BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis.

abstract：:Prestin in the lateral membrane of outer hair cells, is responsible for electromotility (EM) and a corresponding nonlinear capacitance (NLC). Prestin's voltage sensitivity is influenced by intracellular chloride. A regulator of intracellular chloride is a stretch-sensitive, non-selective conductance within the lateral...

journal_title：Scientific reports

authors： Bai JP,Moeini-Naghani I,Zhong S,Li FY,Bian S,Sigworth FJ,Santos-Sacchi J,Navaratnam D

更新日期：2017-04-19 00:00:00

abstract：:Delivery and expression of recombinant genes, a key methodology for many applications in biological research, remains a challenge especially for mature neurons. Here, we report easy, highly efficient and well tolerated transduction of adult peripheral and central neuronal populations of diverse species in culture usin...

journal_title：Scientific reports

authors： Levin E,Diekmann H,Fischer D

更新日期：2016-12-13 00:00:00

abstract：:Decreasing egg quality following oocyte ageing is a major restricting factor for the breeding programs. The mechanisms behind this process has not yet been clarified. To examine the possible involvement of oxidative stress in the oocyte ageing process, the relative mRNA abundance of specific transcripts were determine...

journal_title：Scientific reports

authors： Samarin AM,Samarin AM,Østbye TK,Ruyter B,Sampels S,Burkina V,Blecha M,Policar T

更新日期：2019-07-18 00:00:00

abstract：:Obstacles to widespread deployments of direct air capture of CO2 (DAC) lie in high material and energy costs. By grafting quaternary ammonium (QA) functional group to mesoporous polymers with high surface area, a unique DAC adsorbent with moisture swing adsorption (MSA) ability and ultra-high kinetics was developed in...

journal_title：Scientific reports

authors： Wang T,Wang X,Hou C,Liu J

更新日期：2020-12-08 00:00:00

abstract：:Regional differences in ion channel activity in the heart control the sequence of repolarization and may contribute to differences in contraction. Corticosteroids such as aldosterone or corticosterone increase the L-type Ca2+ current (ICaL) in the heart via the mineralocorticoid receptor (MR). Here, we investigate the...

journal_title：Scientific reports

authors： Wacker C,Dams N,Schauer A,Ritzer A,Volk T,Wagner M

更新日期：2020-07-14 00:00:00

abstract：:The aim was to assess the cognitive dysfunction and physical disability after autologous hematopoietic stem cell transplantation (AHSCT), to explore the potential factors influencing disability regression after AHSCT and to estimate the safety of low-dose immunosuppressive therapy in highly active Multiple Sclerosis (...

journal_title：Scientific reports

authors： Giedraitiene N,Kizlaitiene R,Peceliunas V,Griskevicius L,Kaubrys G

更新日期：2020-12-04 00:00:00

abstract：:By employing a single AlGaN layer with low Al composition, high quality and uniformity AlGaN/GaN heterostructures have been successfully grown on Si substrates by metal-organic chemical vapor deposition (MOCVD). The heterostructures exhibit a high electron mobility of 2150 cm(2)/Vs with an electron density of 9.3 × 10...

journal_title：Scientific reports

authors： Cheng J,Yang X,Sang L,Guo L,Zhang J,Wang J,He C,Zhang L,Wang M,Xu F,Tang N,Qin Z,Wang X,Shen B

更新日期：2016-03-10 00:00:00

abstract：:Cancer vaccines are less effective at old than at young age because of immunosenescence. Besides, in preliminary observations we showed that the immunization with HER-2/neu DNA plasmid in transgenic young mice (standard immunization, SI) delays but not abrogate spontaneous mammary tumours progressively appearing durin...

journal_title：Scientific reports

authors： Provinciali M,Barucca A,Orlando F,Pierpaoli E

更新日期：2017-06-08 00:00:00

abstract：:In recent and future synchrotron radiation facilities, relativistic electron bunches with increasingly high charge density are needed for producing brilliant light at various wavelengths, from X-rays to terahertz. In such conditions, interaction of electron bunches with their own emitted electromagnetic fields leads t...

journal_title：Scientific reports

authors： Bielawski S,Blomley E,Brosi M,Bründermann E,Burkard E,Evain C,Funkner S,Hiller N,Nasse MJ,Niehues G,Roussel E,Schedler M,Schönfeldt P,Steinmann JL,Szwaj C,Walther S,Müller AS

更新日期：2019-07-17 00:00:00

abstract：:As a two-dimensional material, graphene has attracted increasing attention as heat dissipation material owing to its excellent thermal transport property. In this work, we fabricated sisal nanocrystalline cellulose/functionalized graphene papers (NPGs) with high thermal conductivity by vacuum-assisted self-assembly me...

