当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Relationship between Lipoprotein (a) and cognitive function - Results from the Berlin Aging Study II.

Relationship between Lipoprotein (a) and cognitive function - Results from the Berlin Aging Study II.

Abstract：

:It has been suggested that an age-related loss of cognitive function might be driven by atherosclerotic effects associated with altered lipid patterns. However, the relationship between Lipoprotein (a) [Lp(a)] and healthy cognitive aging has not yet been sufficiently investigated. For the current analysis we used the cross-sectional data of 1,380 Berlin Aging Study II (BASE-II) participants aged 60 years and older (52.2% women, mean age 68 ± 4 years). We employed the Consortium to Establish a Registry for Alzheimer's Disease (CERAD)-Plus test battery to establish latent factors representing continuous measures of domain specific cognitive functions. Regression models adjusted for APOE genotypes, lipid parameters and other risk factors for cognitive impairment were applied to assess the association between Lp(a) and performance in specific cognitive domains. Men within the lowest Lp(a)-quintile showed better cognitive performance in the cognitive domain executive functions and processing speed (p = 0.027). No significant results were observed in women. The results of the current analysis of predominantly healthy BASE-II participants point towards an association between low Lp(a) concentrations and better cognitive performance. However, evidence for this relationship resulting from the current analysis and the employment of a differentiated cognitive assessment is rather weak.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Röhr F,Bucholtz N,Toepfer S,Norman K,Spira D,Steinhagen-Thiessen E,Lill CM,Bertram L,Demuth I,Buchmann N,Düzel S

doi

10.1038/s41598-020-66783-3

subject

Has Abstract

pub_date

2020-06-30 00:00:00

pages

10636

issue

1

issn

2045-2322

pii

10.1038/s41598-020-66783-3

journal_volume

10

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • X-ray diffraction and second harmonic imaging reveal new insights into structural alterations caused by pressure-overload in murine hearts.

    abstract：:We demonstrate a label-free imaging approach to study cardiac remodeling of fibrotic and hypertrophic hearts, bridging scales from the whole organ down to the molecular level. To this end, we have used mice subjected to transverse aortic constriction and imaged adjacent cardiac tissue sections by microfocus X-ray diff...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-76163-6

    authors： Nicolas JD,Khan A,Markus A,Mohamed BA,Toischer K,Alves F,Salditt T

    更新日期：2020-11-09 00:00:00

  • Surface ocean carbon dioxide variability in South Pacific boundary currents and Subantarctic waters.

    abstract：:To improve estimates of the long-term response of the marine carbon system to climate change a better understanding of the seasonal and interannual variability is needed. We use high-frequency multi-year data at three locations identified as climate change hotspots: two sites located close to South Pacific boundary cu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44109-2

    authors： C Pardo P,Tilbrook B,van Ooijen E,Passmore A,Neill C,Jansen P,Sutton AJ,Trull TW

    更新日期：2019-05-20 00:00:00

  • Analogue Orientation Control of a Carbon Fibre in a Nematic Liquid Crystal.

    abstract：:A carbon fibre is a rod-like microstructure, the longitudinal axis of which is aligned with the orientation of the director in a nematic liquid crystal. A nematic liquid crystal with negative dielectric anisotropy is mixed with carbon fibres. By applying an electric field perpendicular to the director, the carbon fibr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-56594-6

    authors： Lee JY,Lev B,Kim JH

    更新日期：2019-12-27 00:00:00

  • An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E⁻/⁻ mice.

    abstract：:Oxidized low-density lipoprotein (oxLDL) inhibits mammalian target of rapamycin (mTOR) and induces autophagy and apoptosis in vascular endothelial cells (VECs) that play very critical roles for the cardiovascular homostasis. We recently defined 3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3H)-one (3BDO) as a ne...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep05519

    authors： Peng N,Meng N,Wang S,Zhao F,Zhao J,Su L,Zhang S,Zhang Y,Zhao B,Miao J

    更新日期：2014-07-01 00:00:00

  • Observed 3D Structure, Generation, and Dissipation of Oceanic Mesoscale Eddies in the South China Sea.

