当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Electrospun nerve guide conduits have the potential to bridge peripheral nerve injuries in vivo.

Electrospun nerve guide conduits have the potential to bridge peripheral nerve injuries in vivo.

Abstract：

:Electrospinning can be used to mimic the architecture of an acellular nerve graft, combining microfibers for guidance, and pores for cellular infiltration. We made electrospun nerve guides, from polycaprolactone (PCL) or poly-L-lactic acid (PLLA), with aligned fibers along the insides of the channels and random fibers around them. We bridged a 10 mm rat sciatic nerve defect with the guides, and, in selected groups, added a cell transplant derived from autologous stromal vascular fraction (SVF). For control, we compared to hollow silicone tubes; or autologous nerve grafts. PCL nerve guides had a high degree of autotomy (8/43 rats), a negative indicator with respect to future usefulness, while PLLA supported axonal regeneration, but did not outperform autologous nerve grafts. Transplanted cells survived in the PLLA nerve guides, but axonal regeneration was not enhanced as compared to nerve guides alone. The inflammatory response was partially enhanced by the transplanted cells in PLLA nerve grafts; Schwann cells were poorly distributed compared to nerve guide without cells. Tailor-made electrospun nerve guides support axonal regeneration in vivo, and can act as vehicles for co-transplanted cells. Our results motivate further studies exploring novel nerve guides and the effect of stromal cell-derived factors on nerve generation.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Frost HK,Andersson T,Johansson S,Englund-Johansson U,Ekström P,Dahlin LB,Johansson F

doi

10.1038/s41598-018-34699-8

subject

Has Abstract

pub_date

2018-11-13 00:00:00

pages

16716

issue

1

issn

2045-2322

pii

10.1038/s41598-018-34699-8

journal_volume

8

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells.

    abstract：:This report identifies mitochondrial DNA (mtDNA) as a target and active mediator that links low-level oxidative stress to inflammatory response in pulmonary epithelial cells. Extrusion of mtDNA into the bronchoalveolar lavage fluid occurs as an early event in mice subjected to cigarette smoke injury, concomitantly wit...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-19216-1

    authors： Szczesny B,Marcatti M,Ahmad A,Montalbano M,Brunyánszki A,Bibli SI,Papapetropoulos A,Szabo C

    更新日期：2018-01-17 00:00:00

  • Tmc2 expression partially restores auditory function in a mouse model of DFNB7/B11 deafness caused by loss of Tmc1 function.

    abstract：:Mouse Tmc1 and Tmc2 are required for sensory transduction in cochlear and vestibular hair cells. Homozygous Tmc1∆/∆ mice are deaf, Tmc2∆/∆ mice have normal hearing, and double homozygous Tmc1∆/∆; Tmc2∆/∆ mice have deafness and profound vestibular dysfunction. These phenotypes are consistent with their different spatio...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-29709-8

    authors： Nakanishi H,Kurima K,Pan B,Wangemann P,Fitzgerald TS,Géléoc GS,Holt JR,Griffith AJ

    更新日期：2018-08-14 00:00:00

  • Neural basis of uncertain cue processing in trait anxiety.

    abstract：:Individuals with high trait anxiety form a non-clinical group with a predisposition for an anxiety-related bias in emotional and cognitive processing that is considered by some to be a prerequisite for psychiatric disorders. Anxious individuals tend to experience more worry under uncertainty, and processing uncertain ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep21298

    authors： Zhang M,Ma C,Luo Y,Li J,Li Q,Liu Y,Ding C,Qiu J

    更新日期：2016-02-19 00:00:00

  • Comparison of three models fitting the soil water retention curves in a degraded alpine meadow region.

    abstract：:Soil water retention curve (SWRC) plays an important role in simulating soil water movement and assessing soil water holding capacity and availability. Comparison of fitness between different models to determine the best SWRC model of specific regions is required. In this study, three popular models, van Genuchten, Br...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-54449-8

    authors： Pan T,Hou S,Liu Y,Tan Q

    更新日期：2019-12-05 00:00:00

  • Evaluation of Three Block Anesthesia Methods for Pain Management During Mandibular Third Molar Extraction: A Meta-analysis.

    abstract：:A patient's pain during mandibular third molar extraction often creates problems for a dental surgeon and can also cause immense patient discomfort, such as decreased quality of life, serious complications, or even danger to the patients' lives. Effective pain management is therefore of great importance. Conventional ...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析,评审

    doi：10.1038/srep40987

    authors： Yu F,Xiao Y,Liu H,Wu F,Lou F,Chen D,Bai M,Huang D,Wang C,Ye L

    更新日期：2017-01-20 00:00:00

  • Inhibition of PDGFR signaling prevents muscular fatty infiltration after rotator cuff tear in mice.

