Abstract：
:Type I interferons, particularly interferon-alpha (IFN-α), play a vital role in the host's anti-viral defenses by interfering with viral replication. However, the virus rapidly evolves to exploit the IFN-α response for its replication, spread, and pathogenic function. In this study, we attempted to determine IFN-α susceptibility and productivity of infectious transmitted/founder (TF) (n = 8) and non-transmitted (NT) viruses (n = 8) derived from HIV-1 infected infants. Independent experiments were carried out to determine IFN-α resistance, replication fitness, and viral productivity in CD4+ T cells over a short period. In vitro studies showed that TF viruses were resistant to IFN-α during the very near moment of transmission, but in the subsequent time points, they became susceptible to IFN-α. We did not observe much difference in replicative fitness of the TF viruses in cultures treated with and without IFN-α, but the difference was significant in the case of NT viruses obtained from the same individual. Despite increased susceptibility to IFN-α, NT viruses produced more viral particles than TF viruses. Similar results were also obtained in cultures treated with maraviroc (MVC). The study identified unique characteristics of TF viruses thus prompting further investigation into virus-host interaction occurring during the early stages of HIV infection.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ashokkumar M,Sonawane A,Sperk M,Tripathy SP,Neogi U,Hanna LEdoi
10.1038/s41598-020-59596-xsubject
Has Abstractpub_date
2020-02-17 00:00:00pages
2747issue
1issn
2045-2322pii
10.1038/s41598-020-59596-xjournal_volume
10pub_type
杂志文章abstract：:Medicinal herbs belonging to the same genus are always easily confused due to their extremely similar morphology and metabolites. Previously, to differentiate them, inherently specific biomarkers were screened out via intuitive comparison of their metabolite profiles. Unfortunately, the selected biomarkers have worked...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04712-7
更新日期：2017-07-04 00:00:00
abstract：:Pooled data analysis in the field of maternal and child nutrition rarely incorporates data from low- and middle-income countries and existing studies lack a description of the methods used to harmonize the data and to assess heterogeneity. We describe the creation of the Brazilian Maternal and Child Nutrition Consorti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71612-8
更新日期：2020-09-10 00:00:00
abstract：:We present the design and performance characterization of a Faraday laser directly lasing on the Rb 1529 nm transition (Rb, 5P 3/2 - 4D 5/2) with high stability, narrow spectral linewidth and low cost. This system does not need an additional frequency-stabilized pump laser as a prerequisite to preparing Rb atom from 5...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09501-w
更新日期：2017-08-21 00:00:00
abstract：:Over the past few decades, two-dimensional (2D) and layered materials have emerged as new fields. Due to the zero-band-gap nature of graphene and the low photocatalytic performance of MoS2, more advanced semiconducting 2D materials have been prompted. As a result, semiconductor black phosphorus (BP) is a derived cutti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08691
更新日期：2015-03-03 00:00:00
abstract：:Boehmeria tricuspis includes sexually reproducing diploid and apomictic triploid individuals. Previously, we established that triploid B. tricuspis reproduces through obligate diplospory. To understand the molecular basis of apomictic development in B. tricuspis, we sequenced and compared transcriptomic profiles of th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46043
更新日期：2017-04-06 00:00:00
abstract：:Riverine and atmospheric inputs are often considered as the main terrestrial sources of dissolved inorganic nitrogen (DIN), phosphorus (DIP), and silicon (DSi) in the ocean. However, the fluxes of nutrients via submarine groundwater discharge (SGD) often exceed riverine inputs in different local and regional scale set...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20806-2
更新日期：2018-02-05 00:00:00
abstract：:2-(1-Undecyloxy)-1-ethanol, monochamol, is a male-produced aggregation pheromone of the Monochamus species, which are efficient vectors of the pine wood nematode (PWN), Bursaphelenchus xylophilus, which cause devastating damage to pines worldwide. The nematicidal activity of synthetic monochamol and its homologues (RO...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29300
更新日期：2016-07-11 00:00:00
