Interaction of protocadherin-15 with the scaffold protein whirlin supports its anchoring of hair-bundle lateral links in cochlear hair cells.

abstract：:The 3D MHD nonlinear radiative hybrid nanofluid flow across an irregular dimension sheet with slip effect is studied numerically. The hybrid nanofluid consists of copper oxide (CuO) and magnesium oxide (MgO) nanoparticles embedded in methanol or methyl alcohol (MA). The governing PDEs' are altered as ODEs' using simil...

journal_title：Scientific reports

authors： Tlili I,Nabwey HA,Samrat SP,Sandeep N

更新日期：2020-06-08 00:00:00

abstract：:The remineralization mechanism in dental caries lesions is not completely understood. This study reports on ultrastructural and chemical changes observed within arrested caries lesions. Carious human teeth were observed using scanning electron microscopy (SEM) and focused-ion-beam (FIB)-SEM. The crystals detected in t...

journal_title：Scientific reports

authors： Yoshihara K,Nagaoka N,Nakamura A,Hara T,Hayakawa S,Yoshida Y,Van Meerbeek B

更新日期：2020-03-09 00:00:00

abstract：:This work reports a facile method for preparing the new photoactive In(2)O(3) films as well as their implementation in photoelectrochemical (PEC) application. We firstly investigated the relationship between oxygen vacancies (V(O)) and PEC performance and revealed a rule between them. We found that the optimized In(2)...

journal_title：Scientific reports

authors： Gan J,Lu X,Wu J,Xie S,Zhai T,Yu M,Zhang Z,Mao Y,Wang SC,Shen Y,Tong Y

更新日期：2013-01-01 00:00:00

abstract：:Promoter CpG methylation is a fundamental regulatory process of gene expression. TET proteins are active CpG demethylases converting 5-methylcytosine to 5-hydroxymethylcytosine, with loss of 5 hmC as an epigenetic hallmark of cancers, indicating critical roles of TET proteins in epigenetic tumorigenesis. Through analy...

journal_title：Scientific reports

authors： Li L,Li C,Mao H,Du Z,Chan WY,Murray P,Luo B,Chan AT,Mok TS,Chan FK,Ambinder RF,Tao Q

更新日期：2016-05-26 00:00:00

abstract：:Dysregulation of the ubiquitin proteasome system (UPS) has been linked to schizophrenia but it is not clear if this dysregulation is detectable in both brain and blood. We examined free mono-ubiquitin, ubiquitinated proteins, catalytic ubiquitination, and proteasome activities in frozen postmortem OFC tissue from 76 (...

journal_title：Scientific reports

authors： Bousman CA,Luza S,Mancuso SG,Kang D,Opazo CM,Mostaid MS,Cropley V,McGorry P,Shannon Weickert C,Pantelis C,Bush AI,Everall IP

更新日期：2019-02-19 00:00:00

abstract：:Leishmaniases are an ensemble of diseases caused by the protozoan parasite of the genus Leishmania. Current antileishmanial treatments are limited and present main issues of toxicity and drug resistance emergence. Therefore, the generation of new inhibitors specifically directed against a leishmanial target is an attr...

journal_title：Scientific reports

authors： Mao W,Daligaux P,Lazar N,Ha-Duong T,Cavé C,van Tilbeurgh H,Loiseau PM,Pomel S

更新日期：2017-04-07 00:00:00

abstract：:The FGFR4-388Arg variant has been related to poor prognosis in several types of cancer, including lung cancer. The mechanism underlying this association has not been addressed in detail in patients with this pathology. Here, we report that this FGFR4 variant induces MAPK and STAT3 activation and causes pro-oncogenic e...

journal_title：Scientific reports

authors： Quintanal-Villalonga Á,Ojeda-Márquez L,Marrugal Á,Yagüe P,Ponce-Aix S,Salinas A,Carnero A,Ferrer I,Molina-Pinelo S,Paz-Ares L

更新日期：2018-02-05 00:00:00

abstract：:Vascular leakage is a life-threatening complication of dengue virus (DENV) infection. Previously, association between "paracellular" endothelial hyperpermeability and plasma leakage had been extensively investigated. However, whether "transcellular" endothelial leakage is involved in dengue hemorrhagic fever (DHF) and...

journal_title：Scientific reports

authors： Chanthick C,Kanlaya R,Kiatbumrung R,Pattanakitsakul SN,Thongboonkerd V

更新日期：2016-08-22 00:00:00

abstract：:Phelan McDermid Syndrome (PMDS) is a genetic disorder characterized by features of Autism spectrum disorders. Similar to reports of Zn deficiency in autistic children, we have previously reported high incidence of Zn deficiency in PMDS. However, the underlying mechanisms are currently not well understood. Here, using ...

journal_title：Scientific reports

authors： Pfaender S,Sauer AK,Hagmeyer S,Mangus K,Linta L,Liebau S,Bockmann J,Huguet G,Bourgeron T,Boeckers TM,Grabrucker AM

