Up-regulation of syncytin-1 contributes to TNF-α-enhanced fusion between OSCC and HUVECs partly via Wnt/β-catenin-dependent pathway.

abstract：:Limbal stem cell deficiency can be treated with transplantation of cultured human limbal epithelial cells (LEC). It can be advantageous to produce LEC in centralized labs and thereafter ship them to eye clinics. The present study used transport simulations of LEC to determine if vigorous shaking during transport alter...

journal_title：Scientific reports

authors： Utheim OA,Lyberg T,Eidet JR,Raeder S,Sehic A,Roald B,Messelt E,de la Paz MF,Dartt DA,Utheim TP

更新日期：2018-07-12 00:00:00

abstract：:Cells regulate their intracellular mRNA levels by using specific ribonucleases. Oligoribonuclease (ORN) is a 3'-5' exoribonuclease for small RNA molecules, important in RNA degradation and re-utilisation. However, there is no structural information on the ligand-binding form of ORNs. In this study, the crystal structu...

journal_title：Scientific reports

authors： Lee CW,Park SH,Jeong CS,Cha SS,Park H,Lee JH

更新日期：2019-02-25 00:00:00

abstract：:We investigated a high-quality MgB2 thin film with a thickness of ~1000 nm on an Al2O3 substrate using optical spectroscopy. We measured the reflectance spectra of the film at various temperatures both below, and above, the superconducting transition temperature, T c   [Formula: see text] 40 K. An earlier study showed...

journal_title：Scientific reports

authors： Seo YS,Lee JH,Kang WN,Hwang J

更新日期：2017-08-21 00:00:00

abstract：:Limited continuous replenishment of the mineralization medium is a restriction for in-situ solution-based remineralization of hypomineralized body tissues. Here, we report a process that generated amine-functionalized mesoporous silica nanoparticles for sustained release of biomimetic analog-stabilized amorphous calci...

journal_title：Scientific reports

authors： Zhang W,Luo XJ,Niu LN,Yang HY,Yiu CK,Wang TD,Zhou LQ,Mao J,Huang C,Pashley DH,Tay FR

更新日期：2015-06-08 00:00:00

abstract：:We have previously shown that OX40L/OX40 interaction is critical for TCR-independent selective proliferation of Foxp3+ Tregs, but not Foxp3- effector T-cells (Teff), when CD4+ T-cells are co-cultured with GM-CSF derived bone marrow dendritic cells (G-BMDCs). Events downstream of OX40L/OX40 interaction in Tregs respons...

journal_title：Scientific reports

authors： Alharshawi K,Marinelarena A,Kumar P,El-Sayed O,Bhattacharya P,Sun Z,Epstein AL,Maker AV,Prabhakar BS

更新日期：2017-07-26 00:00:00

abstract：:Sheepgrass (Leymus chinensis) is one of the dominant grass species present on typical steppes of the Inner Mongolia Plateau. However, L. chinensis has developed a dwarfing phenotype in response to the stressful habitat in grasslands that are severely degraded due to heavy grazing. The lack of transcriptomic and genomi...

journal_title：Scientific reports

authors： Ren W,Hou X,Wu Z,Kong L,Guo H,Hu N,Wan D,Zhang J

更新日期：2018-12-17 00:00:00

abstract：:The Next-Generation Sequencing (NGS) platforms provide a major approach to obtaining millions of short reads from samples. NGS has been used in a wide range of analyses, such as for determining genome sequences, analyzing evolutionary processes, identifying gene expression and resolving metagenomic analyses. Usually, ...

journal_title：Scientific reports

authors： Gaia ASC,de Sá PHCG,de Oliveira MS,Veras AAO

更新日期：2019-08-12 00:00:00

abstract：:A relevant part of embolic strokes of undetermined source (ESUS) is assumed to be cardiogenic. As shown previously, certain biomarkers of endothelial pathology are related to atrial fibrillation (AF). In this long-term follow-up study, we aimed to investigate whether these biomarkers are associated with subsequently d...

journal_title：Scientific reports

authors： Ziegler NL,Sieweke JT,Biber S,Gabriel MM,Schuppner R,Worthmann H,Martens-Lobenhoffer J,Lichtinghagen R,Bode-Böger SM,Bavendiek U,Weissenborn K,Grosse GM

更新日期：2019-12-19 00:00:00

abstract：:Lin28 is an evolutionary conserved RNA-binding protein that plays important roles during embryonic development and tumorigenesis. It regulates gene expression through two different post-transcriptional mechanisms. The first one is based on the regulation of miRNA biogenesis, in particular that of the let-7 family, who...

journal_title：Scientific reports

authors： Parisi S,Castaldo D,Piscitelli S,D'Ambrosio C,Divisato G,Passaro F,Avolio R,Castellucci A,Gianfico P,Masullo M,Scaloni A,Russo T

更新日期：2021-01-27 00:00:00

abstract：:The two most important and studied phytocannabinoids present in Cannabis sativa L. are undoubtedly cannabidiol (CBD), a non-psychotropic compound, but with other pharmacological properties, and Δ9-tetrahydrocannabinol (Δ9-THC), which instead possesses psychotropic activity and is responsible for the recreative use of ...

