Abstract：
:The spread of multidrug-resistant Staphylococcus aureus strains, including methicillin-resistant S. aureus (MRSA), has shortened the useful life of anti-staphylococcal drugs enormously. Two approaches can be followed to address this problem: screening various sources for new leads for antibiotics or finding ways to disable the resistance mechanisms to existing antibiotics. Plants are resistant to most microorganisms, but despite extensive efforts to identify metabolites that are responsible for this resistance, no substantial progress has been made. Plants possibly use multiple strategies to deal with microorganisms that evolved over time. For this reason, we searched for plants that could potentiate the effects of known antibiotics. From 29 plant species tested, Cytisus striatus clearly showed such an activity and an NMR-based metabolomics study allowed the identification of compounds from the plant extracts that could act as antibiotic adjuvants. Isoflavonoids were found to potentiate the effect of ciprofloxacin and erythromycin against MRSA strains. For the structure-activity relationship (SAR), 22 isoflavonoids were assessed as antibiotic adjuvants. This study reveals a clear synergy between isoflavonoids and the tested antibiotics, showing their great potential for applications in the clinical therapy of infections with antibiotic-resistant microorganisms such as MRSA.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Abreu AC,Coqueiro A,Sultan AR,Lemmens N,Kim HK,Verpoorte R,van Wamel WJB,Simões M,Choi YHdoi
10.1038/s41598-017-03716-7subject
Has Abstractpub_date
2017-06-19 00:00:00pages
3777issue
1issn
2045-2322pii
10.1038/s41598-017-03716-7journal_volume
7pub_type
杂志文章abstract：:Experiments were conducted to improve jenny conception rates through induced ovulation and timed insemination. Jennies in control, hCG and LH groups were injected intramuscularly with saline alone or saline containing hCG or LH, respectively, when the dominant follicle diameter reached 35 mm. Then, follicle developmen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39757-3
更新日期：2019-03-01 00:00:00
abstract：:Bone homeostasis is maintained by the balance of osteoblasts (OBs) and osteoclasts (OCs). Increased activity of OCs not only contributes to pathological bone resorption, such as osteoporosis and periodontitis, but also is responsible for physiological conditions like orthodontic tooth movement (OTM). However, the deta...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08016
更新日期：2015-01-26 00:00:00
abstract：:Topological objects of nontrivial spin or dipolar field textures, such as skyrmions, merons, and vortices, interacting with applied external fields in ferroic materials are of great scientific interest as an intriguing playground of unique physical phenomena and novel technological paradigms. The quest for new topolog...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35199
更新日期：2016-10-07 00:00:00
abstract：:Bears are iconic mammals with a complex evolutionary history. Natural bear hybrids and studies of few nuclear genes indicate that gene flow among bears may be more common than expected and not limited to polar and brown bears. Here we present a genome analysis of the bear family with representatives of all living spec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46487
更新日期：2017-04-19 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-21981-y
更新日期：2018-03-06 00:00:00
abstract：:An intractable challenge in glaucoma treatment has been to identify druggable targets within the conventional aqueous humor outflow pathway, which is thought to be regulated/dysregulated by elusive mechanosensitive protein(s). Here, biochemical and functional analyses localized the putative mechanosensitive cation cha...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30583
更新日期：2016-08-11 00:00:00
abstract：:In contrast to mild infections of Group A Streptococcus (GAS) invasive infections of GAS still pose a serious health hazard: GAS disseminates from sterile sites into the blood stream or deep tissues and causes sepsis or necrotizing fasciitis. In this case antibiotics do not provide an effective cure as the bacteria ar...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11276-z
更新日期：2017-09-18 00:00:00
abstract：:The Japanese murrelet (Synthliboramphus wumizusume) is an endangered small seabird species in Japan. Molecular sexing using PCR targeting of the gene encoding chromodomain helicase DNA-binding protein 1(CHD1) has been used for sex identification. Specifically, PCR using any of three commonly used primer sets (CHD1F/1R...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65206-7
更新日期：2020-05-22 00:00:00
abstract：:Human lactoferrin (hLF) is a valuable protein for pharmaceutical products and functional foods, and worldwide demand for this protein has steadily increased. However, large-scale recombinant human lactoferrin (rhLF) production using current animal bioreactor techniques is limited by the low expression of foreign prote...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11462-z
更新日期：2017-09-06 00:00:00
abstract：:Three dimensional (3D) microvascular imaging of cubic millimeter to centimeter size volumes often requires much time and expensive instruments. By combining optical clearing with a novel scatter-based optical coherence tomography (OCT) contrast agent, we have greatly extended OCT imaging depth in excised tissues while...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37313-z
更新日期：2019-01-29 00:00:00
abstract：:Using dedicated contrast agents high-quality X-ray imaging of soft tissue structures with isotropic micrometre resolution has become feasible. This technique is frequently titled as virtual histology as it allows production of slices of tissue without destroying the sample. The use of contrast agents is, however, ofte...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30385
更新日期：2016-07-27 00:00:00
abstract：:It is indicated that lipids profiles are associated with carotid plaque and Atherosclerosis. However, studies about the relationship between serum lipid profiles and carotid plaque composition in Chinese Population is limited. We conducted a cross-sectional study among 3,214 participants between January 2015 and Decem...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54285-w
更新日期：2019-11-29 00:00:00
abstract：:Acquisition of the lower jaw (mandible) was evolutionarily important for jawed vertebrates. In humans, syndromic craniofacial malformations often accompany jaw anomalies. The basic helix-loop-helix transcription factor Hand2, which is conserved among jawed vertebrates, is expressed in the neural crest in the mandibula...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28405
更新日期：2016-06-22 00:00:00
abstract：:Telomere DNA ends with a single-stranded 3' overhang. Long 3' overhangs may cause aberrant DNA damage responses and accelerate telomere attrition, which is associated with cancer and aging, respectively. Genetic studies have indicated several important players in preventing 5' end hyper-resection, yet detailed knowled...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08663-x
更新日期：2017-08-18 00:00:00
abstract：:Pseudorabies virus (PRV) is a pathogen of swine resulting in devastating disease and economic losses worldwide. Resveratrol (Res) exhibits inhibitory activity against a wide range of viruses. Despite these important advances, the molecular mechanism(s) by which Res exerts its broad biological effects have not yet been...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09365-0
更新日期：2017-08-18 00:00:00
abstract：:This paper has been retracted at the request of the authors. ...