abstract：:Cryo-electron tomography (cryo-ET) is one of the most advanced technologies for the in situ visualization of molecular machines by producing three-dimensional (3D) biological structures. However, cryo-ET imaging has two serious disadvantages-low dose and low image contrast-which result in high-resolution information b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20945-6
更新日期：2018-02-07 00:00:00
abstract：:Humans are good at selectively listening to specific target conversations, even in the presence of multiple concurrent speakers. In our research, we study how auditory-visual cues modulate this selective listening. We do so by using immersive Virtual Reality technologies with spatialized audio. Exposing 32 participant...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-017-04201-x
更新日期：2017-06-19 00:00:00
abstract：:Here we investigated the feasibility of using microwave spectroscopy for characterization of normal and breast cancer cell lines cultured in vitro. Healthy non-tumorigenic, MCF-10A and breast cancer, MDA-MB-231, Hs578T, T47D and MCF-7 cell lines were electrically characterized using the open-ended coaxial probe techni...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41124-1
更新日期：2019-03-18 00:00:00
abstract：:We present a concept and prototype of a memory element based on current driven magneto-impedance (MI) effect that stores the binary data (0, 1) as the orientation of the magnetization. The magnetization orientation in the surface layer with tilted anisotropy easy axis can be switched controllably between two stable st...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36180
更新日期：2016-10-26 00:00:00
abstract：:This paper reports the application of anthracite particles of different sizes and coated with nine kinds of layered double hydroxides (LDHs) varying in M(II)-M(III) cations, as alternative substrates in the simulated vertical-flow constructed wetland columns. Effects of LDHs-coating and particle size of modified anthr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15146
更新日期：2015-10-12 00:00:00
abstract：:Phytic acid (PA) is the primary phosphorus (P) storage compound in the seeds of cereals and legumes. Low PA crops, which are considered an effective way to improve grain nutrient availability and combat environmental issues relating to seed P have been developed using mutational and reverse genetics approaches. Here, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51485-2
更新日期：2019-10-16 00:00:00
abstract：:Although the demand for high-speed telecommunications has increased in recent years, the performance of transistors fabricated with traditional semiconductors such as silicon, gallium arsenide, and gallium nitride have reached their physical performance limits. Therefore, new materials with high carrier velocities sho...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03951
更新日期：2014-02-04 00:00:00
abstract：:The intention of this observational study is to show the significant impact of comorbidities and smoking on the outcome in aneurysmal subarachnoid hemorrhage (SAH). During this observational study 203 cases of treatment of ruptured intracranial aneurysms were analyzed. We examined and classified prospectively the 12 m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30878-9
更新日期：2018-08-17 00:00:00
abstract：:Obesity is associated with substantial morbidity, costs, and decreased life expectancy, and continues to rise worldwide. While etiological understanding is needed for prevention, epidemiological studies indicated that colonization with Helicobacter pylori (H. pylori) may affect body mass index (BMI), but with inconsis...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14106-4
更新日期：2017-10-31 00:00:00
abstract：:We investigated the association of redox regulator Nuclear factor erythroid 2-related factor 2 (Nrf2) and inflammatory cytokines as well as clinical remission in patients with recent onset type 2 diabetes (DM). Blood was collected from 180 DM patients (105 males/75 females) and 150 control subjects (86 males/64 female...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-018-22913-6
更新日期：2018-03-23 00:00:00
abstract：:Functional magnetic resonance imaging (fMRI) based on the blood oxygen level dependent (BOLD) contrast has gained a prominent position in neuroscience for imaging neuronal activity and studying effective brain connectivity under working state and functional connectivity at resting state. However, the fundamental quest...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02864-0
更新日期：2017-06-02 00:00:00
abstract：:Chromosomal toxin-antitoxin (TA) systems are widespread genetic elements among bacteria, yet, despite extensive studies in the last decade, their biological importance remains ambivalent. The ability of TA-encoded toxins to affect stress tolerance when overexpressed supports the hypothesis of TA systems being associat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65504-0
