Abstract:
:In situ tissue engineering within a stroke cavity is gradually emerging as a novel therapeutic paradigm. Considering the varied lesion topology within each subject, the placement and distribution of cells within the lesion cavity is challenging. The use of multiple cell types to reconstruct damaged tissue illustrates the complexity of the process, but also highlights the challenges to provide a non-invasive assessment. The distribution of implanted cells within the lesion cavity and crucially the contribution of neural stem cells and endothelial cells to morphogenesis could be visualized simultaneously using two paramagnetic chemical exchange saturation transfer (paraCEST) agents. The development of sophisticated imaging methods is essential to guide delivery of the building blocks for in situ tissue engineering, but will also be essential to understand the dynamics of cellular interactions leading to the formation of de novo tissue.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Nicholls FJ,Ling W,Ferrauto G,Aime S,Modo Mdoi
10.1038/srep14597subject
Has Abstractpub_date
2015-09-30 00:00:00pages
14597issn
2045-2322pii
srep14597journal_volume
5pub_type
杂志文章abstract::This report investigated dislocation-twin boundary (TB) interactions that cause the TB to disappear and turn into a high-angle grain boundary (GB). The evolution of the microstructural characteristics of Hadfield steel was shown as a function of severe plastic deformation processing time. Sessile Frank partial disloca...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08981
更新日期:2015-03-11 00:00:00
abstract::Adipose stromal cells (ASC) secrete various trophic factors that assist in the protection of neurons in a variety of neuronal death models. In this study, we tested the effects of human ASC conditional medium (ASC-CM) in human amyotrophic lateral sclerosis (ALS) transgenic mouse model expressing mutant superoxide dism...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16953
更新日期:2015-11-20 00:00:00
abstract::Recently there has not been a systematic, objective assessment of the metabolic capabilities of the human platelet. A manually curated, functionally tested, and validated biochemical reaction network of platelet metabolism, iAT-PLT-636, was reconstructed using 33 proteomic datasets and 354 literature references. The n...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03925
更新日期:2014-01-29 00:00:00
abstract::Multi-modal three dimensional (3D) optical imaging combining both structural sensitivity and molecular specificity is highly desirable in biomedical research. In this paper, we present a method termed oblique scanning laser microscopy (OSLM) to combine optical coherence tomography (OCT), for simultaneously volumetric ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08822-0
更新日期:2017-08-17 00:00:00
abstract::Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, ranging from steatosis to non-alcoholic steatohepatitis (NASH). Recently, cerium oxide nanoparticles (CeO2NPs) have emerged as a new antioxidant agent with hepatoprotective properties in experimental liver disease. T...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49262-2
更新日期:2019-09-06 00:00:00
abstract::The aim of the current study is to assess whether total bile acid (TBA) level in first trimester pregnancy is associated with gestational diabetes mellitus (GDM). Biochemical parameters including serum TBA of 742 pregnant women were collected within 12 weeks of gestation and compared. At 24-28th weeks of gestation, 75...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34070
更新日期:2016-09-26 00:00:00
abstract::Insulin resistance (IR) has become a global epidemic that represents a serious hazard to public health. However, the precise mechanisms modulating IR have not been fully elucidated. The present study aimed to investigate the role of transcriptional factor Twist 1 in adipocyte IR and to further explore the molecular me...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30820-z
更新日期:2018-08-22 00:00:00
abstract::We present experimental evidence for scale invariant behaviour of the excitation spectrum in phase-fluctuating quasi-1d Bose gases after a rapid change of the external trapping potential. Probing density correlations in free expansion, we find that the temperature of an initial thermal state scales with the spatial ex...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09820
更新日期:2015-04-13 00:00:00
abstract::Estimating regional nutrient criteria for streams and rivers is a key step toward protecting river water quality and restoring the health of aquatic ecosystems. Using a multivariable statistical analysis technique, nutrients were identified as the main factor influencing the degradation of the benthic macroinvertebrat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22128-9
更新日期:2018-02-28 00:00:00
abstract::As whales recover from commercial exploitation, they are increasing in abundance in habitats that they have been absent from for decades. However, studying the recovery and habitat use patterns of whales, particularly in remote and inaccessible regions, frequently poses logistical and economic challenges. Here we tria...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69887-y
更新日期:2020-07-31 00:00:00
abstract::Traumatic brain injury (TBI) has been associated with atherosclerosis and cardiovascular mortality in humans. However the causal relationship between TBI and vascular disease is unclear. This study investigated the direct role of TBI on vascular disease using a murine model of atherosclerosis. Apolipoprotein E deficie...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23959-2
更新日期:2018-04-04 00:00:00
abstract::Based on the polarization-sensitive absorption of graphene under conditions of total internal reflection, a novel optical sensor combining graphene and a microfluidic structure was constructed to achieve the sensitive real-time monitoring of refractive indexes. The atomic thickness and strong broadband absorption of g...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00908
更新日期:2012-01-01 00:00:00
abstract::If a cultural feature is transmitted over generations and exposed to stochastic selection when spreading in a population, its evolution may be governed by statistical laws and be partly predictable, as in the case of genetic evolution. Music exhibits steady changes of styles over time, with new characteristics develop...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52380-6
更新日期:2019-11-05 00:00:00
