Abstract:
:Respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and lung infections have critical consequences on mortality and morbidity in humans. The aims of the present study were to examine the mechanisms by which CXCL12 affects MUC1 transcription and airway inflammation, which depend on activator of G-protein signaling (AGS) 3 and to identify specific molecules that suppress CXCL12-induced airway inflammation by acting on G-protein-coupled receptors. Herein, AGS3 suppresses CXCL12-mediated upregulation of MUC1 and TNFα by regulating Gαi. We found that the G-protein regulatory (GPR) motif peptide in AGS3 binds to Gαi and downregulates MUC1 expression; in contrast, this motif upregulates TNFα expression. Mutated GPR Q34A peptide increased the expression of MUC1 and TGFβ but decreased the expression of TNFα and IL-6. Moreover, CXCR4-induced dendritic extensions in 2D and 3D matrix cultures were inhibited by the GPR Q34A peptide compared with a wild-type GPR peptide. The GPR Q34A peptide also inhibited CXCL12-induced morphological changes and inflammatory cell infiltration in the mouse lung, and production of inflammatory cytokines in bronchoalveolar lavage (BAL) fluid and the lungs. Our data indicate that the GPR motif of AGS3 is critical for regulating MUC1/Muc1 expression and cytokine production in the inflammatory microenvironment.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Choi IW,Ahn do W,Choi JK,Cha HJ,Ock MS,You E,Rhee S,Kim KC,Choi YH,Song KSdoi
10.1038/srep27054subject
Has Abstractpub_date
2016-06-07 00:00:00pages
27054issn
2045-2322pii
srep27054journal_volume
6pub_type
杂志文章abstract::Recent studies have shown that L-proline is a natural osmoprotectant and an antioxidant to protect cells from injuries such as that caused by freezing and thawing in many species including plant, ram sperm and human endothelial cells. Nevertheless, this nontoxic cryoprotectant has not yet been applied to mammalian ooc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26326
更新日期:2016-07-14 00:00:00
abstract::Metabolomic and transcriptomic approaches were used to dissect the enhanced disease resistance in the plants harbouring a RNA interfering construct of OsWRKY62 and OsWRKY76 (dsOW62/76) genes. The primary metabolic pathways were activated in dsOW62/76 compared with wild-type (ZH17) plants, revealed by increased accumul...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02643-x
更新日期:2017-05-30 00:00:00
abstract::Recent advances in genetic analyses have significantly refined human type 1 diabetes (T1D) associated loci. The goal of such effort is to identify the causal genes and have a complete understanding of the molecular pathways that independently or interactively influence cellular processes leading to the destruction of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68956-6
更新日期:2020-07-21 00:00:00
abstract::Nitrogen (N) is a major component of the photosynthetic apparatus and is widely used as a fertilizer in crops. However, to the best of our knowledge, the dynamic of photosynthesis establishment due to differential N supply in the bioenergy crop sugarcane has not been reported to date. To address this question, we eval...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20653-1
更新日期:2018-02-02 00:00:00
abstract::After Alzheimer, Parkinson's disease (PD) is the second most common neurodegenerative disorder. Alpha synuclein (SNCA) is deemed as a major component of Lewy bodies, a neuropathological feature of PD. Five point mutations in SNCA have been reported so far, responsible for autosomal dominant PD. This study aims to deci...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24475
更新日期:2016-04-15 00:00:00
abstract::Alzheimer's disease is characterized by neuronal loss and cerebral accumulation of amyloid-β protein (Aβ) and lowering the generation of Aβ is a pivotal approach in the strategy of Alzheimer's disease treatment. Midlife hypertension is a major risk factor for the future onset of sporadic Alzheimer's disease and the us...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12059
更新日期:2015-07-08 00:00:00
abstract::Contact investigation is an important and effective active case-finding strategy, but there is a lack of research on congregate settings in countries with an intermediate incidence. This study determined the incidence of and risk factors for tuberculosis (TB) development after exposure in congregate settings. This ret...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57697-1
更新日期:2020-01-28 00:00:00
abstract::Ghrelin and obestatin are two gastrointestinal peptides, derived from a common precursor. Expression of both peptides have been found in breast cancer tissue and ghrelin has been associated with breast cancer development. Ghrelin expression is associated with longer survival in women diagnosed with invasive and node n...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31783-x
更新日期:2018-09-11 00:00:00
abstract::We analyze a wide gravity low in the Campania Active Volcanic Area and interpret it by a large and deep source distribution of partially molten, low-density material from about 8 to 30 km depth. Given the complex spatial-temporal distribution of explosive volcanism in the area, we model the gravity data consistently w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26346-z
更新日期:2018-05-29 00:00:00
abstract::Glomerular filtration rate (GFR) and urinary albumin excretion rate (UAER) are used to diagnose and classify the severity of chronic kidney disease. Total adiponectin (T-AN) and high molecular weight adiponectin (H-AN) assays were developed using the fully automated immunoassay system, HI-1000 and their significance o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72494-6
更新日期:2020-09-28 00:00:00
abstract::The salmon louse is an ectoparasitic copepod of salmonids in the marine environment, and represents a global challenge to salmon aquaculture. A major issue is the reliance of the industry on a limited number of chemicals to delouse salmonids on farms, and the high levels of resistance that lice have developed to all o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12384-6
更新日期:2017-09-27 00:00:00
abstract::Preventing the protein-protein interaction of the cellular chromatin binding protein Lens Epithelium-Derived Growth Factor (LEDGF) and human immunodeficiency virus (HIV) integrase is an important possible strategy for anti-viral treatment for AIDS. We have used Intracellular Antibody Capture technology to isolate a si...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16742-2
更新日期:2017-12-04 00:00:00
abstract::High-pressure Raman spectroscopy and x-ray diffraction of Sb2S3 up to 53 GPa reveals two phase transitions at 5 GPa and 15 GPa. The first transition is evidenced by noticeable compressibility changes in distinct Raman-active modes, in the lattice parameter axial ratios, the unit cell volume, as well as in specific int...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24246
更新日期:2016-04-06 00:00:00
abstract::Materials and construction methods of nests vary between bird species and at present, very little is known about the relationships between architecture and function in these structures. This study combines computational and experimental techniques to study the structural biology of nests fabricated by the edible nest ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41245-7
更新日期:2019-03-18 00:00:00
abstract::The origin of the enantio- and regioselectivity of ring-opening reaction of oxabicyclic alkenes catalyzed by rhodium/Josiphos has been examined using M06-2X density functional theory(DFT). DFT calculations predict a 98% ee for the enantioselectivity and only the 1,2-trans product as one regio- and diastereomer, in exc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40491
更新日期:2017-01-11 00:00:00
abstract::In the gastrointestinal (GI) epithelium, enterochromaffin (EC) cells are enteroendocrine cells responsible for producing >90% of the body's serotonin (5-hydroxytryptamine, 5-HT). However, the molecular mechanisms of EC cell function are poorly understood. Here, we found that EC cells in mouse primary cultures fired sp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15834-3
更新日期:2017-11-15 00:00:00
abstract::This corrects the article DOI: 10.1038/srep34617. ...
