Abstract：
:In the highly interconnected architectures of the cerebral cortex, recurrent intracortical loops disproportionately outnumber thalamo-cortical inputs. These networks are also capable of generating neuronal activity without feedforward sensory drive. It is unknown, however, what spatiotemporal patterns may be solely attributed to intrinsic connections of the local cortical network. Using high-density microelectrode arrays, here we show that in the isolated, primary somatosensory cortex of mice, neuronal firing fluctuates on timescales from milliseconds to tens of seconds. Slower firing fluctuations reveal two spatially distinct neuronal ensembles, which correspond to superficial and deeper layers. These ensembles are anti-correlated: when one fires more, the other fires less and vice versa. This interplay is clearest at timescales of several seconds and is therefore consistent with shifts between active sensing and anticipatory behavioral states in mice.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kodama NX,Feng T,Ullett JJ,Chiel HJ,Sivakumar SS,Galán RFdoi
10.1038/s41598-017-18097-0subject
Has Abstractpub_date
2018-01-12 00:00:00pages
666issue
1issn
2045-2322pii
10.1038/s41598-017-18097-0journal_volume
8pub_type
杂志文章abstract：:The therapeutic management and health challenges caused by atrial fibrillation (AF) differ between different groups. The purpose of this study was to investigate the clinical features of patients hospitalized with AF and to explore the use of anticoagulation treatments in Han and Uygur patients in Xinjiang, northwest ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45884
更新日期：2017-04-10 00:00:00
abstract：:The current study was conducted to assess the effects of microinjection of different dosages of guide RNA (gRNA)/Cas9 protein on the mutation rate, embryo survival, embryonic development, hatchability and early fry survival in channel catfish, Ictalurus punctatus. Guide RNAs targeting two of the channel catfish immune...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34738-4
更新日期：2018-11-07 00:00:00
abstract：:PCR inhibitors in clinical specimens negatively affect the sensitivity of diagnostic PCR and RT-PCR or may even cause false-negative results. To overcome PCR inhibition, increase the sensitivity of the assays and simplify the detection protocols, simple methods based on quantitative nested real-time PCR and RT-PCR wer...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21224-0
更新日期：2018-02-21 00:00:00
abstract：:Satellite aerosol optical depth (AOD) is widely used to estimate particulate matter with aerodynamic diameter ≤2.5 µm (PM2.5) mass concentrations. Polar orbiting satellite retrieval 1-2 times each day is frequently affected by cloud, snow cover or misclassification of heavy pollution. Novel methods are therefore requi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28535-2
更新日期：2018-07-05 00:00:00
abstract：:The pentameric serum IgMs are critical to immune defense and surveillance through cytotoxicity against microbes and nascent cancer cells. Ficolins, a group of oligomeric lectins with an overall structure similar to C1q and mannose-binding lectin (MBL) participate in microbe infection and apoptotic cell clearance by ac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07824
更新日期：2015-01-16 00:00:00
abstract：:Cellular interactions can be modeled as complex dynamical systems represented by weighted graphs. The functionality of such networks, including measures of robustness, reliability, performance, and efficiency, are intrinsically tied to the topology and geometry of the underlying graph. Utilizing recently proposed geom...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12323
更新日期：2015-07-14 00:00:00
abstract：:A chronic antigenic stimulation is believed to sustain the leukemogenic development of chronic lymphocytic leukemia (CLL) and most of lymphoproliferative malignancies developed from mature B cells. Reproducing a proliferative stimulation ex vivo is critical to decipher the mechanisms of leukemogenesis in these maligna...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36853-8
更新日期：2019-01-24 00:00:00
abstract：:Multilevel severe compressive myelopathy is a challenging disorder for the surgeons, the aim of this study is to assess the efficacy and safety of a newly designed ultrasonic burr as an assistant tool to the ultrasonic scalpel in laminectomy for this disease. This is a retrospective comparative study, the included sub...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22454-y
更新日期：2018-03-05 00:00:00
abstract：:A single closed-form analytical solution of the driven nonlinear Schrödinger equation is developed, reproducing a large class of the behaviors in Kerr-comb systems, including bright-solitons, dark-solitons, and a large class of periodic wavetrains. From this analytical framework, a Kerr-comb area theorem and a pump-de...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24742
更新日期：2016-04-25 00:00:00
abstract：:In this paper, we analyze the synchronization problem of master-slave probabilistic Boolean networks (PBNs). The master Boolean network (BN) is a deterministic BN, while the slave BN is determined by a series of possible logical functions with certain probability at each discrete time point. In this paper, we firstly ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13437
更新日期：2015-08-28 00:00:00
abstract：:Urban coach cabin is an important indoor environment for long journey, formaldehyde (HCHO) is a carcinogenic gas and damages indoor air quality of cabins. In order to control the HCHO pollution, the air samples inside cabins were analysed with a thermally desorbed gas chromatograph, and the HCHO diffusion was simulate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-57263-4
更新日期：2020-01-15 00:00:00
abstract：:We report on an angle resolved photoemission (ARPES) study of bulk electron-doped perovskite iridate, (Sr(1-x)La(x))3Ir2O7. Fermi surface pockets are observed with a total electron count in keeping with that expected from La substitution. Depending on the energy and polarization of the incident photons, these pockets ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08533
更新日期：2015-02-23 00:00:00
abstract：:SRY, a sex-determining gene, induces testis development in chromosomally female (XX) individuals. However, mouse XX Sertoli cells carrying Sry (XX/Sry Sertoli cells) are incapable of fully supporting germ cell development, even when the karyotype of the germ cells is XY. While it has therefore been assumed that XX/Sry...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41912
更新日期：2017-02-02 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-28707-0
