B,Ramadan K,Van Esbroeck M,Jacobs J,Yansouni CP,Chappuis F,Boelaert M,Winkler AS,Verdonck K

更新日期：2019-10-29 00:00:00

abstract：:Plant genomes encode several classes of small regulatory RNAs (sRNAs) that play critical roles in both development and stress responses. Panax notoginseng (Burk.) F.H. Chen (P. notoginseng) is an important traditional Chinese herbal medicinal plant species for its haemostatic effects. Therefore, the root yield of P. n...

journal_title：Scientific reports

authors： Zheng Y,Chen K,Xu Z,Liao P,Zhang X,Liu L,Wei K,Liu D,Li YF,Sunkar R,Cui X

更新日期：2017-08-25 00:00:00

abstract：:Multifactorial lifestyle intervention is known to be more effective for ameliorating cognitive decline than single factor intervention; however, the effects of combining exercise with long-chain polyunsaturated fatty acids (LCPUFA) on the elderlies' cognitive function remain unclear. We conducted a randomised, single-...

journal_title：Scientific reports

authors： Tokuda H,Ito M,Sueyasu T,Sasaki H,Morita S,Kaneda Y,Rogi T,Kondo S,Kouzaki M,Tsukiura T,Shibata H

更新日期：2020-07-31 00:00:00

abstract：:Protective antigen (PA) of Bacillus anthracis is being considered as a vaccine candidate against anthrax and its production has been explored in several heterologous host systems. Since the systems tested introduced adverse issues such as inclusion body formation and endotoxin contamination, the production from B. ant...

journal_title：Scientific reports

authors： Sharma AK,Leppla SH,Pomerantsev AP,Shiloach J

更新日期：2018-10-31 00:00:00

abstract：:Sustainable wastewater treatment has been attracting increasing attentions over the past decades. However, the production of nitrous oxide (N2O), a potent GHG, from the energy-efficient granule-based autotrophic nitrogen removal is largely unknown. This study applied a previously established N2O model, which incorpora...

journal_title：Scientific reports

authors： Peng L,Sun J,Liu Y,Dai X,Ni BJ

更新日期：2017-04-03 00:00:00

abstract：:This study demonstrates that 24 h following viral vector-based vaccination IL-13Rα2 functions as a master sensor on conventional dendritic cells (cDCs), abetted by high protein stability coupled with minimal mRNA expression, to rapidly regulate DC mediated IL-13 responses at the lung mucosae, unlike IL-13Rα1. Under lo...

journal_title：Scientific reports

authors： Roy S,Liu HY,Jaeson MI,Deimel LP,Ranasinghe C

更新日期：2020-01-23 00:00:00

abstract：:Damage of enteric neurons and partial or total loss of selective neuronal populations are reported in intestinal disorders including inflammatory bowel diseases and necrotizing enterocolitis. To develop three-dimensional scaffolds for enteric neurons we propose the decoration of ionic-complementary self-assembling pep...

journal_title：Scientific reports

authors： Brun P,Zamuner A,Peretti A,Conti J,Messina GML,Marletta G,Dettin M

更新日期：2019-04-03 00:00:00

abstract：:Patient misidentification in imaging examinations has become a serious problem in clinical settings. Such misidentification could be prevented if patient characteristics such as sex, age, and body weight could be predicted based on an image of the patient, with an alert issued when a mismatch between the predicted and...

journal_title：Scientific reports

authors： Kawauchi K,Hirata K,Katoh C,Ichikawa S,Manabe O,Kobayashi K,Watanabe S,Furuya S,Shiga T

更新日期：2019-05-10 00:00:00

abstract：:Unconventional superconductivity often emerges at the border of long-range magnetic orders. Understanding the low-energy charge dynamics may provide crucial information on the formation of superconductivity. Here we report the unpolarized/polarized optical conductivity study of high quality MnP single crystals at ambi...

journal_title：Scientific reports

authors： Zheng P,Xu YJ,Wu W,Xu G,Lv JL,Lin FK,Wang P,Yang YF,Luo JL

更新日期：2017-10-27 00:00:00

abstract：:The proteolytic system of Lactobacillus plays an essential role in bacterial growth, contributes to the flavor development of fermented products, and can release bioactive health-beneficial peptides during milk fermentation. In this work, a genomic analysis of all genes involved in the proteolytic system of L. delbrue...