journal_title：Scientific reports

authors： Linciano P,Citti C,Russo F,Tolomeo F,Laganà A,Capriotti AL,Luongo L,Iannotta M,Belardo C,Maione S,Forni F,Vandelli MA,Gigli G,Cannazza G

更新日期：2020-12-16 00:00:00

abstract：:We previously identified Drosophila REPTOR and REPTOR-BP as transcription factors downstream of mTORC1 that play an important role in regulating organismal metabolism. We study here the mammalian ortholog of REPTOR-BP, Crebl2. We find that Crebl2 mediates part of the transcriptional induction caused by mTORC1 inhibiti...

journal_title：Scientific reports

authors： Tiebe M,Lutz M,Senyilmaz Tiebe D,Teleman AA

更新日期：2019-12-27 00:00:00

abstract：:Advances in genomics have the potential to revolutionize clinical diagnostics. Here, we examine the microbiome of vitreous (intraocular body fluid) from patients who developed endophthalmitis following cataract surgery or intravitreal injection. Endophthalmitis is an inflammation of the intraocular cavity and can lead...

journal_title：Scientific reports

authors： Kirstahler P,Bjerrum SS,Friis-Møller A,la Cour M,Aarestrup FM,Westh H,Pamp SJ

更新日期：2018-03-07 00:00:00

abstract：:Four plant tumorigenic strains 932, 1019, 1078T and 1081 isolated from cane gall tumors on thornless blackberry (Rubus sp.) were characterized. They shared low sequence identity with related Rhizobium spp. based on comparisons of 16S rRNA gene (≤98%) and housekeeping genes atpD, recA and rpoB (<90%). Phylogenetic anal...

journal_title：Scientific reports

authors： Kuzmanović N,Smalla K,Gronow S,Puławska J

更新日期：2018-06-13 00:00:00

abstract：:Hollow fiber composite NF membranes with improved anti-fouling property and water flux were prepared via interfacial polymerizationand layer-by-layer method using polyethylenimine (PEI), isophthaloyl dichloride (IPC), and β-cyclodextrin (β-CD). The chemical structures and the morphologies of the resultant NF membranes...

journal_title：Scientific reports

authors： He Y,Miao J,Jiang Z,Tu K,Yang H,Chen S,Zhang L,Zhang R

更新日期：2019-08-27 00:00:00

abstract：:Over the last decades, great strides were made in the development of novel implants for the treatment of bone defects. The increasing versatility and complexity of these implant designs request for concurrent advances in means to assess in vivo the course of induced bone formation in preclinical models. Since its disc...

journal_title：Scientific reports

authors： Lienemann PS,Metzger S,Kiveliö AS,Blanc A,Papageorgiou P,Astolfo A,Pinzer BR,Cinelli P,Weber FE,Schibli R,Béhé M,Ehrbar M

更新日期：2015-05-19 00:00:00

abstract：:Dengue virus (DENV) causes a wide range of illnesses in humans, including dengue fever and dengue haemorrhagic fever. Current animal models of DENV infection are limited for understanding infectious diseases in humans. Bonnet monkeys (Macaca radiata), a type of Old World monkey, have been used to study experimental an...

journal_title：Scientific reports

authors： Kato F,Ishida Y,Kawakami A,Takasaki T,Saijo M,Miura T,Hishiki T

更新日期：2018-02-21 00:00:00

abstract：:The search for efficient chemotherapy drugs and other anti-cancer treatments would benefit from a deeper understanding of the tumor microenvironment (TME) and its role in tumor progression. Because in vivo experimental methods are unable to isolate or control individual factors of the TME and in vitro models often do ...

journal_title：Scientific reports

authors： Nikmaneshi MR,Firoozabadi B,Mozafari A,Munn LL

更新日期：2020-02-20 00:00:00

abstract：:Lower cervical dislocation with facet interlocking is one of the most drastic injuries to the cervical spine. The early reduction is thought critical in preventing progressive secondary spinal cord injury. The authors report a new surgical procedure in the management of lower cervical dislocation with facet interlocki...

journal_title：Scientific reports

authors： Li Y,Zhou P,Cui W,Li C,Xiao W,Wen Y,Wang H,Wang H

更新日期：2019-02-04 00:00:00

abstract：:Agriculture resulted in extensive population growths and human activities. However, whether major human expansions started after Neolithic Time still remained controversial. With the benefit of 1000 Genome Project, we were able to analyze a total of 910 samples from 11 populations in Africa, Europe and Americas. From ...

journal_title：Scientific reports

authors： Zheng HX,Yan S,Qin ZD,Jin L

更新日期：2012-01-01 00:00:00

abstract：:Human lactoferrin (hLF) is a valuable protein for pharmaceutical products and functional foods, and worldwide demand for this protein has steadily increased. However, large-scale recombinant human lactoferrin (rhLF) production using current animal bioreactor techniques is limited by the low expression of foreign prote...