更新日期：2020-06-08 00:00:00
abstract：:Crimean-Congo hemorrhagic fever virus (CCHFV), a tick-borne bunyavirus, can cause a life-threatening hemorrhagic syndrome in humans but not in its animal host. The virus is widely distributed throughout southeastern Europe, the Middle East, Africa, and Asia. Disease management has proven difficult and there are no bro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44210-6
更新日期：2019-05-23 00:00:00
abstract：:Molybdenum disulfide (MoS2) has been attracting much attentions due to its excellent electrical and optical properties. We report here the synthesis of large-scale and uniform MoS2 nanosheets with vertically standing morphology using chemical vapor deposition method. TEM observations clearly reveal the growth mechanis...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21171
更新日期：2016-02-18 00:00:00
abstract：:We have studied the intrinsic fluorescence spectra of a monomeric variant of human transthyretin (M-TTR), a protein involved in the transport of the thyroid hormone and retinol and associated with various forms of amyloidosis, extending our analysis to the second order derivative of the spectra. This procedure allowed...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47230-4
更新日期：2019-07-29 00:00:00
abstract：:We report a daily-updated sequenced/species Tree Of Life (sTOL) as a reference for the increasing number of cellular organisms with their genomes sequenced. The sTOL builds on a likelihood-based weight calibration algorithm to consolidate NCBI taxonomy information in concert with unbiased sampling of molecular charact...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02015
更新日期：2013-01-01 00:00:00
abstract：:Differential host responses may be critical determinants of distinct pathologies of West Nile virus (WNV) NY99 (pathogenic) and WNV Eg101 (non-pathogenic) strains. We employed RNA-seq technology to analyze global differential gene expression in WNV-infected mice brain and to identify the host cellular factors leading ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26350
更新日期：2016-05-23 00:00:00
abstract：:Microtubules (MTs) are cytoskeletal structures that play a central role in a variety of cell functions including cell division and cargo transfer. MTs are also nonlinear electrical transmission lines that produce and conduct electrical oscillations elicited by changes in either electric field and/or ionic gradients. T...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48677-1
更新日期：2019-08-27 00:00:00
abstract：:The development of new materials with reduced noise and vibration levels is an active area of research due to concerns in various aspects of environmental noise pollution and its effects on health. Excessive vibrations also reduce the service live of the structures and limit the fields of their utilization. In oscilla...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20670-0
更新日期：2018-02-06 00:00:00
abstract：:Virus production in the deep-sea environment has been found to be high, and viruses have been suggested to play significant roles in the overall functioning of this ecosystem. Nevertheless, little is known about these viruses, including the mechanisms that control their production, which makes them one of the least un...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21908
更新日期：2016-02-22 00:00:00
abstract：:Recently, CuZr-based bulk metallic glass (BMG) composites reinforced by the TRIP (transformation-induced plasticity) effect have been explored in attempt to accomplish an optimal of trade-off between strength and ductility. However, the design of such BMG composites with advanced mechanical properties still remains a ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42518
更新日期：2017-02-13 00:00:00
abstract：:We report a three dimensional (3D) quantitative visualization of a mammalian mitochondrion by coherent x-ray diffractive imaging (CXDI) using synchrotron radiation. The internal structures of a mitochondrion from a mouse embryonic fibroblast cell line (NIH3T3) were visualized by tomographic imaging at approximately 60...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01833-x
更新日期：2017-05-12 00:00:00
abstract：:Enterovirus 71 (EV71) is the predominant causative pathogen of hand-foot-and-mouth disease (HFMD). Contrary to other HFMD-causing enterovirus, EV71 can lead to severe neurological complications, even death. MicroRNAs (miRNAs) are small non-coding RNAs that constitute the largest family of gene regulators participating...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16616-7
更新日期：2017-11-27 00:00:00
