Abstract:
:After Alzheimer, Parkinson's disease (PD) is the second most common neurodegenerative disorder. Alpha synuclein (SNCA) is deemed as a major component of Lewy bodies, a neuropathological feature of PD. Five point mutations in SNCA have been reported so far, responsible for autosomal dominant PD. This study aims to decipher evolutionary and structural insights of SNCA by revealing its sequence and structural evolutionary patterns among sarcopterygians and its paralogous counterparts (SNCB and SNCG). Rate analysis detected strong purifying selection on entire synuclein family. Structural dynamics divulges that during the course of sarcopterygian evolutionary history, the region encompassed 32 to 58 of N-terminal domain of SNCA has acquired its critical functional significance through the epistatic influence of the lineage specific substitutions. In sum, these findings provide an evidence that the region from 32 to 58 of N-terminal lipid binding alpha helix domain of SNCA is the most critical region, not only from the evolutionary perspective but also for the stability and the proper conformation of the protein as well as crucial for the disease pathogenesis, harboring critical interaction sites.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Siddiqui IJ,Pervaiz N,Abbasi AAdoi
10.1038/srep24475subject
Has Abstractpub_date
2016-04-15 00:00:00pages
24475issn
2045-2322pii
srep24475journal_volume
6pub_type
杂志文章abstract::The interplay between the quasi 1-dimensional CuO-chains and the 2-dimensional CuO2 planes of YBa(2)Cu(3)O(6+x) (YBCO) has been in focus for a long time. Although the CuO-chains are known to be important as charge reservoirs that enable superconductivity for a range of oxygen doping levels in YBCO, the understanding o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07017
更新日期:2014-11-12 00:00:00
abstract::The DNA methyltransferase DNMT3A R882H mutation is observed in 25% of all AML patients. DNMT3A is active as tetramer and the R882H mutation is located in one of the subunit/subunit interfaces. Previous work has reported that formation of mixed wildtype/R882H complexes leads to a strong loss of catalytic activity obser...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31635-8
更新日期:2018-09-05 00:00:00
abstract::Circular Dichroism data are often decomposed into their constituent spectra to quantify the secondary structure of peptides or proteins but the estimation of the secondary structure content fails when light scattering leads to spectral distortion. If peptide-induced liposome self-association occurs, subtracting contro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39450
更新日期:2016-12-22 00:00:00
abstract::DNA is organized and compacted into higher-order structures in order to fit within nuclei and to facilitate gene regulation. Mechanisms by which higher order chromatin structures are established and maintained are poorly understood. In C. elegans, nuclear-localized small RNAs engage the nuclear RNAi machinery to regul...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45052-y
更新日期:2019-06-21 00:00:00
abstract::TRIB1 is a GWAS locus associated with plasma cholesterol and triglycerides (TG) levels. In mice, liver-specific overexpression of TRIB1 lowers plasma lipid levels. Berberine (BBR) is a natural lipid lowering drug that reduces plasma LDL-cholesterol (LDL-C), total cholesterol (TC) and TG in hyperlipidemic patients and ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52253-y
更新日期:2019-10-30 00:00:00
abstract::Gut microbiota mediated low-grade inflammation is involved in the onset of type 2 diabetes (T2DM). In this study, we used a high fat sucrose (HFS) diet-induced pre-insulin resistance and a low dose-STZ HFS rat models to study the effect and mechanism of Lactobacillus casei Zhang in protecting against T2DM onset. Hyper...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05654
更新日期:2014-07-18 00:00:00
abstract::In plants, the shikimate pathway generally occurs in plastids and leads to the biosynthesis of aromatic amino acids. Chorismate synthase (CS) catalyses the last step of the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to chorismate, but the role of CS in the metabolism of higher plants has not been reported...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67671-6
更新日期:2020-07-02 00:00:00
abstract::Ribosomal RNA internal transcribed spacer-1 (ITS1) metabarcoding was used to investigate the distribution patterns of fungal communities and the factors influencing these patterns in subtropical Chinese seas, including the southern and northern Yellow Sea and the Bohai Sea. These seas were found to harbor high levels ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26528
更新日期:2016-05-20 00:00:00
abstract::Periodontal ligament stem cells (PDLSCs) are a major source of mesenchymal stem cells (MSCs) in adults and are effective for tissue engineering, like promoting angiogenesis and bone regeneration. CXCL12 has been reported to be involved in the recruitment and engraftment of MSCs in wound sites. However, whether CXCL12 ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10971-1
更新日期:2017-08-31 00:00:00
abstract::Balancing the upper body is pivotal for upright and efficient gait. While models have identified potentially useful characteristics of biarticular thigh muscles for postural control of the upper body, experimental evidence for their specific role is lacking. Based on theoretical findings, we hypothesised that biarticu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50995-3
更新日期:2019-10-10 00:00:00
abstract::Carrier drift mobility is an important physical constant in the charge transport process of organic solar cells (OSCs). Although time-of-flight and space-charge-limited current techniques have been frequently utilized for mobility measurements, the validity of a new method using modulation photocurrent spectroscopy is...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56945-3
更新日期:2019-12-30 00:00:00
abstract::Obesity and depression are two common medical problems that pregnant women present with in antenatal care. Overweight and obesity at the beginning of the pregnancy, and excessive weight gain during pregnancy, are independent explanatory variables for fetal birthweight and independent risk factors for giving birth to a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42360-1
更新日期:2019-04-17 00:00:00
abstract::Diminished microRNA-29b levels have recently been revealed to provoke increased expression and accumulation of extracellular matrix molecules, such as collagens in fibrotic remodeling. Subsequently, the aim of this study was to find out whether microRNA-29b might also regulate human xylosyltransferase (XT)-I expressio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36217-2