    abstract：:Oceanic mesoscale eddies with horizontal scales of 50-300 km are the most energetic form of flows in the ocean. They are the oceanic analogues of atmospheric storms and are effective transporters of heat, nutrients, dissolved carbon, and other biochemical materials in the ocean. Although oceanic eddies have been ubiqu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep24349

    authors： Zhang Z,Tian J,Qiu B,Zhao W,Chang P,Wu D,Wan X

    更新日期：2016-04-14 00:00:00

  • From EST to novel spider silk gene identification for production of spidroin-based biomaterials.

    abstract：:A cDNA library from a pool of all the seven silk glands from a tropical spider species was constructed. More than 1000 expressed sequence tag (EST) clones were created. Almost 65% of the EST clones were identified and around 50% were annotated. The cellular and functional distribution of the EST clones indicated high ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-13876-1

    authors： Huang W,Zhang Y,Chen Y,Wang Y,Yuan W,Zhang N,Lam TJ,Gong Z,Yang D,Lin Z

    更新日期：2017-10-17 00:00:00

  • Histological grading evaluation of non-alcoholic fatty liver disease after bariatric surgery: a retrospective and longitudinal observational cohort study.

    abstract：:Non-alcoholic fatty liver disease (NAFLD) is a chronic disease with several degrees of histological features which may progress to cirrhosis. Obesity is an important risk factor and although NAFLD has no specific pharmacological treatment, bariatric surgery has been associated with NAFLD regression in severely obese p...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-65556-2

    authors： Chaim FDM,Pascoal LB,Chaim FHM,Palma BB,Damázio TA,da Costa LBE,Carvalho R,Cazzo E,Gestic MA,Utrini MP,Milanski M,Chaim EA,Leal RF

    更新日期：2020-05-22 00:00:00

  • Scattering of spoof surface plasmon polaritons in defect-rich THz waveguides.

    abstract：:We report on the first observation of 'Spoof' Surface Plasmon Polariton (SPP) scattering from surface defects on metal-coated 3D printed, corrugated THz waveguiding surfaces. Surface defects, a result of the printing process, are shown to assist the direct coupling of the incident free-space radiation into a spoof SPP...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-42412-6

    authors： Klein AK,Basden A,Hammler J,Tyas L,Cooke M,Balocco C,Zeze D,Girkin JM,Gallant A

    更新日期：2019-04-18 00:00:00

  • Systemic and sex-biased regulation of OBP expression under semiochemical stimuli.

    abstract：:Constitutive expression of Odorant-Binding Proteins (OBPs) in antennae and other body parts has been examined mainly to infer their involvement in insect olfaction, while their regulation in response to semiochemical stimuli has remained poorly known. Previous studies of semiochemical response were basically done usin...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-24297-z

    authors： Paula DP,Togawa RC,do Carmo Costa MM,Grynberg P,Martins NF,Andow DA

    更新日期：2018-04-16 00:00:00

  • TMAO is Associated with Mortality: Impact of Modestly Impaired Renal Function.

    abstract：:Trimethylamine-N-Oxide (TMAO) is a microbiome-related metabolite that is cleared by the kidney and linked to renal function. We explored the relationship between TMAO and all-cause mortality, and determined whether this association was modified by renal function. A prospective study was performed among PREVEND partici...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-13739-9

    authors： Gruppen EG,Garcia E,Connelly MA,Jeyarajah EJ,Otvos JD,Bakker SJL,Dullaart RPF

    更新日期：2017-10-23 00:00:00

  • Magnetic-assisted triboelectric nanogenerators as self-powered visualized omnidirectional tilt sensing system.

