Abstract：
:The transcriptional regulator JDP2 (Jun dimerization protein 2) has been identified as a prognostic marker for patients to develop heart failure after myocardial infarction. We now performed in vivo studies on JDP2-overexpressing mice, to clarify the impact of JDP2 on heart failure progression. Therefore, during birth up to the age of 4 weeks cardiac-specific JDP2 overexpression was prevented by doxycycline feeding in transgenic mice. Then, JDP2 overexpression was started. Already after 1 week, cardiac function, determined by echocardiography, decreased which was also resembled on the cardiomyocyte level. After 5 weeks blood pressure declined, ejection fraction and cardiac output was reduced and left ventricular dilatation developed. Heart weight/body weight, and mRNA expression of ANP, inflammatory marker genes, collagen and fibronectin increased. Collagen 1 protein expression increased, and fibrosis developed. As an additional sign of elevated extracellular matrix remodeling, matrix metalloproteinase 2 activity increased in JDP2 mice. Thus, JDP2 overexpression is deleterious to heart function in vivo. It can be concluded that JDP2 overexpression provokes cardiac dysfunction in adult mice that is accompanied by hypertrophy and fibrosis. Thus, induction of JDP2 is a maladaptive response contributing to heart failure development.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Heger J,Bornbaum J,Würfel A,Hill C,Brockmann N,Gáspár R,Pálóczi J,Varga ZV,Sárközy M,Bencsik P,Csont T,Török S,Kojonazarov B,Schermuly RT,Böngler K,Parahuleva M,Ferdinandy P,Schulz R,Euler Gdoi
10.1038/s41598-018-26052-wsubject
Has Abstractpub_date
2018-05-16 00:00:00pages
7647issue
1issn
2045-2322pii
10.1038/s41598-018-26052-wjournal_volume
8pub_type
杂志文章abstract：:Organic solar cells (OSCs) are promising alternatives to the conventional inorganic solar cells due to their low-cost processing and compatibility with flexible substrates. The development of low band-gap polymer, e.g., poly-[[4,8-bis[(2-ethylhexyl)oxy]benzo[1,2-b:4,5-b']dithiophene-2,6-diyl] [3-fluoro-2-[(2-ethylhexy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13648
更新日期：2015-09-01 00:00:00
abstract：:In many real-world networks, the ability to withstand targeted or global attacks; extinctions; or shocks is vital to the survival of the network itself, and of dependent structures such as economies (for financial networks) or even the planet (for ecosystems). Previous attempts to characterise robustness include neste...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59959-4
更新日期：2020-02-25 00:00:00
abstract：:Insulin secretion from pancreatic beta-cells is dependent on zinc ions as essential components of insulin crystals, zinc transporters are thus involved in the insulin secretory process. Zip14 (SLC39a14) is a zinc importing protein that has an important role in glucose homeostasis. Zip14 knockout mice display hyperinsu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44954-1
更新日期：2019-06-13 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-58622-2
更新日期：2020-01-28 00:00:00
abstract：:Tsunamis can propagate thousands of kilometres across the ocean. Precise calculations of arrival times are essential for reliable early warning systems, determination of source and earth properties using the inverse problem, and time series modulation due to frequency dependency of phase speed. Far field observatories...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52475-0
更新日期：2019-11-14 00:00:00
abstract：:Identifying similarities and differences in choice behavior across species is informative about how basic mechanisms give rise to more complex processes. In the present study, we compared pre- and post-choice latencies between rats and humans under two paradigms. In Experiment 1, we used a cued choice paradigm where s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20583
更新日期：2016-02-10 00:00:00
abstract：:Adaptive responses to hypoxia regulate hepatic lipid metabolism, but their consequences in nonalcoholic fatty liver disease (NAFLD) are largely unknown. Here, we show that hypoxia inducible factor-1 (HIF-1), a key determinant of hypoxic adaptations, prevents excessive hepatic lipid accumulation in the progression of N...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32586-w
更新日期：2018-09-21 00:00:00
abstract：:In this work, lamellar MnFe2O4 was successfully planted on a wood surface through the association of hydrogen bonds via the one-pot hydrothermal method. Simultaneously, the fluoroalkylsilane (FAS-17) on the surface of the MnFe2O4 layer formed long-chain or network macromolecules through a poly-condensation process and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35549
