Sex-related pharmacokinetic differences and mechanisms of metapristone (RU486 metabolite).

abstract：:Raman microspectroscopy provides the means to obtain local orientations on polycrystalline materials at the submicrometer level. The present work demonstrates how orientation-distribution maps composed of Raman intensity distributions can be acquired on large areas of several hundreds of square micrometers. A polycrys...

journal_title：Scientific reports

authors： Schmid T,Schäfer N,Levcenko S,Rissom T,Abou-Ras D

更新日期：2015-12-17 00:00:00

abstract：:Angulin proteins are a group of evolutionally conserved type I transmembrane proteins that contain an extracellular Ig-like domain. In mammals, three angulin proteins have been identified, namely immunoglobulin-like domain containing receptor 1 (ILDR1), immunoglobulin-like domain containing receptor 2 (ILDR2), and lip...

journal_title：Scientific reports

authors： Liu Y,Nie H,Liu C,Zhai X,Sang Q,Wang Y,Shi D,Wang L,Xu Z

更新日期：2017-08-07 00:00:00

abstract：:We show that the width of an arbitrary function and the width of the distribution of its values cannot be made arbitrarily small simultaneously. In the case of ergodic stochastic processes, an ensuing uncertainty relationship is then demonstrated for the product of correlation length and variance. A closely related un...

journal_title：Scientific reports

authors： Gureyev TE,Kozlov A,Paganin DM,Nesterets YI,Quiney HM

更新日期：2020-05-12 00:00:00

abstract：:Limbal stem cell deficiency can be treated with transplantation of cultured human limbal epithelial cells (LEC). It can be advantageous to produce LEC in centralized labs and thereafter ship them to eye clinics. The present study used transport simulations of LEC to determine if vigorous shaking during transport alter...

journal_title：Scientific reports

authors： Utheim OA,Lyberg T,Eidet JR,Raeder S,Sehic A,Roald B,Messelt E,de la Paz MF,Dartt DA,Utheim TP

更新日期：2018-07-12 00:00:00

abstract：:Endogenous K. pneumoniae endophthalmitis (EKE) has a higher incidence among East Asians, and the most common infectious source of EKE is pyogenic liver abscess (PLA). We investigate the risk factors for poor visual outcomes in patients with PLA-related EKE. The retrospective medical records of 104 patients (120 eyes) ...

journal_title：Scientific reports

authors： Chen YH,Li YH,Lin YJ,Chen YP,Wang NK,Chao AN,Liu L,Wu WC,Lai CC,Chen TL,Chen KJ

更新日期：2019-01-31 00:00:00

abstract：:Hydroxyapatite (HA) is the principal inorganic component of bones and teeth and has been widely used as a bone repair material because of its good biocompatibility and bioactivity. Understanding the interactions between proteins and HA is crucial for designing biomaterials for bone regeneration. In this study, we eval...

journal_title：Scientific reports

authors： Wang Q,Wang M,Lu X,Wang K,Fang L,Ren F,Lu G

更新日期：2017-11-09 00:00:00

abstract：:Animal societies exhibit remarkable variation in their breeding strategies. Individuals can maximize their fitness by either reproducing or by helping relatives. Social hymenopterans have been key taxa for the study of Hamilton's inclusive fitness theory because the haplodiploid sex-determination system results in asy...

journal_title：Scientific reports

authors： Andrade AC,Miranda EA,Del Lama MA,Nascimento FS

更新日期：2016-05-23 00:00:00

abstract：:Cartilage engineering that combines competent seeding cells and a compatible scaffold is increasingly gaining popularity and is potentially useful for the treatment of various bone and cartilage diseases. Intensive efforts have been made by researchers to improve the viability and functionality of seeding cells of eng...

journal_title：Scientific reports

authors： Ma Y,Li J,Yao Y,Wei D,Wang R,Wu Q

更新日期：2016-05-25 00:00:00

abstract：:Proton-sensing ovarian cancer G-protein coupled receptor (OGR1) plays an important role in pH homeostasis. Acidosis occurs at sites of intestinal inflammation and can induce endoplasmic reticulum (ER) stress and the unfolded protein response (UPR), an evolutionary mechanism that enables cells to cope with stressful co...

journal_title：Scientific reports

authors： Maeyashiki C,Melhem H,Hering L,Baebler K,Cosin-Roger J,Schefer F,Weder B,Hausmann M,Scharl M,Rogler G,de Vallière C,Ruiz PA

更新日期：2020-01-29 00:00:00

abstract：:Toll-like receptors (TLRs), as innate immunity sensors, play critical roles in immune responses. Six SNPs of TLR3, TLR7, and TLR8 were genotyped to determine their associations with systemic lupus erythematosus (SLE) and clinical manifestations of SLE. TLR7 SNP rs3853839 was independently associated with SLE susceptib...