    abstract：:Fatty infiltration in muscle is often observed in patients with sizable rotator cuff tear (RCT) and is thought to be an irreversible event that significantly compromises muscle plasticity and contraction strength. These changes in the mechanical properties of the affected muscle render surgical repair of RCT highly fo...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep41552

    authors： Shirasawa H,Matsumura N,Shimoda M,Oki S,Yoda M,Tohmonda T,Kanai Y,Matsumoto M,Nakamura M,Horiuchi K

    更新日期：2017-01-31 00:00:00

  • Tunable high-order sideband spectra generation using a photonic molecule optomechanical system.

    abstract：:A tunable high-order sideband spectra generation scheme is presented by using a photonic molecule optomechanical system coupled to a waveguide beyond the perturbation regime. The system is coherently driven by a two-tone laser consisting of a continuous-wave control field and a pulsed driving field which propagates th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep22920

    authors： Cao C,Mi SC,Gao YP,He LY,Yang D,Wang TJ,Zhang R,Wang C

    更新日期：2016-03-10 00:00:00

  • Circulation of a novel strain of dolphin morbillivirus (DMV) in stranded cetaceans in the Mediterranean Sea.

    abstract：:Dolphin morbillivirus (DMV) has been responsible for several outbreaks of systemic infection and has resulted in cetacean strandings in the Mediterranean. In August-October 2016, seven striped dolphins (Stenella coeruleoalba) stranded on the Sicilian coastline (Italy) tested positive for DMV. Tissue samples from brain...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-46096-w

    authors： Mira F,Rubio-Guerri C,Purpari G,Puleio R,Caracappa G,Gucciardi F,Russotto L,Loria GR,Guercio A

    更新日期：2019-07-05 00:00:00

  • Effects of a microbial restoration substrate on plant growth and rhizosphere bacterial community in a continuous tomato cropping greenhouse.

    abstract：:Continuous cropping of tomato is increasingly practiced in greenhouse cultivation, leading to several soil-related obstacles. In this study, a type of microbial restoration substrate (MRS) was used to amend soils from the re-cropping of tomato for 8 years under greenhouse-cultivated conditions. Two treatments were est...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-70737-0

    authors： Zheng X,Wang Z,Zhu Y,Wang J,Liu B

    更新日期：2020-08-13 00:00:00

  • Novel diversity within marine Mamiellophyceae (Chlorophyta) unveiled by metabarcoding.

    abstract：:Mamiellophyceae (unicellular green algae) are a key phytoplankton group in coastal waters. Although extensively studied over the last 20 years, the overall oceanic distribution of the major species/clades is still poorly known. To address this problem, we analyzed the 2014 Ocean Sampling Day (OSD) metabarcoding datase...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-41680-6

    authors： Tragin M,Vaulot D

    更新日期：2019-03-26 00:00:00

  • Author Correction: Hidden diversity in the Brazilian Atlantic rainforest: the discovery of Jurasaidae, a new beetle family (Coleoptera, Elateroidea) with neotenic females.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-60629-8

    authors： Rosa SP,Costa C,Kramp K,Kundrata R

    更新日期：2020-02-25 00:00:00

  • Cell-death-inducing DFFA-like Effector B Contributes to the Assembly of Hepatitis C Virus (HCV) Particles and Interacts with HCV NS5A.

    abstract：:Hepatitis C virus (HCV) uses components of the very-low-density lipoprotein (VLDL) pathway for assembly/release. We previously reported that hepatocyte nuclear factor 4α (HNF4α) participates in HCV assembly/release through downstream factors those participate in VLDL assembly/secretion. Cell-death-inducing DFFA-like e...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27778

    authors： Cai H,Yao W,Li L,Li X,Hu L,Mai R,Peng T

    更新日期：2016-06-10 00:00:00

  • Hybrid sequencing and map finding (HySeMaFi): optional strategies for extensively deciphering gene splicing and expression in organisms without reference genome.

    abstract：:Using second-generation sequencing (SGS) RNA-Seq strategies, extensive alterative splicing prediction is impractical and high variability of isoforms expression quantification is inevitable in organisms without true reference dataset. we report the development of a novel analysis method, termed hybrid sequencing and m...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep43793

    authors： Ning G,Cheng X,Luo P,Liang F,Wang Z,Yu G,Li X,Wang D,Bao M

    更新日期：2017-03-08 00:00:00

  • Long-term exercise training improves memory in middle-aged men and modulates peripheral levels of BDNF and Cathepsin B.

