Abstract：
:Biliverdin (BV) possesses antioxidant and anti-inflammatory properties, with previous reports identifying protection against oxidant and inflammatory injury in animal models. Recent reports indicate that intra-duodenal administration of BV results in the formation of an uncharacterised metabolite, which is potently absorbed into the blood and excreted into the bile. This compound may be responsible for protection against inflammatory responses. This study aimed to identify novel, enterally-derived BV metabolites and determine the source of their metabolic transformation. Rat duodena and bacterial cultures of Citrobacter youngae were treated with BV and subsequently analysed via high performance liquid chromatography/high resolution tandem mass spectrometry to identify and characterise metabolites of BV. A highly abundant metabolite was detected in duodenal wash and bacterial culture supernatants with a 663.215 m/z (3 ppm mass accuracy) and a composition of C33N4O9H36S, which conformed to the predicted structure of bilirubin-10-sulfonate (BRS) and possessed a λmax of 440 nm. Bilirubin-10-sulfonate was then synthesized for comparative LCMS/MS analysis and matched with that of the biologically formed BV metabolite. This report confirms the formation of a previously undocumented metabolite of BV in mammals, indicating that a new metabolic pathway likely exists for BV metabolism requiring enteric bacteria, Citrobacter youngae. These data may have important implications with regard to understanding and harnessing the therapeutic efficacy of oral BV administration.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Shiels RG,Vidimce J,Pearson AG,Matthews B,Wagner KH,Battle AR,Sakellaris H,Bulmer ACdoi
10.1038/s41598-019-39548-wsubject
Has Abstractpub_date
2019-02-27 00:00:00pages
2988issue
1issn
2045-2322pii
10.1038/s41598-019-39548-wjournal_volume
9pub_type
杂志文章abstract：:Exposure to an adverse early-life environment leads to long-term health problems, many of which are recapitulated in subsequent generations. The female reproductive tract is particularly sensitive to early-life influences, and plays a pivotal role in programming the conceptus. We examine the influence of suboptimal gr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16175
更新日期：2015-11-03 00:00:00
abstract：:This work reports the oxygen reduction reaction (ORR) kinetics of metal nanoparticle catalysts between 500 and 600 °C at low oxygen partial pressures. Ex situ and in situ TEM measurements demonstrate catalyzed nanowire growth initially follows linear kinetics; characteristic of being ORR rate limited. The ORR rates of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07717-4
更新日期：2017-08-01 00:00:00
abstract：:In order to study the effect of water-rock interactions on shear strength characteristics, we performed shearing tests under varying hydrochemical environments. Moreover, a custom meso-shear test equipment for coal rock was used for the tests. Through 3D scanning of the shear fractures and scanning electron microscope...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56196-2
更新日期：2019-12-27 00:00:00
abstract：:Photosynthetic activity is indispensable for plant growth and survival and it depends on the synthesis of plastidial isoprenoids as chlorophylls and carotenoids. In the non-mevalonate pathway (MEP), the 1-deoxy-D-xylulose-5-phosphate synthase 1 (DXS1) enzyme has been postulated to catalyze the rate-limiting step in th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45333
更新日期：2017-03-28 00:00:00
abstract：:Polarization control using single plasmonic nanoantennas is of interest for subwavelength optical components in nano-optical circuits and metasurfaces. Here, we investigate the role of two mechanisms for polarization conversion by plasmonic antennas: Structural asymmetry and plasmon hybridization through strong coupli...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40906
更新日期：2017-01-19 00:00:00
abstract：:Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP-2) is a cytoplasmic tyrosine phosphatase that is highly expressed in hematopoietic cells and in the CNS and exerts opposite effects on signal transduction by exerting a neuroprotective or proapoptotic effect. Several mutations of SHP-2 have been foun...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06401-x
更新日期：2017-07-20 00:00:00
abstract：:Seed size/weight is a major agronomic trait which determine crop productivity in legumes. To understand the genetic basis of seed size determination, we sought to identify DNA polymorphisms between two small (Himchana 1 and Pusa 362) and two large-seeded (JGK 3 and PG 0515) chickpea cultivars via whole genome resequen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35140-w
更新日期：2018-11-14 00:00:00
abstract：:C-phycocyanin (C-PC) pigment, as a natural blue dye, has particular applications in various fields. It is a water-soluble protein which has anticancer, antioxidant and anti-inflammatory properties. Here, we introduce an efficient procedure for the purification of C-PC pigment, followed by conducting a comprehensive in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45905-6
更新日期：2019-07-01 00:00:00
abstract：:Increased glucose uptake and aerobic glycolysis are striking features of many cancers. These features have led to many techniques for screening and diagnosis, but many are expensive, less feasible or have harmful side-effects. Here, we report a sensitive 1H/2H NMR method to measure the kinetics of lactate isotopomer a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65839-8
更新日期：2020-06-01 00:00:00
abstract：:We analyze the entire publication database of the American Physical Society generating longitudinal (50 years) citation networks geolocalized at the level of single urban areas. We define the knowledge diffusion proxy, and scientific production ranking algorithms to capture the spatio-temporal dynamics of Physics know...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01640
更新日期：2013-01-01 00:00:00
abstract：:Fano resonance presents an asymmetric line shape formed by an interference of a continuum coupled with a discrete autoionized state. In this paper, we show several simple circuits for Fano resonances from the stable-input impedance mechanism, where the elements consisting of inductors and capacitors are formulated for...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31884
更新日期：2016-08-22 00:00:00
abstract：:The success of Bacillus amyloliquefaciens as a biological control agent relies on its ability to outgrow plant pathogens. It is also thought to interact with its plant host by inducing systemic resistance. In this study, the ability of B. amyloliquefaciens MBI600 to elicit defense (or other) responses in tomato seedli...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55645-2
