TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye.

abstract：:Metapristone is the primary metabolite of the abortifacient mifepristone (RU486), and is being developed as a safe and effective cancer metastatic chemopreventive agent for both sexes. Here, we systematically investigated the sex-related pharmacokinetics of metapristone in both rats and dogs, and explored the related ...

journal_title：Scientific reports

authors： Chen W,Xiao Y,Chen J,Liu J,Shao J,Li T,Zhu Y,Ma J,Gao Y,Wang J,Xu J,Lu Y,Jia L

更新日期：2017-12-07 00:00:00

abstract：UNLABELLED:To fabricate high-performance metal-halide perovskite solar cells, a thermal annealing process is indispensable in preparing high quality perovskite film. And usually such annealing is performed on hot plate. However hot-plate annealing could cause problems such as inhomogeneous heating (induced by non-tight...

journal_title：Scientific reports

authors： Zhou Q,Jin Z,Li H,Wang J

更新日期：2016-02-16 00:00:00

abstract：:The authors present the preparation procedure and a computational model of a three-layered fibrous scaffold for prolonged drug release. The scaffold, produced by emulsion/sequential electrospinning, consists of a poly(D,L-lactic-co-glycolic acid) (PLGA) fiber layer sandwiched between two poly(ε-caprolactone) (PCL) lay...

journal_title：Scientific reports

authors： Milosevic M,Stojanovic DB,Simic V,Grkovic M,Bjelovic M,Uskokovic PS,Kojic M

更新日期：2020-07-07 00:00:00

abstract：:Brain-computer interface (BCI) systems having the ability to classify brain waves with greater accuracy are highly desirable. To this end, a number of techniques have been proposed aiming to be able to classify brain waves with high accuracy. However, the ability to classify brain waves and its implementation in real-...

journal_title：Scientific reports

authors： Kumar S,Sharma A,Tsunoda T

更新日期：2019-06-24 00:00:00

abstract：:For nearly a century, researchers have tried to understand the swimming of aquatic animals in terms of a balance between the forward thrust from swimming movements and drag on the body. Prior approaches have failed to provide a separation of these two forces for undulatory swimmers such as lamprey and eels, where most...

journal_title：Scientific reports

authors： Bale R,Shirgaonkar AA,Neveln ID,Bhalla AP,MacIver MA,Patankar NA

更新日期：2014-12-10 00:00:00

abstract：:Ovarian cancer is the second most common gynaecologic malignancy and the main cause of death from gynaecologic cancer, due to late diagnosis and chemoresistance. Studies have reported the role of cysteine in cancer, by contributing for hydrogen sulphide (H2S) generation and as a precursor of glutathione (GSH). However...

journal_title：Scientific reports

authors： Nunes SC,Ramos C,Lopes-Coelho F,Sequeira CO,Silva F,Gouveia-Fernandes S,Rodrigues A,Guimarães A,Silveira M,Abreu S,Santo VE,Brito C,Félix A,Pereira SA,Serpa J

更新日期：2018-06-22 00:00:00

abstract：:Hemodialysis patients are a special group of patients with higher mortality rates. Hemodialysis patients with vitamin D deficiency {plasma levels of 25-hydroxyvitamin D [25(OH)D] below 20 ng/mL} are associated with even higher mortality rates. The prognostic importance of vitamin D deficiency in hemodialysis patients ...

journal_title：Scientific reports

authors： Hsu HJ,Wu IW,Hsu KH,Sun CY,Chen CY,Lee CC

更新日期：2020-05-05 00:00:00

abstract：:Si and Ge nanocrystals in oxides are of a large interest for photo-effect applications due to the fine-tuning of the optical bandgap by quantum confinement in nanocrystals. In this work, dense Ge nanocrystals suitable for enhanced photoconduction were fabricated from 60% Ge in TiO2 amorphous layers by low temperature ...

journal_title：Scientific reports

authors： Lepadatu AM,Slav A,Palade C,Dascalescu I,Enculescu M,Iftimie S,Lazanu S,Teodorescu VS,Ciurea ML,Stoica T

更新日期：2018-03-20 00:00:00

abstract：:Light pollution and its consequences on ecosystems are increasing worldwide. Knowledge on the threshold levels of light pollution at which significant ecological impacts emerge and the size of dark refuges to maintain natural nocturnal processes is crucial to mitigate its negative consequences. Seabird fledglings are ...

journal_title：Scientific reports

authors： Rodríguez A,Rodríguez B,Negro JJ

更新日期：2015-06-02 00:00:00

abstract：:The biggest challenge in colorectal cancer therapy is to avoid intestinal drug absorption before reaching the colon, while focusing on tumor specific delivery with high local concentration and minimal toxicity. In our work, thymoquinone (TQ)-loaded polymeric nanocapsules were prepared using the nanoprecipitation techn...

