Abstract：
:Insufficient glenoid fixation is one of the main reasons for failure in total shoulder arthroplasty. This is predominantly caused by the inert nature of the ultra-high molecular weight polyethylene (UHMWPE) used in the glenoid component of the implant, which makes it difficult to adhesively bind to bone cement or bone. Previous studies have shown that this adhesion can be ameliorated by changing the surface chemistry using plasma technology. An atmospheric pressure plasma jet is used to treat UHMWPE substrates and to modify their surface chemistry. The modifications are investigated using several surface analysis techniques. The adhesion with bone cement is assessed using pull-out tests while osteoblast adhesion and proliferation is also tested making use of several cell viability assays. Additionally, the treated samples are put in simulated body fluid and the resulting calcium phosphate (CaP) deposition is evaluated as a measure of the in vitro bioactivity of the samples. The results show that the plasma modifications result in incorporation of oxygen in the surface, which leads to a significant improved adhesion to bone cement, an enhanced osteoblast proliferation and a more pronounced CaP deposition. The plasma-treated surfaces are therefore promising to act as a shoulder implant.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Van Vrekhem S,Vloebergh K,Asadian M,Vercruysse C,Declercq H,Van Tongel A,De Wilde L,De Geyter N,Morent Rdoi
10.1038/s41598-018-22921-6subject
Has Abstractpub_date
2018-03-16 00:00:00pages
4720issue
1issn
2045-2322pii
10.1038/s41598-018-22921-6journal_volume
8pub_type
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