Abstract：
:Primary dysmenorrhea (PDM) is the most prevalent gynecological problem. Many key brain systems are engaged in pain processing. In light of dynamic communication within and between systems (or networks) in shaping pain experience and behavior, the intra-regional functional connectivity (FC) in the hub regions of the systems may be altered and the functional interactions in terms of inter-regional FCs among the networks may be reorganized to cope with the repeated stress of menstrual pain in PDM. Forty-six otherwise healthy PDM subjects and 49 age-matched, healthy female control subjects were enrolled. Intra- and inter-regional FC were assessed using regional homogeneity (ReHo) and ReHo-seeded FC analyses, respectively. PDM women exhibited a trait-related ReHo reduction in the ventromedial prefrontal cortex, part of the default mode network (DMN), during the periovulatory phase. The trait-related hypoconnectivity of DMN-salience network and hyperconnectivity of DMN-executive control network across the menstrual cycle featured a dynamic transition from affective processing of pain salience to cognitive modulation. The altered DMN-sensorimotor network may be an ongoing representation of cumulative menstrual pain. The findings indicate that women with long-term PDM may develop adaptive neuroplasticity and functional reorganization with a network shift from affective processing of salience to the cognitive modulation of pain.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wu TH,Tu CH,Chao HT,Li WC,Low I,Chuang CY,Yeh TC,Cheng CM,Chou CC,Chen LF,Hsieh JCdoi
10.1038/srep24543subject
Has Abstractpub_date
2016-04-19 00:00:00pages
24543issn
2045-2322pii
srep24543journal_volume
6pub_type
杂志文章abstract：:Alternate bearing (AB) refers to the tendency of trees to have an irregular crop load from 1 year (ON) to the next year (OFF). Despite its economic importance, it is not fully understood how gene networks and their related metabolic pathways may influence the irregular bearing in olive trees. To unravel molecular mech...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72895-7
更新日期：2020-09-25 00:00:00
abstract：:Chromosomal polymorphism is widespread in the Drosophila genus, with extensive evidence supporting its adaptive character in diverse species. Moreover, inversions are the major contributors to the genus chromosomal evolution. The molecular characterization of a reduced number of polymorphic inversion breakpoints in Dr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36248
更新日期：2016-10-26 00:00:00
abstract：:We show that the width of an arbitrary function and the width of the distribution of its values cannot be made arbitrarily small simultaneously. In the case of ergodic stochastic processes, an ensuing uncertainty relationship is then demonstrated for the product of correlation length and variance. A closely related un...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64539-7
更新日期：2020-05-12 00:00:00
abstract：:The Pannexin 1 (Panx1) ion and metabolite channel is expressed in a wide variety of cells where it regulates a number of cell behaviours including proliferation and differentiation. Panx1 is expressed on the cell surface as well as intracellular membranes. Previous work suggests that a region within the proximal Panx1...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46144-5
更新日期：2019-07-05 00:00:00
abstract：:Caterpillars of the silk moth genus Hyalophora (Lepidoptera; Saturniidae) construct multilayered cocoons that function as overwintering housing during the pupal to adult developmental period. While all cocoons share the primary function of protecting the developing moth, cocoons spun by different Hyalophora silk moth ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62547-1
更新日期：2020-03-27 00:00:00
abstract：:In ART programs in sub-Saharan Africa, a growing proportion of HIV-infected persons initiating first-line antiretroviral therapy (ART) have a history of prior antiretroviral drug use (PAU). We assessed the effect of PAU on the risk of pre-treatment drug resistance (PDR) and virological failure (VF) in a multicountry c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33538-0
更新日期：2018-10-25 00:00:00
abstract：:Acquisition of nutrients during intra-vacuolar growth of L. pneumophila within macrophages or amoebae is poorly understood. Since many genes of L. pneumophila are acquired by inter-kingdom horizontal gene transfer from eukaryotic hosts, we examined the presence of human solute carrier (SLC)-like transporters in the L....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26782-x
更新日期：2018-05-29 00:00:00
abstract：:Metamagnetism occuring inside a ferromagnetic phase is peculiar. Therefore, Sr4Ru3O10, a T C = 105 K ferromagnet, has attracted much attention in recent years, because it develops a pronounced metamagnetic anomaly below T C for magnetic fields applied in the crystallographic ab-plane. The metamagnetic transition move...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03648-2
更新日期：2017-06-20 00:00:00
abstract：:We present an optimized non-thermal atmospheric plasma (NTAP)-based reaction-discharge system that was applied for a continuous-flow treatment of apple juice (AJ). To optimize this system for a high-throughput production of AJ with ameliorated properties, the effect of several parameters was studied using design of ex...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78131-6
更新日期：2020-12-03 00:00:00
abstract：:Airway smooth muscle (ASM) cells exhibit plastic phenotypic behavior marked by reversible modulation and maturation between contractile and proliferative phenotypic states. Integrins are a class of transmembrane proteins that have been implicated as novel therapeutic targets for asthma treatment. We previously showed ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46260-2
更新日期：2019-07-09 00:00:00
abstract：:Melting is considered to be one of the most fundamental problems in physical science. Generally, dimensionality plays an important role in melting. In three-dimension, it's well known that a crystal melts directly into a liquid via a first-order transition. In two-dimension (2D), however, the melting process has been ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24056
更新日期：2016-04-07 00:00:00
abstract：:Understanding source-sink dynamics is important for conservation management, particularly when climatic events alter species' distributions. Following a 2011 'marine heatwave' in Western Australia, we observed high recruitment of the endemic fisheries target species Choerodon rubescens, towards the cooler (southern) e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09224-y
更新日期：2017-08-17 00:00:00
abstract：:This study explores the radiation field temperatures introduced by the laser spot, the re-emitting wall in a hohlraum and the entire hohlraum drive source. This investigation, which is the first of its kind, is based on the radiation fluxes from the laser spot and the re-emitting wall, which have been accurately measu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41424-6
