Long-term exposure of human endothelial cells to metformin modulates miRNAs and isomiRs.

abstract：:The proteins AtSEOR1 and AtSEOR2 occur as conjugates in the form of filaments in sieve elements of Arabidopsis thaliana. A reduced phytoplasma titre found in infected defective-mutant Atseor1ko plants in previous work raised the speculation that non-conjugated SEOR2 is involved in the phytohormone-mediated suppression...

journal_title：Scientific reports

authors： Bernardini C,Pagliari L,De Rosa V,Almeida-Trapp M,Santi S,Martini M,Buoso S,Loschi A,Loi N,Chiesa F,Mithöfer A,van Bel AJE,Musetti R

更新日期：2020-09-08 00:00:00

abstract：:Conventional concentrators with inhomogeneous coating materials that fully enclose the destined region pose great challenges for fabrication. In this paper, we propose to design an EM concentrator with homogeneous materials. Distinguished from conventional ones, the elaborately designed EM concentrator features a conc...

journal_title：Scientific reports

authors： Madni HA,Hussain K,Jiang WX,Liu S,Aziz A,Iqbal S,Mahboob A,Cui TJ

更新日期：2018-06-25 00:00:00

abstract：:During Antarctic isolation personnel are exposed to extreme photoperiods. A frequent observation is a sleep onset phase delay during winter. It is not known if, as a result, daytime sleeping in the form of naps increases. We sought to assess sleep patterns - with focus on daytime sleeping - and alertness in a Latin Am...

journal_title：Scientific reports

authors： Folgueira A,Simonelli G,Plano S,Tortello C,Cuiuli JM,Blanchard A,Patagua A,Brager AJ,Capaldi VF,Aubert AE,Barbarito M,Golombek DA,Vigo DE

更新日期：2019-07-26 00:00:00

abstract：:Although intestinal trefoil factor (ITF) can alleviate the burn-induced intestinal mucosa injury, the underlying mechanisms remains elusive. In this study, we investigated if ITF alters glutamine transport on the brush border membrane vesicles (BBMVs) of the intestines in Sprague-Dawley rats inflicted with 30% TBSA an...

journal_title：Scientific reports

authors： Hu J,Shi Y,Wang C,Wan H,Wu D,Wang H,Peng X

更新日期：2018-02-16 00:00:00

abstract：:Two-dimensional (2D) porous carbon AC-SPN-3 possessing of amazing high micropore volume ratio of 83% and large surface area of about 1069 m(2) g(-1) is high-yield obtained by pyrolysis of natural waste Pistachio nutshells with KOH activation. The AC-SPN-3 has a curved 2D lamellar morphology with the thickness of each ...

journal_title：Scientific reports

authors： Xu J,Gao Q,Zhang Y,Tan Y,Tian W,Zhu L,Jiang L

更新日期：2014-07-02 00:00:00

abstract：:The mechanism by which chronic metabolic acidosis (CMA) regulates sodium (Na(+))-chloride (Cl(-)) cotransporter (NCC) in the renal distal convoluted tubules remains unexplored. We examined the role of STE20/SPS1-related proline/alanine-rich kinase (SPAK) and with-no-lysine kinase 4 (WNK4) on expression of NCC in mouse...

journal_title：Scientific reports

authors： Fang YW,Yang SS,Cheng CJ,Tseng MH,Hsu HM,Lin SH

更新日期：2016-01-05 00:00:00

abstract：:In insects, the transition from juvenile development to the adult stage is controlled by juvenile hormone (JH) synthesized from the corpora allata (CA) glands. Whereas a JH-free period during the last juvenile instar triggers metamorphosis and the end of the growth period, the reappearance of this hormone after the im...

journal_title：Scientific reports

authors： Borras-Castells F,Nieva C,Maestro JL,Maestro O,Belles X,Martín D

更新日期：2017-01-11 00:00:00

abstract：:Identification of biomarkers for endometriosis is an unmet medical need that demands to be fulfilled. In this study, we first used a mouse model of endometriosis and evaluated the potential utility of select biomarkers based on serial observations. Since fibrosis is the end result of lesional development, we chose hig...

journal_title：Scientific reports

authors： Cao Y,Liu X,Guo SW

更新日期：2019-06-25 00:00:00

abstract：:In this paper, a novel explanation on high directive emission of Fabry-Perot resonator antenna with subwavelength metasurface is proposed. Based on image theory and effective constitutive parameter retrieval, the whole Fabry-Perot resonant cavity structure composed of a single-layer metasurface with square ring elemen...

journal_title：Scientific reports

authors： Liu ZG,Lu WB,Yang W

更新日期：2017-09-13 00:00:00

abstract：:There is growing evidence that hydrogen sulfide (H2S) is involved in many physiological processes in plants, but the role of H2S in dark-induced leaf senescence remains unknown. In this work, we found that H2S not only inhibited chlorophyll degradation but also caused the accumulation of photoreactive pheide a in deta...