journal_title：Scientific reports

authors： Brown L,Villegas JM,Elean M,Fadda S,Mozzi F,Saavedra L,Hebert EM

更新日期：2017-08-17 00:00:00

abstract：:There is a demand for ultra low-loss metal films with high-quality single crystals and perfect surface for nanophotonics and quantum information processing. Many researches are devoted to alternative materials, but silver is by far theoretically the most preferred low-loss material at optical and near-IR frequencies. ...

journal_title：Scientific reports

authors： Rodionov IA,Baburin AS,Gabidullin AR,Maklakov SS,Peters S,Ryzhikov IA,Andriyash AV

更新日期：2019-08-22 00:00:00

abstract：:Aminoacyl-tRNA synthetases are the key enzymes for protein synthesis. Glycine, alanine, serine and tyrosine are the major amino acids composing fibroin of silkworm. Among them, the genes of alanyl-tRNA synthetase (AlaRS) and glycyl-tRNA synthetase (GlyRS) have been cloned. In this study, the seryl-tRNA synthetase (Ser...

journal_title：Scientific reports

authors： Hu J,Tian J,Li F,Xue B,Hu J,Cheng X,Li J,Shen W,Li B

更新日期：2017-01-30 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have been found to play important roles in various biological processes; however, many of their functions remain unclear. In this study, we present a novel approach to identify the lncRNA-associated protein-protein interaction (PPI) modules and ascertain their functions in human lung squ...

journal_title：Scientific reports

authors： Wu CH,Hsu CL,Lu PC,Lin WC,Juan HF,Huang HC

更新日期：2016-10-27 00:00:00

abstract：:The linkage between oxidative stress and idiopathic chronic fatigue (ICF) has not been explored in detail. This study thoroughly compared the serum levels of biomarkers for oxidative stress and antioxidants from 103 subjects with ICF (20 men and 83 women) to those of 82 healthy volunteers (27 men and 55 women). Oxidat...

journal_title：Scientific reports

authors： Lee JS,Kim HG,Lee DS,Son CG

更新日期：2018-08-27 00:00:00

abstract：:There is a well-established relationship between joint hypermobility and anxiety in humans, that has not previously been investigated in other species. A population of 5575 assistance dogs were scored for both hip hypermobility and 13 behaviour characteristics using previously validated methods. Our results suggest a ...

journal_title：Scientific reports

authors： Bowen J,Fatjó J,Serpell JA,Bulbena-Cabré A,Leighton E,Bulbena A

更新日期：2019-06-13 00:00:00

abstract：:A physically active lifestyle is associated with better health in body and mind, and it is urgent that supporting agents for such lifestyles be developed. In rodents, voluntary locomotor activity as an active physical behavior may be mediated by dopaminergic neurons (DNs). Thiamine phosphate esters can stimulate DNs, ...

journal_title：Scientific reports

authors： Saiki M,Matsui T,Soya M,Kashibe T,Shima T,Shimizu T,Naruto T,Kitayoshi T,Akimoto K,Ninomiya S,Soya H

更新日期：2018-07-11 00:00:00

abstract：:Chromosomal toxin-antitoxin (TA) systems are widespread genetic elements among bacteria, yet, despite extensive studies in the last decade, their biological importance remains ambivalent. The ability of TA-encoded toxins to affect stress tolerance when overexpressed supports the hypothesis of TA systems being associat...

journal_title：Scientific reports

authors： Rosendahl S,Tamman H,Brauer A,Remm M,Hõrak R

更新日期：2020-06-08 00:00:00

abstract：:From the viewpoint of thermodynamics, the formation of DNA loops and the interaction between them, which are all non-equilibrium processes, result in the change of free energy, affecting gene expression and further cell-to-cell variability as observed experimentally. However, how these processes dissipate free energy ...

journal_title：Scientific reports

authors： Huang L,Liu P,Yuan Z,Zhou T,Yu J

更新日期：2017-10-03 00:00:00

abstract：:Cyclin Y (CCNY) is a member of the cyclin protein family, known to regulate cell division in proliferating cells. Interestingly, CCNY is expressed in neurons that do not undergo cell division. Here, we report that CCNY negatively regulates long-term potentiation (LTP) of synaptic strength through inhibition of AMPA re...

journal_title：Scientific reports

authors： Cho E,Kim DH,Hur YN,Whitcomb DJ,Regan P,Hong JH,Kim H,Ho Suh Y,Cho K,Park M

