Abstract：
:Risk of hospital readmission and cardiac mortality increases with atmospheric pollution for patients with heart failure. The underlying mechanisms are unclear. Carbon monoxide (CO) a ubiquitous environmental pollutant could be involved. We explored the effect of daily exposure of CO relevant to urban pollution on post-myocardial infarcted animals. Rats with ischemic heart failure were exposed 4 weeks to daily peaks of CO mimicking urban exposure or to standard filtered air. CO exposure worsened cardiac contractile dysfunction evaluated by echocardiography and at the cardiomyocyte level. In line with clinical reports, the animals exposed to CO also exhibited a severe arrhythmogenic phenotype with numerous sustained ventricular tachycardias as monitored by surface telemetric electrocardiograms. CO did not affect cardiac β-adrenergic responsiveness. Instead, mitochondrial dysfunction was exacerbated leading to additional oxidative stress and Ca2+ cycling alterations. This was reversed following acute antioxidant treatment of cardiomyocytes with N-acetylcysteine confirming involvement of CO-induced oxidative stress. Exposure to daily peaks of CO pollution aggravated cardiac dysfunction in rats with ischemic heart failure by specifically targeting mitochondria and generating ROS-dependent alterations. This pathway may contribute to the high sensibility and vulnerability of individuals with cardiac disease to environmental outdoor air quality.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Reboul C,Boissière J,André L,Meyer G,Bideaux P,Fouret G,Feillet-Coudray C,Obert P,Lacampagne A,Thireau J,Cazorla O,Richard Sdoi
10.1038/srep39715subject
Has Abstractpub_date
2017-01-03 00:00:00pages
39715issn
2045-2322pii
srep39715journal_volume
7pub_type
杂志文章abstract：:BEST1 is a Ca2+-activated Cl- channel predominantly expressed in retinal pigment epithelium (RPE), and over 250 genetic mutations in the BEST1 gene have been identified to cause retinal degenerative disorders generally known as bestrophinopathies. As most BEST1 mutations are autosomal dominant, it is of great biomedic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54892-7
更新日期：2019-12-13 00:00:00
abstract：:Autism spectrum disorder involves persistent difficulties in social communication. Although these difficulties affect both verbal and nonverbal communication, there are no quantitative behavioral studies to date investigating the cross-modal coordination of verbal and nonverbal communication in autism. The objective o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54587-z
更新日期：2019-12-04 00:00:00
abstract：:We have employed a model system, inspired by SNARE proteins, to facilitate membrane fusion between Giant Unilamellar Vesicles (GUVs) and Large Unilamellar Vesicles (LUVs) under physiological conditions. In this system, two synthetic lipopeptide constructs comprising the coiled-coil heterodimer-forming peptides K4, (KI...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59926-z
更新日期：2020-02-20 00:00:00
abstract：:Assessment of intraventricular pressure gradients (IVPG) using color Doppler M-mode echocardiography has gained increasing interest in the evaluation of cardiac function. However, standardized analysis tools for IVPG quantification are missing. We aimed to evaluate the feasibility, the test-retest observer reproducibi...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-020-64059-4
更新日期：2020-04-28 00:00:00
abstract：:Fourier ptychographic microscopy (FPM) is a novel computational coherent imaging technique for high space-bandwidth product imaging. Mathematically, Fourier ptychographic (FP) reconstruction can be implemented as a phase retrieval optimization process, in which we only obtain low resolution intensity images correspond...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27384
更新日期：2016-06-10 00:00:00
abstract：:Generalized vitiligo is an autoimmune disease characterized by melanocyte loss, which results in patchy depigmentation of skin and hair. Recent studies suggested the key role of CD8+T lymphocytes for mediating immune response in vitiligo through melanocyte differentiation antigens, including tyrosinase, gp100 and Mela...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36360
更新日期：2016-11-08 00:00:00
abstract：:Structural neuroimaging studies of posttraumatic stress disorder (PTSD) have typically reported reduced cortical thickness (CT) and gray matter volume (GMV) in subcortical structures and networks involved in memory retrieval, emotional processing and regulation, and fear acquisition and extinction. Although PTSD is mo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80776-2
更新日期：2021-01-19 00:00:00
abstract：:Seed number per pod (SNPP) is one of the major yield components and breeding targets in rapeseed that shows great variation and is invaluable for genetic improvement. To elucidate the genetic architecture and uncover the mechanism of SNPP, we identified five quantitative trait loci (QTLs) using the BnaZNRIL population...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24124
更新日期：2016-04-12 00:00:00
abstract：:Generation of multiple mRNAs by alternative splicing is well known in the group of cytokines and has recently been reported for the human erythropoietin (EPO) gene. Here, we focus on the alternatively spliced EPO transcript characterized by deletion of exon 3 (hEPOΔ3). We show co-regulation of EPO and hEPOΔ3 in human ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03167-0
更新日期：2017-06-16 00:00:00
abstract：:The addition of a small amount of dopant impurities to crystals is a common method to tune the properties of materials. Usually the doping grade is restricted by the low solubility of the dopants; increasing the doping concentration beyond this solubility limit leads to supersaturated solutions in which dopant cluster...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12730-8
更新日期：2017-10-03 00:00:00
abstract：:Extranodal NK/T-cell lymphoma, nasal type (NKTL) is an aggressive type of non-Hodgkin lymphoma closely associated with Epstein-Barr virus and characterized by varying degrees of systemic inflammation. We aim to examine the prognostic significance of peripheral blood neutrophil-lymphocyte ratio (NLR) in patients with N...