    abstract：:The triboelectric nanogenerator (TENG) is a promising device in energy harvesting and self-powered sensing. In this work, we demonstrate a magnetic-assisted TENG, utilizing the magnetic force for electric generation. Maximum power density of 541.1 mW/m(2) is obtained at 16.67 MΩ for the triboelectric part, while the e...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep04811

    authors： Han M,Zhang XS,Sun X,Meng B,Liu W,Zhang H

    更新日期：2014-04-28 00:00:00

  • Andy's Algorithms: new automated digital image analysis pipelines for FIJI.

    abstract：:Quantification of cellular antigens and their interactions via antibody-based detection methods are widely used in scientific research. Accurate high-throughput quantitation of these assays using general image analysis software can be time consuming and challenging, particularly when attempted by users with limited im...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-15885-6

    authors： Law AMK,Yin JXM,Castillo L,Young AIJ,Piggin C,Rogers S,Caldon CE,Burgess A,Millar EKA,O'Toole SA,Gallego-Ortega D,Ormandy CJ,Oakes SR

    更新日期：2017-11-16 00:00:00

  • Few-layer Phosphorene: An Ideal 2D Material For Tunnel Transistors.

    abstract：:2D transition metal dichalcogenides (TMDs) have attracted a lot of attention recently for energy-efficient tunneling-field-effect transistor (TFET) applications due to their excellent gate control resulting from their atomically thin dimensions. However, most TMDs have bandgaps (Eg) and effective masses (m(*)) outside...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep28515

    authors： Ameen TA,Ilatikhameneh H,Klimeck G,Rahman R

    更新日期：2016-06-27 00:00:00

  • 3-D radar imaging unlocks the untapped behavioral and biomechanical archive of Pleistocene ghost tracks.

    abstract：:Footprint evidence of human-megafauna interactions remains extremely rare in the archaeological and palaeontological records. Recent work suggests ancient playa environments may hold such evidence, though the prints may not be visible. These so-called "ghost tracks" comprise a rich archive of biomechanical and behavio...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-52996-8

    authors： Urban TM,Bennett MR,Bustos D,Manning SW,Reynolds SC,Belvedere M,Odess D,Santucci VL

    更新日期：2019-11-11 00:00:00

  • Fine-tuning of macrophage activation using synthetic rocaglate derivatives.

    abstract：:Drug-resistant bacteria represent a significant global threat. Given the dearth of new antibiotics, host-directed therapies (HDTs) are especially desirable. As IFN-gamma (IFNγ) plays a central role in host resistance to intracellular bacteria, including Mycobacterium tuberculosis, we searched for small molecules to au...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep24409

    authors： Bhattacharya B,Chatterjee S,Devine WG,Kobzik L,Beeler AB,Porco JA Jr,Kramnik I

    更新日期：2016-04-18 00:00:00

  • Interrelationship of rotavirus infection and Creatine Kinase-MB isoenzyme levels in children hospitalized with acute gastroenteritis in Guangzhou, China, 2012-2015.

    abstract：:Elevated levels of Creatine Kinase-MB (CK-MB) Isoenzyme are a common phenomenon among rotavirus (RV) diarrhea. However, few studies have addressed this issue using large sample size. In current study, 1,118 children (age <5 years) hospitalized with diarrhea in Guangzhou Women and Children's Medical Center from 2012 to...

    journal_title：Scientific reports

    pub_type： 历史文章,杂志文章

    doi：10.1038/s41598-017-07636-4

    authors： Zheng J,Zheng H,Gupta RK,Li H,Shi H,Pan L,Gong S,Liang H

    更新日期：2017-08-09 00:00:00

  • Analysis of diet-induced differential methylation, expression, and interactions of lncRNA and protein-coding genes in mouse liver.