更新日期：2019-03-25 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-57959-y
更新日期：2020-02-05 00:00:00
abstract：:Obesity is one of the major risk factor for cardiovascular and metabolic diseases. A disproportional accumulation of fat at visceral (VAT) compared to subcutaneous sites (SAT) has been suspected as a key detrimental event. We used non-targeted metabolomics profiling to reveal metabolic pathways associated with higher ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58430-8
更新日期：2020-01-30 00:00:00
abstract：:Multidrug-resistant pathogens causing nosocomial and community acquired infections delineate a significant threat to public health. It had urged to identify new antimicrobials and thus, generated interest in studying macrocyclic metal complex, which has been studied in the past for their antimicrobial activity. Hence,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26483-5
更新日期：2018-05-23 00:00:00
abstract：:The most important goals of brain network analyses are to (a) detect pivotal regions and connections that contribute to disproportionate communication flow, (b) integrate global information, and (c) increase the brain network efficiency. Most centrality measures assume that information propagates in networks with the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42322-7
更新日期：2019-04-11 00:00:00
abstract：:microRNAs are an abundant class of small non-coding RNAs that control gene expression post-transcriptionally. Importantly, microRNA activity participates in the regulation of cellular processes and is a potentially valuable source of biomarkers in the diagnosis and prognosis of human diseases. Here we introduce miQPCR...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11590
更新日期：2015-06-25 00:00:00
abstract：:Advances in single-photon sources (SPSs) and single-photon detectors (SPDs) promise unique applications in the field of quantum information technology. In this paper, we report long-distance quantum key distribution (QKD) by using state-of-the-art devices: a quantum-dot SPS (QD SPS) emitting a photon in the telecom ba...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14383
更新日期：2015-09-25 00:00:00
abstract：:Despite increasing work detailing the presence of foraging specializations across a range of taxa, limited attention so far has been given to the role of spatiotemporal variation in food predictability in shaping individual resource selection. Here, we studied the exploitation of human-provided carrion resources diffe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33564-y
更新日期：2018-10-11 00:00:00
abstract：:Identifying early life-stage transitions limiting seagrass recruitment could improve our ability to target demographic processes most responsive to management. Here we determine the magnitude of life-stage transitions along gradients in physical disturbance limiting seedling establishment for the marine angiosperm, Po...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13833-y
更新日期：2017-11-01 00:00:00
abstract：:Although blood-based liquid biopsies have emerged as a promising non-invasive method to detect biomarkers in various cancers, limited progress has been made for brain tumors. One major obstacle is the blood-brain barrier (BBB), which hinders efficient passage of tumor biomarkers into the peripheral circulation. The ob...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24516-7
更新日期：2018-04-26 00:00:00
abstract：:Exotic pattern formation as a result of drying of an aqueous solution containing DNA and silica nanoparticles is reported. The pattern due to segregation was found to critically depend on the relative ratio of nanoparticles and DNA, as revealed by polarization microscopy, scanning electron microscopy, and fluorescence...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03660
更新日期：2014-01-13 00:00:00
abstract：:Pyriform sinus fistula (PSF) is a rare congenital entity. We hypothesized that clinical features, diagnosis and treatment may differ between newborns and children. 190 patients diagnosed with PSF were divided into two groups: neonatal (n = 15) and childhood (n = 175). The medical records including demographic and clin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55050-9
更新日期：2019-12-06 00:00:00
abstract：:The Longwangzhuang pluton is a typical example of Paleoproterozoic A-type granite intrusions at the southern margin of the North China Craton. This pluton is composed of arfvedsonite granite and minor aegirine-augite granites. Samples from both granite types display similar zircon U-Pb ages with 207U-206Pb ages of 161...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56820-1
更新日期：2020-01-09 00:00:00
abstract：:Incomplete or partial observations of network structures pose a serious challenge to theoretical and engineering studies of real networks. To remedy the missing links in real datasets, topology-based link prediction is introduced into the studies of various networks. Due to the complexity of network structures, the ac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31254-3
更新日期：2018-09-06 00:00:00
abstract：:Rheumatoid arthritis (RA) is an autoimmune disease characterized by progressive immune-mediated joint deterioration. Current treatments are not antigen specific and are associated with various adverse. We have previously demonstrated that tolerogenic dendritic cells (Tol-DC) are potent antigen-specific immune regulato...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43188
更新日期：2017-02-23 00:00:00
abstract：:Circular RNAs (circRNAs) are a group of single-stranded RNAs in closed circular form. They are splicing-generated, widely expressed in various tissues and have functional implications in development and diseases. To facilitate genome-wide characterization of circRNAs using RNA-Seq data, we present a freely available s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38820
更新日期：2016-12-08 00:00:00
abstract：:We assessed the association between depression status and prevalent and incident type 2 diabetes (T2D) as well as the interaction between depression and a genetic risk score (GS) based on 20 T2D single-nucleotide polymorphisms (SNPs) in a multi-ethnic longitudinal study. We studied 17,375 participants at risk for dysg...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01406-y
更新日期：2017-05-09 00:00:00
abstract：:We are reporting a 3D printable composite paste having strong thixotropic rheology. The composite has been designed and investigated with highly conductive silver nanowires. The optimized electrical percolation threshold from both simulation and experiment is shown from 0.7 vol. % of silver nanowires which is signific...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03365-w
更新日期：2017-06-12 00:00:00