journal_title：Scientific reports
pub_type： 杂志文章,多中心研究
doi：10.1038/s41598-019-51522-0
更新日期：2019-10-18 00:00:00
abstract：:Cattleyak are interspecific hybrids between cattle and yak, exhibiting the same prominent adaptability as yak and much higher performances than yak. However, male infertility of cattleyak resulted from spermatogenic arrest has greatly restricted their effective utilization in yak breeding. In past decades, much work h...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18607-0
更新日期：2018-01-12 00:00:00
abstract：:Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a direct role in hum...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08267-5
更新日期：2017-08-15 00:00:00
abstract：:Activated sludge granules and flocs have their inherent advantages and disadvantages for wastewater treatment due to their different characteristics. So far quantitative information on their evaluation is still lacking. This work provides a quantitative and comparative evaluation on the characteristics and pollutant r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42910
更新日期：2017-02-17 00:00:00
abstract：:Our study focused on radiocaesium (137Cs) partitioning in forests, three vegetation periods after the Fukushima Daiichi nuclear power plant accident. 137Cs distribution in forest components (organic and mineral soil layers as well as tree compartments: stem, bark, needles, branches and roots) was measured for two Japa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37618
更新日期：2016-11-23 00:00:00
abstract：:RAS genotyping is mandatory to predict anti-EGFR monoclonal antibodies (mAbs) therapy resistance and BRAF genotyping is a relevant prognosis marker in patients with metastatic colorectal cancer. Although the role of hotspot mutations is well defined, the impact of uncommon mutations is still unknown. In this study, we...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43646-0
更新日期：2019-05-08 00:00:00
abstract：:Migration and interactions of immune cells are routinely studied by time-lapse microscopy of in vitro migration and confrontation assays. To objectively quantify the dynamic behavior of cells, software tools for automated cell tracking can be applied. However, many existing tracking algorithms recognize only rather sh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39725-x
更新日期：2019-03-01 00:00:00
abstract：:Hirsutella sinensis mycelium (HSM), the anamorph of Cordyceps sinensis, is a traditional Chinese medicine that has been shown to possess various pharmacological properties. We previously reported that this fungus suppresses interleukin-1β and IL-18 secretion by inhibiting both canonical and non-canonical inflammasomes...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15282
更新日期：2015-10-26 00:00:00
abstract：:Currently, blueberry bruising is evaluated by either human visual/tactile inspection or firmness measurement instruments. These methods are destructive, time-consuming, and subjective. The goal of this paper was to develop a non-destructive approach for blueberry bruising detection and quantification. Experiments were...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35679
更新日期：2016-10-21 00:00:00
abstract：:In this study, we analyze the role of different structural variants of proteins in the speciation processes. We separate human and mouse proteomes (taken as a reference) into three previously defined variants of disorder: ordered proteins (ORDPs), structured proteins with intrinsically disordered protein regions (IDPR...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61466-5
更新日期：2020-03-11 00:00:00
abstract：:We study heat dissipation of a multi-wall carbon nanotube (MWCNT) device fabricated from two crossed nanotubes on a SiNx substrate under the influence of a constant (DC) electric bias. By monitoring the temperature of the substrate, we observe negligible Joule heating within the nanotube lattice itself and instead hea...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46944-9
更新日期：2019-07-25 00:00:00
abstract：:Oligomannose-type glycans on HIV-1 gp120 form a patch that is targeted by several broadly neutralizing antibodies (bnAbs) and that therefore is of interest to vaccine design. However, attempts to elicit similar oligomannose-specific bnAbs by immunizing with oligomannosidic glycoconjugates have only been modestly succe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64500-8
更新日期：2020-05-05 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-43503-0
更新日期：2019-05-03 00:00:00
abstract：:Angiogenesis is a key restorative process following stroke but has also been linked to increased vascular permeability and blood brain barrier (BBB) disruption. Previous pre-clinical approaches primarily focused on the administration of vascular endothelial growth factor (VEGF) to promote vascular repair after stroke....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56634-1
更新日期：2019-12-27 00:00:00
abstract：:Modification of lattice thermal conductivity (κL) of a solid by means of hydrostatic pressure (P) has been a crucially interesting approach that targets a broad range of advanced materials from thermoelectrics and thermal insulators to minerals in mantle. Although it is well documented knowledge that thermal conductiv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29801
更新日期：2016-07-19 00:00:00
abstract：:An antimicrobial peptide, nisin Z, was embedded within polyelectrolyte multilayers (PEMs) composed of natural polysaccharides in order to explore the potential of forming a multilayer with antimicrobial properties. Using attenuated total reflection Fourier transform infrared spectroscopy (ATR FTIR), the formation of c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79702-3
更新日期：2021-01-18 00:00:00
abstract：:This study investigated lead concentrations in the hairs of radiographers working in the radiological departments of general hospitals that used lead shielding for radiation protection. We collected scalp hair samples from 32 radiographers working in four radiology departments with lead shielding and 18 administration...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80721-3
更新日期：2021-01-08 00:00:00
abstract：:To improve estimates of the long-term response of the marine carbon system to climate change a better understanding of the seasonal and interannual variability is needed. We use high-frequency multi-year data at three locations identified as climate change hotspots: two sites located close to South Pacific boundary cu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44109-2
更新日期：2019-05-20 00:00:00
abstract：:Hypertension and diabetes mellitus (DM) have become major public health issues, and previous studies have shown that there is an association between hypertension and DM. However, there is a lack of detailed information about this association. This study aimed to explore how different blood pressure (BP) levels were as...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26323-6
更新日期：2018-05-21 00:00:00
abstract：:This study presents analysis of four chimney samples in terms of glycerol dialkyl glycerol tetraether lipids (GDGTs), representing different growing stages of sulfide chimneys at the Deyin hydrothermal field, the southern mid-Atlantic ridge. The modified Bligh-Dyer method was used for lipid extraction and purification...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26166-1
更新日期：2018-05-23 00:00:00