    abstract：:Aging is accompanied by a decline in memory and other brain functions. Physical exercise may mitigate this decline through the modulation of factors participating in the crosstalk between skeletal muscle and the brain, such as neurotrophins and oxidative stress parameters. We aimed to determine whether long term exerc...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-40040-8

    authors： De la Rosa A,Solana E,Corpas R,Bartrés-Faz D,Pallàs M,Vina J,Sanfeliu C,Gomez-Cabrera MC

    更新日期：2019-03-04 00:00:00

  • Biosynthesis of CuO nanoparticles using aqueous extract of herbal tea (Stachys Lavandulifolia) flowers and evaluation of its catalytic activity.

    abstract：:Plant derived biogenic synthesis of nanoparticles (NP) has been the recent trend in material science as featured sustainable catalysts. A great deal of the current nanocatalytic research has been oriented on the bio-inspired green catalysts based on their wide applicability. In this context, CuO NPs are synthesized fo...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-021-81320-6

    authors： Veisi H,Karmakar B,Tamoradi T,Hemmati S,Hekmati M,Hamelian M

    更新日期：2021-01-21 00:00:00

  • Machine Learning-Assisted Network Inference Approach to Identify a New Class of Genes that Coordinate the Functionality of Cancer Networks.

    abstract：:Emerging evidence indicates the existence of a new class of cancer genes that act as "signal linkers" coordinating oncogenic signals between mutated and differentially expressed genes. While frequently mutated oncogenes and differentially expressed genes, which we term Class I cancer genes, are readily detected by mos...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-07481-5

    authors： Ghanat Bari M,Ung CY,Zhang C,Zhu S,Li H

    更新日期：2017-08-01 00:00:00

  • Receptor occupancy of dual glucagon-like peptide 1/glucagon receptor agonist SAR425899 in individuals with type 2 diabetes.

    abstract：:Unimolecular dual agonists for the glucagon-like peptide 1 receptor (GLP1R) and glucagon receptor (GCGR) are emerging as a potential new class of important therapeutics in type 2 diabetes (T2D). Reliable and quantitative assessments of in vivo occupancy on each receptor would improve the understanding of the efficacy ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-73815-5

    authors： Eriksson O,Haack T,Hijazi Y,Teichert L,Tavernier V,Laitinen I,Berglund JE,Antoni G,Velikyan I,Johansson L,Pierrou S,Wagner M,Tillner J

    更新日期：2020-10-07 00:00:00

  • Author Correction: Dual-energy CT perfusion imaging for differentiating WHO subtypes of thymic epithelial tumors.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-64341-5

    authors： Yu C,Li T,Zhang R,Yang X,Yang Z,Xin L,Zhao Z

    更新日期：2020-04-29 00:00:00

  • Exosomes derived from human adipose mensenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts.

    abstract：:Prolonged healing and scar formation are two major challenges in the treatment of soft tissue trauma. Adipose mesenchymal stem cells (ASCs) play an important role in tissue regeneration, and recent studies have suggested that exosomes secreted by stem cells may contribute to paracrine signaling. In this study, we inve...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep32993

    authors： Hu L,Wang J,Zhou X,Xiong Z,Zhao J,Yu R,Huang F,Zhang H,Chen L

    更新日期：2016-09-12 00:00:00

  • Non-sequential double ionization with near-single cycle laser pulses.

    abstract：:A three-dimensional semiclassical model is used to study double ionization of Ar when driven by a near-infrared and near-single-cycle laser pulse for intensities ranging from 0.85 × 1014 W/cm2 to 5 × 1014 W/cm2. Asymmetry parameters, distributions of the sum of the two electron momentum components along the direction ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-07635-5

    authors： Chen A,Kübel M,Bergues B,Kling MF,Emmanouilidou A

    更新日期：2017-08-08 00:00:00

  • Anisotropic characteristics and improved magnetic performance of Ca-La-Co-substituted strontium hexaferrite nanomagnets.

    abstract：:Recent studies on next-generation permanent magnets have focused on filling in the gap between rare-earth magnets and rare-earth-free magnets, taking into account both the cost-effectiveness and magnetic performance of the magnetic materials. As an improved rare-earth-free magnet candidate, here, Ca-substituted M-type...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-72608-0

    authors： Lee J,Lee EJ,Hwang TY,Kim J,Choa YH

    更新日期：2020-09-28 00:00:00

  • The dynamics of plant nutation.

    abstract：:In this article we advance a cutting-edge methodology for the study of the dynamics of plant movements of nutation. Our approach, unlike customary kinematic analyses of shape, period, or amplitude, is based on three typical signatures of adaptively controlled processes and motions, as reported in the biological and be...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-76588-z

    authors： Raja V,Silva PL,Holghoomi R,Calvo P

    更新日期：2020-11-10 00:00:00

  • Streamflow variations across the Andes (18°-55°S) during the instrumental era.

