Abstract：
:Porcine reproductive and respiratory syndrome virus (PRRSV) activates NF-κB during infection. We examined the ability of all 22 PRRSV genes for NF-κB regulation and determined the nucleocapsid (N) protein as the NF-κB activator. Protein inhibitor of activated STAT1 (signal transducer and activator of transcription 1) (PIAS1) was identified as a cellular protein binding to N. PIAS1 is known to bind to p65 (RelA) in the nucleus and blocks its DNA binding, thus functions as a repressor of NF-κB. Binding of N to PIAS1 released p65 for NF-κB activation. The N-terminal half of PIAS1 was mapped as the N-binding domain, and this region overlapped its p65-binding domain. For N, the region between 37 and 72 aa was identified as the binding domain to PIAS1, and this domain alone was able to activate NF-κB. A nuclear localization signal (NLS) knock-out mutant N did not activate NF-κB, and this is mostly likely due to the lack of its interaction with PIAS1 in the nucleus, demonstrating the positive correlation between the binding of N to PIAS1 and the NF-κB activation. Our study reveals a role of N in the nucleus for NF-κB activation and proinflammatory cytokine production during infection.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ke H,Lee S,Kim J,Liu HC,Yoo Ddoi
10.1038/s41598-019-47495-9subject
Has Abstractpub_date
2019-07-30 00:00:00pages
11042issue
1issn
2045-2322pii
10.1038/s41598-019-47495-9journal_volume
9pub_type
杂志文章abstract：:In this paper, we demonstrate the fabrication of conductive porous polymers based on foaming of an aqueous dispersion of polymeric particles and multi-walled carbon nanotubes (CNT). By tuning the surface energy of the constituents, we direct their preferential adsorption at the air-liquid (bubble) interface or within ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01770-9
更新日期：2017-05-11 00:00:00
abstract：:The American mink (Neovison vison) is a semiaquatic species of mustelid native to North America. It's an important animal for the fur industry. Many efforts have been made to locate genes influencing fur quality and color, but this search has been impeded by the lack of a reference genome. Here we present the first dr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15169-z
更新日期：2017-11-06 00:00:00
abstract：:The mechanism whereby lactic acid bacteria extend the lifespan of Caenorhabditis elegans has previously been elucidated. However, the role of Weissella species has yet not been studied. We show that Weissella koreensis and Weissella cibaria significantly (p < 0.05) extend the lifespan of C. elegans compared with Esche...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17128
更新日期：2015-11-25 00:00:00
abstract：:It is generally believed that anthropogenic aerosols cool the atmosphere; therefore, they offset the global warming resulting from greenhouse gases to some extent. Reduction in sulphate, a primary anthropogenic aerosol, is necessary for mitigating air pollution, which causes atmospheric warming. Here, the changes in t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78805-1
更新日期：2020-12-10 00:00:00
abstract：:Based on a panel of 30 provinces and a timeframe from January 2009 to December 2013, we estimate the association between monthly human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) incidence and the relevant Internet search query volumes in Baidu, the most widely used search engine among the Ch...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27413-1
更新日期：2018-06-13 00:00:00
abstract：:Reversible phosphorylation of proteins and the assembly of thylakoid complexes are the important protective mechanism against environmental stresses in plants. This research was aimed to investigate the different responses of the antioxidant defense system and photosystem II (PSII) to osmotic stress between drought-re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13145-1
更新日期：2017-10-05 00:00:00
abstract：:The extracellular matrix (ECM) impacts stem cell differentiation, but identifying formulations supportive of differentiation is challenging in 3D models. Prior efforts involving combinatorial ECM arrays seemed intuitively advantageous. We propose an alternative that suggests reducing sample size and technological burd...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18705
更新日期：2015-12-21 00:00:00
abstract：:Little is known about the relationship between soil microbial communities and soil properties in southern boreal forests. To further our knowledge about that relationship, we compared the soil samples in southern boreal forests of the Greater Khingan Mountains-the southernmost boreal forest biome in the world. The for...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79206-0
更新日期：2020-12-16 00:00:00
abstract：:Chronic lymphocytic leukaemia (CLL) is characterised by a heterogeneous clinical course. Such heterogeneity is associated with a number of markers, including TP53 gene inactivation. While TP53 gene alterations determine resistance to chemotherapy, it is not clear whether they can influence early disease progression. T...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75364-3
更新日期：2020-10-28 00:00:00
abstract：:The association of fasting glucose with the risk of death according to sex and age remains unclear, and insufficient information is available on sex- and age-specific glucose concentrations within ethnic groups. This study analyzed a sample of 12,455,361 Korean adults who participated in health examinations during 200...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08498-6
更新日期：2017-08-15 00:00:00
abstract：:Lnc2Catlas ( http://lnc2catlas.bioinfotech.org/ ) is an atlas of long noncoding RNAs (lncRNAs) associated with cancer risk. LncRNAs are a class of functional noncoding RNAs with lengths over 200 nt and play a vital role in diverse biological processes. Increasing evidence shows that lncRNA dysfunction is associated wi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20232-4
更新日期：2018-01-30 00:00:00
abstract：:Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease that is associated with the destruction of immune tolerance and activation of B cells. Interleukin (IL)-35 and IL-35-producing (IL-35+) regulatory B cells (Bregs) have been demonstrated to possess immunosuppressive functions, but their roles in t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49748-z
更新日期：2019-09-13 00:00:00
abstract：:The hair bundle of cochlear hair cells is the site of auditory mechanoelectrical transduction. It is formed by three rows of stiff microvilli-like protrusions of graduated heights, the short, middle-sized, and tall stereocilia. In developing and mature sensory hair cells, stereocilia are connected to each other by var...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73158-1
更新日期：2020-10-02 00:00:00