更新日期：2018-08-07 00:00:00
abstract：:Corticosteroids may produce a paradoxical worsening of myasthenia gravis (MG) symptoms within the first weeks of treatment. We therefore wanted to assess the hypothesis that a prior infusion of intravenous immunoglobulin (IVIG) may have a protective effect. Our primary objectives were to show that the coadministration...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-020-70539-4
更新日期：2020-08-11 00:00:00
abstract：:This retrospective study was undertaken to identify predictors for the development of hypocalcaemia even with prophylactic administration of calcium and vitamin D, and to help guide future strategies to improve the safety, efficacy, and QOL of patients receiving denosumab. Between January 2016 and February 2020, a tot...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80243-y
更新日期：2021-01-13 00:00:00
abstract：:Society's increasing interactions with technology are creating extensive "digital traces" of our collective human behavior. These new data sources are fuelling the rapid development of the new field of computational social science. To investigate user attention to the Hurricane Sandy disaster in 2012, we analyze data ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03141
更新日期：2013-11-05 00:00:00
abstract：:In this work, a broadband and broad-angle polarization-independent random coding metasurface structure is proposed for radar cross section (RCS) reduction. An efficient genetic algorithm is utilized to obtain the optimal layout of the unit cells of the metasurface to get a uniform backscattering under normal incidence...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40782
更新日期：2017-01-20 00:00:00
abstract：:We aimed to develop a brief, preclinical test to screen the reduced hippocampal volume that is a marker of early dementia [Cognitive Quotient (CQ) test]. We performed an observational study of adult subjects who underwent brain MRI in seven institutions from February 2018 to May 2019. The CQ test consists of five comp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74019-7
更新日期：2020-10-07 00:00:00
abstract：:Sensitive in situ detection of organic molecules is highly demanded in environmental monitoring. In this work, the surface enhanced Raman spectroscopy (SERS) is adopted in microfluidics to detect the organic molecules with high accuracy and high sensitivity. Here the SERS substrate in microchannel consists of Ag nanop...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53478-7
更新日期：2019-11-27 00:00:00
abstract：:A facile green route has been employed for the synthesis of ZnO and Ag-doped ZnO using Cannabis sativa as a reducing and stabilizing agent. The as-synthesized nanoparticles were characterized and tested for photocatalytic dye degradation and antimicrobial activity. The results suggested that nanoparticles have shown a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64419-0
更新日期：2020-05-12 00:00:00
abstract：:Beta-glucans are a heterologous group of fibrous glucose polymers that are a major constituent of cell walls in Ascomycetes and Basidiomycetes fungi. Synthesis of β (1,3)- and (1,6)-glucans is coordinated with fungal cell growth and development, thus, is under tight genetic regulation. Here, we report that β-glucan sy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10199
更新日期：2015-05-11 00:00:00
abstract：:Sesame is prized for its oil. Genetic improvement of sesame can be enhanced through marker-assisted breeding. However, few simple sequence repeat (SSR) markers and SSR-based genetic maps were available in sesame. In this study, 7,357 SSR markers were developed from the sesame genome and transcriptomes, and a genetic m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08858-2
更新日期：2017-08-21 00:00:00
abstract：:Monolayer molybdenum disulfide (MoS2) has recently attracted intense interests due to its remarkable optical properties of valley-selected optical response, strong nonlinear wave mixing and photocurrent/photovoltaic generation and many corresponding potential applications. However, the nature of atomic-thin thickness ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23626
更新日期：2016-03-31 00:00:00
abstract：:A toolbox for the quantum simulation of polarons in ultracold atoms is presented. Motivated by the impressive experimental advances in the area of ultracold atomic mixtures, we theoretically study the problem of ultracold atomic impurities immersed in a Bose-Einstein condensate mixture (BEC). The coupling between impu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02398-5
更新日期：2017-05-24 00:00:00
abstract：:Magnetic resonance imaging (MRI) has evolved into an outstandingly versatile diagnostic modality, as it has the ability to non-invasively produce detailed information on a tissue's structure and function. Complementary data is normally obtained in separate measurements, either as contrast-weighted images, which are fa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44832-w
更新日期：2019-06-11 00:00:00
abstract：:Preclinical studies show that the dopamine D3 receptor (D3R) is involved in the reinstatement of drug seeking and motivation for drugs of abuse. A D3R gene variant, Ser9Gly (rs6280) has been linked to nicotine dependence, yet the mechanisms underlying its involvement in nicotine dependence is unclear. This study inves...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60940-4
更新日期：2020-03-05 00:00:00
abstract：:The dynamics of networks of neuronal cultures has been recently shown to be strongly dependent on the network geometry and in particular on their dimensionality. However, this phenomenon has been so far mostly unexplored from the theoretical point of view. Here we reveal the rich interplay between network geometry and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28236-w
更新日期：2018-07-02 00:00:00
abstract：:Diabetes is expected to accelerate age-related ganglion cell-inner plexiform layer (GC-IPL) loss, but there is limited information on the rate of reduction in GC-IPL thicknesses. We aimed to evaluate the reduction rate of GC-IPL thickness in diabetic patients, and to compare the rates between patients without and with...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58465-x
更新日期：2020-01-30 00:00:00
abstract：:The influenza virus neuraminidase (NA) is essential for the virus life cycle. The rise of resistance mutations against current antiviral therapies has increased the need for the development of novel inhibitors. Recent efforts have targeted a cavity adjacent to the catalytic site (the 150-cavity) in addition to the pri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02871
更新日期：2013-10-16 00:00:00
