Abstract:
:Type I interferons, particularly interferon-alpha (IFN-α), play a vital role in the host's anti-viral defenses by interfering with viral replication. However, the virus rapidly evolves to exploit the IFN-α response for its replication, spread, and pathogenic function. In this study, we attempted to determine IFN-α susceptibility and productivity of infectious transmitted/founder (TF) (n = 8) and non-transmitted (NT) viruses (n = 8) derived from HIV-1 infected infants. Independent experiments were carried out to determine IFN-α resistance, replication fitness, and viral productivity in CD4+ T cells over a short period. In vitro studies showed that TF viruses were resistant to IFN-α during the very near moment of transmission, but in the subsequent time points, they became susceptible to IFN-α. We did not observe much difference in replicative fitness of the TF viruses in cultures treated with and without IFN-α, but the difference was significant in the case of NT viruses obtained from the same individual. Despite increased susceptibility to IFN-α, NT viruses produced more viral particles than TF viruses. Similar results were also obtained in cultures treated with maraviroc (MVC). The study identified unique characteristics of TF viruses thus prompting further investigation into virus-host interaction occurring during the early stages of HIV infection.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ashokkumar M,Sonawane A,Sperk M,Tripathy SP,Neogi U,Hanna LEdoi
10.1038/s41598-020-59596-xsubject
Has Abstractpub_date
2020-02-17 00:00:00pages
2747issue
1issn
2045-2322pii
10.1038/s41598-020-59596-xjournal_volume
10pub_type
杂志文章abstract::The heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is considered as a human carcinogenic or mutagenic compound that is produced from the co-condensation of creatinine and amino acids as meats cook at high temperatures. The cooking of meats at high temperatures produces fumes, and these fumes...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11502-8
更新日期:2017-09-07 00:00:00
abstract::Age and sleep both affect emotional functioning. Since sleep patterns change over the lifespan, we investigated the effects of short sleep and age on empathic responses. In a randomized cross-over experimental design, healthy young and older volunteers (n = 47 aged 20-30 years and n = 39 aged 65-75 years) underwent fu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12098-9
更新日期:2017-09-25 00:00:00
abstract::A novel dinuclear Ir(III) complex 5 was discovered to be specific to G-quadruplex DNA, and was utilized in a label-free G-quadruplex-based detection platform for transcription factor activity. The principle of this assay was demonstrated by using HIF-1α as a model protein. Moreover, this HIF-1α detection assay exhibit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22458
更新日期:2016-03-02 00:00:00
abstract::Physical activity (PA) is known to influence cognitive function. However, the impact of PA on patients with cerebrovascular disease (CVD) has not yet been elucidated. PA and cognitive function have not been measured simultaneously over time, which makes it difficult to evaluate their relationship. The purpose of this ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40460-6
更新日期:2019-03-07 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41598-020-70939-6
更新日期:2020-08-12 00:00:00
abstract::Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are desirable for diabetes, especially in patients with overweight/obesity. We aimed to determine whether GLP-1RAs exhibit different glucose-lowering efficacies between Asian type 2 diabetes (T2D) patients with and without overweight/obesity. Randomized controlled t...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-017-16018-9
更新日期:2017-11-22 00:00:00
abstract::Gelatin-methacryloyl (GelMA) is one of the most commonly used photopolymerizable biomaterials in bio-applications. However, GelMA synthesis remains suboptimal, as its reaction parameters have not been fully investigated. The goal of this study is to establish an optimal route for effective and controllable GelMA synth...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep31036
更新日期:2016-08-09 00:00:00
abstract::A major task of episodic memory is to create unique, distinguishable representations of highly overlapping perceptual inputs. Several studies on this basic function have shown that it is based on the intact functioning of certain subregions of the hippocampus and is among the most sensitive behavioral indicators of mi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73374-9
更新日期:2020-10-02 00:00:00
abstract::Recently, electromagnetic (EM) waves carrying orbital angular momentum (OAM) has received considerable attention in increasingly many different realms, such as communication systems, super-resolution imaging, optical communications and quantum state manipulation. In this paper, two different kinds of two dimensional (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64278-9
更新日期:2020-04-30 00:00:00
abstract::The dominant seagrass in Port Phillip Bay (PPB), Australia, Zostera nigricaulis, declined between 2000 and 2011, coinciding with the 'Millennium drought' that ended in 2009. These seagrasses are nitrogen-limited, underpinning the need to develop nitrogen budgets for better ecosystem management. Environmentally realist...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35549-3
更新日期:2018-11-21 00:00:00
abstract::Our study purpose was to evaluate mitochondrial (mt)DNA and RNA in peripheral blood mononuclear cells (PBMCs) and body shape changes (BSC) in HBV-infected patients. mtDNA and mtRNA were measured in PBMCs. The presence of BSC was evaluated through a questionnaire and clinical evaluation. A total of 157 subjects were en...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-020-58837-3
更新日期:2020-02-06 00:00:00
abstract::Strong hydrogen bonds such as F···H···F offer new strategies to fabricate molecular architectures exhibiting novel structures and properties. Along these lines and, to potentially realize hydrogen-bond mediated superexchange interactions in a frustrated material, we synthesized [H2F]2[Ni3F6(Fpy)12][SbF6]2 (Fpy = 3-flu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23054-6
更新日期:2018-03-16 00:00:00
abstract::Ferti-fortification of wheat with zinc, an essential micronutrient is one of the strategies for combating 'hidden hunger' in a large proportion of people all over the world. During fertilization, application of large quantities of micronutrients often results in nutrient wastage and subsequent environmental pollution....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-25247-5
