当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Exploring the wound healing, anti-inflammatory, anti-pathogenic and proteomic effects of lactic acid bacteria on keratinocytes.

Exploring the wound healing, anti-inflammatory, anti-pathogenic and proteomic effects of lactic acid bacteria on keratinocytes.

Abstract：

:The topical application of lactic acid bacteria (LAB) is recognized as a useful approach to improve skin health. This work aims to characterize by a multidisciplinary approach, the wound healing, anti-inflammatory, anti-pathogens and proteomic effects of six LAB lysates, belonging to the genus Lactobacillus. Our results demonstrated that the lysates of tested LAB stimulated the proliferation of keratinocytes, and that L. plantarum SGL 07 and L. salivarius SGL 19 accelerated the re-epithelization by inducing keratinocyte migration. The bacterial lysates also reduced the secretion of specific pro-inflammatory mediators from keratinocytes. Furthermore, viable L. salivarius SGL 19 and L. fermentum SGL 10 had anti-pathogenic effects against S. aureus and S. pyogenes, while L. brevis SGL 12 and L. paracasei SGL 04 inhibited S. aureus and S. pyogenes, respectively. The tested lactobacilli lysates also induced specific proteome modulation of the exposed keratinocytes, involving dysregulation of proteins (such as interleukin enhancer-binding factor 2 and ATP-dependent RNA helicase) and pathways (such as cytokine, NF-kB, Hedgehog, and RUNX signaling) associated with their specific wound healing and anti-inflammatory effects. This study indicates the different potential of selected lactobacilli, suggesting that they may be successfully used in the future together with conventional therapies to bring relief from skin disorders.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Brandi J,Cheri S,Manfredi M,Di Carlo C,Vita Vanella V,Federici F,Bombiero E,Bazaj A,Rizzi E,Manna L,Cornaglia G,Marini U,Valenti MT,Marengo E,Cecconi D

doi

10.1038/s41598-020-68483-4

subject

Has Abstract

pub_date

2020-07-14 00:00:00

pages

11572

issue

1

issn

2045-2322

pii

10.1038/s41598-020-68483-4

journal_volume

10

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • FGF23/FGFR4-mediated left ventricular hypertrophy is reversible.

    abstract：:Fibroblast growth factor (FGF) 23 is a phosphaturic hormone that directly targets cardiac myocytes via FGF receptor (FGFR) 4 thereby inducing hypertrophic myocyte growth and the development of left ventricular hypertrophy (LVH) in rodents. Serum FGF23 levels are highly elevated in patients with chronic kidney disease ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-02068-6

    authors： Grabner A,Schramm K,Silswal N,Hendrix M,Yanucil C,Czaya B,Singh S,Wolf M,Hermann S,Stypmann J,Di Marco GS,Brand M,Wacker MJ,Faul C

    更新日期：2017-05-16 00:00:00

  • Lattice topology dictates photon statistics.

    abstract：:Propagation of coherent light through a disordered network is accompanied by randomization and possible conversion into thermal light. Here, we show that network topology plays a decisive role in determining the statistics of the emerging field if the underlying lattice is endowed with chiral symmetry. In such lattice...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-09236-8

    authors： Kondakci HE,Abouraddy AF,Saleh BEA

    更新日期：2017-08-21 00:00:00

  • Sentinel nurseries to assess the phytosanitary risks from insect pests on importations of live plants.

    abstract：:Ornamental plants represent a major pathway of invasion for alien pests worldwide. Commodity risk analyses are carried out to assess the risk posed by a new trade in a commodity, but they are restricted by our limited knowledge of the pests carried by traded plants. We used the sentinel nursery technique to identify i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-29551-y

    authors： Kenis M,Li H,Fan JT,Courtial B,Auger-Rozenberg MA,Yart A,Eschen R,Roques A

    更新日期：2018-07-25 00:00:00

  • Chemerin regulates β-cell function in mice.