journal_title:Scientific reports
pub_type: 杂志文章,已发布勘误
doi:10.1038/srep42267
更新日期:2017-09-27 00:00:00
abstract::Using the Ermakov-Lewis invariants appearing in KvN mechanics, the time-dependent frequency harmonic oscillator is studied. The analysis builds upon the operational dynamical model, from which it is possible to infer quantum or classical dynamics; thus, the mathematical structure governing the evolution will be the sa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26759-w
更新日期:2018-05-30 00:00:00
abstract::We describe a spin wave modulator - spintronic device aimed to control spin wave propagation by an electric field. The modulator consists of a ferromagnetic film serving as a spin wave bus combined with a synthetic multiferroic comprising piezoelectric and magnetostrictive materials. Its operation is based on the stre...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28878-w
更新日期:2018-07-18 00:00:00
abstract::Direct measures of energy expenditure are difficult to obtain in marine mammals, and accelerometry may be a useful proxy. Recently its utility has been questioned as some analyses derived their measure of activity level by calculating the sum of accelerometry-based values and then comparing this summation to summed (t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11576-4
更新日期:2017-09-18 00:00:00
abstract::A correction to this article has been published and is linked from the HTML version of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-24796-z
更新日期:2018-04-19 00:00:00
abstract::Carrier drift mobility is an important physical constant in the charge transport process of organic solar cells (OSCs). Although time-of-flight and space-charge-limited current techniques have been frequently utilized for mobility measurements, the validity of a new method using modulation photocurrent spectroscopy is...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56945-3
更新日期:2019-12-30 00:00:00
abstract::The honeybee's drinking process has generally been simplified because of its high speed and small scale. In this study, we clearly observed the drinking cycle of the Italian honeybee using a specially designed high-speed camera system. We analysed the pattern of glossal hair erection and the movement kinematics of the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15002
更新日期:2015-10-08 00:00:00
abstract::The synthesis of a new series of Gd(III)-arylphosphonium complexes is described and the solution stability of selected compounds is reported. Their lipophilicity and uptake in human glial (SVG p12) and human glioblastoma multiforme (T98G) cell lines are presented. The in vitro cytotoxicity of all complexes was determi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79893-9
更新日期:2021-01-12 00:00:00
abstract::Defects of vitamin B6 metabolism are responsible for severe neurological disorders, such as pyridoxamine 5'-phosphate oxidase deficiency (PNPOD; OMIM: 610090), an autosomal recessive inborn error of metabolism that usually manifests with neonatal-onset severe seizures and subsequent encephalopathy. At present, 27 path...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70598-7
更新日期:2020-08-12 00:00:00
abstract::We evaluated the performance of three PGx panels to estimate biogeographical ancestry: the DMET panel, and the VIP and Preemptive PGx panels described in the literature. Our analysis indicate that the three panels capture quite well the individual variation in admixture proportions observed in recently admixed populat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80389-9
更新日期:2021-01-13 00:00:00
abstract::Dietary information is lacking in most of small to mid-sized carnivores due to their elusive predatory behaviour and versatile feeding habits. The leopard cat (LPC; Prionailurus bengalensis) and the Asiatic golden cat (AGC; Catopuma temminckii) are two important yet increasingly endangered carnivore species in the tem...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41909
更新日期:2017-02-14 00:00:00
abstract::Tomatoes are known to have ameliorative effects on cardiovascular disease and cancer. The nutritional value of tomatoes can be enhanced by increasing flavonoids content through genetic modification. The regulatory gene PAP1 (production of anthocyanin pigment 1) from Arabidopsis is reported to increase initial flavonoi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12355-x
更新日期:2017-09-28 00:00:00
abstract::It is a significant challenge to regenerate full-thickness skin defects with sweat glands. Various skin substitutes have been developed to resolve this issue with minimal success. In this study, to yield a novel construct for in situ regeneration of sweat glands, the collagen-chitosan porous scaffold was combined with...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17967-x
更新日期:2017-12-15 00:00:00
abstract::High-k dielectric oxides are supposedly ideal gate-materials for ultra-high doping in graphene and other 2D-crystals. Here, we report a temperature-dependent electronic transport study on chemical vapor deposited-graphene gated with SrTiO₃ (STO) thin film substrate. At carrier densities away from charge neutrality poi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06173
更新日期:2014-08-22 00:00:00