Abstract：
:Dopamine is a key neurotransmitter in the retina and plays a central role in the light adaptive processes of the visual system. The sole source of retinal dopamine is dopaminergic amacrine cells (DACs). We and others have previously demonstrated that DACs are activated by rods, cones, and intrinsically photosensitive retinal ganglion cells (ipRGCs) upon illumination. However, it is still not clear how each class of photosensitive cells generates light responses in DACs. We genetically isolated cone function in mice to specifically examine the cone-mediated responses of DACs and their neural pathways. In addition to the reported excitatory input to DACs from light-increment (ON) bipolar cells, we found that cones alternatively signal to DACs via a retrograde signalling pathway from ipRGCs. Cones also produce ON and light-decrement (OFF) inhibitory responses in DACs, which are mediated by other amacrine cells, likely driven by type 1 and type 2/3a OFF bipolar cells, respectively. Dye injections indicated that DACs had similar morphological profiles with or without ON/OFF inhibition. Our data demonstrate that cones utilize specific parallel excitatory and inhibitory circuits to modulate DAC activity and efficiently regulate dopamine release and the light-adaptive state of the retina.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Qiao SN,Zhang Z,Ribelayga CP,Zhong YM,Zhang DQdoi
10.1038/srep28916subject
Has Abstractpub_date
2016-06-30 00:00:00pages
28916issn
2045-2322pii
srep28916journal_volume
6pub_type
杂志文章abstract：:Arbuscular mycorrhizal (AM) symbioses are an attractive means of improving the efficiency of soil phosphorus (P) that difficult to be used by plants and may provide a sustainable way of maintaining high yields while reducing P applications. However, quantifying the contribution of indigenous AM fungi on phosphorus upt...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80074-x
更新日期：2021-01-13 00:00:00
abstract：:Harvesting light for optical torque is of significant importance, owing to its ability to rotate nano- or micro-objects. Nevertheless, applying a strong optical torque remains a challenging task: angular momentum must conserve but light is limited. A simple argument shows the tendency for two objects with strong mutua...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27927
更新日期：2016-06-13 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep18803. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/srep46987
更新日期：2018-05-22 00:00:00
abstract：:Caspase-3-related DEVDase activity is initiated upon apoptosis in unfertilized starfish eggs. In this study, we cloned a starfish procaspase-3 corresponding to mammalian effector caspase containing a CARD that is similar to the amino terminal CARD of mammalian capsase-9, and we named it procaspase-3/9. Recombinant pro...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19845-6
更新日期：2018-01-25 00:00:00
abstract：:Although Hepatitis B virus (HBV) X gene mutations are frequently detected in HBV-related human hepatocellular carcinoma (HCC) patients, causative HBx mutations in the development of HCC have not yet been determined. We herein identified C1485T and C1653T mutations in the HBx gene as independent risk of HCC for HBV thr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10570-0
更新日期：2017-09-05 00:00:00
abstract：:Measuring handgrip strength is the initial step to diagnose sarcopenia. To investigate whether the serum creatinine (Cr)/cystatin C (CysC) ratio could serve as a case-finding tool for low handgrip strength, we conducted a diagnostic accuracy study. Adults (aged ≥ 40 years) with normal renal function were recruited. Tr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71028-4
更新日期：2020-08-20 00:00:00
abstract：:Circadian disruption resulting from exposure to irregular light-dark patterns and sleep deprivation has been associated with beta amyloid peptide (Aβ) aggregation, which is a major event in Alzheimer's disease (AD) pathology. We exposed 5XFAD mice and littermate controls to dim-light vs. bright-light photophases to in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68199-5
更新日期：2020-07-10 00:00:00
abstract：:Diffusion processes are widespread in biological and chemical systems, where they play a fundamental role in the exchange of substances at the cellular level and in determining the rate of chemical reactions. Recently, the classical picture that portrays diffusion as random uncorrelated motion of molecules has been re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14486
更新日期：2015-09-30 00:00:00
abstract：:Image classification uses computers to simulate human understanding and cognition of images by automatically categorizing images. This study proposes a faster image classification approach that parallelizes the traditional Adaboost-Backpropagation (BP) neural network using the MapReduce parallel programming model. Fir...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38201
更新日期：2016-12-01 00:00:00
abstract：:This corrects the article DOI: 10.1038/srep40037. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/srep46991
更新日期：2018-05-22 00:00:00
abstract：:Biliverdin (BV) possesses antioxidant and anti-inflammatory properties, with previous reports identifying protection against oxidant and inflammatory injury in animal models. Recent reports indicate that intra-duodenal administration of BV results in the formation of an uncharacterised metabolite, which is potently ab...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39548-w
更新日期：2019-02-27 00:00:00
abstract：:In situ tissue engineering within a stroke cavity is gradually emerging as a novel therapeutic paradigm. Considering the varied lesion topology within each subject, the placement and distribution of cells within the lesion cavity is challenging. The use of multiple cell types to reconstruct damaged tissue illustrates ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14597
更新日期：2015-09-30 00:00:00
abstract：:Extravillous trophoblasts (EVTs) have the potential to provide the entire fetal genome for prenatal testing. Previous studies have demonstrated the presence of EVTs in the cervical canal and the ability to retrieve a small quantity of these cells by cervical sampling. However, these small quantities of trophoblasts ar...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48346-3
更新日期：2019-08-20 00:00:00
abstract：:The methyl farnesoate receptor (MfR) orchestrates aspects of reproduction and development such as male sex determination in branchiopod crustaceans. Phenotypic endpoints regulated by the receptor have been well-documented, but molecular interactions involved in receptor activation remain elusive. We hypothesized that ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45071