    abstract：:Although various function of chemerin have been suggested, its physiological role remains to be elucidated. Here we show that chemerin-deficient mice are glucose intolerant irrespective of exhibiting reduced macrophage accumulation in adipose tissue. The glucose intolerance was mainly due to increased hepatic glucose ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep00123

    authors： Takahashi M,Okimura Y,Iguchi G,Nishizawa H,Yamamoto M,Suda K,Kitazawa R,Fujimoto W,Takahashi K,Zolotaryov FN,Hong KS,Kiyonari H,Abe T,Kaji H,Kitazawa S,Kasuga M,Chihara K,Takahashi Y

    更新日期：2011-01-01 00:00:00

  • Crystalline Soda Can Metamaterial exhibiting Graphene-like Dispersion at subwavelength scale.

    abstract：:Graphene, a honeycomb lattice of carbon atoms ruled by tight-binding interaction, exhibits extraordinary electronic properties due to the presence of Dirac cones within its band structure. These intriguing singularities have naturally motivated the discovery of their classical analogues. In this work, we present a gen...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-15335-3

    authors： Yves S,Lemoult F,Fink M,Lerosey G

    更新日期：2017-11-10 00:00:00

  • Persistence of a stage-structured food-web.

    abstract：:Contrary to a theoretical prediction, natural communities comprise many interacting species, thereby developing complex ecosystems. Earlier theoretical studies assumed that each component species within an ecological network has a simple life history, despite the fact that the interaction partners of many species, suc...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-11686-z

    authors： Mougi A

    更新日期：2017-09-08 00:00:00

  • A potential adjuvant chemotherapeutics, 18β-glycyrrhetinic acid, inhibits renal tubular epithelial cells apoptosis via enhancing BMP-7 epigenetically through targeting HDAC2.

    abstract：:Cisplatin, a highly effective and widely used chemotherapeutic agent, has a major limitation for its nephrotoxicity. We recently identified a novel strategy for attenuating its nephrotoxicity in chemotherapy by an effective adjuvant via epigenetic modification through targeting HDAC2. Molecular docking and SPR assay f...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep25396

    authors： Ma T,Huang C,Meng X,Li X,Zhang Y,Ji S,Li J,Ye M,Liang H

    更新日期：2016-05-05 00:00:00

  • Intravenous immunoglobulins may prevent prednisone-exacerbation in myasthenia gravis.

    abstract：:Corticosteroids may produce a paradoxical worsening of myasthenia gravis (MG) symptoms within the first weeks of treatment. We therefore wanted to assess the hypothesis that a prior infusion of intravenous immunoglobulin (IVIG) may have a protective effect. Our primary objectives were to show that the coadministration...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/s41598-020-70539-4

    authors： Díez-Porras L,Homedes C,Alberti MA,Vélez-Santamaría V,Casasnovas C

    更新日期：2020-08-11 00:00:00

  • Probing rapid carbon fixation in fast-growing seaweed Ulva meridionalis using stable isotope 13C-labelling.

    abstract：:The high growth rate of Ulva seaweeds makes it a potential algal biomass resource. In particular, Ulva meridionalis grows up to fourfold a day. Here, we demonstrated strong carbon fixation by U. meridionalis using 13C stable isotope labelling and traced the 13C flux through sugar metabolites with isotope-ratio mass sp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-77237-1

    authors： Tsubaki S,Nishimura H,Imai T,Onda A,Hiraoka M

    更新日期：2020-11-23 00:00:00

  • Selection of suitable reference genes for quantitative real-time PCR gene expression analysis in Salix matsudana under different abiotic stresses.

