Identification of Novel HLA-A*0201-Restricted CTL Epitopes in Chinese Vitiligo Patients.

abstract：:De novo uridine-diphosphate-N-acetylglucosamine (UDP-GlcNAc) biosynthesis requires glucose, glutamine, acetyl-CoA and uridine, however GlcNAc salvaged from glycoconjugate turnover and dietary sources also makes a significant contribution to the intracellular pool. Herein we ask whether dietary GlcNAc regulates nutrien...

journal_title：Scientific reports

authors： Ryczko MC,Pawling J,Chen R,Abdel Rahman AM,Yau K,Copeland JK,Zhang C,Surendra A,Guttman DS,Figeys D,Dennis JW

更新日期：2016-03-14 00:00:00

abstract：:Patients with dengue virus (DENV) infection may also present acute viral encephalitis through an unknown mechanism. Here, we report that encephalitic DENV-infected mice exhibited progressive hunchback posture, limbic seizures, limbic weakness, paralysis, and lethality 7 days post-infection. These symptoms were accompa...

journal_title：Scientific reports

authors： Tsai TT,Chen CL,Lin YS,Chang CP,Tsai CC,Cheng YL,Huang CC,Ho CJ,Lee YC,Lin LT,Jhan MK,Lin CF

更新日期：2016-06-09 00:00:00

abstract：:Severely injured patients frequently suffer compromised fracture healing because of systemic post-traumatic inflammation. An important trigger of the posttraumatic immune response is the complement anaphylatoxin C5a, which acts via two receptors, C5aR1 and C5aR2, expressed on immune and bone cells. The blockade of C5a...

journal_title：Scientific reports

authors： Kovtun A,Bergdolt S,Hägele Y,Matthes R,Lambris JD,Huber-Lang M,Ignatius A

更新日期：2017-10-25 00:00:00

abstract：:Magnetic skyrmions are promising candidates for the next generation of spintronic devices due to their small size and topologically protected structure. One challenge for using these magnetic states in applications lies on controlling the nucleation process and stabilization that usually requires an external force. He...

journal_title：Scientific reports

authors： Brandão J,Dugato DA,Seeger RL,Denardin JC,Mori TJA,Cezar JC

更新日期：2019-03-11 00:00:00

abstract：:Suffering from giant size of objective lenses and infeasible manipulations of distant targets, telescopes could not seek helps from present super-resolution imaging, such as scanning near-field optical microscopy, perfect lens and stimulated emission depletion microscopy. In this paper, local light diffraction shrinka...

journal_title：Scientific reports

authors： Wang C,Tang D,Wang Y,Zhao Z,Wang J,Pu M,Zhang Y,Yan W,Gao P,Luo X

更新日期：2015-12-18 00:00:00

abstract：:Heart failure is the most common cause of morbidity and hospitalization in the western civilization. Protein phosphatases play a key role in the basal cardiac contractility and in the responses to β-adrenergic stimulation with type-1 phosphatase (PP-1) being major contributor. We propose here that formation of transie...

journal_title：Scientific reports

authors： Singh S,Lämmle S,Giese H,Kämmerer S,Meyer-Roxlau S,Alfar EA,Dihazi H,Guan K,El-Armouche A,Richter F

更新日期：2018-12-07 00:00:00

abstract：:Metabolites detectible in human biofluids are attractive biomarkers for the diagnosis of early Lyme disease (ELD), a vector-borne infectious disease. Urine represents an easily obtained clinical sample that can be applied for diagnostic purposes. However, few studies have explored urine for biomarkers of ELD. In this ...

journal_title：Scientific reports

authors： Pegalajar-Jurado A,Fitzgerald BL,Islam MN,Belisle JT,Wormser GP,Waller KS,Ashton LV,Webb KJ,Delorey MJ,Clark RJ,Molins CR

更新日期：2018-08-15 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) patients are at higher risk of developing lung cancer and its metastasis, but no suitable biomarker has been reported for differential diagnosis of these patients. Levels of serum biomarkers (VEGF, IL-8, MMP-9 and MMP-2) were analyzed in these patients, which were compared ...

journal_title：Scientific reports

authors： Balla MM,Desai S,Purwar P,Kumar A,Bhandarkar P,Shejul YK,Pramesh CS,Laskar S,Pandey BN

更新日期：2016-11-04 00:00:00

abstract：:For people suffering from severe paralysis, communication can be difficult or nearly impossible. Technology systems called brain-computer interfaces (BCIs) are being developed to assist these people with communication by using their brain activity to control a computer without any muscle activity. To benefit the devel...

journal_title：Scientific reports

authors： Salari E,Freudenburg ZV,Branco MP,Aarnoutse EJ,Vansteensel MJ,Ramsey NF

更新日期：2019-10-02 00:00:00

abstract：:The Centiloid (CL) is a method for standardizing amyloid beta (Aβ) quantification through different ligands and methods. To find the most appropriate reference region to reduce the variance in the Aβ CL unit between 18F-florbetaben (FBB) and 18F-flutemetamol (FMM), we conducted head-to-head comparisons from 56 partici...