    abstract：:Long non-coding RNAs (lncRNAs) regulate expression of protein-coding genes in cis through chromatin modifications including DNA methylation. Here we interrogated whether lncRNA genes may regulate transcription and methylation of their flanking or overlapping protein-coding genes in livers of mice exposed to a 12-week ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-29993-4

    authors： Silva JP,van Booven D

    更新日期：2018-08-01 00:00:00

  • Multisensory learning between odor and sound enhances beta oscillations.

    abstract：:Multisensory interactions are essential to make sense of the environment by transforming the mosaic of sensory inputs received by the organism into a unified perception. Brain rhythms allow coherent processing within areas or between distant brain regions and could thus be instrumental in functionally connecting remot...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-47503-y

    authors： Gnaedinger A,Gurden H,Gourévitch B,Martin C

    更新日期：2019-08-02 00:00:00

  • In-vivo shift of the microbiota in oral biofilm in response to frequent sucrose consumption.

    abstract：:Caries is associated with shifts of microbiota in dental biofilms and primarily driven by frequent sucrose consumption. Data on environmentally induced in vivo microbiota shifts are scarce therefore we investigated the influence of frequent sucrose consumption on the oral biofilm. Splint systems containing enamel slab...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-32544-6

    authors： Anderson AC,Rothballer M,Altenburger MJ,Woelber JP,Karygianni L,Lagkouvardos I,Hellwig E,Al-Ahmad A

    更新日期：2018-09-21 00:00:00

  • Broadband gradient impedance matching using an acoustic metamaterial for ultrasonic transducers.

    abstract：:High-quality broadband ultrasound transducers yield superior imaging performance in biomedical ultrasonography. However, proper design to perfectly bridge the energy between the active piezoelectric material and the target medium over the operating spectrum is still lacking. Here, we demonstrate a new anisotropic cone...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep42863

    authors： Li Z,Yang DQ,Liu SL,Yu SY,Lu MH,Zhu J,Zhang ST,Zhu MW,Guo XS,Wu HD,Wang XL,Chen YF

    更新日期：2017-02-17 00:00:00

  • Surgical treatment in Paget's disease with invasive ductal carcinoma: an observational study based on SEER.

    abstract：:The aim is to analyse the clinical presentation, treatment and outcomes in patients with Paget's disease with invasive ductal carcinoma (PD-IDC), with special emphasis on the role of surgical treatment. Using data obtained by the Surveillance, Epidemiology, and End Results (SEER) program from 2010-2013, we investigate...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep45510

    authors： Wu Q,Ding X,Li J,Sun S,Zhu S,Wu J,Liu Q,Yao F,Sun S

    更新日期：2017-04-19 00:00:00

  • 'Candidatus Cochliophilus cryoturris' (Coxiellaceae), a symbiont of the testate amoeba Cochliopodium minus.

    abstract：:Free-living amoebae are well known for their role in controlling microbial community composition through grazing, but some groups, namely Acanthamoeba species, also frequently serve as hosts for bacterial symbionts. Here we report the first identification of a bacterial symbiont in the testate amoeba Cochliopodium. Th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03642-8

    authors： Tsao HF,Scheikl U,Volland JM,Köhsler M,Bright M,Walochnik J,Horn M

    更新日期：2017-06-13 00:00:00

  • Evaluation of the immunological profile of antibody-functionalized metal-filled single-walled carbon nanocapsules for targeted radiotherapy.

    abstract：:This study investigates the immune responses induced by metal-filled single-walled carbon nanotubes (SWCNT) under in vitro, ex vivo and in vivo settings. Either empty amino-functionalized CNTs [SWCNT-NH2 (1)] or samarium chloride-filled amino-functionalized CNTs with [SmCl3@SWCNT-mAb (3)] or without [SmCl3@SWCNT-NH2 (...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep42605

    authors： Perez Ruiz de Garibay A,Spinato C,Klippstein R,Bourgognon M,Martincic M,Pach E,Ballesteros B,Ménard-Moyon C,Al-Jamal KT,Tobias G,Bianco A