    abstract：:Salix matsudana is a deciduous, rapidly growing willow species commonly cultivated in China, which can tolerate drought, salt, and heavy metal stress conditions. Selection of suitable reference genes for quantitative real-time PCR is important for normalizing the expression of the key genes associated with various str...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep40290

    authors： Zhang Y,Han X,Chen S,Zheng L,He X,Liu M,Qiao G,Wang Y,Zhuo R

    更新日期：2017-01-25 00:00:00

  • Publisher Correction: A Computational Method to Quantify the Effects of Slipped Strand Mispairing on Bacterial Tetranucleotide Repeats.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-58622-2

    authors： Harhay GP,Harhay DM,Bono JL,Capik SF,DeDonder KD,Apley MD,Lubbers BV,White BJ,Larson RL,Smith TPL

    更新日期：2020-01-28 00:00:00

  • Meta-analysis of the prevalence of anxiety disorders in mainland China from 2000 to 2015.

    abstract：:Although anxiety disorders (ADs) have been recognized as one of the most prevalent mental disorders in mainland China, the prevalence of ADs has not been reported until now. The lack of a consolidated and comparable review on the prevalence of ADs in mainland China necessitated this meta-analysis to measure the preval...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析

    doi：10.1038/srep28033

    authors： Guo X,Meng Z,Huang G,Fan J,Zhou W,Ling W,Jiang J,Long J,Su L

    更新日期：2016-06-16 00:00:00

  • 3D Printed Auxetic Mechanical Metamaterial with Chiral Cells and Re-entrant Cores.

    abstract：:By combining the two basic deformation mechanisms for auxetic open-cell metamaterials, re-entrant angle and chirality, new hybrid chiral mechanical metamaterials are designed and fabricated via a multi-material 3D printer. Results from mechanical experiments on the 3D printed prototypes and systematic Finite Element (...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-20795-2

    authors： Jiang Y,Li Y

    更新日期：2018-02-05 00:00:00

  • Efficient Blood-Brain Barrier Opening in Primates with Neuronavigation-Guided Ultrasound and Real-Time Acoustic Mapping.

    abstract：:Brain diseases including neurological disorders and tumors remain under treated due to the challenge to access the brain, and blood-brain barrier (BBB) restricting drug delivery which, also profoundly limits the development of pharmacological treatment. Focused ultrasound (FUS) with microbubbles is the sole method to ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-25904-9

    authors： Wu SY,Aurup C,Sanchez CS,Grondin J,Zheng W,Kamimura H,Ferrera VP,Konofagou EE

    更新日期：2018-05-22 00:00:00

  • Compact Shielding of Graphene Monolayer Leads to Extraordinary SERS-Active Substrate with Large-Area Uniformity and Long-Term Stability.

    abstract：:Surface-enhanced Raman scattering (SERS) can significantly boost the inherently weak Raman scattering signal and provide detailed structural information and binding nature of the molecules on the surface. Despite the long history of this technology, SERS has yet to become a sophisticated analytical tool in practical a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep17167

    authors： Liu X,Wang J,Wu Y,Fan T,Xu Y,Tang L,Ying Y

    更新日期：2015-11-30 00:00:00

  • Short-term Dynamics after Single- and Three-piece Acrylic Intraocular Lens Implantation: A Swept-source Anterior Segment Optical Coherence Tomography Study.

    abstract：:Accurate alignment of an intraocular lens (IOL) is indispensable for achieving accurate postoperative refractive outcomes. Thus, we evaluated decentration and tilt of single- and three-piece IOLs, as well as anterior chamber depth (ACD), at 3 hours, 24 hours, 2 weeks, and 4 weeks after cataract surgery, using swept-so...

    journal_title：Scientific reports

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/s41598-018-28609-1

    authors： Sato T,Shibata S,Yoshida M,Hayashi K

    更新日期：2018-07-06 00:00:00

  • Endothelial Antioxidant-1: a Key Mediator of Copper-dependent Wound Healing in vivo.

