Abstract：
:Chronic lymphocytic leukaemia (CLL) is characterised by a heterogeneous clinical course. Such heterogeneity is associated with a number of markers, including TP53 gene inactivation. While TP53 gene alterations determine resistance to chemotherapy, it is not clear whether they can influence early disease progression. To clarify this issue, TP53 mutations and deletions of the corresponding locus [del(17p)] were evaluated in 469 cases from the O-CLL1 observational study that recruited a cohort of clinically and molecularly characterised Binet stage A patients. Twenty-four cases harboured somatic TP53 mutations [accompanied by del(17p) in 9 cases], 2 patients had del(17p) only, and 5 patients had TP53 germ-line variants. While del(17p) with or without TP53 mutations was capable of significantly predicting the time to first treatment, a reliable measure of disease progression, TP53 mutations were not. This was true for cases with high or low variant allele frequency. The lack of predictive ability was independent of the functional features of the mutant P53 protein in terms of transactivation and dominant negative potential. TP53 mutations alone were more frequent in patients with mutated IGHV genes, whereas del(17p) was associated with the presence of adverse prognostic factors, including CD38 positivity, unmutated-IGHV gene status, and NOTCH1 mutations.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Monti P,Lionetti M,De Luca G,Menichini P,Recchia AG,Matis S,Colombo M,Fabris S,Speciale A,Barbieri M,Gentile M,Zupo S,Dono M,Ibatici A,Neri A,Ferrarini M,Fais F,Fronza G,Cutrona G,Morabito Fdoi
10.1038/s41598-020-75364-3subject
Has Abstractpub_date
2020-10-28 00:00:00pages
18427issue
1issn
2045-2322pii
10.1038/s41598-020-75364-3journal_volume
10pub_type
杂志文章abstract：:Recombinant protein and virus-like particle (VLP) production based on the baculovirus expression vector system is fast, flexible, and offers high yields. Independent from the product, a multitude of parameters are screened during process development/optimisation. Early development acceleration is a key requirement for...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57761-w
更新日期：2020-01-23 00:00:00
abstract：:Next generation sequencing (NGS) of DNAs amplified by rolling circle amplification from 6 tomato (Solanum lycopersicum) plants with leaf curl symptoms identified a number of monopartite begomoviruses, including Tomato yellow leaf curl virus (TYLCV), and a betasatellite (Tomato leaf curl betasatellite [ToLCB]). Both TY...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53106-4
更新日期：2019-11-12 00:00:00
abstract：:Color vision requires the activity of cone photoreceptors to be compared in post-receptoral circuitry. Decades of psychophysical measurements have quantified the nature of these comparative interactions on a coarse scale. How such findings generalize to a cellular scale remains unclear. To answer that question, we qua...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26754-1
更新日期：2018-06-04 00:00:00
abstract：:Macrophages are immune cells responsible for tissue debridement and fighting infection. Clofazimine, an FDA-approved antibiotic, accumulates and precipitates as rod-shaped, crystal-like drug inclusions within macrophage lysosomes. Drug treatment as well as pathophysiological states could induce changes in macrophage m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42180-3
更新日期：2019-04-05 00:00:00
abstract：:Human motor skill learning is driven by the necessity to adapt to new situations. While supportive contacts are essential for many tasks, little is known about their impact on motor learning. To study the effect of contacts an innovative full-body experimental paradigm was established. The task of the subjects was to ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28455
更新日期：2016-06-22 00:00:00
abstract：:Our previous studies indicated that combination of Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and PPARγ ligand Troglitazone (TZD), can induce significant apoptosis in various TRAIL-resistant prostate and hepatocellular carcinoma (HCC) cells. These also suggested serine/threonine kinase AMP-activat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23780-x
更新日期：2018-04-03 00:00:00
abstract：:Adaptive responses to hypoxia regulate hepatic lipid metabolism, but their consequences in nonalcoholic fatty liver disease (NAFLD) are largely unknown. Here, we show that hypoxia inducible factor-1 (HIF-1), a key determinant of hypoxic adaptations, prevents excessive hepatic lipid accumulation in the progression of N...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32586-w
更新日期：2018-09-21 00:00:00