更新日期：2016-10-17 00:00:00
abstract：:Acute physical exercise improves memory functions by increasing neural plasticity in the hippocampus. In animals, a single session of physical exercise has been shown to boost anandamide (AEA), an endocannabinoid known to promote hippocampal plasticity. Hippocampal neuronal networks encode episodic memory representati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72108-1
更新日期：2020-09-18 00:00:00
abstract：:The study of network topology provides insight into the function and behavior of physical, social, and biological systems. A natural step towards discovering the organizing principles of these complex topologies is to identify a reduced network representation using cohesive subgroups or communities. This procedure oft...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30401-0
更新日期：2018-08-09 00:00:00
abstract：:In this paper, we study a system with two interacting qubits described by the Heisenberg model with dissipative terms, and analyze decay dynamics and the steady-state of geometric quantum discords. Our results indicate that we can ignore the interaction force in the z-direction and adjust the parameters to change the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67698-9
更新日期：2020-07-02 00:00:00
abstract：:Infection with Mycobacterium ulcerans causes Buruli Ulcer, a neglected tropical disease. Mosquito vectors are suspected to participate in the transmission and environmental maintenance of the bacterium. However, mechanisms and consequences of mosquito contamination by M. ulcerans are not well understood. We evaluated ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09242
更新日期：2015-03-18 00:00:00
abstract：:Early life overfeeding is associated with cognitive decline and anxiety-like behaviors in later life. It is not clear whether there are individual differences in the effects of early life overfeeding and what the underlying mechanistic pathways are. We investigated the long-lasting effects of small litter size, an exp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29595-0
更新日期：2018-07-26 00:00:00
abstract：:Chromobox 6 (CBX6) is a subunit of Polycomb Repressive Complex 1 (PRC1) that mediates epigenetic gene repression and acts as an oncogene or tumor suppressor in a cancer type-dependent manner. The specific function of CBX6 in breast cancer is currently undefined. In this study, a comprehensive analysis of The Cancer Ge...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36560-4
更新日期：2019-01-17 00:00:00
abstract：:Induced pluripotent stem cells (iPSCs) are promising candidate cells for cardiomyogenesis in the failing heart. However, teratoma/tumour formation originating from undifferentiated iPSCs contaminating the graft is a critical concern for clinical application. Here, we hypothesized that brentuximab vedotin, which target...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21923-8
更新日期：2018-02-27 00:00:00
abstract：:In face-to-face communication, audio-visual (AV) stimuli can be fused, combined or perceived as mismatching. While the left superior temporal sulcus (STS) is presumably the locus of AV integration, the process leading to combination is unknown. Based on previous modelling work, we hypothesize that combination results ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75201-7
更新日期：2020-10-22 00:00:00
abstract：:Sunflower see/ds (Helianthus annuus L.) were roasted in an electric forced air oven for 15, 30, 45, and 60 min at 125, 135 and 145 °C. The effect of temperature and time on the flavor profile of the samples were evaluated by headspace solid-phase microextraction coupled with gas chromatography-mass spectroscopy (HS-SP...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47811-3
更新日期：2019-08-05 00:00:00
abstract：:Dysfunctional epicardial adipose tissue (EAT) secretome can influence the heart's stretch response. However, the molecular mechanisms are still poorly understood. The aim of this study was to clarify how dysfunctional EAT promotes maladaptive heart remodeling in cardiovascular disease (CVD) through ST2 production asso...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46676-w
更新日期：2019-07-17 00:00:00
abstract：:The aim of this prospective study was to evaluate the changes in stereopsis in patients who underwent vitrectomy for macular hole (MH) and assess the relationship between stereopsis and retinal microstructures. Fifty-two patients who underwent successful vitrectomy for unilateral MH and 20 control participants were re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76648-4