journal_title：Scientific reports

authors： Cho SH,Choe YS,Park S,Kim YJ,Kim HJ,Jang H,Kim SJ,Kim JP,Jung YH,Kim BC,Na DL,Moon SH,Seo SW

更新日期：2020-09-11 00:00:00

abstract：:Environmental pollution by emerging contaminants, e.g. pharmaceuticals, has become a matter of widespread concern in recent years. We investigated the membrane transport of diclofenac and its toxic effects on gene expression and the development of zebrafish embryos. The association of diclofenac with the embryos confo...

journal_title：Scientific reports

authors： Chen JB,Gao HW,Zhang YL,Zhang Y,Zhou XF,Li CQ,Gao HP

更新日期：2014-05-02 00:00:00

abstract：:Although the cause of Alzheimer's disease (AD) is unknown, glial-induced neuroinflammation is an early symptom. Familial AD is caused by increases in amyloid-beta (Aβ) peptide, particularly soluble oligomeric (oAβ), considered a proximal neurotoxin and neuroinflammatory stimuli. APOE4, a naturally occurring genotype o...

journal_title：Scientific reports

authors： Ghura S,Tai L,Zhao M,Collins N,Che CT,Warpeha KM,LaDu MJ

更新日期：2016-07-07 00:00:00

abstract：:Although a slowing of electroencephalographic (EEG) activity during wakefulness and -to some extent- sleep of Alzheimer disease (AD) patients (i.e., increased slow-frequency activity) was documented, recent findings in healthy elderly show a decreased 0.6-1 Hz slow wave activity (SWA) during NREM, which was associated...

journal_title：Scientific reports

authors： De Gennaro L,Gorgoni M,Reda F,Lauri G,Truglia I,Cordone S,Scarpelli S,Mangiaruga A,D'atri A,Lacidogna G,Ferrara M,Marra C,Rossini PM

更新日期：2017-01-03 00:00:00

abstract：:Sexual conflict over parental investment can result in suboptimal reproductive output. A recent hypothesis suggests that equality in investment, and hence conflict resolution, may be reached via coordination of parental activities like alternating nest visits. However, how robust patterns of care within couples are ag...

journal_title：Scientific reports

authors： Iserbyt A,Griffioen M,Eens M,Müller W

更新日期：2019-02-26 00:00:00

abstract：:Understanding of lipid oxidation mechanisms (e.g., auto-oxidation and photo-oxidation) in foods and cosmetics is deemed essential to maintain the quality of such products. In this study, the oxidation mechanisms in foods and cosmetics were evaluated through analysis of linoleic acid hydroperoxide (LAOOH) and linoleic ...

journal_title：Scientific reports

authors： Ito J,Komuro M,Parida IS,Shimizu N,Kato S,Meguro Y,Ogura Y,Kuwahara S,Miyazawa T,Nakagawa K

更新日期：2019-05-14 00:00:00

abstract：:The Leading Edge Vortex (LEV) is a universal mechanism enhancing lift in flying organisms. LEVs, generally illustrated as a single vortex attached to the wing throughout the downstroke, have not been studied quantitatively in freely flying insects. Previous findings are either qualitative or from flappers and tethered...

journal_title：Scientific reports

authors： Johansson LC,Engel S,Kelber A,Heerenbrink MK,Hedenström A

更新日期：2013-11-20 00:00:00

abstract：:Respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and lung infections have critical consequences on mortality and morbidity in humans. The aims of the present study were to examine the mechanisms by which CXCL12 affects MUC1 transcription and airway inflammation, which depend on activa...

journal_title：Scientific reports

authors： Choi IW,Ahn do W,Choi JK,Cha HJ,Ock MS,You E,Rhee S,Kim KC,Choi YH,Song KS

更新日期：2016-06-07 00:00:00

abstract：:Anthracnose, caused by the Colletotrichum species of fungi, is one of the most serious diseases affecting jute in China. The disease causes chlorotic regions with black brown sunken necrotic pits on the surfaces of stems. In late stages of disease, plants undergo defoliation, dieback and blight, which make anthracnose...

journal_title：Scientific reports

authors： Niu X,Gao H,Qi J,Chen M,Tao A,Xu J,Dai Z,Su J

更新日期：2016-04-28 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Shikano K,Bessho Y,Kato M,Iwakoshi-Ukena E,Taniuchi S,Furumitsu M,Tachibana T,Bentley GE,Kriegsfeld LJ,Ukena K

更新日期：2018-04-13 00:00:00

abstract：:The crystal structure of the Sb6O13 oxide, exhibiting a defect pyrochlore crystal structure with atomic vacancies, has been studied using a complete set of state-of-the-art techniques. The degree of antimony disproportionation in Sb3+ and Sb5+ valence states has been directly determined around 36% and 64%, respectivel...

journal_title：Scientific reports

authors： Mayer SF,Rodrigues JE,Marini C,Fernández-Díaz MT,Falcón H,Asensio MC,Alonso JA