abstract：:We here investigated whether the unique capacity of mesenchymal stem cells (MSCs) to re-establish tissue homeostasis depends on their potential to sense danger associated molecular pattern (DAMP) and to mount an adaptive response in the interest of tissue repair. Unexpectedly, after injection of MSCs which had been pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24425-9
更新日期：2018-04-18 00:00:00
abstract：:We have developed an optimized protocol for plasma targeted mRNA sequencing in our previous study. Here, we performed plasma targeted mRNA sequencing for 40 colorectal adenoma patients and 39 colonoscopy-proven normal controls in order to find potential circulating mRNA markers for colorectal adenoma. Results showed t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49445-x
更新日期：2019-09-10 00:00:00
abstract：:Tomato spotted wilt virus is a wide-spread plant disease in the world. It can threaten thousands of plants with a persistent and propagative manner. Early disease detection is expected to be able to control the disease spread, to facilitate management practice, and further to guarantee accompanying economic benefits. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40066-y
更新日期：2019-03-13 00:00:00
abstract：:According to the Source Monitoring Framework, the origin of a memory is remembered through the retrieval of specific features (e.g. perceptive, sensitive, affective signals). In two source discrimination tasks, we studied the ability of cuttlefish to remember the modality in which an item had been presented several ho...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62335-x
更新日期：2020-03-25 00:00:00
abstract：:In a 250-kyr transient simulation of the Community Earth System Model (CESM), we identified a precessional forced seesaw of the summer middle-upper tropospheric eddy temperature between Asia and the North Pacific as the paleo-APO (Asian-Pacific oscillation). The paleo-APO variability is out of phase with the precessio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28349
更新日期：2016-07-06 00:00:00
abstract：:Although extensive studies have focused on the development of acute mountain sickness (AMS), the exact mechanisms of AMS are still obscure. In this study, we used isobaric tags for relative and absolute quantitation (iTRAQ) proteomic analysis to identify novel AMS-associated biomarkers in human plasma. After 9 hours o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19818-9
更新日期：2018-01-19 00:00:00
abstract：:We report on the first observation of 'Spoof' Surface Plasmon Polariton (SPP) scattering from surface defects on metal-coated 3D printed, corrugated THz waveguiding surfaces. Surface defects, a result of the printing process, are shown to assist the direct coupling of the incident free-space radiation into a spoof SPP...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42412-6
更新日期：2019-04-18 00:00:00
abstract：:Unexpectedly large ocean waves or 'rogues' are sometimes claimed to be the cause of damage to ships at sea and to offshore structures. While wind-driven wave models are capable of predicting the average characteristics of waves, the maximum height of rogues that may occur is yet unknown. Rogues form in the open ocean ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44124
更新日期：2017-03-08 00:00:00
abstract：:The synthetic cyclic hexapeptide cWFW (cyclo(RRRWFW)) has a rapid bactericidal activity against both Gram-positive and Gram-negative bacteria. Its detailed mode of action has, however, remained elusive. In contrast to most antimicrobial peptides, cWFW neither permeabilizes the membrane nor translocates to the cytoplas...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44332
更新日期：2017-03-09 00:00:00
abstract：:Agrellite, NaCa2Si4O10F, is a tubular silicate mineral which crystal structure is characterized by extended [Si8O20]8- tubes and has a two-dimensional channel system. The mineral is a representative of a complex silicate family which contains some structural voids but cannot be considered as microporous because of sma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72631-1
更新日期：2020-09-23 00:00:00
abstract：:In situ tissue engineering within a stroke cavity is gradually emerging as a novel therapeutic paradigm. Considering the varied lesion topology within each subject, the placement and distribution of cells within the lesion cavity is challenging. The use of multiple cell types to reconstruct damaged tissue illustrates ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14597
更新日期：2015-09-30 00:00:00
abstract：:Although most papillary thyroid carcinomas (PTCs) have a good prognosis, a small but certain fraction shows aggressive behavior. Therefore, a novel and well-performing molecular marker is needed. In the present study, we assessed the impact of the combination of the TERT promoter/BRAF mutations and Ki-67 labeling inde...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41752