journal_title：Scientific reports

authors： Ramzy L,Metwally AA,Nasr M,Awad GAS

更新日期：2020-07-03 00:00:00

abstract：:Differential host responses may be critical determinants of distinct pathologies of West Nile virus (WNV) NY99 (pathogenic) and WNV Eg101 (non-pathogenic) strains. We employed RNA-seq technology to analyze global differential gene expression in WNV-infected mice brain and to identify the host cellular factors leading ...

journal_title：Scientific reports

authors： Kumar M,Belcaid M,Nerurkar VR

更新日期：2016-05-23 00:00:00

abstract：:Mercury pollution in soil poses serious risks to human health through consumption of contaminated vegetables. We used a meta-analysis to examine the mercury enrichment ability of different vegetables and the main factors affecting mercury uptake. We drew the following conclusions. (1) Plants with a lower bioconcentrat...

journal_title：Scientific reports

authors： Yu H,Li J,Luan Y

更新日期：2018-01-19 00:00:00

abstract：:Electrophysiological field potential dynamics have been widely used to investigate brain functions and related psychiatric disorders. Considering recent demand for its applicability to freely moving subjects, especially for animals in a group and socially interacting with each other, here we propose a new method based...

journal_title：Scientific reports

authors： Inagaki S,Agetsuma M,Ohara S,Iijima T,Yokota H,Wazawa T,Arai Y,Nagai T

更新日期：2019-05-16 00:00:00

abstract：:Alterations in the composition of commensal bacterial populations, a phenomenon known as dysbiosis, are linked to multiple gastrointestinal disorders, such as inflammatory bowel disease and irritable bowel syndrome, or to infections by diverse enteric pathogens. Blastocystis is one of the most common single-celled euk...

journal_title：Scientific reports

authors： Audebert C,Even G,Cian A,Blastocystis Investigation Group.,Loywick A,Merlin S,Viscogliosi E,Chabé M

更新日期：2016-05-05 00:00:00

abstract：:High-quality broadband ultrasound transducers yield superior imaging performance in biomedical ultrasonography. However, proper design to perfectly bridge the energy between the active piezoelectric material and the target medium over the operating spectrum is still lacking. Here, we demonstrate a new anisotropic cone...

journal_title：Scientific reports

authors： Li Z,Yang DQ,Liu SL,Yu SY,Lu MH,Zhu J,Zhang ST,Zhu MW,Guo XS,Wu HD,Wang XL,Chen YF

更新日期：2017-02-17 00:00:00

abstract：:IFI16 and AIM2 are important DNA sensors in antiviral immunity. To characterize these two molecules in a woodchuck model, which is widely used to study hepatitis B virus (HBV) infection, we cloned and analyzed the complete coding sequences (CDSs) of woodchuck IFI16 and AIM2, and found that AIM2 was highly conserved in...

journal_title：Scientific reports

authors： Yan Q,Li M,Liu Q,Li F,Zhu B,Wang J,Lu Y,Liu J,Wu J,Zheng X,Lu M,Wang B,Yang D

更新日期：2016-06-29 00:00:00

abstract：:Rab27 is an essential molecule of vesicle fusion and trafficking in exosome secretion process, which plays important roles in cancer progression and metastasis. Recent studies reported that Rab27 expression is also associated with cancer prognosis. Therefore, we performed a meta-analysis to reveal the prognostic signi...

journal_title：Scientific reports

authors： Koh HM,Jang BG,Kim DC

更新日期：2020-08-24 00:00:00

abstract：:Understanding the neural basis of poor impulse control in Internet addiction (IA) is important for understanding the neurobiological mechanisms of this syndrome. The current study investigated how neuronal pathways implicated in response inhibition were affected in IA using a Go-Stop paradigm and functional magnetic r...

journal_title：Scientific reports

authors： Li B,Friston KJ,Liu J,Liu Y,Zhang G,Cao F,Su L,Yao S,Lu H,Hu D

更新日期：2014-05-22 00:00:00

abstract：:The northern microrefugia that existed during the Last Glacial Maximum (LGM) are a key factor in the demographic history of species. Pinus koraiensis has a unique distribution in northeast Asia. The Changbai Mountains and the Korean peninsula (CM/KP) are usually considered to be the LGM refugia for P. koraiensis. Howe...

journal_title：Scientific reports

authors： Bao L,Kudureti A,Bai W,Chen R,Wang T,Wang H,Ge J

更新日期：2015-12-22 00:00:00

abstract：:Human sociality depends upon the benefits of mutual aid and extensive communication. However, diverse norms and preferences complicate mutual aid, and ambiguity in meaning hinders communication. Here we demonstrate that these two problems can work together to enhance cooperation through the strategic use of deliberate...

