Abstract:
:The attenuated Sabin strains contained in the oral poliomyelitis vaccine are genetically unstable, and their circulation in poorly immunized populations can lead to the emergence of pathogenic circulating vaccine-derived polioviruses (cVDPVs). The recombinant nature of most cVDPV genomes and the preferential presence of genomic sequences from certain cocirculating non-polio enteroviruses of species C (EV-Cs) raise questions about the permissiveness of genetic exchanges between EV-Cs and the phenotypic impact of such exchanges. We investigated whether functional constraints limited genetic exchanges between Sabin strains and other EV-Cs. We bypassed the natural recombination events by constructing 29 genomes containing a Sabin 2 capsid-encoding sequence and other sequences from Sabin 2 or from non-polio EV-Cs. Most genomes were functional. All recombinant viruses replicated similarly in vitro, but recombination modulated plaque size and temperature sensitivity. All viruses with a 5'UTR from Sabin 2 were attenuated in mice, whereas almost all viruses with a non-polio 5'UTR caused disease. These data highlight the striking conservation of functional compatibility between different genetic domains of cocirculating EV-Cs. This aspect is only one of the requirements for the generation of recombinant cVDPVs in natural conditions, but it may facilitate the generation of viable intertypic recombinants with diverse phenotypic features, including pathogenicity.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Bessaud M,Joffret ML,Blondel B,Delpeyroux Fdoi
10.1038/srep38831subject
Has Abstractpub_date
2016-12-13 00:00:00pages
38831issn
2045-2322pii
srep38831journal_volume
6pub_type
杂志文章abstract::Conserving crop wild relatives (CWR) is critical for maintaining food security. However, CWR-focused conservation plans are lacking, and are often based on the entire genus, even though only a few taxa are useful for crop improvement. We used taxonomic and geographic prioritisation to identify the best locations for i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05247
更新日期:2014-06-17 00:00:00
abstract::To investigate wavefront aberrations in the entire eye and in the internal optics (lens) and retinal image qualities according to different lenticular opacity types and densities. Forty-one eyes with nuclear cataract, 33 eyes with cortical cataract, and 29 eyes with posterior subcapsular cataract were examined. In eac...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-017-15245-4
更新日期:2017-11-10 00:00:00
abstract::The transglutaminase (TG) family comprises eight isozymes that form the isopeptide bonds between glutamine and lysine residues and contribute to the fibrotic diseases via crosslinking-mediated stabilization of ECM and the activation of TGF-β in several tissues. However, despite a growing body of evidence implicating T...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45049
更新日期:2017-03-22 00:00:00
abstract::The topical application of lactic acid bacteria (LAB) is recognized as a useful approach to improve skin health. This work aims to characterize by a multidisciplinary approach, the wound healing, anti-inflammatory, anti-pathogens and proteomic effects of six LAB lysates, belonging to the genus Lactobacillus. Our resul...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68483-4
更新日期:2020-07-14 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-44437-3
更新日期:2019-06-05 00:00:00
abstract::Bats are the only mammals capable of true, powered flight, which drives an extremely high metabolic rate. The "Free Radical Theory of Ageing" (FTRA) posits that a high metabolic rate causes mitochondrial heteroplasmy and the progressive ageing phenotype. Contrary to this, bats are the longest-lived order of mammals gi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31093-2
更新日期:2018-09-11 00:00:00
abstract::Lath martensite is the dominant microstructural feature in quenched low-carbon Fe-C alloys. Its formation mechanism is not clear, despite extensive research. The microstructure of an Fe-0.05 C (wt.%) alloy water-quenched at various austenitizing temperatures has been investigated using transmission electron microscopy...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32679-6
更新日期:2018-09-24 00:00:00
abstract::MicroRNAs (miRNAs) are important effectors in mediating host-pathogen interaction. In this report, coelomocytes miRNA libraries of three Japanese sea cucumbers Apostichopus japonicus were built by Illumina(®) Hiseq2000 from different time points after lipopolysaccharide challenge (at time 0 h, 6 h and 12 h). The clean...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17763
更新日期:2015-12-04 00:00:00
abstract::To manage health conditions of farmed fish and other living creatures, a simple method to measure bioelectric signals of the creatures in seawater is expected. A novel method to measure bioelectric signals by utilizing the conductivity of seawater surrounding the entire body of a fish is proposed. As for the proposed ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73485-3
更新日期:2020-10-01 00:00:00
abstract::Accumulating evidence implies that cell fusion is one of the driving forces of cancer invasion and metastasis. However, considerably less is still known about the triggering factors and underlying mechanisms associated with cancer-host cell fusion, particularly in inflammatory tumor microenvironment. In this study, we...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40983
更新日期:2017-01-23 00:00:00
abstract::Dementia is a major cause of disability and dependency among older people. If the lives of people with dementia are to be improved, research and its translation into druggable target are crucial. Ancient systems of healthcare (Ayurveda, Siddha, Unani and Sowa-Rigpa) have been used from centuries for the treatment vasc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-57199-9
更新日期:2020-01-14 00:00:00
abstract::Administration of lipopolysaccharide (LPS) by various routes produces profound inflammatory pain hypersensitivity. However, the molecular events that induce this response remain largely uncharacterized. In the present study, we sought to elucidate the role of the Rho/Rho kinase (ROCK) pathway in the release of tumor n...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14553
更新日期:2015-09-29 00:00:00
abstract::Spreading broadly refers to the notion of an entity propagating throughout a networked system via its interacting components. Evidence of its ubiquity and severity can be seen in a range of phenomena, from disease epidemics to financial systemic risk. In order to understand the dynamics of these critical phenomena, co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22770-3
更新日期:2018-03-12 00:00:00