更新日期:2018-05-01 00:00:00
abstract::Decarboxylation of fatty acids over non-noble metal catalysts without added hydrogen was studied. Ni/C catalysts were prepared and exhibited excellent activity and maintenance for decarboxylation. Thereafter, the effects of nickel loading, catalyst loading, temperature, and carbon number on the decarboxylation of fatt...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27820
更新日期:2016-06-13 00:00:00
abstract::Most risk analysis models systematically underestimate the probability and impact of catastrophic events (e.g., economic crises, natural disasters, and terrorism) by not taking into account interconnectivity and interdependence of risks. To address this weakness, we propose the Cascading Alternating Renewal Process (C...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06873-x
更新日期:2017-07-27 00:00:00
abstract::Nanomaterials are being extensively produced and applied in society. Human and environmental exposures are, therefore, inevitable and so increased attention is being given to nanotoxicity. While silica nanoparticles (NP) are one of the top five nanomaterials found in consumer and biomedical products, their toxicity pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37145
更新日期:2016-11-22 00:00:00
abstract::All models of evolution of human behaviour depend on the correct identification and interpretation of bone surface modifications (BSM) on archaeofaunal assemblages. Crucial evolutionary features, such as the origin of stone tool use, meat-eating, food-sharing, cooperation and sociality can only be addressed through co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24071-1
更新日期:2018-04-10 00:00:00
abstract::Traumatic brain injury (TBI) is a frequent cause of chronic headache, fatigue, insomnia, hyperactivity, memory deficits, irritability and posttraumatic stress disorder. Recent evidence suggests beneficial effects of pro-cannabinoid treatments. We assessed in mice levels of endocannabinoids in association with the occu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71879-x
更新日期:2020-09-10 00:00:00
abstract::We study a three-mode (i.e., a clockwise mode, a counterclockwise mode, and a mechanical mode) coherent coupling regime of the optical whispering-gallery-mode (WGM) microresonator optomechanical system by considering a pair of counterpropagating modes in a general case. The WGM microresonator is coherently driven by a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39781
更新日期:2017-01-03 00:00:00
abstract::Metabolic disorders in T2DM generate multiple sources of free radicals and oxidative stress that accelerate nonenzymatic degenerative protein modifications (DPMs) such as protein oxidation, disrupt redox signaling and physiological function, and remain a major risk factor for clinical diabetic vascular complications. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62341-z
更新日期:2020-04-15 00:00:00
abstract::Two-dimensional (2D) cell cultures growing on plastic do not recapitulate the three dimensional (3D) architecture and complexity of human tumors. More representative models are required for drug discovery and validation. Here, 2D culture and 3D mono- and stromal co-culture models of increasing complexity have been est...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28951
更新日期:2016-07-01 00:00:00
abstract::Plasmodiophora brassicae causes clubroot, a major disease of Brassica oil and vegetable crops worldwide. P. brassicae is a Plasmodiophorid, obligate biotrophic protist in the eukaryotic kingdom of Rhizaria. Here we present the 25.5 Mb genome draft of P. brassicae, developmental stage-specific transcriptomes and a tran...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11153
更新日期:2015-06-18 00:00:00
abstract::Biomimetic scales provide a convenient template to tailor the bending stiffness of the underlying slender substrate due to their mutual sliding after engagement. Scale stiffness can therefore directly impact the substrate behavior, opening a potential avenue for substrate stiffness tunability. Here, we have developed ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74147-0
更新日期:2020-10-13 00:00:00
abstract::Previous studies of protein fold space suggest that fold coverage is plateauing. However, sequence sampling has been -and remains to a large extent- heavily biased, focusing on culturable phyla. Sustained technological developments have fuelled the advent of metagenomics and single-cell sequencing, which might correct...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14717
更新日期:2015-10-05 00:00:00
abstract::Most published sleep studies use three species: human, house mouse, or Norway rat. The degree to which data from these species captures variability in mammalian sleep remains unclear. To gain insight into mammalian sleep diversity, we examined sleep architecture in the spiny basal murid rodent Acomys cahirinus. First,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67859-w
更新日期:2020-07-02 00:00:00
abstract::Hbs1, which is homologous to the GTPase eRF3, is a small G protein implicated in mRNA quality control. It interacts with a translation-release factor 1-like protein Dom34/Pelota to direct decay of mRNAs with ribosomal stalls. Although both proteins are evolutionarily conserved in eukaryotes, the biological function of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39530-6
更新日期:2019-03-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-53132-2
更新日期:2019-11-08 00:00:00
abstract::It is well established that CD8(+) T cells play an important role in protective immunity against protozoan infections. However, their role in the course of Neospora caninum infection has not been fully elucidated. Here we report that CD8-deficient mice infected with N. caninum presented higher parasitic loads in the b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14913
更新日期:2015-10-09 00:00:00
abstract::The aminopeptidase gene from Mesorhizobium SEMIA3007 was cloned and overexpressed in Escherichia coli. The enzyme called MesoAmp exhibited optimum activity at pH 8.5 and 45 °C and was strongly activated by Co2+ and Mn2+. Under these reaction conditions, the enzyme displayed Km and kcat values of 0.2364 ± 0.018 mM and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10932-8
更新日期:2017-09-06 00:00:00
abstract::The L-iduronic acid (IdoA) residue is a critically important structural component in heparan sulphate polysaccharide for the biological functions. The pyranose ring of IdoA is present in (1)C4-chair, (2)SO-skew boat, and less frequently, in (4)C1-chair conformations. Here, we analyzed the conformation of IdoA residue ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29602
更新日期:2016-07-14 00:00:00