journal_title：Scientific reports

authors： Wei B,Zhang W,Chao J,Zhang T,Zhao T,Noctor G,Liu Y,Han Y

更新日期：2017-06-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Boonma K,Kumar A,Garcia-Castellanos D,Jiménez-Munt I,Fernández M

更新日期：2020-01-15 00:00:00

abstract：:The 28,000-year-old remains of a woolly mammoth, named 'Yuka', were found in Siberian permafrost. Here we recovered the less-damaged nucleus-like structures from the remains and visualised their dynamics in living mouse oocytes after nuclear transfer. Proteomic analyses demonstrated the presence of nuclear components ...

journal_title：Scientific reports

authors： Yamagata K,Nagai K,Miyamoto H,Anzai M,Kato H,Miyamoto K,Kurosaka S,Azuma R,Kolodeznikov II,Protopopov AV,Plotnikov VV,Kobayashi H,Kawahara-Miki R,Kono T,Uchida M,Shibata Y,Handa T,Kimura H,Hosoi Y,Mitani T,Matsumo

更新日期：2019-03-11 00:00:00

abstract：:Sea-surface temperature (SST) warming events, which are projected to increase in frequency and intensity with climate change, represent major threats to coral reefs. How these events impact reef carbonate budgets, and thus the capacity of reefs to sustain vertical growth under rising sea levels, remains poorly quantif...

journal_title：Scientific reports

authors： Perry CT,Morgan KM

更新日期：2017-01-13 00:00:00

abstract：:The identification of the modes of action of bioactive compounds is a major challenge in chemical systems biology of diseases. Genome-wide expression profiling of transcriptional responses to compound treatment for human cell lines is a promising unbiased approach for the mode-of-action analysis. Here we developed a n...

journal_title：Scientific reports

authors： Iwata M,Sawada R,Iwata H,Kotera M,Yamanishi Y

更新日期：2017-01-10 00:00:00

abstract：:Measurements of skeletal muscle cross-sectional area, index, and radiation attenuation utilizing clinical computed tomography (CT) scans are used in assessments of sarcopenia, the loss of skeletal muscle mass and function associated with aging. To classify individuals as sarcopenic, sex-specific cutoffs for 'low' valu...

journal_title：Scientific reports

authors： Derstine BA,Holcombe SA,Ross BE,Wang NC,Su GL,Wang SC

更新日期：2018-07-27 00:00:00

abstract：:Although it is clear that lipids are responsible for insulin resistance, it is poorly understood what types of lipids are involved. In this study, we verified the characteristic lipid species in skeletal muscle of a chronic exercise training model and a high-fat induced-obesity model. Three different lipidomics analys...

journal_title：Scientific reports

authors： Goto-Inoue N,Yamada K,Inagaki A,Furuichi Y,Ogino S,Manabe Y,Setou M,Fujii NL

更新日期：2013-11-20 00:00:00

abstract：:Primary dysmenorrhea (PDM) is the most prevalent gynecological problem. Many key brain systems are engaged in pain processing. In light of dynamic communication within and between systems (or networks) in shaping pain experience and behavior, the intra-regional functional connectivity (FC) in the hub regions of the sy...

journal_title：Scientific reports

authors： Wu TH,Tu CH,Chao HT,Li WC,Low I,Chuang CY,Yeh TC,Cheng CM,Chou CC,Chen LF,Hsieh JC

更新日期：2016-04-19 00:00:00

abstract：:Body contouring achieved via subcutaneous adipose tissue reduction has notably advanced over the past century, from suction assisted lipectomy to techniques with reduced degrees of invasiveness including laser, radiofrequency, high frequency focused ultrasound, cryolipolysis, and drug-based injection approaches. These...

journal_title：Scientific reports

authors： Pham TT,Stokolosa AM,Borden PA,Hansen KD,Hong EM,Krasieva TB,Sivoraphonh RH,Moy WJ,Heidari AE,Lee LH,Kim EH,Sun CH,Jia W,Mo J-,Kim S,Hill MG,Wong BJF

更新日期：2020-11-27 00:00:00

abstract：:Phasins or PhaPs are a group of amphiphilic proteins that are found attached to the surface of microbial polyhydroxyalkanoate (PHA) granules. They have both structural and regulatory functions and can affect intracellular PHA accumulation and mediate protein folding. The molecular basis for the diverse functions of th...

journal_title：Scientific reports

authors： Zhao H,Wei H,Liu X,Yao Z,Xu M,Wei D,Wang J,Wang X,Chen GQ

更新日期：2016-12-23 00:00:00

abstract：:Monochamus beetles are the dispersing vectors of the nematode Bursaphelenchus xylophilus, the causative agent of pine wilt disease (PWD). PWD inflicts significant damages in Eurasian pine forests. Symbiotic microorganisms have a large influence in insect survival. The aim of this study was to characterize the bacteria...