更新日期：2017-02-02 00:00:00
abstract：:The ability to extract the direction of the other's gaze allows us to shift our attention to an object of interest to the other and to establish joint attention. By mapping one's own intentions on the object of joint attention, humans develop a Theory of (the other's) Mind (TOM), a functional sequence possibly disrupt...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51783-9
更新日期：2019-10-25 00:00:00
abstract：:Atropa acuminata Royle Ex Lindl (Atropa acuminata) under tremendous threat of extinction in its natural habitat. However, the antimicrobial, antileishmanial and anticancer effects of the plant's extracts have not been reported yet. In the current study, an attempt has been made to evaluate the pharmacological potentia...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29231-x
更新日期：2018-07-23 00:00:00
abstract：:Knowledge of the structure-property-function relationship of humic substances (HSs) is key for understanding their role in soil. Despite progress, studies on this topic are still under discussion. We analyzed 37 humic fractions with respect to their isotopic composition, structural characteristics, and properties resp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20798
更新日期：2016-02-10 00:00:00
abstract：:We investigate the behaviour of the recently proposed Quantum PageRank algorithm, in large complex networks. We find that the algorithm is able to univocally reveal the underlying topology of the network and to identify and order the most relevant nodes. Furthermore, it is capable to clearly highlight the structure of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02773
更新日期：2013-10-04 00:00:00
abstract：:We have studied both experimentally and theoretically the reprogrammable spin wave band structure in Permalloy(10 nm)/Cu(5 nm)/Permalloy(30 nm) nanowire arrays of width w = 280 nm and inter-wire separation in the range from 80 to 280 nm. We found that, depending on the inter-wire separation, the anti-parallel configur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40131-6
更新日期：2019-03-15 00:00:00
abstract：:Studies of past human-landscape interactions rely upon the integration of archaeological, biological and geological information within their geographical context. However, detecting the often ephemeral traces of human activities at a landscape scale remains difficult with conventional archaeological field survey. Geop...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01517
更新日期：2013-01-01 00:00:00
abstract：:Mutations affecting the transcription factor FOXP2 cause a rare form of severe speech and language disorder. Although it is clear that sufficient FOXP2 expression is crucial for normal brain development, little is known about how this transcription factor is regulated. To investigate post-translational mechanisms for ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20911
更新日期：2016-02-12 00:00:00
abstract：:The proteolytic system of Lactobacillus plays an essential role in bacterial growth, contributes to the flavor development of fermented products, and can release bioactive health-beneficial peptides during milk fermentation. In this work, a genomic analysis of all genes involved in the proteolytic system of L. delbrue...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09124-1
更新日期：2017-08-17 00:00:00
abstract：:Biomass waste products from green algae have recently been given new life, as these polysaccharides have potential applications in industry, agriculture, and medicine. One such polysaccharide group called ulvans displays many different, potentially useful properties that arise from their structural versatility. Hence,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44115
更新日期：2017-03-22 00:00:00
abstract：:Iron deposits are a phenotypic trait of tumor-associated macrophages (TAMs). Histological iron imaging and contrast-agent free magnetic resonance imaging (MRI) can detect these deposits, but their presence in human cancer, and correlation with immunotherapeutic response is largely untested. Here, primarily using thes...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37408-7
更新日期：2019-01-29 00:00:00
abstract：:Baroreflex dysfunction is a diffuse chronic condition that is expected to be followed by a profound loss of organization of BP and HR variability. Nevertheless, long-term effects of baroreflex withdrawal are still debated. Aim of our work was to study BP and HR changes long term after sino-aortic denervation (SAD). In...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37970-0
更新日期：2019-02-04 00:00:00
