Abstract：
:A single closed-form analytical solution of the driven nonlinear Schrödinger equation is developed, reproducing a large class of the behaviors in Kerr-comb systems, including bright-solitons, dark-solitons, and a large class of periodic wavetrains. From this analytical framework, a Kerr-comb area theorem and a pump-detuning relation are developed, providing new insights into soliton- and wavetrain-based combs along with concrete design guidelines for both. This new area theorem reveals significant deviation from the conventional soliton area theorem, which is crucial to understanding cavity solitons in certain limits. Moreover, these closed-form solutions represent the first step towards an analytical framework for wavetrain formation, and reveal new parameter regimes for enhanced Kerr-comb performance.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Renninger WH,Rakich PTdoi
10.1038/srep24742subject
Has Abstractpub_date
2016-04-25 00:00:00pages
24742issn
2045-2322pii
srep24742journal_volume
6pub_type
杂志文章abstract：:Cisplatin (CDDP) is potent anticancer agent used for several tumor types. Thymoquinone (TQ) is naturally occurring compound drawing great attention as anticancer and chemomodulator for chemotherapies. Herein, we studied the potential cytotoxicity of thymoquinone, CDDP and their combination against human oral squamous ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13357-5
更新日期：2017-10-13 00:00:00
abstract：:The biological functions of nitric oxide (NO) depend on its concentration, and excessive levels of NO induce various harmful situations known as nitrosative stress. Therefore, organisms possess many kinds of strategies to regulate the intracellular NO concentration and/or to detoxify excess NO. Here, we used genetic s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62890-3
更新日期：2020-04-07 00:00:00
abstract：:SHH Medulloblastoma (SHH-MB) is a pediatric brain tumor characterized by an inappropriate activation of the developmental Hedgehog (Hh) signaling. SHH-MB patients treated with the FDA-approved vismodegib, an Hh inhibitor that targets the transmembrane activator Smoothened (Smo), have shown the rapid development of dru...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44079
更新日期：2017-03-09 00:00:00
abstract：:Platelet-derived growth factor receptor beta (PDGFRβ) affects in numerous human cancers and has been recognized as a promising molecular target for cancer therapies. The overexpression of PDGFRβ could be a biomarker for cancer diagnosis. Radiolabeled ligands having high affinity for the molecular target could be usefu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28529-0
更新日期：2018-07-10 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-58622-2
更新日期：2020-01-28 00:00:00
abstract：:Multi-domain voltage-gated ion channels appear to have evolved through sequential rounds of intragenic duplication from a primordial one-domain precursor. Whereas modularity within one-domain symmetrical channels is established, little is known about the roles of individual regions within more complex asymmetrical cha...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38426
更新日期：2016-12-12 00:00:00
abstract：:Allergic contact hypersensitivity (CHS) is an inflammatory skin disease mediated by allergen specific T cells. In this study, we investigated the role of transcription factor NFAT1 in the pathogenesis of contact hypersensitivity. NFAT1 knock out (KO) mice spontaneously developed CHS-like skin inflammation in old age. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19453
更新日期：2016-01-18 00:00:00
abstract：:Land use change is one of the important aspects of the regional ecological restoration research. With remote sensing (RS) image in 2003, 2007 and 2012, using geographic information system (GIS) technologies, the land use pattern changes in Yimeng Mountain ecological restoration area in China and its driving force fact...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11038
更新日期：2015-06-05 00:00:00
abstract：:The prevention and control of peri-implantitis is a challenge in dental implant surgery. Dental implants with sustained antimicrobial coating are an ideal way of preventing peri-implantitis. This study reports development of a non- immunotoxicity multilayered coating on a titanium surface that had sustained antimicrob...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16336
更新日期：2015-11-09 00:00:00
abstract：:Immunotherapies demand for predictive biomarkers to avoid unnecessary adverse effects and costs. Analytic morphomics is the technique to use body composition measures as imaging biomarkers for underlying pathophysiology to predict prognosis or outcome to therapy. We investigated different body composition measures to ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46189-6
更新日期：2019-07-05 00:00:00
abstract：:We are presenting a compact radar range system with a scale factor of 105. Replacing the radio frequency (RF) by optical wavelength (300 THz), the system easily fit on a tabletop. We used interferometric time-of-flight to reproduce radar ranging measurements. Sub-micron range accuracy was achieved with a 100 fs laser ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32846-9
更新日期：2018-09-27 00:00:00
abstract：:Biological invasions are a major threat to biodiversity and ecosystem functioning. Successful invasions depend on the interplay of multiple abiotic and biotic factors, however, the process of the invasion itself is often overlooked. The temporal variation of environmental factors suggests that a 'window of opportunity...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44737-8
更新日期：2019-06-05 00:00:00
abstract：:Interleukin 27 (IL-27), a member of the IL-12 family, is important for T cell differentiation; however, little is known about its effect on dendritic cells (DCs). IL-27 can activate multiple signaling cascades, including the JAK/STAT pathway, and depending on the setting it can both promote and antagonize inflammatory...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57507-8
更新日期：2020-01-16 00:00:00
abstract：:Serotonin 5-HT2C receptor is a G-protein coupled excitatory receptor that regulates several biochemical pathways and has been implicated in obesity, mental state, sleep cycles, autism, neuropsychiatric disorders and neurodegenerative diseases. The activity of 5-HT2CR is regulated via alternative splicing and A to I ed...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39940-6
更新日期：2019-03-12 00:00:00