journal_title：Scientific reports
pub_type： 撤回出版物
doi：10.1038/s41598-018-29892-8
更新日期：2018-08-02 00:00:00
abstract：:Evidence showed preventive impacts of the highly active antiretroviral therapy (HAART) on the Human Immunodeficiency Virus (HIV) transmission amomg heterosexual population, however, that is of deficit among men who have sex with men (MSM). The aim was to systematically examine the efficacy of HAART on HIV transmission...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-019-56530-8
更新日期：2020-01-23 00:00:00
abstract：:MicroRNA-200 (miR-200) family is highly expressed in ovarian cancer. We evaluated the levels of family members relative to the internal control miR-103a in ovarian cancer and control blood specimens collected from American and Hong Kong Chinese institutions, as well as from a laying hen spontaneous ovarian cancer mode...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77068-0
更新日期：2020-11-18 00:00:00
abstract：:This study aimed to examine the effect of transcutaneous electrical nerve stimulation (TENS) on stair climbing capacity in individuals with pre-radiographic to mild knee osteoarthritis (OA). This is a secondary analysis of data from a single, participant-blinded, randomized controlled trial with a pre-post design. Par...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-020-64176-0
更新日期：2020-04-29 00:00:00
abstract：:State of charge (SOC) is a crucial index used in the assessment of electric vehicle (EV) battery storage systems. Thus, SOC estimation of lithium-ion batteries has been widely investigated because of their fast charging, long-life cycle, and high energy density characteristics. However, precise SOC assessment of lithi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61464-7
更新日期：2020-03-13 00:00:00
abstract：:Increased risk of comorbidities has been reported in Rheumatic and Musculoskeletal Diseases (RMD). We aimed to evaluate the prevalence and pattern of comorbidities in RMD patients nationwide, to identify multimorbidity clusters and to evaluate the gap between recommendations and real screening. Cross-sectional, multic...
journal_title：Scientific reports
pub_type： 杂志文章,多中心研究
doi：10.1038/s41598-020-64732-8
更新日期：2020-05-06 00:00:00
abstract：:Southern hemisphere humpback whales are classified as high-fidelity Antarctic krill consumers and as such are vulnerable to variability and long-term changes in krill biomass. Evidence of heterogeneous feeding patterns of east coast of Australia migrating humpback whales has been observed, warranting a comprehensive a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75370-5
更新日期：2020-10-26 00:00:00
abstract：:Sex differentiation is a puzzling problem in fish due to the variety of reproductive systems and the flexibility of their sex determination mechanisms. The Sparidae, a teleost family, reflects this remarkable diversity of sexual mechanisms found in fish. Our aim was to capture the transcriptomic signature of different...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21992-9
更新日期：2018-02-23 00:00:00
abstract：:We consider the finite-temperature properties of the extended Bose-Hubbard model realized recently in an ETH experiment [Nature 532, 476 (2016)]. Competing short- and global-range interactions accommodate fascinating collective phenomena. We formulate a self-consistent mean-field theory to describe the behaviors of th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66054-1
更新日期：2020-06-03 00:00:00
abstract：:Understanding the complex architecture, connectivity, and pathology of the human brain is a major application of magnetic resonance imaging (MRI). However, the cellular basis of MR signal is still poorly understood. The advent of MR microscopy (MRM) enables imaging biological samples at cellular resolution, helping to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08920
更新日期：2015-03-10 00:00:00
abstract：:Interfacial Dzyaloshinskii-Moriya interaction (IDMI) is important for its roles in stabilizing the skyrmionic lattice as well as soliton-like domain wall motion leading towards new generation spintronic devices. However, achievement and detection of IDMI is often hindered by various spurious effects. Here, we demonstr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32592
更新日期：2016-09-02 00:00:00
abstract：:Knowledge of the genomic variation among different strains of a pathogenic microbial species can help in selecting optimal candidates for diagnostic assays and vaccine development. Pooled sequencing (Pool-seq) is a cost effective approach for population level genetic studies that require large numbers of samples such ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45771
更新日期：2017-03-31 00:00:00
abstract：:This study aimed to evaluate the effects of ketorolac, a commonly used non-steroidal anti-inflammatory drug (NSAID) as patient controlled intravenous infusion analgesia (PCIA) for the patients underwent radical cystectomy (RC) due to bladder cancer regarding post-operational indices of recovery. Total seventy patients...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-018-22677-z
更新日期：2018-03-15 00:00:00
abstract：:Microglia are the resident phagocytic cells with various functions in the central nervous system, and the morphologies of microglia imply the different stages and functions. In optical nerve transection (ONT) model in the retina, the retrograde degeneration of retinal ganglion cells (RGCs) induces microglial activatio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10788
更新日期：2015-06-02 00:00:00
abstract：:Still recently, bacterial fluid suspensions have motivated a lot of works, both experimental and theoretical, with the objective to understand their collective dynamics from universal and simple rules. Since some species are active, most of these works concern the strong interactions that these bacteria exert on a for...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21269
更新日期：2016-02-18 00:00:00