journal_title：Scientific reports

authors： Wang M,Sun Z,Yu T,Ding F,Li L,Wang X,Fu M,Wang H,Huang J,Li N,Dai Y

更新日期：2017-09-06 00:00:00

abstract：:Although the perception of faces depends on low-level neuronal processes, it is also affected by high-level social processes. Faces from a social in-group, such as people of a similar age, receive more in-depth processing and are processed holistically. To explore whether own-age biases affect subconscious face percep...

journal_title：Scientific reports

authors： Nicholls MER,Churches O,Loetscher T

更新日期：2018-08-23 00:00:00

abstract：:Studies of the molecular mechanisms involved in the formation of the albino leaf cells are important for understanding the development of chimera leaves in Ananas comosus var. bracteatus. In this study, we identified a total of 163 novel miRNAs involved in the development of complete white (CWh) and complete green (CG...

journal_title：Scientific reports

authors： Xiong YY,Ma J,He YH,Lin Z,Li X,Yu SM,Li RX,Jiang FX,Li X,Huang Z,Sun LX

更新日期：2018-01-31 00:00:00

abstract：:Muscle specific receptor tyrosine kinase (MuSK) is an essential postsynaptic transmembrane molecule that mediates clustering of acetylcholine receptors (AChR). MUSK exon 10 is alternatively skipped in human, but not in mouse. Skipping of this exon disrupts a cysteine-rich region (Fz-CRD), which is essential for Wnt-me...

journal_title：Scientific reports

authors： Nasrin F,Rahman MA,Masuda A,Ohe K,Takeda J,Ohno K

更新日期：2014-10-30 00:00:00

abstract：:Psoriasis is a chronic, relapsing inflammatory skin disease. The pathogenesis of psoriasis is complex and has not been fully understood. C10orf99 was a recently identified human antimicrobial peptide whose mRNA expression is elevated in psoriatic human skin samples. In this study, we investigated the functional roles ...

journal_title：Scientific reports

authors： Chen C,Wu N,Duan Q,Yang H,Wang X,Yang P,Zhang M,Liu J,Liu Z,Shao Y,Zheng Y

更新日期：2018-06-05 00:00:00

abstract：:Atmospheric nitrated polycyclic aromatic hydrocarbons (NPAHs), which have been shown to have adverse health effects such as carcinogenicity, are formed in part through nitration reactions of their parent polycyclic aromatic hydrocarbons (PAHs) in the atmosphere. However, little is known about heterogeneous nitration r...

journal_title：Scientific reports

authors： Kameda T,Azumi E,Fukushima A,Tang N,Matsuki A,Kamiya Y,Toriba A,Hayakawa K

更新日期：2016-04-14 00:00:00

abstract：:The factors regulating phytoplankton community composition play a crucial role in structuring aquatic food webs. However, consensus is still lacking about the mechanisms underlying the observed biogeographical differences in cell size composition of phytoplankton communities. Here we use a trait-based model to disenta...

journal_title：Scientific reports

authors： Acevedo-Trejos E,Brandt G,Bruggeman J,Merico A

更新日期：2015-03-09 00:00:00

abstract：:A clinical study was designed to record a wide range of physiological values from patients undergoing haemodialysis treatment in the Renal Unit of the Churchill Hospital in Oxford. Video was recorded for a total of 84 dialysis sessions from 40 patients during the course of 1 year, comprising an overall video recording...

journal_title：Scientific reports

authors： Villarroel M,Jorge J,Meredith D,Sutherland S,Pugh C,Tarassenko L

更新日期：2020-10-28 00:00:00

abstract：:The accumulation of repetitive DNA sequences on the sex-limited W or Y chromosomes is a well-known process that is likely triggered by the suppression of recombination between the sex chromosomes, which leads to major differences in their sizes and genetic content. Here, we report an analysis conducted on the satellit...

journal_title：Scientific reports

authors： Utsunomia R,Silva DMZA,Ruiz-Ruano FJ,Goes CAG,Melo S,Ramos LP,Oliveira C,Porto-Foresti F,Foresti F,Hashimoto DT

更新日期：2019-04-10 00:00:00

abstract：:Few studies have examined the potential transcription factor (TF) simultaneously associated with cisplatin resistance and metastasis in ovarian cancer. To assess a related mechanism, a 345-channel protein/DNA array and transcriptional activity ELISA were performed to compare the TF activities in the cisplatin-sensitiv...

journal_title：Scientific reports

authors： Sun P,Song Y,Liu D,Liu G,Mao X,Dong B,Braicu EI,Sehouli J

更新日期：2018-09-07 00:00:00

abstract：:Silicon has emerged as the most promising high-capacity material for lithium-ion batteries. Waste glass can be a potential low cost and environmentally benign silica resource enabling production of nanosized silicon at the industry level. Windshields are generally made of laminated glass comprising two separate glass ...

journal_title：Scientific reports

authors： Choi M,Kim JC,Kim DW

更新日期：2018-01-17 00:00:00