更新日期：2019-12-13 00:00:00
abstract：:This paper illustrates the potential for seasonal prediction of wind and solar energy resources through a case study in the Yangtze River estuary. Sea surface temperature and geopotential height-based climate predictors, each with high correlation to ensuing seasonal wind speed and solar radiation at the Baoshan weath...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65281-w
更新日期：2020-05-25 00:00:00
abstract：:The regeneration capacity of knee cartilage can be enhanced by applying periosteal grafts, but this effect varies depending on the different sources of the periosteal grafts applied for cartilage formation. Tibia periosteum can be used to enhance cartilage repair. However, long-term analysis has not been conducted. Th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65448-5
更新日期：2020-05-20 00:00:00
abstract：:The innate immune system helps animals to navigate the microbial world. The response to microbes relies on the specific recognition of microbial-associated molecular patterns (MAMPs) by immune receptors. Sponges (phylum Porifera), as early-diverging animals, provide insights into conserved mechanisms for animal-microb...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34330-w
更新日期：2018-10-31 00:00:00
abstract：:A superhydrophilic and underwater superoleophobic surface is fabricated by simply coating silica nanospheres onto a glass fiber membrane through a sol-gel process. Such membrane has a complex framework with micro and nano structures covering and presents a high efficiency (more than 98%) of oil-in-water emulsion separ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32540
更新日期：2016-09-06 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-42527-w
更新日期：2019-04-12 00:00:00
abstract：:There is a global concern about the effects of climate change driven shifts in species phenology on crop pests. Using geographically and temporally extensive data set of moth trap catches and temperatures across the cotton growing states of India, we predicted the phenology of cotton pink bollworm Pectinophora gossypi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80184-6
更新日期：2021-01-11 00:00:00
abstract：:Spin injection, manipulation and detection are the integral parts of spintronics devices and have attracted tremendous attention in the last decade. It is necessary to judiciously choose the right combination of materials to have compatibility with the existing semiconductor technology. Conventional metallic magnets w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05588
更新日期：2014-07-07 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-59025-z
更新日期：2020-02-07 00:00:00
abstract：:Diagnostic testing often assesses the cardiovascular or respiratory systems in isolation, ignoring the major pathophysiologic interactions between the systems in many diseases. When both systems are assessed currently, multiple modalities are utilized in costly fashion with burdensome logistics and decreased accessibi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04676-8
更新日期：2017-07-13 00:00:00
abstract：:The aging process is regarded as the progressive loss of physiological integrity, leading to impaired biological functions and the increased vulnerability to death. Among various biological functions, stress response capacity enables cells to alter gene expression patterns and survive when facing internal and external...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72167-4
更新日期：2020-09-16 00:00:00
abstract：:We aimed to examine the prospective association between first trimester HbA1c and gestational diabetes (GDM) and explore the utility of HbA1c for prediction of GDM. We used data from a case-control study within the prospective NICHD Fetal Growth Studies-Singleton Cohort (2009-2013), which enrolled 2,802 women at 12 U....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30833-8
更新日期：2018-08-16 00:00:00
abstract：:Nowadays, increasing awareness of environment and fossil fuels protection stimulates intensive research on clean and renewable sources of energy. Production of hydrogen from water through solar-driven splitting reactions is one of the most promising approaches in the field of photoelectrochemistry (PEC). In this work ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29247-3
更新日期：2018-07-18 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-39693-2
更新日期：2019-04-17 00:00:00
abstract：:We have previously shown that MicroRNA (miR) -144 is a key modulator of the acute cardioprotection associated with remote ischemic preconditioning and post myocardial infarction (MI) remodeling. In this study we examine the biology of the remodeling response after permanent ligation of the left anterior descending cor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35314-6
更新日期：2018-11-15 00:00:00
abstract：:The capacity of marine organisms to adapt and/or acclimate to climate change might differ among distinct populations, depending on their local environmental history and phenotypic plasticity. Kelp forests create some of the most productive habitats in the world, but globally, many populations have been negatively impa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-82094-7
更新日期：2021-01-28 00:00:00
abstract：:Three-dimensional (3D) image reconstruction of tumors based on serial histological sectioning is one of the most powerful methods for accurate high-resolution visualization of tumor structures. However, 3D histological reconstruction of whole tumor has not yet been achieved. We established a high-resolution 3D model o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76081-7
更新日期：2020-11-03 00:00:00
abstract：:This study investigated the effect of various prebiotics (indigestible dextrin, α-cyclodextrin, and dextran) on human colonic microbiota at a dosage corresponding to a daily intake of 6 g of prebiotics per person (0.2% of dietary intake). We used an in vitro human colonic microbiota model based on batch fermentation s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18877-8
更新日期：2018-01-11 00:00:00
abstract：:Estrogens protect against diet-induced obesity in women and female rodents. For example, a lack of estrogens in postmenopausal women is associated with an increased risk of weight gain, cardiovascular diseases, low-grade inflammation, and cancer. Estrogens act with leptin to regulate energy homeostasis in females. Lep...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56723-1
更新日期：2019-12-27 00:00:00