abstract::We demonstrate the optical orbital angular momentum conservation during the transfer process from subwavelength plasmonic vortex lens (PVLs) to light and the generating process of surface plasmon polaritons (SPPs). Illuminating plasmonic vortex lenses with beams carrying optical orbital angular momentum, the SP vortic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03191
更新日期:2013-11-12 00:00:00
abstract::Inhibition of programmed death 1 (PD-1), expressed on activated T cells, can break through immune resistance and elicit durable responses in human melanoma as well as other types of cancers. Canine oral malignant melanoma is one of the most aggressive tumors bearing poor prognosis due to its high metastatic potency. H...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75533-4
更新日期:2020-10-27 00:00:00
abstract::We study the dynamical Casimir-Polder force on a two-level atom with different initial states in the one-dimensional dielectric cavity with output coupling, and obtain the analytical expression of the expectation value of dynamical Casimir-Polder force. Results show that the expectation values of dynamical Casimir-Pol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68546-6
更新日期:2020-07-20 00:00:00
abstract::Rice bacterial blight caused by Xanthomonas oryzae pv. oryzae (Xoo) is a major rice disease. In Taiwan, the tropical indica type of Oryza sativa originally grown in this area is mix-cultivated with the temperate japonica type of O. sativa, and this might have led to adaptive changes of both rice host and Xoo isolates....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36575-x
更新日期:2019-01-22 00:00:00
abstract::The purpose of this paper is to develop a lightweight apron that will be used for shielding low intensity radiation in medical imaging radiography room and to apply it to a custom-made effective shielding. The quality of existing aprons made for protecting our bodies from direct radiation are improved so that they are...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27721
更新日期:2016-07-27 00:00:00
abstract::Linearly polarized microwave radiation is shown to have its plane of polarization converted to the orthogonal state upon reflection from an ultrathin (λ/25) cavity array. The structure benefits from an uncomplicated design consisting of a metallic grating closely separated from a ground plane by a dielectric spacer. A...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09366
更新日期:2015-03-23 00:00:00
abstract::In this study, we aimed to disclose the association of pre- and post-stroke glycemic status with clinical outcome in patients with spontaneous intracerebral hemorrhage (sICH). It was a multicenter, prospective, observational cohort study, conducted in 13 hospitals in Beijing from January 2014 to September 2016. The as...
journal_title:Scientific reports
pub_type: 杂志文章,多中心研究
doi:10.1038/s41598-019-55610-z
更新日期:2019-12-13 00:00:00
abstract::We demonstrated tailored plasmon-induced transparency (PIT) in a metal (Au)-insulator (SiO2)-metal (Ag) (MIM) structure, where the Fano interference between the MIM waveguide mode and the surface plasmon polariton (SPP) resonance mode induced a transparency window in an otherwise opaque wavenumber (k) region. A series...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-17847-4
更新日期:2017-12-19 00:00:00
abstract::The biological function of multiple repetitions of single amino acids, or homo-repeats, is largely unknown, but their occurrence in proteins has been associated with more than 20 hereditary diseases. Analysing 122 bacterial and eukaryotic genomes, we observed that the number of proteins containing homo-repeats is sign...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26941
更新日期:2016-06-03 00:00:00
abstract::A wet-chemical method combined with spark plasma sintering was used to prepare a W-Y2O3 alloy. High-temperature tensile tests and nano-indentation microhardness tests were used to characterize the mechanical properties of the alloy. After He-ion irradiation, fuzz and He bubbles were observed on the irradiated surface....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep12755
更新日期:2015-07-31 00:00:00
abstract::Many plant essential oils and their terpenoid constituents possess bioactivities including insecticidal activity, and they sometimes act synergistically when mixed. Although several hypotheses for this have been proposed, the underlying mechanism has not been fully elucidated thus far. In the present study, we report ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42432
更新日期:2017-02-09 00:00:00
abstract::Aspergillus flavus is a pathogenic fungus infecting maize and producing aflatoxins that are health hazards to humans and animals. Characterizing host defense mechanism and prioritizing candidate resistance genes are important to the development of resistant maize germplasm. We investigated methods amenable for the ana...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04815
更新日期:2014-04-28 00:00:00
abstract::The knowledge of diffusion processes in semiconducting alloys is very important both technologically and from a theoretical point of view. Here we show that, self-diffusion in Si1-x Ge x alloys as a function of temperature and Ge concentration can be described by the cBΩ thermodynamic model. This model connects the ac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01301-6
更新日期:2017-05-02 00:00:00
abstract::This study investigates magnetic ordering temperature in nano- and mesoscale structural features in an iron arsenide. Although magnetic ground states in quantum materials can be theoretically predicted from known crystal structures and chemical compositions, the ordering temperature is harder to pinpoint due to potent...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56301-5
更新日期:2019-12-27 00:00:00
abstract::Nucleotide excision repair (NER) excises bulky DNA lesions induced by mutagens and carcinogens. The repair process includes recognition of DNA damage, excision of a short patch of nucleotides containing the damaged base, re-synthesis of a new DNA strand and ligation of the nicks to restore the sequence integrity. Muta...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04894
更新日期:2014-05-08 00:00:00
abstract::It has been suggested that an age-related loss of cognitive function might be driven by atherosclerotic effects associated with altered lipid patterns. However, the relationship between Lipoprotein (a) [Lp(a)] and healthy cognitive aging has not yet been sufficiently investigated. For the current analysis we used the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66783-3
更新日期:2020-06-30 00:00:00
abstract::Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosphoribosyltransferase domain containing 1 (NAPRT1) are the main human NAD salvage enzymes. NAD regulates energy metabolism and cell signaling, and the enzymes that control NAD availability are linked to pathologies such as cancer and neurodegeneration. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06311
更新日期:2014-09-09 00:00:00