journal_title：Scientific reports

authors： Wang CM,Chang SW,Wu YJ,Lin JC,Ho HH,Chou TC,Yang B,Wu J,Chen JY

更新日期：2014-01-21 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is caused by chronic inflammation. Many inflammatory mediators induce the low grade systemic inflammation of COPD. Haptoglobin (Hp) is synthesized in the liver and by lung epithelial and alveolar macrophage cells. However, associations of the serum concentration and phenoty...

journal_title：Scientific reports

authors： Lee PL,Lee KY,Cheng TM,Chuang HC,Wu SM,Feng PH,Liu WT,Chen KY,Ho SC

更新日期：2019-01-17 00:00:00

abstract：:Metal-insulator transition is observed in the La0.8Sr0.2MnO3 thin films with thickness larger than 5 unit cells. Insulating phase at lower temperature appeared in the ultrathin films with thickness ranging from 6 unit cells to 10 unit cells and it is found that the Mott variable range hopping conduction dominates in t...

journal_title：Scientific reports

authors： Feng Y,Jin KJ,Gu L,He X,Ge C,Zhang QH,He M,Guo QL,Wan Q,He M,Lu HB,Yang G

更新日期：2016-03-01 00:00:00

abstract：:Lon is an essential, multitasking AAA(+) protease regulating many cellular processes in species across all kingdoms of life. Altered expression levels of the human mitochondrial Lon protease (hLon) are linked to serious diseases including myopathies, paraplegia, and cancer. Here, we present the first 3D structure of f...

journal_title：Scientific reports

authors： Kereïche S,Kováčik L,Bednár J,Pevala V,Kunová N,Ondrovičová G,Bauer J,Ambro Ľ,Bellová J,Kutejová E,Raška I

更新日期：2016-09-16 00:00:00

abstract：:Atomistic molecular dynamics simulations were performed with 13 non-peptidic neurotransmitters (NTs) in three different membrane environments. The results provide compelling evidence that NTs are divided into membrane-binding and membrane-nonbinding molecules. NTs adhere to the postsynaptic membrane surface whenever t...

journal_title：Scientific reports

authors： Postila PA,Vattulainen I,Róg T

更新日期：2016-01-19 00:00:00

abstract：:Type 2 diabetes mellitus is a major health concern worldwide; however, the molecular mechanism underlying its development is poorly understood. The hormone amylin is postulated to be involved, as human amylin forms amyloid in the pancreases of diabetic patients, and oligomers have been shown to be cytotoxic to β-cells...

journal_title：Scientific reports

authors： Nie T,Zhang S,Vazhoor Amarsingh G,Liu H,McCann MJ,Cooper GJS

更新日期：2019-10-10 00:00:00

abstract：:Control of nonlinear large-scale dynamical networks, e.g., collective behavior of agents interacting via a scale-free connection topology, is a central problem in many scientific and engineering fields. For the linear version of this problem, the so-called controllability Gramian has played an important role to quanti...

journal_title：Scientific reports

authors： Kashima K

更新日期：2016-06-06 00:00:00

abstract：:A bubble merged from two parent bubbles with different size tends to be placed closer to the larger parent. This phenomenon is known as the coalescence preference. Here we demonstrate that the coalescence preference can be blocked inside a densely packed cluster of bubbles. We utilized high-speed high-resolution X-ray...

journal_title：Scientific reports

authors： Kim Y,Lim SJ,Gim B,Weon BM

更新日期：2015-01-13 00:00:00

abstract：:There are large health, societal, and economic costs associated with attrition from psychological services. The recently emerged, innovative statistical tool of complex network analysis was used in the present proof-of-concept study to improve the prediction of attrition. Fifty-eight patients undergoing psychological ...

journal_title：Scientific reports

authors： Lutz W,Schwartz B,Hofmann SG,Fisher AJ,Husen K,Rubel JA

更新日期：2018-05-18 00:00:00

abstract：:After injury to the mature central nervous system (CNS), myelin-derived inhibitory ligands bind to the Nogo-66 tripartite receptor complex expressed on axonal growth cones, comprised of LINGO-1 and p75NTR/TROY and induce growth cone collapse through the RhoA pathway. We have also shown that amphoterin-induced gene and...

journal_title：Scientific reports

authors： Almutiri S,Berry M,Logan A,Ahmed Z

更新日期：2018-07-16 00:00:00

abstract：:Prolonged tomato consumption can mitigate ultraviolet (UV) light induced sunburn via unknown mechanisms. Dietary carotenoids distributed to skin are hypothesized to protect skin against UV-induced damage, although other phytochemicals may play a role. We hypothesize that tomato consumption would protect against skin c...