    abstract：:The rivers originating in the southern Andes (18°-55°S) support numerous ecosystems and a large number of human populations and socio-economic activities in the adjacent lowlands of Chile, Argentina and Bolivia. Here we show that ca. 75% of the total variance in the streamflow records from this extensive region can be...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-53981-x

    authors： Masiokas MH,Cara L,Villalba R,Pitte P,Luckman BH,Toum E,Christie DA,Le Quesne C,Mauget S

    更新日期：2019-11-29 00:00:00

  • Microsphere-mediated optical contrast tuning for designing imaging systems with adjustable resolution gain.

    abstract：:Upon illumination, a dielectric microsphere (μS) can generate a photonic nanojet (PNJ), which plays a role in the super-resolution imaging of a sample placed in the μS's immediate proximity. Recent microscopy implementations pioneered this concept but, despite the experimental characterization and theoretical modeling...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-33604-7

    authors： Migliozzi D,Gijs MAM,Huszka G

    更新日期：2018-10-12 00:00:00

  • Magnetic metamaterial superlens for increased range wireless power transfer.

    abstract：:The ability to wirelessly power electrical devices is becoming of greater urgency as a component of energy conservation and sustainability efforts. Due to health and safety concerns, most wireless power transfer (WPT) schemes utilize very low frequency, quasi-static, magnetic fields; power transfer occurs via magneto-...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep03642

    authors： Lipworth G,Ensworth J,Seetharam K,Huang D,Lee JS,Schmalenberg P,Nomura T,Reynolds MS,Smith DR,Urzhumov Y

    更新日期：2014-01-10 00:00:00

  • Insights into grapevine defense response against drought as revealed by biochemical, physiological and RNA-Seq analysis.

    abstract：:Grapevine is an important and extensively grown fruit crop, which is severely hampered by drought worldwide. So, comprehending the impact of drought on grapevine genetic resources is necessary. In the present study, RNA-sequencing was executed using cDNA libraries constructed from both drought-stress and control plant...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-13464-3

    authors： Haider MS,Zhang C,Kurjogi MM,Pervaiz T,Zheng T,Zhang C,Lide C,Shangguan L,Fang J

    更新日期：2017-10-13 00:00:00

  • Insights into the structures and electronic properties of Cun+1μ and CunS μ (n = 1-12; μ = 0, ±1) clusters.

    abstract：ABSTARCT:The stability and reactivity of clusters are closely related to their valence electronic configuration. Doping is a most efficient method to modify the electronic configuration and properties of a cluster. Considering that Cu and S posses one and six valence electrons, respectively, the S doped Cu clusters wit...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-01444-6

    authors： Li CG,Shen ZG,Hu YF,Tang YN,Chen WG,Ren BZ

    更新日期：2017-05-02 00:00:00

  • The Effect of Rotational Disorder on the Microwave Transmission of Checkerboard Metal Square Arrays.

    abstract：:The effect of rotational disorder on the microwave transmission through thin metallic checkerboard arrays has been experimentally studied. Broad resonant features below the onset of diffraction, attributed to electromagnetic radiation coupling through the structure via the evanescent fields of bound surface waves, are...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep16608

    authors： Tremain B,Durrant CJ,Carter IE,Hibbins AP,Sambles JR

    更新日期：2015-11-16 00:00:00

  • Multiscale Modeling of Fiber Fragmentation Process in Aligned ZnO Nanowires Enhanced Single Fiber Composites.

    abstract：:A three-dimensional multiscale modeling framework is developed to analyze the failure procedure of radially aligned zinc oxide (ZnO) enhanced single fiber composites (SFC) under tensile loading to understand the interfacial improvement between the fiber and the matrix. The model introduces four levels in the computati...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-56503-x

    authors： Marashizadeh P,Abshirini M,Wang J,C Saha M,Liu Y

    更新日期：2019-12-27 00:00:00

  • Epidemiological and etiological characteristics of hand, foot, and mouth disease in Henan, China, 2008-2013.

    abstract：:Hand, foot, and mouth disease (HFMD) is a common childhood illness caused by enteroviruses. HFMD outbreaks and reported cases have sharply increased in China since 2008. Epidemiological and clinical data of HFMD cases reported in Henan Province were collected from 2008 to 2013. Clinical specimens were obtained from a ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep08904

    authors： Huang X,Wei H,Wu S,Du Y,Liu L,Su J,Xu Y,Wang H,Li X,Wang Y,Liu G,Chen W,Klena JD,Xu B

    更新日期：2015-03-10 00:00:00