    abstract：:Copper (Cu), an essential nutrient, promotes wound healing, however, target of Cu action and underlying mechanisms remain elusive. Cu chaperone Antioxidant-1 (Atox1) in the cytosol supplies Cu to the secretory enzymes such as lysyl oxidase (LOX), while Atox1 in the nucleus functions as a Cu-dependent transcription fac...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep33783

    authors： Das A,Sudhahar V,Chen GF,Kim HW,Youn SW,Finney L,Vogt S,Yang J,Kweon J,Surenkhuu B,Ushio-Fukai M,Fukai T

    更新日期：2016-09-26 00:00:00

  • De Novo Transcriptome Assembly and Functional Annotation in Five Species of Bats.

    abstract：:High-throughput RNA sequencing is a powerful tool that allows us to perform gene prediction and analyze tissue-specific overexpression of genes, but also at species level comparisons can be performed, although in a more restricted manner. In the present study complete liver transcriptomes of five tropical bat species ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-42560-9

    authors： Moreno-Santillán DD,Machain-Williams C,Hernández-Montes G,Ortega J

    更新日期：2019-04-17 00:00:00

  • The Impact of COMT and Childhood Maltreatment on Suicidal Behaviour in Affective Disorders.

    abstract：:The inconsistent findings on the association between COMT (catecholamine-O-methyl-transferase) and suicidal behaviour gave reason to choose a clear phenotype description of suicidal behaviour and take childhood maltreatment as environmental factor into account. The aim of this candidate-gene-association study was to e...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-19040-z

    authors： Bernegger A,Kienesberger K,Carlberg L,Swoboda P,Ludwig B,Koller R,Inaner M,Zotter M,Kapusta N,Aigner M,Haslacher H,Kasper S,Schosser A

    更新日期：2018-01-12 00:00:00

  • Two novel fish paralogs provide insights into the Rid family of imine deaminases active in pre-empting enamine/imine metabolic damage.

    abstract：:Reactive Intermediate Deaminase (Rid) protein superfamily includes eight families among which the RidA is conserved in all domains of life. RidA proteins accelerate the deamination of the reactive 2-aminoacrylate (2AA), an enamine produced by some pyridoxal phosphate (PLP)-dependent enzymes. 2AA accumulation inhibits ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-66663-w

    authors： Digiovanni S,Visentin C,Degani G,Barbiroli A,Chiara M,Regazzoni L,Di Pisa F,Borchert AJ,Downs DM,Ricagno S,Vanoni MA,Popolo L

    更新日期：2020-06-23 00:00:00

  • A sensitive scoring system for the longitudinal clinical evaluation and prediction of lethal disease outcomes in newborn mice.

    abstract：:Neonatal animal models are increasingly employed in order to unravel age-specific disease mechanisms. Appropriate tools objectifying the clinical condition of murine neonates are lacking. In this study, we tested a scoring system specifically designed for newborn mice that relies on clinical observation and examinatio...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-42414-4

    authors： Fehlhaber B,Heinemann AS,Rübensam K,Willers M,Völlger L,Pfeifer S,von Köckritz-Blickwede M,Viemann D

    更新日期：2019-04-11 00:00:00

  • People Can Create Iconic Vocalizations to Communicate Various Meanings to Naïve Listeners.

    abstract：:The innovation of iconic gestures is essential to establishing the vocabularies of signed languages, but might iconicity also play a role in the origin of spoken words? Can people create novel vocalizations that are comprehensible to naïve listeners without prior convention? We launched a contest in which participants...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-20961-6

    authors： Perlman M,Lupyan G

    更新日期：2018-02-08 00:00:00

  • TLR4 counteracts BVRA signaling in human leukocytes via differential regulation of AMPK, mTORC1 and mTORC2.