更新日期：2017-03-27 00:00:00

abstract：:Most Atlantic hurricanes form in the Main Development Region between 9°N to 20°N along the northern edge of the Intertropical Convergence Zone (ITCZ). Previous research has suggested that meridional shifts in the ITCZ position on geologic timescales can modulate hurricane activity, but continuous and long-term storm r...

journal_title：Scientific reports

authors： van Hengstum PJ,Donnelly JP,Fall PL,Toomey MR,Albury NA,Kakuk B

更新日期：2016-02-24 00:00:00

abstract：:Emergence of drug-resistant strains of the pathogen Mycobacterium tuberculosis (Mtb) and the ineffectiveness of BCG in curtailing Mtb infection makes vaccine development for tuberculosis an important objective. Identifying immunogenic CD8+ T cell peptide epitopes is necessary for peptide-based vaccine strategies. We p...

journal_title：Scientific reports

authors： Nair SK,Tomaras GD,Sales AP,Boczkowski D,Chan C,Plonk K,Cai Y,Dannull J,Kepler TB,Pruitt SK,Weinhold KJ

更新日期：2014-04-23 00:00:00

abstract：:Haber-Bosch nitrogen (N) has been increasingly used in industrial products, e.g., nylon, besides fertilizer. Massive numbers of species of industrial reactive N (Nr) have emerged and produced definite consequences but receive little notice. Based on a comprehensive inventory, we show that (1) the industrial N flux has...

journal_title：Scientific reports

authors： Gu B,Chang J,Min Y,Ge Y,Zhu Q,Galloway JN,Peng C

更新日期：2013-01-01 00:00:00

abstract：:Cenozoic plant relicts are those groups that were once widespread in the Northern Hemisphere but are now restricted to some small isolated areas as a result of drastic climatic changes. They are good proxies to study how plants respond to climatic changes since their modern climatic requirements are known. Herein we l...

journal_title：Scientific reports

authors： Huang Y,Jacques FM,Su T,Ferguson DK,Tang H,Chen W,Zhou Z

更新日期：2015-09-15 00:00:00

abstract：:An atmospheric component of the Philippine-Taiwan Oscillations (PTOa) is used to examine its potential connection with tropical cyclone (TC) frequency in the western North Pacific in the period of 1979-2014. During positive PTOa years, more TCs are observed in the tropical western Pacific south of 18 °N where cyclonic...

journal_title：Scientific reports

authors： Chang YK,Miyazawa Y,Kodaira T,Behera S

更新日期：2018-11-29 00:00:00

abstract：:Stimuli presented at short temporal delays before functional magnetic resonance imaging (fMRI) can have a robust impact on the organization of synchronous activity in resting state networks. This presents an opportunity to investigate how sensory, affective and cognitive stimuli alter functional connectivity in rodent...

journal_title：Scientific reports

authors： Pompilus M,Colon-Perez LM,Grudny MM,Febo M

更新日期：2020-11-16 00:00:00

abstract：:The understanding of the relationship between topology and behaviour in interconnected networks would allow to charac- terise and predict behaviour in many real complex networks since both are usually not simultaneously known. Most previous studies have focused on the relationship between topology and synchronisation....

journal_title：Scientific reports

authors： Baptista MS,Szmoski RM,Pereira RF,Pinto SE

更新日期：2016-03-04 00:00:00

abstract：:Bark beetles often serve as forest damaging agents, causing landscape-level mortality. Understanding the biology and ecology of beetles are important for both, gathering knowledge about important forest insects and forest protection. Knowledge about the bark beetle gut-associated bacteria is one of the crucial yet sur...

journal_title：Scientific reports

authors： Chakraborty A,Ashraf MZ,Modlinger R,Synek J,Schlyter F,Roy A

更新日期：2020-10-29 00:00:00

abstract：:Three-dimensional (3D) cell cultures produce more in vivo-like multicellular structures such as spheroids that cannot be obtained in two-dimensional (2D) cell cultures. Thus, they are increasingly employed as models for cancer and drug research, as well as tissue engineering. It has proven challenging to stabilize sph...

journal_title：Scientific reports

authors： Lou YR,Kanninen L,Kaehr B,Townson JL,Niklander J,Harjumäki R,Jeffrey Brinker C,Yliperttula M

更新日期：2015-09-01 00:00:00

abstract：:Topological objects of nontrivial spin or dipolar field textures, such as skyrmions, merons, and vortices, interacting with applied external fields in ferroic materials are of great scientific interest as an intriguing playground of unique physical phenomena and novel technological paradigms. The quest for new topolog...

journal_title：Scientific reports

authors： Shimada T,Lich LV,Nagano K,Wang JS,Wang J,Kitamura T

更新日期：2016-10-07 00:00:00

abstract：:Rotaviruses (RVs) are the most common cause of severe diarrheal disease. To date two rotavirus oral vaccines are licensed: Rotarix and Rotateq. Our aim was to contribute to the post-marketing evaluation of these vaccines safety profile. We collected all RV vaccines-related reports of Adverse Events Following Immunizat...