abstract::In North America, red blood cells (RBCs) are cryopreserved in a clinical setting using high glycerol concentrations (40% w/v) with slow cooling rates (~1°C/min) prior to storage at -80°C, while European protocols use reduced glycerol concentrations with rapid freezing rates. After thawing and prior to transfusion, gly...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09692
更新日期:2015-04-08 00:00:00
abstract::Miscarriage affects ~20% of pregnancies and maternal infections account for ~15% of early miscarriages. Chlamydia trachomatis (Ct) has been associated with miscarriage but the underlying mechanisms are unknown. Successful implantation requires endometrial stromal cell (ESC) decidualisation. Maintenance of pregnancy re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02223-z
更新日期:2017-05-17 00:00:00
abstract::The enhancement and control of non-linear phenomena at a nanometer scale has a wide range of applications in science and in industry. Among these phenomena, high-harmonic generation in solids is a recent focus of research to realize next generation petahertz optoelectronic devices or compact all solid state EUV source...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41642-y
更新日期:2019-04-05 00:00:00
abstract::Atrial fibrillation (AF) is known to cause adverse remodeling of left atrium (LA). Radiofrequency catheter ablation (RFCA) of AF is associated with decrease in LA volume. However, the impact of RFCA on left atrial appendage (LAA) volume and hemodynamic function is not fully understood. We analyzed 123 patients who und...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26212-y
更新日期:2018-05-18 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-74322-3
更新日期:2020-10-06 00:00:00
abstract::Culture medium of mesenchymal stromal cells (MSCs) is usually supplemented with either human platelet lysate (HPL) or fetal calf serum (FCS). Many studies have demonstrated that proliferation and cellular morphology are affected by these supplements - it is therefore important to determine if they favor outgrowth of d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05207-1
更新日期:2017-07-11 00:00:00
abstract::Highly Tm(3+) doped optical fibers are urgently desirable for 2.0 μm compact single-frequency fiber laser and high-repetition-rate mode-locked fiber laser. Here, we systematically investigated the optical parameters, energy transfer processes and thermal properties of Tm(3+) doped barium gallo-germanate (BGG) glasses....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20344
更新日期:2016-02-01 00:00:00
abstract::Dectin-1, a classical pattern-recognition receptor, was now identified as an important regulator in immune homeostasis and cancer immunity through its extensive ligands binding functions and subsequent cytokines production. The aim of this study was to assess the clinical significance of dectin-1 expression in 290 pat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32657
更新日期:2016-09-07 00:00:00
abstract::Sensing infrared radiation is done inexpensively with pyroelectric detectors that generate a temporary voltage when they are heated by the incident infrared radiation. Unfortunately the performance of these detectors deteriorates for longer wavelengths, leaving the detection of, for instance, millimetre-wave radiation...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21079
更新日期:2016-02-16 00:00:00
abstract:BACKGROUND:Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency leads to impaired cortisol biosynthesis. Treatment includes glucocorticoid supplementation. We studied the specific metabolomics signatures in CAH patients using two different algorithms. METHODS:In a case-control study of CAH patients ma...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65897-y
更新日期:2020-06-01 00:00:00
abstract::Ongoing studies of a multiple track-bearing horizons from massive excavations in the Jinju Formation (Lower Cretaceous) of South Korea have yielded a remarkable diversity of avian, non-avian dinosaur, pterosaur, crocodilian and mammal tracks, many very small and well preserved. Here we report diminutive, didactyl trac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35289-4
更新日期:2018-11-15 00:00:00
abstract::Tinnitus (phantom auditory perception associated with hearing loss) can seriously affect wellbeing. Its neural substrate is unknown however it has been linked with abnormal activity in auditory pathways. Though no cure currently exists, repetitive transcranial magnetic stimulation (rTMS) has been shown to reduce tinni...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38234
更新日期:2016-12-01 00:00:00
abstract::The effect of initial evenness on the temporal trajectory of synthetic communities in comprehensive, low-volume microcosm studies remains unknown. We used flow cytometric fingerprinting and 16S rRNA gene amplicon sequencing to assess the impact of time on community structure in one hundred synthetic ecosystems of fixe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18668-1
更新日期:2018-01-10 00:00:00
abstract::Cucumber green mottle mosaic virus (CGMMV) belongs to the Tobamovirus genus and is a major global plant virus on cucurbit plants. It causes severe disease symptoms on infected watermelon plants (Citrullus lanatus), particularly inducing fruit decay. However, little is known about the molecular mechanism of CGMMV-induc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17140-4
更新日期:2017-12-01 00:00:00
abstract::Next generation sequencing has disrupted genetic testing, allowing far more scope in the tests applied. The appropriate sections of the genome to be tested can now be readily selected, from single mutations to whole-genome sequencing. One product offering within this spectrum are focused exomes, targeting ~5,000 genes...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60215-y
更新日期:2020-02-24 00:00:00
abstract::Roquins are a family of highly conserved RNA-binding proteins that also contain a RING-type E3 ubiquitin ligase domain. They repress constitutive decay elements containing mRNAs and play a critical role in RNA homeostasis and immunological self-tolerance. Here we present the crystal structures of the RNA-binding regio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15660
更新日期:2015-10-22 00:00:00
abstract::In day-to-day life, humans usually perceive the location of sound sources as outside their heads. This externalized auditory spatial perception can be reproduced through headphones by recreating the sound pressure generated by the source at the listener's eardrums. This requires the acoustical features of the recordin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37342
更新日期:2016-11-17 00:00:00