更新日期：2020-11-11 00:00:00
abstract：:Safe management of high level nuclear waste is a worldwide significant issue for which vitrification has been selected by many countries. There exists a crucial need for improving our understanding of the ageing of the glass under irradiation. While external irradiation by ions provides a rapid simulation of damage in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25499
更新日期：2016-05-05 00:00:00
abstract：:Agamococcidians are enigmatic and poorly studied parasites of marine invertebrates with unexplored diversity and unclear relationships to other sporozoans such as the human pathogens Plasmodium and Toxoplasma. It is believed that agamococcidians are not capable of sexual reproduction, which is essential for life cycle...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72287-x
更新日期：2020-09-28 00:00:00
abstract：:We examined how plant-pollinator interactions were affected by time since habitat restoration and landscape connectivity by comparing plant-pollinator networks in restored, abandoned and continuously grazed semi-natural pastures in south-central Sweden. We measured richness of flowering plants and pollinators, and loc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51912-4
更新日期：2019-10-29 00:00:00
abstract：:Settlement-inducing protein complex (SIPC) is a pheromone that triggers conspecific larval settlement in the barnacle Amphibalanus amphitrite. In the present study, immunostaining and scanning electron microscopy of SIPC revealed signals in the frontal horn pores and the secretions from carapace pores, suggesting that...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29376
更新日期：2016-07-20 00:00:00
abstract：:Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare disease, characterised by the aplasia of vagina and uterus in women with a 46,XX karyotype. Most cases are sporadic, but familial recurrence has also been described. Herein, we investigated an Italian cohort of 36 unrelated MRKH patients to explore the presence ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79827-5
更新日期：2021-01-11 00:00:00
abstract：:Increased activity of brown adipose tissue (BAT) activity in adults is thought to prevent obesity. Therefore, regulators of BAT activity might serve as anti-obesity therapy in future, but are not investigated thoroughly up to now. In our study, we assessed retrospectively the association of BAT activity with several e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37924-6
更新日期：2019-02-13 00:00:00
abstract：:It is recognized that T helper 2 (Th2) polarization plays a critical role in a large number of immune disorders. Yet, the remedies for reconciling the established Th2 polarization are still limited currently. Published data indicate that micro RNA-17-92 cluster is associated with the skewed immune response; 25 vitamin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00431-1
更新日期：2017-04-03 00:00:00
abstract：:Gluconobacter oxydans sorbitol dehydrogenase (GoSLDH) exhibits a higher catalytic efficiency than other L-sorbose producing enzymes. During the reaction catalysed by GoSLDH, NADP+ is reduced to NADPH and D-sorbitol is oxidized to L-sorbose. However, GoSLDH activity is inhibited by the NADPH (Ki = 100 μM) formed during...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37401-0
更新日期：2019-01-28 00:00:00
abstract：:We have developed an optimized protocol for plasma targeted mRNA sequencing in our previous study. Here, we performed plasma targeted mRNA sequencing for 40 colorectal adenoma patients and 39 colonoscopy-proven normal controls in order to find potential circulating mRNA markers for colorectal adenoma. Results showed t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49445-x
更新日期：2019-09-10 00:00:00
abstract：:Archeological researches have proposed arguments for human mobility and long-distance trading over the Eurasia before the Silk Roads. Here we utilize biologically available strontium isotope analysis to assess the extent of pre-Silk Road population movements and cultural communications across the Asian interior. From ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35162
更新日期：2016-10-20 00:00:00
abstract：:Empowering an indirect band-gap material like Si with optical functionalities, firstly light emission, represents a huge advancement constantly pursued in the realization of any integrated photonic device. We report the demonstration of giant photoluminescence (PL) emission by a newly synthesized material consisting o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02674
更新日期：2013-01-01 00:00:00