journal_title：Scientific reports

authors： Cooperstone JL,Tober KL,Riedl KM,Teegarden MD,Cichon MJ,Francis DM,Schwartz SJ,Oberyszyn TM

更新日期：2017-07-11 00:00:00

abstract：:Two-dimensional (2D) cell cultures growing on plastic do not recapitulate the three dimensional (3D) architecture and complexity of human tumors. More representative models are required for drug discovery and validation. Here, 2D culture and 3D mono- and stromal co-culture models of increasing complexity have been est...

journal_title：Scientific reports

authors： Stock K,Estrada MF,Vidic S,Gjerde K,Rudisch A,Santo VE,Barbier M,Blom S,Arundkar SC,Selvam I,Osswald A,Stein Y,Gruenewald S,Brito C,van Weerden W,Rotter V,Boghaert E,Oren M,Sommergruber W,Chong Y,de Hoogt R,Grae

更新日期：2016-07-01 00:00:00

abstract：:This corrects the article DOI: 10.1038/srep20029. ...

journal_title：Scientific reports

authors： Yu C,Gao K,Zhu L,Wang W,Wang L,Zhang F,Liu C,Li M,Wormald MR,Rudd PM,Wang J

更新日期：2017-06-30 00:00:00

abstract：:Despite important progress, uncertainty persists regarding the ecological forces driving microbial community assembly. Here, we present the first study to use phylogenetic information to interpret the structure and diversity of diatom communities. We examined local phylogenetic divergence and beta- phylogenetic divers...

journal_title：Scientific reports

authors： Keck F,Kahlert M

更新日期：2019-08-12 00:00:00

abstract：:Advanced age is associated with a decline in cognitive function, likely caused by a combination of modifiable and non-modifiable factors such as genetics and lifestyle choices. Mounting evidence suggests that humanin and other mitochondrial derived peptides play a role in several age-related conditions including neuro...

journal_title：Scientific reports

authors： Yen K,Wan J,Mehta HH,Miller B,Christensen A,Levine ME,Salomon MP,Brandhorst S,Xiao J,Kim SJ,Navarrete G,Campo D,Harry GJ,Longo V,Pike CJ,Mack WJ,Hodis HN,Crimmins EM,Cohen P

更新日期：2018-09-21 00:00:00

abstract：:The suprachiasmatic nucleus (SCN) central clock comprises two coupled oscillators, with light entraining the retinorecipient vasoactive intestinal peptide (VIP)-positive ventrolateral oscillator, which then entrains the arginine vasopressin (AVP)-positive dorsomedial oscillator. While glucose availability is known to ...

journal_title：Scientific reports

authors： Yang JJ,Cheng RC,Cheng PC,Wang YC,Huang RC

更新日期：2017-04-04 00:00:00

abstract：:To appraise the content and pollution level of cadmium (Cd), arsenic (As), mercury (Hg), nickel (Ni) and lead (Pb) in bus stop dusts, representative samples (n = 53) were collected from the city of Qingyang in Gansu province, NW China. The Cd, As, Hg, Ni, and Pb contents and physicochemical properties (particle size, ...

journal_title：Scientific reports

authors： Wu Y,Lu X

更新日期：2018-08-22 00:00:00

abstract：:The amount of Paper Board Mill Effluent Treatment Plant Sludge (PBM-ETPS) dumped from paper mills are huge and its conversion into hydrochar for the purpose of energy has broad prospects. This study investigated the optimum conditions for the production of PBM-ETPS derived hydrochar (PBM-ETPSH) through Reponse Surface...

journal_title：Scientific reports

authors： Oumabady S,S PS,Kamaludeen SPB,Ramasamy M,Kalaiselvi P,Parameswari E

更新日期：2020-01-21 00:00:00

abstract：:Remote earthquake triggering is a well-established phenomenon. Triggering is commonly identified from statistically significant increases in earthquake rate coincident with the passage of seismic energy. In establishing rate changes, short duration earthquake catalogs are commonly used, and triggered sequences are not...

journal_title：Scientific reports

authors： Pankow KL,Kilb D

更新日期：2020-03-05 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Bruneau N,Toumi R,Wang S

更新日期：2018-04-17 00:00:00

abstract：:Previous observational studies supported a positive association of glycated hemoglobin A1c (HbA1c) level with serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). However, the causal relationship between HbA1c and either one of ...

journal_title：Scientific reports

authors： Jia X,Hou Y,Xu M,Zhao Z,Xuan L,Wang T,Li M,Xu Y,Lu J,Bi Y,Wang W,Chen Y

更新日期：2019-04-02 00:00:00