journal_title：Scientific reports

authors： Ren L,Wang M,Lu S,Pan L,Xiong Z,Zhang Z,Peng Q,Li Y,Yu J

更新日期：2019-03-14 00:00:00

abstract：:Trimethylamine-N-Oxide (TMAO) is a microbiome-related metabolite that is cleared by the kidney and linked to renal function. We explored the relationship between TMAO and all-cause mortality, and determined whether this association was modified by renal function. A prospective study was performed among PREVEND partici...

journal_title：Scientific reports

authors： Gruppen EG,Garcia E,Connelly MA,Jeyarajah EJ,Otvos JD,Bakker SJL,Dullaart RPF

更新日期：2017-10-23 00:00:00

abstract：:To better understand the effects of transient thermal stress in an aquatic insect, we first identified static temperatures associated with fitness deficits, and then reared larvae from egg hatch to adulthood under diurnally variable regimens including daily forays into deleterious temperatures. We sampled mature larva...

journal_title：Scientific reports

authors： Chou H,Jima DD,Funk DH,Jackson JK,Sweeney BW,Buchwalter DB

更新日期：2020-11-05 00:00:00

abstract：:In the present study, a surface-active enzyme, lipase was immobilized in polyethyleneimine (PEI) microcapsules and then modified with oxidized multiwall carbon nanotubes (MWCNTs). The resulting lipase microcapsules exhibited higher activity and stability, since the activity of microcapsules was 21.9 folds than that of...

journal_title：Scientific reports

authors： Su F,Li G,Fan Y,Yan Y

更新日期：2016-07-18 00:00:00

abstract：:Worldwide, prostate cancer (PCa) is the second most common malignancy in males. We undertook a meta-analysis to compare the efficacy and safety of conventional laparoscopic radical prostatectomy with a transperitoneal (TLRP) approach, versus that of an extraperitoneal (ELRP) approach, for treatment of localized PCa. A...

journal_title：Scientific reports

authors： De Hong C,Liang Ren L,Qiang W,Jia W,Ying Chun H,Lu Y,Zheng Hua L,Heng Ping L,Shi Bing Y,Yun Xiang L

更新日期：2015-10-13 00:00:00

abstract：:Converging evidence from laboratory models pointed that the widely used antidiabetic drug metformin has direct effects on cancer cells. Thus far, relatively little attention has been addressed to the drug exposures used experimentally relative to those achievable clinically. Here, we demonstrated that metformin loaded...

journal_title：Scientific reports

authors： Yoo S,Hou J,Yi W,Li Y,Chen W,Meng L,Si J,Hou X

更新日期：2017-04-21 00:00:00

abstract：:Habitat degradation is among the top drivers of the loss of global biodiversity. This problem is particularly acute in coral reef system. Here we investigated whether coral degradation influences predator risk assessment and learning for damselfish. When in a live coral environment, Ambon damselfish were able to learn...

journal_title：Scientific reports

authors： Chivers DP,McCormick MI,Allan BJ,Ferrari MC

更新日期：2016-09-09 00:00:00

abstract：:Vapor condensation is routinely used as an effective means of transferring heat or separating fluids. Dropwise condensation, where discrete droplets form on the condenser surface, offers a potential improvement in heat transfer of up to an order of magnitude compared to filmwise condensation, where a liquid film cover...

journal_title：Scientific reports

authors： Preston DJ,Lu Z,Song Y,Zhao Y,Wilke KL,Antao DS,Louis M,Wang EN

更新日期：2018-01-11 00:00:00

abstract：:The ability to avoid predators is crucial to wild prey animals' survival. Potential danger is signalled, among others, by the presence of predator scents. These odors are used in research both to trigger and to study fear reactions in laboratory animals; they are also employed as repellents against pest rodent species...

journal_title：Scientific reports

authors： Stryjek R,Mioduszewska B,Spaltabaka-Gędek E,Juszczak GR

更新日期：2018-06-21 00:00:00

abstract：:The present work presents and discusses the results of a comprehensive study on the bioactive properties of Nb-substituted silicate glass derived from 45S5 bioglass. In vitro and in vivo experiments were performed. We undertook three different types of in vitro analyses: (i) investigation of the kinetics of chemical r...

journal_title：Scientific reports

authors： Souza L,Lopes JH,Encarnação D,Mazali IO,Martin RA,Camilli JA,Bertran CA

更新日期：2018-08-24 00:00:00

abstract：:We report on the synthesis and thermal conductivity of gold nanoparticles (AuNPs) decorated graphene nanosheets (GNs) based nanofluids. The GNs-AuNPs nanocomposites were synthesised using a nanosecond pulsed Nd:YAG laser (wavelength = 1,064 nm) to ablate graphite target followed by Au in ethylene glycol (EG) base flui...

journal_title：Scientific reports

authors： Mbambo MC,Madito MJ,Khamliche T,Mtshali CB,Khumalo ZM,Madiba IG,Mothudi BM,Maaza M