journal_title：Scientific reports

authors： Bonaldo G,Noseda R,Ceschi A,Vaccheri A,Motola D

更新日期：2020-08-12 00:00:00

abstract：:Corticofugal fibers target the subthalamic nucleus (STN), a component nucleus of the basal ganglia, in addition to the striatum, their main input. The cortico-subthalamic, or hyperdirect, pathway, is thought to supplement the cortico-striatal pathways in order to interrupt/change planned actions. To explore the previo...

journal_title：Scientific reports

authors： Froux L,Le Bon-Jego M,Miguelez C,Normand E,Morin S,Fioramonti S,Barresi M,Frick A,Baufreton J,Taupignon A

更新日期：2018-06-11 00:00:00

abstract：:Intrasynovial tendon injuries are among the most challenging in orthopedics. Despite significant improvements in operative and rehabilitation methods, functional outcomes continue to be limited by adhesions, gap formation, and rupture. Adhesions result from excessive inflammation, whereas tendon gapping and rupture re...

journal_title：Scientific reports

authors： Shen H,Jayaram R,Yoneda S,Linderman SW,Sakiyama-Elbert SE,Xia Y,Gelberman RH,Thomopoulos S

更新日期：2018-07-23 00:00:00

abstract：:Direct estimation of Lagrangian turbulence statistics is essential for the proper modeling of dispersion and transport in highly obstructed canopy flows. However, Lagrangian flow measurements demand very high rates of data acquisition, resulting in bottlenecks that prevented the estimation of Lagrangian statistics in ...

journal_title：Scientific reports

authors： Shnapp R,Shapira E,Peri D,Bohbot-Raviv Y,Fattal E,Liberzon A

更新日期：2019-05-15 00:00:00

abstract：:It is well known that haem serves as the prosthetic group of various haemoproteins that function in oxygen transport, respiratory chain, and drug metabolism. However, much less is known about the functions of the catabolites of haem in mammalian cells. Haem is enzymatically degraded to iron, carbon monoxide (CO), and ...

journal_title：Scientific reports

authors： Takeda TA,Mu A,Tai TT,Kitajima S,Taketani S

更新日期：2015-05-20 00:00:00

abstract：:We report low-temperature solution-processed p-CuO nanorods (NRs)/n-ZnO NRs heterojunction light emitting diode (LED), exploiting the native point defects of ZnO NRs. ZnO NRs were synthesized at 90 °C by using hydrothermal method while CuO NRs were synthesized at 100 °C by using microwave reaction system. The electric...

journal_title：Scientific reports

authors： Biswas P,Baek SD,Lee SH,Park JH,Lee SJ,Lee TI,Myoung JM

更新日期：2015-12-09 00:00:00

abstract：:Microneedles, fabricated by nano-moulding technology show great promise in the field of drug delivery by enabling the painless self-administration of drugs in a patient-friendly manner. In this study, double-stranded salmon DNA (SDNA) was used as both a drug-delivery vehicle and structural material with a microneedle ...

journal_title：Scientific reports

authors： Lee Y,Dugansani SR,Jeon SH,Hwang SH,Kim JH,Park SH,Jeong JH

更新日期：2017-08-29 00:00:00

abstract：:The platinum-based chemotherapeutic agent, oxaliplatin, is used to treat advanced colorectal cancer (CRC). Unfortunately, nearly all patients acquire resistance to oxaliplatin after long-term use, limiting its therapeutic efficacy. Since COX-2 and PGE2 signaling can impact colon cancer cell proliferation and survival,...

journal_title：Scientific reports

authors： Huang H,Aladelokun O,Ideta T,Giardina C,Ellis LM,Rosenberg DW

更新日期：2019-03-20 00:00:00

abstract：:Many cardiac pathologies involve changes in tissue structure. Conventional analysis of structural features is extremely time-consuming and subject to observer bias. The possibility to determine spatial interrelations between these features is often not fully exploited. We developed a staining protocol and an ImageJ-ba...

journal_title：Scientific reports

authors： Winters J,von Braunmuhl ME,Zeemering S,Gilbers M,Brink TT,Scaf B,Guasch E,Mont L,Batlle M,Sinner M,Hatem S,Mansour MK,Fabritz L,Sommerfeld LC,Kirchhof P,Isaacs A,Stoll M,Schotten U,Verheule S

更新日期：2020-11-18 00:00:00

abstract：:Insects are extremely successful animals whose odor perception is very prominent due to their sophisticated olfactory system. The main chemosensory organ, antennae play a critical role in detecting odor in ambient environment before initiating appropriate behavioral responses. The antennal chemosensory receptor genes ...

journal_title：Scientific reports

authors： Ahmed T,Zhang T,Wang Z,He K,Bai S

更新日期：2016-04-19 00:00:00

abstract：:Interleukin-8 (IL-8) as an important cytokine involving in inflammatory and immune response, has been studied as effective adjuvants for vaccines in mammals. However, there are fewer reports about the characterization and adjuvant effects of IL-8 in fish. In this study, cloning and sequence analysis of IL-8 coding reg...

journal_title：Scientific reports

authors： Wang E,Wang J,Long B,Wang K,He Y,Yang Q,Chen D,Geng Y,Huang X,Ouyang P,Lai W

更新日期：2016-07-04 00:00:00