journal_title：Scientific reports

authors： Smaldino PE,Flamson TJ,McElreath R

更新日期：2018-03-20 00:00:00

abstract：:Silver has long been employed as an electrically conductive component, and morphology-dependent properties have been actively investigated. Here we present a novel scalable synthesis method of flower-shaped silver nanoparticles (silver nanoflowers, Ag NFs). The preferential affinity of citrate molecules on (111) surfa...

journal_title：Scientific reports

authors： C MA,K P F,Singh S,Baik S

更新日期：2016-10-07 00:00:00

abstract：:Stable isotopes in water (e.g., δ2H and δ18O) are important indicators of hydrological and ecological patterns and processes. Tap water can reflect integrated features of regional hydrological processes and human activities. China is a large country with significant meteorological and geographical variations. This rep...

journal_title：Scientific reports

authors： Zhao S,Hu H,Tian F,Tie Q,Wang L,Liu Y,Shi C

更新日期：2017-03-02 00:00:00

abstract：:With the advent of nanotechnology, a variety of nanoarchitectures with varied physicochemical properties have been designed. Owing to the unique characteristics, DNAs have been used as a functional building block for novel nanoarchitecture. In particular, a self-assembly of long DNA molecules via a piece DNA staple ha...

journal_title：Scientific reports

authors： Song IH,Shin SW,Park KS,Lansac Y,Jang YH,Um SH

更新日期：2015-12-04 00:00:00

abstract：:The early life stages represent a crucial period that can strongly influence population dynamics. We studied the development of foraging behaviour in the red-footed booby, a tropical seabird with an extensive post-fledging care period (3 to 6 months). Adults and juveniles were observed from shore and tracked at sea us...

journal_title：Scientific reports

authors： Mendez L,Prudor A,Weimerskirch H

更新日期：2017-10-24 00:00:00

abstract：:The majority of oligomeric proteins form clusters which have rotational or dihedral symmetry. Despite the many advantages of symmetric packing, protein oligomers are only nearly symmetric, and the origin of this phenomenon is still in need to be fully explored. Here we apply near-symmetry analyses by the Continuous Sy...

journal_title：Scientific reports

authors： Bonjack M,Avnir D

更新日期：2020-05-20 00:00:00

abstract：:Three dimensional (3D) co-cultures to mimic cellular dynamics have brought significant impacts in tissue engineering approaches for biomedical research. Herein, we present a novel sample holder combined with time-lapse fluorescence imaging technique, referred as 4D live cell imaging, allowing direct visualization of v...

journal_title：Scientific reports

authors： Septiadi D,Bourquin J,Durantie E,Petri-Fink A,Rothen-Rutishauser B

更新日期：2018-06-29 00:00:00

abstract：:Myocardial infarction (MI) can result in sympathetic nerve loss in the infarct region. However, the contribution of hypo-innervation to electrophysiological remodeling, independent from MI-induced ischemia and fibrosis, has not been comprehensively investigated. We present a novel mouse model of regional cardiac sympa...

journal_title：Scientific reports

authors： Tapa S,Wang L,Francis Stuart SD,Wang Z,Jiang Y,Habecker BA,Ripplinger CM

更新日期：2020-11-02 00:00:00

abstract：:Postmortem diagnosis of cantharidin-induced myocardial injury and postmortem interval estimation (PMI) are the challenges in forensic science. Cardiac biomarkers play an important role in the prediction and diagnosis of myocardial injury and can be used to determine the PMI. Based on the evidence, we aimed to explore ...

journal_title：Scientific reports

authors： Zhang Y,Yu Y,Zhang J,Guan C,Liu L,Ren L

更新日期：2020-07-21 00:00:00

abstract：:5-hydroxymethylation (5-hmC) is an epigenetic modification on DNA that results from the conversion of 5-methylcytosine by Ten-Eleven Translocation (TET) proteins. 5-hmC is widely present in the brain and is subjected to dynamic regulation during development and upon neuronal activity. It was recently shown to be invol...

journal_title：Scientific reports

authors： Kremer EA,Gaur N,Lee MA,Engmann O,Bohacek J,Mansuy IM

更新日期：2018-01-26 00:00:00

abstract：:Inhibitory/repressor-receptors are upregulated significantly on activated T cells, and have been the molecules of attention as targets for inducing immune tolerance. Induction of effective antigen specific tolerance depends on concurrent engagement of the TCR and one or more of these inhibitory receptors. Here, we sho...

journal_title：Scientific reports

authors： Gudi RR,Karumuthil-Melethil S,Perez N,Li G,Vasu C

更新日期：2019-08-19 00:00:00