更新日期：2020-09-07 00:00:00

abstract：:It is well recognized that osteocytes communicate with each other via gap junctions and that connxin43 (Cx43) shows its great potential in gap junction for the contribution enabling transmission of small molecules and operating in an autocrine/a paracrine manner. Fibroblast growth factors (FGFs) play significant roles...

journal_title：Scientific reports

authors： Liu XY,Li X,Bai MR,Chen X,Wang CL,Xie J,Ye L

更新日期：2018-10-04 00:00:00

abstract：:Nitric oxide (NO) produced by endothelial cells in response to cytokines displays anti-inflammatory activity by preventing the adherence, migration and activation of neutrophils. The molecular mechanism by which NO operates at the blood-endothelium interface to exert anti-inflammatory properties is largely unknown. He...

journal_title：Scientific reports

authors： Lai TS,Lindberg RA,Zhou HL,Haroon ZA,Dewhirst MW,Hausladen A,Juang YL,Stamler JS,Greenberg CS

更新日期：2017-11-23 00:00:00

abstract：:Gut microbiota acts as a barrier against intestinal pathogens, but species-specific protection of the host from infection remains relatively unexplored. Although lactobacilli and bifidobacteria produce beneficial lactic and short-chain fatty acids in the mammalian gut, the significance of intestinal Escherichia coli p...

journal_title：Scientific reports

authors： Christofi T,Panayidou S,Dieronitou I,Michael C,Apidianakis Y

更新日期：2019-10-08 00:00:00

abstract：:This study aimed to evaluate the application value of diffusion-weighted imaging (DWI) for assessing paradoxical puborectalis syndrome (PPS) in patients with obstructive defecation syndrome (ODS). The medical records of 72 ODS patients who underwent magnetic resonance (MR)-DWI and MR-defecography were retrospectively ...

journal_title：Scientific reports

authors： Liu G,Cui Z,Dai Y,Yao Q,Xu J,Wu G

更新日期：2017-06-07 00:00:00

abstract：:Soybean seeds are an important source of vegetable oil and biomaterials. The content of individual triacylglycerol species (TAG) in soybean seeds is difficult to quantify in an accurate and rapid way. The present study establishes an approach to quantify TAG species in soybean seeds utilizing an electrospray ionizatio...

journal_title：Scientific reports

authors： Li M,Butka E,Wang X

更新日期：2014-10-10 00:00:00

abstract：:The development of physiologically active semiochemicals is largely limited by the labor-consuming searching process. How to screen active semiochemicals efficiently is of significance to the extension of behavior regulation in pest control. Here pharmacophore modeling and shape-based virtual screening were combined t...

journal_title：Scientific reports

authors： Liu J,Tian Z,Zhang Y

更新日期：2016-10-06 00:00:00

abstract：:Platelet-driven reduction in blood clot volume (clot contraction or retraction) has been implicated to play a role in hemostasis and thrombosis. Although these processes are often linked with inflammation, the role of inflammatory cells in contraction of blood clots and thrombi has not been investigated. The aim of th...

journal_title：Scientific reports

authors： Peshkova AD,Le Minh G,Tutwiler V,Andrianova IA,Weisel JW,Litvinov RI

更新日期：2017-07-11 00:00:00

abstract：:Although recent studies have shed insights on some of the potential causes of male infertility, new underlining molecular mechanisms still remain to be elucidated. Makorin-2 (Mkrn2) is an evolutionarily conserved gene whose biological functions are not fully known. We developed an Mrkn2 knockout mouse model to study t...

journal_title：Scientific reports

authors： Qian X,Wang L,Zheng B,Shi ZM,Ge X,Jiang CF,Qian YC,Li DM,Li W,Liu X,Yin Y,Zheng JT,Shen H,Wang M,Guo XJ,He J,Lin M,Liu LZ,Sha JH,Jiang BH

更新日期：2016-12-23 00:00:00

abstract：:DNA-based data storage has emerged as a promising method to satisfy the exponentially increasing demand for information storage. However, practical implementation of DNA-based data storage remains a challenge because of the high cost of data writing through DNA synthesis. Here, we propose the use of degenerate bases a...

journal_title：Scientific reports

authors： Choi Y,Ryu T,Lee AC,Choi H,Lee H,Park J,Song SH,Kim S,Kim H,Park W,Kwon S

更新日期：2019-04-29 00:00:00

abstract：:Tobacco smoking is the major cause of many chronic diseases, especially lung cancer. Knowledge about population-wide tobacco use and exposure is essential to characterise its burden on public health and evaluate policy efficacy. Obtaining such knowledge remains challenging with current methods (e.g., surveys, biomonit...

journal_title：Scientific reports

authors： Lai FY,Lympousi K,Been F,Benaglia L,Udrisard R,Delémont O,Esseiva P,Thomaidis NS,Covaci A,van Nuijs ALN

更新日期：2018-09-05 00:00:00