abstract：:Many studies have now consistently reported that the phase angle of ongoing oscillatory activity (measured using EEG/MEG), at time of stimulus presentation influences detection when stimuli are near-threshold. However, studies examining whether the adjustment of the phase angle of oscillations is under top-down attent...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20423-z
更新日期：2018-02-14 00:00:00
abstract：:Experts have the superior cognitive capability of quickly understanding complex information in their domain; however, little is known about the neural processes underlying this ability. Here, using a board game named shogi (Japanese chess), we investigated the brain activity in expert players that was involved in thei...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05894
更新日期：2014-07-31 00:00:00
abstract：:Mitigating climate change effects involves strategic decisions by individuals that may choose to limit their emissions at a cost. Everyone shares the ensuing benefits and thereby individuals can free ride on the effort of others, which may lead to the tragedy of the commons. For this reason, climate action can be conv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52524-8
更新日期：2019-11-07 00:00:00
abstract：:Global change is predicted to cause shifts in species distributions and biodiversity in arctic tundra. We applied factorial warming and nutrient manipulation to a nutrient and species poor alpine/arctic heath community for seven years. Vascular plant abundance in control plots increased by 31%. There were also notable...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10197
更新日期：2015-05-07 00:00:00
abstract：:The direct fabrication of microstructures, having a non-symmetrical morphology with controllable inclination, presents nowadays a challenging task. Natural examples of surfaces with inclined topographies have shown to provide anisotropic functionalities, which have attracted the interest of several researchers in the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41902-x
更新日期：2019-04-01 00:00:00
abstract：:Previously, we cloned a new gene termed 'tongue cancer resistance-associated protein 1' (TCRP1), which modulates tumorigenesis, enhances cisplatin (cDDP) resistance in cancers, and may be a potential target for reversing drug resistance. However, the mechanisms for regulating TCRP1 expression remain unclear. Herein, w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03763-0
更新日期：2017-06-16 00:00:00
abstract：:This study investigates the relationship between objective cognitive impairment (OCI), subjective cognitive complaints and depressive symptoms in men and women with classical and non-classical Fabry disease (FD). Cognitive functioning was assessed using a neuropsychological test battery, subjective cognitive complaint...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37320-0
更新日期：2019-01-17 00:00:00
abstract：:The pathophysiology of diabetic nephropathy (DN) in type 2 diabetes (T2D) patients is minimally understood. We compared untargeted high-resolution accurate mass (HRAM) orbitrap-based plasma metabolomic profiles of 31 T2D-DN (with estimated glomerular filtration rate ≤80 mL/min/1.73 m2), 29 T2D and 30 normal glucose to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54584-2
更新日期：2019-12-02 00:00:00
abstract：:Aberrant immune responses characterize autoimmune disorders like Rheumatoid Arthritis (RA) wherein lymphocytes are recognized as key players. Role of CD8+ T cells in RA has been less defined however we found that these cells are activated in RA patients with increased expression of cytolytic granules and inflammatory ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01033-7
更新日期：2017-04-19 00:00:00
abstract：:Reverse transcription quantitative-polymerase chain reaction (RT-qPCR) is a routine method for gene expression analysis, and reliable results depend on proper normalization by stable reference genes. Caloric restriction (CR) is a robust lifestyle intervention to slow aging and delay onset of age-associated diseases vi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38513
更新日期：2016-12-06 00:00:00
abstract：:Uncertainty in the form of risk or ambiguity can arise from the interaction with nature and other players, while strategic uncertainty arises only in interactions with others. Here, we systematically compare binary decisions between a safe option and a potentially higher paying but uncertain option in four experimenta...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21962-1
更新日期：2018-02-23 00:00:00
abstract：:The porosity and utilization of platinum catalysts have a direct impact on their performance within proton exchange membrane fuel cells. It is desirable to identify methods that can prepare these catalysts with the desired features, and that can be widely implemented using existing and industrially scalable techniques...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38855-6
更新日期：2019-03-11 00:00:00
abstract：:We report the temperature dependence of the dielectric function ε = ε1 + iε2 and critical point (CP) energies of biaxial α-SnS in the spectral energy region from 0.74 to 6.42 eV and temperatures from 27 to 350 K using spectroscopic ellipsometry. Bulk SnS was grown by temperature gradient method. Dielectric response fu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75383-0
更新日期：2020-10-27 00:00:00
abstract：:Because of their exceptional local-field enhancement and ultrasmall mode volume, plasmonic components can integrate photonics and electronics at nanoscale, and active control of plasmons is the key. However, all-optical modulation of plasmonic response with nanometer mode volume and unity modulation depth is still lac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24293
更新日期：2016-04-11 00:00:00
abstract：:The secreted frizzled-related protein 5 gene (SFRP5) that antagonize the Wnt/β-catenin signaling is frequently inactivated by promoter methylation and oncogenic activation of the Wnt signaling pathway is common in many cancers. The curcumin-rich Curcuma longa has been reported to potent anti-cancer property involved i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53509-3
更新日期：2019-11-21 00:00:00
abstract：:Peritrichs are a major group of ciliates with worldwide distribution. Yet, its internal phylogeny remains unresolved owing to limited sampling. Additionally, ecological distributions of peritrichs are poorly known. We performed substantially expanded phylogenetic analyses of peritrichs that incorporated SSU rDNA seque...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21695
更新日期：2016-02-16 00:00:00
abstract：:Several studies provide evidence of a link between vector-borne disease outbreaks and El Niño driven climate anomalies. Less investigated are the effects of the North Atlantic Oscillation (NAO). Here, we test its impact on outbreak occurrences of 13 infectious diseases over Europe during the last fifty years, controll...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01774
更新日期：2013-01-01 00:00:00