    abstract：:TLR4 is implicated in diseases associated with chronic low-grade inflammation, yet homeostatic signaling mechanisms that prevent and/or are affected by chronic TLR4 activation are largely uncharacterized. We recently reported that LPS/TLR4 activates in human leukocytes signaling intermediates (SI), abbreviated TLR4-SI...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43347-8

    authors： Zhang Z,Amorosa LF,Petrova A,Coyle S,Macor M,Nair M,Lee LY,Haimovich B

    更新日期：2019-05-07 00:00:00

  • Author Correction: A Recombinant Newcastle Disease Virus (NDV) Expressing S Protein of Infectious Bronchitis Virus (IBV) Protects Chickens against IBV and NDV.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-57826-w

    authors： Shirvani E,Paldurai A,Manoharan VK,Varghese BP,Samal SK

    更新日期：2020-01-15 00:00:00

  • Controlled Deposition of Particles in Porous Media for Effective Aquifer Nanoremediation.

    abstract：:In this study, a model assisted strategy is developed to control the distribution of colloids in porous media in the framework of nanoremediation, an innovative environmental nanotechnology aimed at reclaiming contaminated aquifers. This approach is exemplified by the delivery of humic acid-stabilized iron oxide nanop...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-13423-y

    authors： Bianco C,Patiño Higuita JE,Tosco T,Tiraferri A,Sethi R

    更新日期：2017-10-11 00:00:00

  • Machine learning plus optical flow: a simple and sensitive method to detect cardioactive drugs.

    abstract：:Current preclinical screening methods do not adequately detect cardiotoxicity. Using human induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs), more physiologically relevant preclinical or patient-specific screening to detect potential cardiotoxic effects of drug candidates may be possible. However, one of ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep11817

    authors： Lee EK,Kurokawa YK,Tu R,George SC,Khine M

    更新日期：2015-07-03 00:00:00

  • Micronucleus frequency in buccal mucosa cells of patients with neurodegenerative diseases.

    abstract：:Neurodegenerative diseases show an increase in prevalence and incidence, with the most prominent example being Alzheimer's disease. DNA damage has been suggested to play a role in the pathogenesis, but the exact mechanisms remain elusive. We enrolled 425 participants with and without neurodegenerative diseases and ana...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-78832-y

    authors： Reimann H,Stopper H,Polak T,Lauer M,Herrmann MJ,Deckert J,Hintzsche H

    更新日期：2020-12-17 00:00:00

  • Author Correction: Preparation and antimicrobial activity of ZnO-NPs coated cotton/starch and their functionalized ZnO-Ag/cotton and Zn(II) curcumin/cotton materials.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-020-65025-w

    authors： El-Nahhal IM,Salem J,Anbar R,Kodeh FS,Elmanama A

    更新日期：2020-05-27 00:00:00

  • Dirac gap opening and Dirac-fermion-mediated magnetic coupling in antiferromagnetic Gd-doped topological insulators and their manipulation by synchrotron radiation.

    abstract：:A new kind of magnetically-doped antiferromagnetic (AFM) topological insulators (TIs) with stoichiometry Bi1.09Gd0.06Sb0.85Te3 has been studied by angle-resolved photoemission spectroscopy (ARPES), superconducting magnetometry (SQUID) and X-ray magnetic circular dichroism (XMCD) with analysis of its electronic structu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-41137-w

    authors： Shikin AM,Estyunin DA,Surnin YI,Koroleva AV,Shevchenko EV,Kokh KA,Tereshchenko OE,Kumar S,Schwier EF,Shimada K,Yoshikawa T,Saitoh Y,Takeda Y,Kimura A

    更新日期：2019-03-18 00:00:00

  • A novel motif in the proximal C-terminus of Pannexin 1 regulates cell surface localization.

    abstract：:The Pannexin 1 (Panx1) ion and metabolite channel is expressed in a wide variety of cells where it regulates a number of cell behaviours including proliferation and differentiation. Panx1 is expressed on the cell surface as well as intracellular membranes. Previous work suggests that a region within the proximal Panx1...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-46144-5

    authors： Epp AL,Ebert SN,Sanchez-Arias JC,Wicki-Stordeur LE,Boyce AKJ,Swayne LA

    更新日期：2019-07-05 00:00:00