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Surgical treatment in Paget's disease with invasive ductal carcinoma: an observational study based on SEER.

Abstract：

:The aim is to analyse the clinical presentation, treatment and outcomes in patients with Paget's disease with invasive ductal carcinoma (PD-IDC), with special emphasis on the role of surgical treatment. Using data obtained by the Surveillance, Epidemiology, and End Results (SEER) program from 2010-2013, we investigated the differences in characteristics, overall survival (OS), and breast cancer-specific mortality (BCSM) between patients with PD-IDC and those with invasive ductal carcinoma (IDC). Compared with IDC group, patients with PD-IDC had a better prognosis and lower mortality in adjusted analyses. In the multivariate analysis of cases with PD-IDC, history of ALND was significantly associated with OS while Her2 status were associated with BCSM. Further, subgroup analysis demonstrated no difference between surgical treatment subgroups for either OS or BCSM. The results demonstrated that PD-IDC appears to alter the association between prognosis and Her2 status. Meanwhile, breast-conserving surgery with radiotherapy may be a feasible treatment alternative and sentinel lymph node biopsy should be considered as an appropriate treatment for patients with PD-IDC.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Wu Q,Ding X,Li J,Sun S,Zhu S,Wu J,Liu Q,Yao F,Sun S

doi

10.1038/srep45510

subject

Has Abstract

pub_date

2017-04-19 00:00:00

pages

45510

issn

2045-2322

pii

srep45510

journal_volume

7

pub_type

杂志文章

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