更新日期：2020-10-12 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Stringer BW,Day BW,D'Souza RCJ,Jamieson PR,Ensbey KS,Bruce ZC,Lim YC,Goasdoué K,Offenhäuser C,Akgül S,Allan S,Robertson T,Lucas P,Tollesson G,Campbell S,Winter C,Do H,Dobrovic A,Inglis PL,Jeffree RL,Johns TG,Boy

更新日期：2020-01-21 00:00:00

abstract：:Myosin phosphatase (MP) holoenzyme is a protein phosphatase-1 (PP1) type Ser/Thr specific enzyme that consists of a PP1 catalytic (PP1c) and a myosin phosphatase target subunit-1 (MYPT1). MYPT1 is an ubiquitously expressed isoform and it targets PP1c to its substrates. We identified the protein arginine methyltransfer...

journal_title：Scientific reports

authors： Sipos A,Iván J,Bécsi B,Darula Z,Tamás I,Horváth D,Medzihradszky KF,Erdődi F,Lontay B

更新日期：2017-01-11 00:00:00

abstract：:Tract tracing with neuronal tracers not only represents a straightforward approach to identify axonal projection connection between regions of the nervous system at distance but also provides compelling evidence for axonal regeneration. An ideal neuronal tracer meets certain criteria including high labeling efficacy, ...

journal_title：Scientific reports

authors： Mi D,Yuan Y,Zhang Y,Niu J,Wang Y,Yan J,Yang Y,Hu W

更新日期：2019-07-09 00:00:00

abstract：:The human cervical cancer oncogene (HCCR) has been found to be overexpressed in a variety of human cancers. However, the level of expression of HCCR and its biological function in gastric cancer are largely unknown. In this study, we evaluated HCCR expression in several gastric cancer cell lines and in one normal gast...

journal_title：Scientific reports

authors： Zhang JL,Liu XZ,Wang PY,Chen GW,Jiang Y,Qiao SK,Zhu J,Wang X,Pan YS,Liu YC

更新日期：2016-04-07 00:00:00

abstract：:Arabidopsis VIRE2-INTERACTING PROTEIN2 (VIP2) was previously described as a protein with a NOT domain, and Arabidopsis vip2 mutants are recalcitrant to Agrobacterium-mediated root transformation. Here we show that VIP2 is a transcription regulator and the C-terminal NOT2 domain of VIP2 interacts with VirE2. Interestin...

journal_title：Scientific reports

authors： Raman V,Anand A,Vasudevan B,Morsy MR,Pant BD,Lee HK,Tang Y,Mysore KS

更新日期：2019-09-18 00:00:00

abstract：:We present the continuous-time evolution of an online organism network from birth to death which crosses all organizational and temporal scales, from individual components through to the mesoscopic and entire system scale. These continuous-time data reveal a lifespan driven by punctuated, real-time co-evolution of the...

journal_title：Scientific reports

authors： Zheng M,Cao Z,Vorobyeva Y,Manrique P,Song C,Johnson NF

更新日期：2018-02-23 00:00:00

abstract：:Muscle wasting and atrophy are regulated by multiple molecular processes, including mRNA processing. Reduced levels of the polyadenylation binding protein nucleus 1 (PABPN1), a multifactorial regulator of mRNA processing, cause muscle atrophy. A proteomic study in muscles with reduced PABPN1 levels suggested dysregula...

journal_title：Scientific reports

authors： Olie CS,van der Wal E,Domagoj C,Maton L,de Greef JC,Lin IH,Chen YF,Kareem E,Penninger JM,Kessler BM,Raz V

更新日期：2020-10-19 00:00:00

abstract：:Fibrates, which are widely used lipidaemic-modulating drugs, are emerging environmental pollutants. However, fibrate concentrations in the environment have not been thoroughly surveyed. Here, we determined concentrations of the most commonly used fibrates and their metabolites in source water and drinking water sample...

journal_title：Scientific reports

authors： Ido A,Hiromori Y,Meng L,Usuda H,Nagase H,Yang M,Hu J,Nakanishi T

更新日期：2017-04-12 00:00:00

abstract：:Cell competition is a cell-cell interaction by which a cell compares its fitness to that of neighboring cells. The cell with the relatively lower fitness level is the "loser" and actively eliminated, while the cell with the relatively higher fitness level is the "winner" and survives. Recent studies have shown that ce...

journal_title：Scientific reports

authors： Chiba T,Ishihara E,Miyamura N,Narumi R,Kajita M,Fujita Y,Suzuki A,Ogawa Y,Nishina H

更新日期：2016-06-21 00:00:00

abstract：:Two-dimensional (2D) cell cultures growing on plastic do not recapitulate the three dimensional (3D) architecture and complexity of human tumors. More representative models are required for drug discovery and validation. Here, 2D culture and 3D mono- and stromal co-culture models of increasing complexity have been est...

journal_title：Scientific reports

authors： Stock K,Estrada MF,Vidic S,Gjerde K,Rudisch A,Santo VE,Barbier M,Blom S,Arundkar SC,Selvam I,Osswald A,Stein Y,Gruenewald S,Brito C,van Weerden W,Rotter V,Boghaert E,Oren M,Sommergruber W,Chong Y,de Hoogt R,Grae

更新日期：2016-07-01 00:00:00