journal_title：Scientific reports

authors： Alves M,Pereira A,Matos P,Henriques J,Vicente C,Aikawa T,Hasegawa K,Nascimento F,Mota M,Correia A,Henriques I

更新日期：2016-04-05 00:00:00

abstract：:The Great East Japan Earthquake on 11 March 2011, caused the release of radioactive materials from the Fukushima Daiichi Nuclear Power Plant (FDNPP), contaminating eastern Japan, particularly in part of Fukushima Prefecture. In 2012 and 2014, the radiocaesium concentration in brown rice did not exceed regulatory level...

journal_title：Scientific reports

authors： Matsunami H,Murakami T,Fujiwara H,Shinano T

更新日期：2016-02-04 00:00:00

abstract：:The salmon louse is an ectoparasitic copepod of salmonids in the marine environment, and represents a global challenge to salmon aquaculture. A major issue is the reliance of the industry on a limited number of chemicals to delouse salmonids on farms, and the high levels of resistance that lice have developed to all o...

journal_title：Scientific reports

authors： Kaur K,Besnier F,Glover KA,Nilsen F,Aspehaug VT,Fjørtoft HB,Horsberg TE

更新日期：2017-09-27 00:00:00

abstract：:The current study was conducted to assess the effects of microinjection of different dosages of guide RNA (gRNA)/Cas9 protein on the mutation rate, embryo survival, embryonic development, hatchability and early fry survival in channel catfish, Ictalurus punctatus. Guide RNAs targeting two of the channel catfish immune...

journal_title：Scientific reports

authors： Elaswad A,Khalil K,Ye Z,Liu Z,Liu S,Peatman E,Odin R,Vo K,Drescher D,Gosh K,Qin G,Bugg W,Backenstose N,Dunham R

更新日期：2018-11-07 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Zhang H,Li G,Su B,Deng M,Liu YX,Gu YC,Wang QM

更新日期：2018-03-06 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Radeck J,Meyer D,Lautenschläger N,Mascher T

更新日期：2018-03-06 00:00:00

abstract：:Wildfires burn large parts of the tropics every year, shaping ecosystem structure and functioning. Yet the complex interplay between climate, vegetation and human factors that drives fire dynamics is still poorly understood. Here we show that on all continents, except Australia, tropical fire regimes change drasticall...

journal_title：Scientific reports

authors： Hantson S,Scheffer M,Pueyo S,Xu C,Lasslop G,van Nes EH,Holmgren M,Mendelsohn J

更新日期：2017-10-30 00:00:00

abstract：:Carbapenem resistant Enterobacteriaceae (CRE) pose an urgent risk to global human health. CRE that are non-susceptible to all commercially available antibiotics threaten to return us to the pre-antibiotic era. Using Single Molecule Real Time (SMRT) sequencing we determined the complete genome of a pandrug-resistant Kl...

journal_title：Scientific reports

authors： Zowawi HM,Forde BM,Alfaresi M,Alzarouni A,Farahat Y,Chong TM,Yin WF,Chan KG,Li J,Schembri MA,Beatson SA,Paterson DL

更新日期：2015-10-19 00:00:00

abstract：:The detection and assessment of leakage in retinal fluorescein angiogram images is important for the management of a wide range of retinal diseases. We have developed a framework that can automatically detect three types of leakage (large focal, punctate focal, and vessel segment leakage) and validated it on images fr...

journal_title：Scientific reports

authors： Zhao Y,MacCormick IJ,Parry DG,Leach S,Beare NA,Harding SP,Zheng Y

更新日期：2015-06-01 00:00:00

abstract：:Ribosome biogenesis and turnover are processes necessary for cell viability and proliferation, and many kinds of proteins are known to regulate these processes. However, many questions still remain, especially in the Archaea. Generally, several ribonucleases are required to process precursor rRNAs to their mature form...

journal_title：Scientific reports

authors： Ikeda Y,Okada Y,Sato A,Kanai T,Tomita M,Atomi H,Kanai A

更新日期：2017-10-04 00:00:00

abstract：:Convenient drug-resistance testing of viral mutants is indispensable to effective treatment of viral infection. We developed a novel fluorometric assay for phenotypic differentiation of drug-resistant mutants of human immunodeficiency virus-I protease (HIV-PR) which uses enzymatic and peptide-specific fluorescence (FL...

journal_title：Scientific reports

authors： Zhu Q,Yu Z,Kabashima T,Yin S,Dragusha S,El-Mahdy AF,Ejupi V,Shibata T,Kai M

更新日期：2015-05-19 00:00:00