abstract：:Solar powered hydrogen evolution reaction (HER) is one of the key reactions in solar-to-chemical energy conversion. It is desirable to develop photocathodic materials that exhibit high activity toward photoelectrochemical (PEC) HER at more positive potentials because a higher potential means a lower overpotential for ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35158
更新日期：2016-10-17 00:00:00
abstract：:Multiplexed gene expression optimization via modulation of gene translation efficiency through ribosome binding site (RBS) engineering is a valuable approach for optimizing artificial properties in bacteria, ranging from genetic circuits to production pathways. Established algorithms design smart RBS-libraries based o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12395-3
更新日期：2017-09-26 00:00:00
abstract：:The manuscript highlights the efficacy of silver ions to act as a unique probe for the detection of bacterial contamination in water samples. The bacterial cell membrane adherence property of the silver ions was employed to develop two different bacterial detection assays employing colorimetric and electrochemical tec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68803-8
更新日期：2020-07-20 00:00:00
abstract：:Noisy galvanic vestibular stimulation (nGVS) delivered at imperceptible intensities can improve vestibular function in health and disease. Here we evaluated whether nGVS effects on vestibular function are only present during active stimulation or may exhibit relevant post-stimulation after-effects. Initially, nGVS amp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59374-9
更新日期：2020-02-13 00:00:00
abstract：:In vitro amplification assays, such as real-time quaking-induced conversion (RT-QuIC) are used to detect aggregation activity of misfolded prion protein (PrP) in brain, cerebrospinal fluid (CSF) and urine samples from patients with a prion disease. We believe that the method also has a much broader application spectru...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28711
更新日期：2016-07-07 00:00:00
abstract：:Human aldose reductase (hAR, AKR1B1) has been explored as drug target since the 1980s for its implication in diabetic complications. An activated form of hAR was found in cells from diabetic patients, showing a reduced sensitivity to inhibitors in clinical trials, which may prevent its pharmacological use. Here we rep...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39722-0
更新日期：2019-02-28 00:00:00
abstract：:While carbon-based materials have spearheaded numerous breakthroughs in biomedicine, they also have procreated many logical concerns on their overall toxicity. Carbon dots (CDs) as a respectively new member have been extensively explored in nucleus directed delivery and bioimaging due to their intrinsic fluorescence p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70796-3
更新日期：2020-08-17 00:00:00
abstract：:Chloroplast genomes have been widely considered an informative and valuable resource for molecular marker development and phylogenetic reconstruction in plant species. This study evaluated the complete chloroplast genomes of the traditional Chinese medicine Gleditsia sinensis and G. japonica, an adulterant of the form...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73392-7
更新日期：2020-10-01 00:00:00
abstract：:The last decade has seen an exponential expansion of interest in conjugating multiple enzymes of cascades in close proximity to each other, with the overarching goal being to accelerate the overall reaction rate. However, some evidence has emerged that there is no effect of proximity channeling on the reaction velocit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37034-3
更新日期：2019-01-24 00:00:00
abstract：:Mycoplasma pneumoniae infection is conventionally diagnosed using serum antibody testing, microbial culture, and genetic testing. Recently, immunochromatography-based rapid mycoplasma antigen test kits have been developed and commercialised for rapid diagnosis of M. pneumoniae infection. However, as these kits do not ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19734-y
更新日期：2018-01-23 00:00:00
abstract：:Understanding the molecular mechanism by which epithelial mesenchymal transition (EMT)-mediated cancer metastasis and how microRNA (miRNA) regulates lung cancer progression via Twist1-activated EMT may provide potential therapeutic targets for cancer therapy. Here we found that miR-33a, an intronic miRNA located withi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13677
更新日期：2015-09-02 00:00:00
abstract：:Tsunamis can propagate thousands of kilometres across the ocean. Precise calculations of arrival times are essential for reliable early warning systems, determination of source and earth properties using the inverse problem, and time series modulation due to frequency dependency of phase speed. Far field observatories...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52475-0
更新日期：2019-11-14 00:00:00
abstract：:Here we report the discovery and partial characterization of a novel herpesvirus tentatively named Bufonid herpesvirus 1 (BfHV1) from severe dermatitis in free ranging common toads (Bufo bufo) in Switzerland. The disease has been observed in toads every year since 2014, in spring, during the mating season, at differen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32841-0
更新日期：2018-10-03 00:00:00
abstract：:To investigate the safety, cost-effectiveness, and clinical outcomes of simultaneous bilateral total knee arthroplasty (TKA) in hemophilic arthropathy (HA), the requirements for transfusions, complications, costs, hospital stays, Hospital for Special Surgery (HSS) knee scores, knee range of motion (ROM) and revision r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19852-7
更新日期：2018-01-25 00:00:00
abstract：:Hirschsprung disease (HSCR) is a common cause of functional colonic obstruction in children. The currently available genetic testing is often inadequate as it mainly focuses on RET and several other genes, accounting for only 15-20% of cases. To identify novel, potentially pathogenic variants, we isolated a panel of g...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-017-14835-6
更新日期：2017-11-01 00:00:00
abstract：:We investigate whether the collapse of the quantum state of a single photon split between two space-like separated places takes a nonvanishing time. We realize this by using a source of heralded single photons, then splitting the resulting single photon state and letting it propagate over distances much larger than th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48387-8
更新日期：2019-08-15 00:00:00