更新日期:2018-12-12 00:00:00
abstract::We delineate the four principal surface plasmon polariton coupling and interaction mechanisms in subwavelength gratings, and demonstrate their significant roles in shaping the optical response of plasmonic gratings. Within the framework of width-graded metal-insulator-metal nano-gratings, electromagnetic field confine...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79815-9
更新日期:2021-01-12 00:00:00
abstract::Chemical conjugation is commonly used to enhance the pharmacokinetics, biodistribution, and potency of protein therapeutics, but often leads to non-specific modification or loss of bioactivity. Here, we present a simple, versatile and widely applicable method that allows exquisite N-terminal specific modification of p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18363
更新日期:2015-12-17 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV-1) infection promotes a generalized activation of host responses that involves not only CD4 T cells, but also cells of the microenvironment, which are not directly infected, such as endothelial cells. The mechanisms triggering HIV-1-associated vascular alterations remain poorly...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44743-w
更新日期:2019-07-16 00:00:00
abstract::Aldehyde dehydrogenase (ALDH) is a key enzyme for the catalytic oxidation of acetaldehyde to acetic acid. Genetic polymorphisms of ALDH2 have been associated with a wide range of diseases and cancers. However, little information is found about the association between ALDH2 polymorphisms and lumbar disc herniation (LDH...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31491-6
更新日期:2018-08-30 00:00:00
abstract::Whether the stress-loading of faults to failure in earthquakes appears to be random or to an extent explainable, given constraints on fault/shear-zone interaction and the build-up and release of stress over many earthquake cycles, is a key question for seismic hazard assessment. Here we investigate earthquake recurren...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69681-w
更新日期:2020-07-29 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-25179-0
更新日期:2018-05-10 00:00:00
abstract::Alzheimer's disease (AD) is mainly characterized by the deposition of extracellular amyloid plaques and intracellular accumulation of neurofibrillary tangles (NFTs). While the recent 5xFAD AD mouse model exhibits many AD-related phenotypes and a relatively early and aggressive amyloid β production, it does not show NF...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79344-5
更新日期:2021-01-14 00:00:00
abstract::Dogs (Canis familiaris) are the first animals to be domesticated by humans and the only ones domesticated by mobile hunter-gatherers. Wolves and humans were both persistent, pack hunters of large prey. They were species competing over resources in partially overlapping ecological niches and capable of killing each oth...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78214-4
更新日期:2021-01-07 00:00:00
abstract::Recent studies have shown that cellular metabolism plays an important role in regulating immune cell functions. In immune cell differentiation, both interleukin-17-producing T (Th17) cells and dendritic cells (DCs) exhibit increased glycolysis through the upregulation of glycolytic enzymes, such as hexokinase-2 (HK2)....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42412
更新日期:2017-02-10 00:00:00
abstract::Neural responses to incentives are altered in chronic pain and by opioid use. To understand how opioid use modulates the neural response to reward/value in chronic pain, we compared brain functional magnetic resonance imaging (fMRI) responses to a monetary incentive delay (MID) task in patients with fibromyalgia takin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45961-y
更新日期:2019-07-03 00:00:00
abstract::NbP is a recently realized Weyl semimetal (WSM), hosting Weyl points through which conduction and valence bands cross linearly in the bulk and exotic Fermi arcs appear. The most intriguing transport phenomenon of a WSM is the chiral anomaly-induced negative magnetoresistance (NMR) in parallel electric and magnetic fie...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43394
更新日期:2017-03-06 00:00:00
abstract::Alterations in the gut microbiota play a crucial role in host physiology and metabolism; however, the molecular pathways underlying these changes in diet-induced obesity are unclear. Mechanistic target of rapamycin (mTOR) signaling pathway is associated with metabolic disorders such as obesity and type 2 diabetes (T2D...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30887
更新日期:2016-07-29 00:00:00
abstract::Patients with schizophrenia have a higher risk for cardiovascular disease (CVD) than the general population. Research has suggested that autonomic imbalance is a common pathway to increased morbidity and mortality for CVD. Heart rate variability (HRV) analysis is a non-invasive method that assesses autonomic imbalance...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07394
更新日期:2014-12-09 00:00:00
abstract::With the great development of sequencing technologies and systematic methods, our understanding of evolutionary relationships at deeper levels within the tree of life has greatly improved over the last decade. However, the current taxonomic methodology is insufficient to describe the growing levels of diversity in bot...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28308
更新日期:2016-06-17 00:00:00
abstract::Detailed structural analyses of the mushroom body which plays critical roles in olfactory learning and memory revealed that it is directly connected with multiple primary sensory centers in Drosophila. Connectivity patterns between the mushroom body and primary sensory centers suggest that each mushroom body lobe proc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29481
更新日期:2016-07-11 00:00:00
abstract::A robust method is presented for the segmentation of the full cerebral vasculature in 4-dimensional (4D) computed tomography (CT). The method consists of candidate vessel selection, feature extraction, random forest classification and postprocessing. Image features include among others the weighted temporal variance i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15617-w
更新日期:2017-11-15 00:00:00
abstract::In the present study, the synergistic effect on the corrosion protection properties of Mg alloys subjected to plasma electrolytic oxidation and chemically treated with thiourea as an inhibitor is investigated by surface microstructure analysis, evaluation of the electrochemical performance, and chemical quantum calcul...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29299-5
更新日期:2018-07-19 00:00:00