更新日期：2017-03-21 00:00:00
abstract：:Milk oligosaccharides (MOs) are complex carbohydrates with multifunctional health benefits for the neonate. Poor reproductive performance in primiparous gilts limits their productivity. Changes in the structure and abundance of porcine MO (PMOs) through lactation with parity remains unknown and may explain superior ne...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23025-x
更新日期：2018-03-16 00:00:00
abstract：:We have assembled the complete sequence of the Durio zibethinus chloroplast genome using long PacBio reads. Durian is a valuable commercial tree that produces durian fruit, which is popular in Southeast Asia. The chloroplast genome assembled into a single 143 kb cyclic contig that contained 111 genes. There were 46 sh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73549-4
更新日期：2020-10-07 00:00:00
abstract：:Under the usual approximation of treating a biological particle as a spheroidal droplet, we consider the analysis of its size and shape with the high frequency photoacoustics and develop a numerical method which can simulate its characteristic photoacoustic waves. This numerical method is based on the calculation of s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14801
更新日期：2015-10-07 00:00:00
abstract：:We demonstrate the surface-plasmon-induced enhancement of Förster resonance energy transfer (FRET)using a model multilayer core-shell nanostructure consisting of an Au core and surrounding FRET pairs, i.e., CdSe quantum dot donors and S101 dye acceptors. The multilayer configuration was demonstrated to exhibit synergi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04735
更新日期：2014-04-22 00:00:00
abstract：:Epilepsy is a chronic neurological disease with a variable therapeutic response. To design effective treatment strategies for epilepsy, it is important to understand treatment responses and predictive factors. However, limited data are available in Africa, including Ethiopia. The aim of this study was therefore to ass...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52574-y
更新日期：2019-11-07 00:00:00
abstract：:Nutrient resorption processes in the plants infected by pathogen remain poorly understood. Huanglongbing (HLB) is a destructive disease of citrus. HLB-pathogen 'Candidatus Liberibacter asiaticus' grows specifically in the phloem of hosts and may cause problems in the plant vascular system after infection. Therefore, i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14675
更新日期：2015-09-30 00:00:00
abstract：:The number of magnetoelectric multiferroic materials reported to date is scarce, as magnetic structures that break inversion symmetry and induce an improper ferroelectric polarization typically arise through subtle competition between different magnetic interactions. The (NH4)2[FeCl5(H2O)] compound is a rare case wher...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14475
更新日期：2015-09-29 00:00:00
abstract：:It is well known that collective migrations of oxygen vacancies in oxide is the key principle of resistance change in oxide-based resistive memory (OxRAM). The practical usefulness of OxRAM mainly arises from the fact that these oxygen vacancy migrations take place at relatively low operating voltages. The activation ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53498-3
更新日期：2019-11-19 00:00:00
abstract：:This study was carried out to use hyperspectral imaging technique for determining color (L*, a* and b*) and eggshell strength and identifying cracked chicken eggs. Partial least squares (PLS) models based on full and selected wavelengths suggested by regression coefficient (RC) method were established to predict the f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21130
更新日期：2016-02-17 00:00:00
abstract：:The transcriptional responses of yeast cells to diverse stresses typically include gene activation and repression. Specific stress defense, citric acid cycle and oxidative phosphorylation genes are activated, whereas protein synthesis genes are coordinately repressed. This view was achieved from comparative transcript...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26170-5
更新日期：2018-05-21 00:00:00
abstract：:We aimed to establish the collective influence of four lifestyle practices (physical activity, diet, smoking and alcohol consumption) on the prevalence and incidence of AMD. At baseline, 2428 participants aged 49+ with complete lifestyle and AMD data were examined, and of these, 1903 participants were re-examined 15 y...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04697-3
更新日期：2017-06-28 00:00:00
abstract：:Using second-generation sequencing (SGS) RNA-Seq strategies, extensive alterative splicing prediction is impractical and high variability of isoforms expression quantification is inevitable in organisms without true reference dataset. we report the development of a novel analysis method, termed hybrid sequencing and m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43793
更新日期：2017-03-08 00:00:00
abstract：:Short-term exposures to outdoor air pollutants have been associated with lower lung function, but the results are inconsistence. The effects of different pollutant levels on lung function changes are still unclear. We quantified the effects of outdoor air pollution exposure (NO2, PM10, O3, and PM2.5) on lung function ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34947
更新日期：2016-10-13 00:00:00
abstract：:BPA is an oestrogenic endocrine disrupting chemical compound. Exposure to BPA in as early as pregnancy leads to lifelong effects. Since endocrine and immune systems interact in a bidirectional manner, endocrine disruption may cause permanent alterations of the immune system, affecting a future anti-tumoral response. N...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10135-1
更新日期：2017-09-05 00:00:00
abstract：:We investigated the effect of a new Rho kinase inhibitor, SB772077B (SB77) on aqueous outflow facility (OF) in human eyes using human organ-cultured anterior segment (HOCAS). IOP was monitored for 24 h post-treatment with either SB77 (0.1/10/50 µM) or vehicle after a stable baseline pressure. The hydrodynamic pattern ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33932-8
更新日期：2018-10-19 00:00:00
abstract：:Renewable natural resources, such as solar radiation, rainfall, wind, and geothermal heat, together with ecosystem services, provide the elementary supports for the sustainable development of human society. To improve regional sustainability, we studied the spatial distributions and quantities of renewable natural res...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37552
更新日期：2016-11-18 00:00:00
