Abstract：
:5-hydroxymethylation (5-hmC) is an epigenetic modification on DNA that results from the conversion of 5-methylcytosine by Ten-Eleven Translocation (TET) proteins. 5-hmC is widely present in the brain and is subjected to dynamic regulation during development and upon neuronal activity. It was recently shown to be involved in memory processes but currently, little is known about how it is controlled in the brain during memory formation. Here, we show that Tet3 is selectively up-regulated by activity in hippocampal neurons in vitro, and after formation of fear memory in the hippocampus. This is accompanied by a decrease in miR-29b expression that, through complementary sequences, regulates the level of Tet3 by preferential binding to its 3'UTR. We newly reveal that SAM68, a nuclear RNA-binding protein known to regulate splicing, acts upstream of miR-29 by modulating its biogenesis. Together, these findings identify novel players in the adult brain necessary for the regulation of 5-hmC during memory formation.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kremer EA,Gaur N,Lee MA,Engmann O,Bohacek J,Mansuy IMdoi
10.1038/s41598-018-19806-zsubject
Has Abstractpub_date
2018-01-26 00:00:00pages
1678issue
1issn
2045-2322pii
10.1038/s41598-018-19806-zjournal_volume
8pub_type
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