更新日期：2015-07-29 00:00:00

abstract：:Exolysin (ExlA) is a recently-identified pore-forming toxin secreted by a subset of Pseudomonas aeruginosa strains identified worldwide and devoid of Type III secretion system (T3SS), a major virulence factor. Here, we characterized at the ultrastructural level the lesions caused by an ExlA-secreting strain, CLJ1, in ...

journal_title：Scientific reports

authors： Bouillot S,Munro P,Gallet B,Reboud E,Cretin F,Golovkine G,Schoehn G,Attrée I,Lemichez E,Huber P

更新日期：2017-05-18 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Nakagawa A,Naito AT,Sumida T,Nomura S,Shibamoto M,Higo T,Okada K,Sakai T,Hashimoto A,Kuramoto Y,Oka T,Lee JK,Harada M,Ueda K,Shiojima I,Limbourg FP,Adams RH,Noda T,Sakata Y,Akazawa H,Komuro I

更新日期：2018-10-29 00:00:00

abstract：:Under specific reaction conditions, levansucrase from Bacillus subtilis (SacB) catalyzes the synthesis of a low molecular weight levan through the non-processive elongation of a great number of intermediates. To deepen understanding of the polymer elongation mechanism, we conducted a meticulous examination of the fruc...

journal_title：Scientific reports

authors： Raga-Carbajal E,López-Munguía A,Alvarez L,Olvera C

更新日期：2018-10-09 00:00:00

abstract：:There is strong in vitro cell survival evidence that the relative biological effectiveness (RBE) of protons is variable, with dependence on factors such as linear energy transfer (LET) and dose. This is coupled with the growing in vivo evidence, from post-treatment image change analysis, of a variable RBE. Despite thi...

journal_title：Scientific reports

authors： Smith EAK,Henthorn NT,Warmenhoven JW,Ingram SP,Aitkenhead AH,Richardson JC,Sitch P,Chadwick AL,Underwood TSA,Merchant MJ,Burnet NG,Kirkby NF,Kirkby KJ,Mackay RI

更新日期：2019-12-27 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) infection promotes a generalized activation of host responses that involves not only CD4 T cells, but also cells of the microenvironment, which are not directly infected, such as endothelial cells. The mechanisms triggering HIV-1-associated vascular alterations remain poorly...

journal_title：Scientific reports

authors： Balducci E,Leroyer AS,Lacroix R,Robert S,Todorova D,Simoncini S,Lyonnet L,Chareyre C,Zaegel-Faucher O,Micallef J,Poizot-Martin I,Roll P,Dignat-George F

更新日期：2019-07-16 00:00:00

abstract：:Aftershocks are the most striking evidence of earthquake interactions and the physical mechanisms at the origin of their occurrence are still intensively debated. Novel insights stem from recent results on the influence of the faulting style on the aftershock organisation in magnitude and time. Our study shows that th...

journal_title：Scientific reports

authors： Lippiello E,Giacco F,Marzocchi W,Godano C,de Arcangelis L

更新日期：2015-10-26 00:00:00

abstract：:The use of smart colloidal microgels for advanced applications critically depends on their response kinetics. We use pressure jump small angle neutron scattering with supreme time resolution to study the rapid volume phase transition kinetics of such microgels. Utilizing the pressure induced microphase separation insi...

journal_title：Scientific reports

authors： Wrede O,Reimann Y,Lülsdorf S,Emmrich D,Schneider K,Schmid AJ,Zauser D,Hannappel Y,Beyer A,Schweins R,Gölzhäuser A,Hellweg T,Sottmann T

更新日期：2018-09-13 00:00:00

abstract：:A tool to predict peritonitis-associated treatment failure among peritoneal dialysis (PD) patients has not yet been established. We conducted a multicentre, retrospective cohort study among 1,025 PD patients between 2006 and 2016 in Thailand to develop and internally validate such a tool. Treatment failure was defined...

journal_title：Scientific reports

authors： Nochaiwong S,Ruengorn C,Koyratkoson K,Thavorn K,Awiphan R,Chaisai C,Phatthanasobhon S,Noppakun K,Suteeka Y,Panyathong S,Dandecha P,Chongruksut W,Nanta S,Thai Renal Outcomes Research (THOR) Investigators.

更新日期：2018-10-04 00:00:00