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Imaging local brain activity of multiple freely moving mice sharing the same environment.

Abstract：

:Electrophysiological field potential dynamics have been widely used to investigate brain functions and related psychiatric disorders. Considering recent demand for its applicability to freely moving subjects, especially for animals in a group and socially interacting with each other, here we propose a new method based on a bioluminescent voltage indicator LOTUS-V. Using our fiber-free recording method based on the LOTUS-V, we succeeded in capturing dynamic change of brain activity in freely moving mice. Because LOTUS-V is the ratiometric indicator, motion and head-angle artifacts were not significantly detected. Taking advantage of our method as a fiber-free system, we further succeeded in simultaneously recording from multiple independently-locomotive mice that were freely interacting with one another. Importantly, this enabled us to find that the primary visual cortex, a center of visual processing, was activated during the interaction of mice. This methodology may further facilitate a wide range of studies in neurobiology and psychiatry.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Inagaki S,Agetsuma M,Ohara S,Iijima T,Yokota H,Wazawa T,Arai Y,Nagai T

doi

10.1038/s41598-019-43897-x

subject

Has Abstract

pub_date

2019-05-16 00:00:00

pages

7460

issue

1

issn

2045-2322

pii

10.1038/s41598-019-43897-x

journal_volume

9

pub_type

杂志文章

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