    更新日期：2017-02-15 00:00:00

  • Genomic DNA variation confirmed Seriola lalandi comprises three different populations in the Pacific, but with recent divergence.

    abstract：:Captive breeding programs and aquaculture production have commenced worldwide for the globally distributed yellowtail kingfish (Seriola lalandi), and captive bred fingerlings are being shipped from the Southern Hemisphere to be farmed in the Northern Hemisphere. It was recently proposed that Pacific S. lalandi compris...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-07419-x

    authors： Premachandra HKA,la Cruz FL,Takeuchi Y,Miller A,Fielder S,O'Connor W,Frère CH,Nguyen NH,Bar I,Knibb W

    更新日期：2017-08-24 00:00:00

  • Sideroflexin 4 affects Fe-S cluster biogenesis, iron metabolism, mitochondrial respiration and heme biosynthetic enzymes.

    abstract：:Sideroflexin4 (SFXN4) is a member of a family of nuclear-encoded mitochondrial proteins. Rare germline mutations in SFXN4 lead to phenotypic characteristics of mitochondrial disease including impaired mitochondrial respiration and hematopoetic abnormalities. We sought to explore the function of this protein. We show t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-55907-z

    authors： Paul BT,Tesfay L,Winkler CR,Torti FM,Torti SV

    更新日期：2019-12-23 00:00:00

  • Experimental detection of transverse particle movement with structured light.

    abstract：:One procedure widely used to detect the velocity of a moving object is by using the Doppler effect. This is the perceived change in frequency of a wave caused by the relative motion between the emitter and the detector, or between the detector and a reflecting target. The relative movement, in turn, generates a time-v...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep02815

    authors： Rosales-Guzmán C,Hermosa N,Belmonte A,Torres JP

    更新日期：2013-10-02 00:00:00

  • A rapid assay for measuring nucleotide excision repair by oligonucleotide retrieval.

    abstract：:Nucleotide excision repair (NER) excises bulky DNA lesions induced by mutagens and carcinogens. The repair process includes recognition of DNA damage, excision of a short patch of nucleotides containing the damaged base, re-synthesis of a new DNA strand and ligation of the nicks to restore the sequence integrity. Muta...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep04894

    authors： Shen JC,Fox EJ,Ahn EH,Loeb LA

    更新日期：2014-05-08 00:00:00

  • Tracking capsule activation and crack healing in a microcapsule-based self-healing polymer.

    abstract：:Structural polymeric materials incorporating a microencapsulated liquid healing agent demonstrate the ability to autonomously heal cracks. Understanding how an advancing crack interacts with the microcapsules is critical to optimizing performance through tailoring the size, distribution and density of these capsules. ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-54242-7

    authors： McDonald SA,Coban SB,Sottos NR,Withers PJ

    更新日期：2019-11-28 00:00:00

  • Annealing induced a well-ordered single crystal δ-MnO2 and its electrochemical performance in zinc-ion battery.

    abstract：:Herein, the formation and electrochemical performance of a novel binder-free turbostratic stacked/ well-ordered stacked δ-MnO2-carbon fiber composite cathodes in deep eutectic solvent (DES) based zinc-ion battery (ZIB) is reported. Results of morphological, elemental, and structural analyses revealed directly grown an...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-51692-x

    authors： Corpuz RD,De Juan LMZ,Praserthdam S,Pornprasertsuk R,Yonezawa T,Nguyen MT,Kheawhom S

    更新日期：2019-10-22 00:00:00

  • Prevalence of normal weight central obesity among Thai healthcare providers and their association with CVD risk: a cross-sectional study.

    abstract：:This study aims to determine the prevalence of health personnel with normal weight central obesity and to investigate whether this group had higher cardiovascular disease (CVD) risk factors than those of the people with normal weight and without central obesity. A waist-to-height ratio was calculated as waist circumfe...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/srep37100

    authors： Thaikruea L,Thammasarot J

    更新日期：2016-11-16 00:00:00